Gary Daughdrill, PhD

Associations

• Cancer Biology & Evolution Program

Education & Training

Graduate:

• University of Oregon, PhD - Biochemistry

• Gregory E, Daughdrill GW. Sequence Properties of An Intramolecular Interaction That Inhibits p53 DNA Binding. Biomolecules. 2022 Oct.12(11). Pubmedid: 36358908. Pmcid: PMC9687289.
• Fenton M, Borcherds W, Chen L, Anbanandam A, Levy R, Chen J, Daughdrill G. The MDMX Acidic Domain Uses Allovalency to Bind Both p53 and MDMX. J Mol Biol. 2022 Nov.434(22):167844. Pubmedid: 36181774. Pmcid: PMC9644833.
• Sang P, Shi Y, Lu J, Chen L, Yang L, Borcherds W, Abdulkadir S, Li Q, Daughdrill G, Chen J, Cai J. Correction to α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53-MDM2/MDMX Protein-Protein Interactions. J Med Chem. 2020 Sep.63(17):10087. Pubmedid: 32822169. Pmcid: PMC7853636.
• Shi Y, Sang P, Lu J, Higbee P, Chen L, Yang L, Odom T, Daughdrill G, Chen J, Cai J. Rational Design of Right-Handed Heterogeneous Peptidomimetics as Inhibitors of Protein-Protein Interactions. J Med Chem. 2020 Nov.63(21):13187-13196. Pubmedid: 33140956. Pmcid: PMC8170677.
• Li Q, Karim RM, Cheng M, Das M, Chen L, Zhang C, Lawrence HR, Daughdrill GW, Schonbrunn E, Ji H, Chen J. Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity. Oncogene. 2020 Jul.39(29):5187-5200. Pubmedid: 32555331. Pmcid: PMC7398576.
• Daughdrill GW. Disorder for Dummies: Functional Mutagenesis of Transient Helical Segments in Disordered Proteins. Methods Mol Biol. 2020 Jul.2141:3-20. Pubmedid: 32696350.
• Sang P, Shi Y, Lu J, Chen L, Yang L, Borcherds W, Abdulkadir S, Li Q, Daughdrill GW, Chen J, Cai J. α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53-MDM2/MDMX Protein-Protein Interactions. J Med Chem. 2020 Feb.63(3):975-986. Pubmedid: 31971801. Pmcid: PMC7025332.
• Sang P, Shi Y, Higbee P, Wang M, Abdulkadir S, Lu J, Daughdrill GW, Chen J, Cai J. Rational Design and Synthesis of Right-Handed d-Sulfono-γ-AApeptide Helical Foldamers as Potent Inhibitors of Protein-Protein Interactions. J Org Chem. 2020 Aug.85(16):10552-10560. Pubmedid: 32700908. Pmcid: PMC8204676.
• Levy R, Gregory E, Borcherds W, Daughdrill G. p53 Phosphomimetics Preserve Transient Secondary Structure but Reduce Binding to Mdm2 and MdmX. Biomolecules. 2019 Mar.9(3). Pubmedid: 30832340. Pmcid: PMC6468375.
• Sowemimo OT, Knox-Brown P, Borcherds W, Rindfleisch T, Thalhammer A, Daughdrill GW. Conserved Glycines Control Disorder and Function in the Cold-Regulated Protein, COR15A. Biomolecules. 2019 Mar.9(3). Pubmedid: 30832369. Pmcid: PMC6468432.
• Borcherds WM, Daughdrill GW. Using NMR Chemical Shifts to Determine Residue-Specific Secondary Structure Populations for Intrinsically Disordered Proteins. Methods Enzymol. 2019 Jul.611:101-136. Pubmedid: 30471686. Pmcid: PMC8130511.
• He F, Borcherds W, Song T, Wei X, Das M, Chen L, Daughdrill GW, Chen J. Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding. Proc Natl Acad Sci U S A. 2019 Apr.116(18):8859-8868. Pubmedid: 30988205. Pmcid: PMC6500136.
• Poosapati A, Gregory E, Borcherds WM, Chemes LB, Daughdrill GW. Uncoupling the Folding and Binding of an Intrinsically Disordered Protein. J Mol Biol. 2018 Aug.430(16):2389-2402. Pubmedid: 29890118. Pmcid: PMC6082395.
• Borcherds W, Becker A, Chen L, Chen J, Chemes LB, Daughdrill GW. Optimal Affinity Enhancement by a Conserved Flexible Linker Controls p53 Mimicry in MdmX. Biophys J. 2017 May.112(10):2038-2042. Pubmedid: 28487147. Pmcid: PMC5443996.
• Chen L, Borcherds W, Wu S, Becker A, Schonbrunn E, Daughdrill GW, Chen J. Autoinhibition of MDMX by intramolecular p53 mimicry. Proc Natl Acad Sci U S A. 2015 Apr.112(15):4624-4629. Pubmedid: 25825738. Pmcid: PMC4403185.
• Ytreberg FM, Borcherds W, Wu H, Daughdrill GW. Using chemical shifts to generate structural ensembles for intrinsically disordered proteins with converged distributions of secondary structure. Intrinsically Disord Proteins. 2015.3(1):e984565. Pubmedid: 28232883. Pmcid: PMC5314943.
• Borcherds W, Kashtanov S, Wu H, Daughdrill GW. Structural divergence is more extensive than sequence divergence for a family of intrinsically disordered proteins. Proteins. 2013 Oct.81(10):1686-1698. Pubmedid: 23606624.
• Zhan YA, Wu H, Powell AT, Daughdrill GW, Ytreberg FM. Impact of the K24N mutation on the transactivation domain of p53 and its binding to murine double-minute clone 2. Proteins. 2013 Oct.81(10):1738-1747. Pubmedid: 23609977. Pmcid: PMC4160123.
• Kennedy JA, Daughdrill GW, Schmidt KH. A transient α-helical molecular recognition element in the disordered N-terminus of the Sgs1 helicase is critical for chromosome stability and binding of Top3/Rmi1. Nucleic Acids Res. 2013 Dec.41(22):10215-10227. Pubmedid: 24038467. Pmcid: PMC3905885.
• Doi K, Li R, Sung SS, Wu H, Liu Y, Manieri W, Krishnegowda G, Awwad A, Dewey A, Liu X, Amin S, Cheng C, Qin Y, Schonbrunn E, Daughdrill G, Loughran TP, Sebti S, Wang HG. Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation. J Biol Chem. 2012 Mar.287(13):10224-10235. Pubmedid: 22311987. Pmcid: PMC3323047.
• Daughdrill GW, Kashtanov S, Stancik A, Hill SE, Helms G, Muschol M, Receveur-Bréchot V, Ytreberg FM. Understanding the structural ensembles of a highly extended disordered protein. Mol Biosyst. 2012 Jan.8(1):308-319. Pubmedid: 21979461. Pmcid: PMC3645981.
• Daughdrill GW, Borcherds WM, Wu H. Disorder predictors also predict backbone dynamics for a family of disordered proteins. PLoS One. 2012 Aug.6(12):e29207. Pubmedid: 22195023. Pmcid: PMC3240651.
• Kashtanov S, Borcherds W, Wu H, Daughdrill GW, Ytreberg FM. Using chemical shifts to assess transient secondary structure and generate ensemble structures of intrinsically disordered proteins. Methods Mol Biol. 2012.895:139-152. Pubmedid: 22760318.
• Daughdrill GW. Protein dynamics: bridging the gap. Nat Chem Biol. 2011 Apr.7(4):193-194. Pubmedid: 21423160.
• Sota M, Yano H, Hughes JM, Daughdrill GW, Abdo Z, Forney LJ, Top EM. Shifts in the host range of a promiscuous plasmid through parallel evolution of its replication initiation protein. ISME J. 2010 Dec.4(12):1568-1580. Pubmedid: 20520653. Pmcid: PMC3042886.
• Daughdrill GW, Narayanaswami P, Gilmore SH, Belczyk A, Brown CJ. Dynamic behavior of an intrinsically unstructured linker domain is conserved in the face of negligible amino acid sequence conservation. J Mol Evol. 2007 Sep.65(3):277-288. Pubmedid: 17721672.
• Vise P, Baral B, Stancik A, Lowry DF, Daughdrill GW. Identifying long-range structure in the intrinsically unstructured transactivation domain of p53. Proteins. 2007 May.67(3):526-530. Pubmedid: 17335006.
• Olson KE, Narayanaswami P, Vise PD, Lowry DF, Wold MS, Daughdrill GW. Secondary structure and dynamics of an intrinsically unstructured linker domain. J Biomol Struct Dyn. 2005 Oct.23(2):113-124. Pubmedid: 16060685.