Immunology Department Metrics

View the clinical trials, grants and publications from the Department of Immunology.

Clinical Trials
Phase II study of stereotactic body radiation therapy and atezolizumab in the management of recurrent, persistent, or metastatic cervical cancer
Condition: Gynecological Tumor
Intervention: Atezolizumab (Tecentriq)

Managed Access Program (MAP) To Provide Access To CTL019, For Acute Lymphoblastic Leukemia (ALL) Or Diffuse Large B-Cell Lymphoma (DLBCL) Patients With Out Of Specification Leukapheresis Product And/Or Manufactured Tisagenlecleucel Out Of Specification For Commercial Release
Condition: Malignant Hematology

CD8 Depleted, Non-Engrafting, HLA Mismatched Unrelated Donor Lymphocyte Infusion in Patients with MDS and Secondary AML
Condition: Malignant Hematology
Intervention: Cladribine (); Cytarabine (Cytosine Arabinoside); Daunomycin (daunorubicin); G-CSF (); Idarubicin (); Zevados (Idarubicin); daunorubicin ()

Neoadjuvant Immunotherapy with Intratumoral Tavokinogene Telseplasmid (Tavo) plus Electroporation in Combination with Intravenous Nivolumab in Patients with Operable Locally- Regionally Advanced Melanoma
Condition: Cutaneous
Intervention: BMS-936558 (Nivolumab); Nivolumab (Opdivo); Tavo-EP ()

Phase I/II Study of Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in the Management of HER2+ Breast Leptomeningeal Disease
Condition: Breast
Intervention: Herceptin (Trastuzumab); Pertuzumab (); Radiotherapy (); Trastuzumab (); rhuMAb HER2 (Trastuzumab)

A Single-Arm, Open-Label, Phase 1/2 Study Evaluating the Safety, Efficacy, and Cellular Kinetics/Pharmocodynamics of ALLO-501A, an Anti-CD19 Allogeneic Car T Cell Therapy in Subjects with Relapsed/Refractory Large B-Cell Lymphoma (LBCL)
Condition: Malignant Hematology
Intervention: ALLO-501A (); ALLO-647 (); cyclophosphamide (); cytoxan (cyclophosphamide); fludarabine (Fludarabine phosphate)

A Phase 1 Study of CG0070 Combined with Nivolumab in Cisplatin Ineligible Patients with Muscle Invasive Bladder Cancer (MIBC)
Condition: Genitourinary
Intervention: BMS-936558 (Nivolumab); CG0070 (); DDM (); Nivolumab (Opdivo)

Optimizing Cellular and Humoral Immunity to Pneumococcus by Vaccination with Pneumococcal 13-valent conjugate vaccine before and after CD19-targeted CAR T-cell Immunotherapy
Condition: Immunotherapy
Intervention: CD19 CAR T Cells (); PCV13 ()

Expanded Access Protocol (EAP) for Subjects Receiving Lisocabtagene Maraleucel That is Nonconforming for Commercial Release
Condition: Malignant Hematology
Intervention: cyclophosphamide (); cytoxan (cyclophosphamide); fludarabine (Fludarabine phosphate); lisocabtagene maraleucel ()

S1827, MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK)
Condition: Thoracic

Phase III Randomized Trial of Pleurectomy/Decortication plus Chemotherapy with or without Adjuvant Hemithoracic Intensity-Modulated Pleural Radiation Therapy (IMPRINT) for Malignant Pleural Mesothelioma (MPM)
Condition: Thoracic

A Phase Ib /Randomized Phase III Trial of Patients with Advanced Hematologic Malignancies Undergoing Allogeneic Hematopoietic Cell Transplantation with Either Orca-T, a T-cell-Depleted Graft with Additional Infusion of Conventional T cells and Regulatory T cells, or Standard-of-Care Allogeneic Graft
Condition: Malignant Hematology
Intervention: FK506 (Tacrolimus); Rapamune (Sirolimus); Rapamycin (Sirolimus); Sirolimus (); Tacrolimus ()

Neoadjuvant Cemiplimab in Newly Diagnosed or Recurrent Stage I-II Merkel Cell Carcinoma: Safety and Biomarker Analysis
Condition: Cutaneous
Intervention: Cemiplimab (); REGN2810 (Cemiplimab)

A Phase I/II Trial of Maintenance Fedratinib to Prevent Post-Transplant Relapse in Myeloproliferative Neoplasms
Condition: Malignant Hematology
Intervention: Fedratinib ()

Phase I/II Study of Stereotactic Radiation and Abemaciclib in the Management of Hormone Receptor Positive HER2 Negative Breast Cancer Brain Metastases
Condition: Breast
Intervention: Abemaciclib (); Endocrine Therapy (); LY2835219 (Abemaciclib); Radiotherapy ()

A Phase II Study of Binimetinib plus Belinostat for Subjects with Metastatic Uveal Melanoma
Condition: Cutaneous
Intervention: Belinostat (); Binimetinib (); PXD101 (Belinostat)

A Phase 1, Open-Label, Dose-Escalation, and Dose-Expansion Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of SRK-181 Administered Alone or in Combination with a Checkpoint Inhibitor in Patients with Locally Advanced or Metastatic Solid Tumors (DRAGON)
Condition: Multiple
Intervention: Atezolizumab (Tecentriq); BMS-936558 (Nivolumab); Cemiplimab (); Nivolumab (Opdivo); Pembrolizumab (Keytruda); REGN2810 (Cemiplimab); SRK-181 ()

Randomized Phase II/III Study of Nivolumab plus Ipilimumab plus Sargramostim versus Nivolumab plus Ipilimumab in Patients with Unresectable Stage III or Stage IV Melanoma
Condition: Cutaneous
Intervention: BMS-936558 (Nivolumab); Ipilimumab (); Nivolumab (Opdivo); Sargramostim (); Yervoy (Ipilimumab)

A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients with Melanoma (Morpheus-Melanoma)
Condition: Cutaneous
Intervention: Atezolizumab (Tecentriq); BMS-936558 (Nivolumab); Ipilimumab (); Nivolumab (Opdivo); RO7247669 (); Tiragolumab (); Yervoy (Ipilimumab)

Phase 2/3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of ALVR105 (Viralym-M) Compared to Placebo for the Prevention of AdV, BKV, CMV, EBV, HHV-6, and JCV Infection and/or Disease, in High-Risk Patients After Allogeneic Hematopoietic Cell Transplant
Condition: Malignant Hematology

Phase II Study of Screening Brain MRIs in Stage IV Breast Cancer
Condition: Breast

Evaluating Gut Microbiome As A Biomarker Of Pathological Complete Response In Patients With Early Triple Negative Breast Cancer - A Pilot Study (TCC)
Condition: Breast

A Phase 1/2 Study of bbT369, a Dual Targeting CAR T cell Drug Product with a Gene Edit, in Relapsed and/or Refractory B cell Non-Hodgkin s Lymphoma
Condition: Immunotherapy
Intervention: Lymphodepletion (); bbT369 (); cyclophosphamide (); cytoxan (cyclophosphamide); fludarabine (Fludarabine phosphate)

A Phase 1/2 Dose-Escalation and Dose-Expansion of the Safety and Efficacy of Anti-CD7 Allogeneic CAR-T cells (WU-CART-007) in Patients with Relapsed or Refractory T-cell Acute Lymphoblastic Leukemia /Lymphoblastic Lymphoma (T-ALL)/Lymphoblastic Lymphoma (LBL)
Condition: Malignant Hematology
Intervention: WU-CART-007 ()

A Phase 1 Study of AGEN2373, an Anti-CD137 Monoclonal Antibody, as Monotherapy and in Combination with AGEN1181, an Fc-Enqineered Anti-CTLA-4 Monoclonal Antibody, in Patients with Advanced Cancer
Condition: Cutaneous
Intervention: AGEN1181 (); AGEN2373 ()

Phase II Study of Genomically Guided Radiation Dose Personalization in the Management of Triple Negative Breast Cancer
Condition: Breast
Intervention: Radiotherapy ()

A Phase 3 Study of CG0070 In Patients with Non- Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Bacillus Calmette-Guerin (BCG)
Condition: Genitourinary
Intervention: CG0070 (); DDM ()

  • 2/2 Ponce School of Medicine-Moffitt Cancer Center Partnership
    Sponsor: Nat Institutes of Health
    PI (Contact):Wright, K.,PI (MPI):Monteiro, A.
  • Augmenting T Cell Trafficking and Functionality through Novel Combinations of Epigenetic Agents and PD-1 Blockade
    Sponsor: Nat Institutes of Health
    PI:Beg, A.
  • Regulatory Dendritic Cells in Cancer
    Sponsor: Nat Institutes of Health
    PI:Conejo-Garcia, J.
  • Regulation of dendritic cell function and tumor immunity by TIM-3
    Sponsor: Nat Institutes of Health
    PI:Ruffell, B.
  • B Cell-dependent Anti-tumor Immunity in Ovarian Cancer
    Sponsor: Nat Institutes of Health
    PI:Conejo-Garcia, J.
  • Functional reprogramming of tumor-MDSC through antibody-based therapies Targeting Notch Ligands
    Sponsor: Nat Institutes of Health
    PI:Rodriguez, P.
  • Imaging Acidosis and Immune Therapy in PDAC
    Sponsor: Nat Institutes of Health
    PI (Contact):Pilon-Thomas, S.,PI:Ibrahim Hashim, A.
  • Targetable Epidgenetic Mechanism Driving Cutaneous T Cell Lymphoma
    Sponsor: Nat Institutes of Health
    PI (Contact):Conejo-Garcia, J.,PI:Pinilla, J.,PI:Sokol, L.
  • Understanding the influence of bone-metastatic prostate cancer and mesenchymal stromal cells on γδ T cells, in the bone microenvironment.
    Sponsor: Nat Institutes of Health
    PI:Abate Daga, D.
  • Intellia Research Collaboration - Project 1: Advancing Neoantigen-Specific T Cells
    Sponsor: Intellia Therapeutics
    PI:Pilon-Thomas, S.,CO-PI:Abate Daga, D.
  • A Phase II Biomarker Trial of CC-122 in Combination with Nivolumab in Advanced Melanoma
    Sponsor: Celgene Corp.
    PI:Pilon-Thomas, S.
  • Notch signaling boosts T cell-based immunotherapy
    Sponsor: Florida Biomedical Research Program (FBRP)
    PI:Rodriguez, P.,CO-PI:Luca, V.
    Sponsor: Nat Institutes of Health
    PI:Conejo-Garcia, J.
  • Dissecting the immunological mechanisms associated with prostate cancer progression in African-American men and exploring epigenetics-based immune modulation for therapy
    Sponsor: Nat Institutes of Health
    PI:Adeegbe, D.
  • Utilize patient-derived PCa explants to define the mechanism of RT-induced changes in Tumor Microenvironment to promote response to immune-modulatory therapy
    Sponsor: Moffitt Cancer Center
    PI:Rodriguez, P.
  • Role of Bcl11b in CD4+ T Cells and Innate Lymphoid Cells
    Sponsor: Nat Institutes of Health
    PI:Avram, D.
  • High throughput screening assays to identify chemical probes targeting Hectd3, an E3 ubiquitin ligase
    Sponsor: Nat Institutes of Health
    PI (MPI):Avram, D.
  • Directing Tryptophan Immunometabolism to Ameliorate Liver Ischemic-Reperfusion Injury
    Sponsor: Nat Institutes of Health
    PI:Avram, D.
  • Bile acids restrict functional reprogramming of myeloid-derived suppressor cells in tumor beds
    Sponsor: Nat Institutes of Health
    PI:Rodriguez, P.
  • Plant-derived extracts regulate immunosuppressive myelopoiesis in Breast cancer patients
    Sponsor: Nat Institutes of Health
    PI:Rodriguez, P.
  • Mechanisms of functional heterogeneity of tumor associated macrophages in glioblastoma
    Sponsor: Ivy (Ben & Catherine) Fdtn
    PI:Veglia, F.
  • Institutional Research Grant - Moffitt Cancer Center
    Sponsor: Amer Cancer Society
    PI:Wright, K.
  • Platinum-induced lipid reprogramming and tumor immune microenvironment in SCLC
    Sponsor: Nat Institutes of Health
    PI:Avram, D.
  • Study of Anti-Tumor Immunity and Tissue Resident Memory Cell Development by NKG2D and Ribosomal Protein S6 Signaling in T cells
    Sponsor: Nat Institutes of Health
    PI:Guevara, J.
  • Tech Transfer support and clinical protocol development for the use of TIL in patients with melanoma
    Sponsor: Turnstone Biologics
    PI:Pilon-Thomas, S.,CO-PI:Mulé, J.
  • Development of Adoptive T-Cell Therapy in Bladder Cancer Incorporating Patient-Specific Tumor Microenvironment
    Sponsor: US Army
    PI:Pilon-Thomas, S.
  • Heterogeneity of metastatic small cell lung cancer; implications for the design of effective immunotherapies
    Sponsor: Florida Biomedical Research Program (FBRP)
    PI (Contact):Conejo-Garcia, J.,CO-PI:Perez, B.
  • Targeting ENPP1 to promote immunity during PARP inhibition in TNBC
    Sponsor: US Army
    PI:Ruffell, B.
  • Transdermal Alkalinization Treatment as an Adjunct in Melanoma Therapy
    Sponsor: Dyve Biosciences
    PI:Pilon-Thomas, S.,CO-PI:Gillies, R.
  • Mitochondrial stress promotes immunosuppressive potential of myeloid subsets in tumors
    Sponsor: Nat Institutes of Health
    PI:Rodriguez, P.
  • The Role of Hypoxia on Tumor Infiltrating Lymphocytes (TIL) from Renal Cell Carcinoma (RCC)
    Sponsor: US Army
    PI (Contact):Pilon-Thomas, S.,CO-PI:Chahoud, J.
  • Defining Tumor Infiltrating B Cells and Their Role in the Modulation of TIL Immunotherapy
    Sponsor: The Mark Foundation for Cancer Research
    PI:Pilon-Thomas, S.,CO-PI:Abate Daga, D.
  • Targeting dendritic cells to improve cancer immunotherapy
    Sponsor: Cancer Research Institute
    PI:Ruffell, B.
  • Olfactory Receptor OR2H1 as an effective target for CAR T cells in human epithelial tumors
    Sponsor: Cancer Research Institute
    PI:Conejo-Garcia, J.
  • Improving melanoma immunotherapy through connections of TLSs, TIL, STING, and MARCO
    Sponsor: Adelson (Miriam & Sheldon) Medical Res Fdtn
    PI:Mulé, J.
  • Liveringhouse CL, Latifi K, Asous AG, Lam NB, Rosenberg SA, Dilling TJ, MacMillan GV, Chiappori AA, Haura EB, Creelan B, Gray JE, Tanvetyanon T, Shafique MR, Saltos AN, Weiner AA, Clarke J, Kelsey CR, Kim S, Caudell JJ, Rose TA, Conejo-Garcia JR, Li J, Schell MJ, Antonia SJ, Perez BA. Dose Limiting Pulmonary Toxicity in a Phase I/II Study of Radiation and Chemotherapy with Ipilimumab followed by Nivolumab for Patients with Stage III Unresectable Non-small Cell Lung Cancer. Int J Radiat Oncol Biol Phys. 2023 Jan. Pubmedid: 36657497.
  • Hathaway CA, Wang T, Townsend MK, Vinci C, Jake-Schoffman DE, Saeed-Vafa D, Moran Segura C, Nguyen JV, Conejo-Garcia JR, Fridley BL, Tworoger SS. Lifetime Exposure to Cigarette Smoke and Risk of Ovarian Cancer by T-cell Tumor Immune Infiltration. Cancer Epidemiol Biomarkers Prev. 2023 Jan.32(1):66-73. Pubmedid: 36318652. Pmcid: PMC9839509.
  • Gonzalez-Perez D, Das S, Antfolk D, Ahsan HS, Medina E, Dundes CE, Jokhai RT, Egan ED, Blacklow SC, Loh KM, Rodriguez PC, Luca VC. Affinity-matured DLL4 ligands as broad-spectrum modulators of Notch signaling. Nat Chem Biol. 2023 Jan.19(1):9-17. Pubmedid: 36050494.
  • Martin AL, Powell C, Nagy MZ, Innamarato P, Powers J, Nichols D, Anadon CM, Chaurio RA, Kim S, Wang MH, Gong B, Wang X, Scheutz TJ, Antonia SJ, Conejo-Garcia JR, Perez BA. Anti-4-1BB immunotherapy enhances systemic immune effects of radiotherapy to induce B and T cell-dependent anti-tumor immune activation and improve tumor control at unirradiated sites. Cancer Immunol Immun. 2022 Dec. Pubmedid: 36469096.
  • Zhang H, Tomar VS, Li J, Basavaraja R, Yan F, Gui J, McBrearty N, Costich TL, Beiting DP, Blanco MA, Nefedova Y, Conejo-Garcia JR, Saggu G, Berger AJ, Gabrilovich DI, Fuchs SY. Protection of Regulatory T Cells from Fragility and Inactivation in the Tumor Microenvironment. Cancer Immunol Res. 2022 Dec.10(12):1490-1505. Pubmedid: 36255418. Pmcid: PMC9722544.
  • Hall MS, Mullinax JE, Cox CA, Hall AM, Beatty MS, Blauvelt J, Innamarato P, Nagle L, Branthoover H, Wiener D, Schachner B, Martinez AJ, Richards AD, Rich CJ, Colón Colón M, Schell MJ, Teer JK, Khushalani NI, Weber JS, Mule JJ, Sondak VK, Pilon-Thomas S, Sarnaik AA. Combination Nivolumab, CD137 Agonism, and Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes for Patients with Metastatic Melanoma. Clin Cancer Res. 2022 Dec.28(24):5317-5329. Pubmedid: 36215121.
  • Tarhini AA, Hanayneh WB, Powers JJ, Segura CMM, Conejo-Garcia JR, Lam CA, Hakam A, Hoffman MS. Case Report: Durable complete pathologic response and organ preservation following ipilimumab and nivolumab for locally advanced primary vaginal mucosal melanoma. Front Oncol. 2022 Nov.12:1044587. Pubmedid: 36531031. Pmcid: PMC9748561.
  • Gallen C, Dukes CW, Aldrich A, Macaisa L, Mo Q, Cubitt CL, Pilon-Thomas S, Giuliano AR, Czerniecki BJ, Costa RLB. Long-Term CD4+ T-Cell and Immunoglobulin G Immune Responses in Oncology Workers following COVID-19 Vaccination: An Interim Analysis of a Prospective Cohort Study. Vaccines (Basel). 2022 Nov.10(11). Pubmedid: 36423026. Pmcid: PMC9696551.
  • Lathia JD, Bayik D, Bartels CF, Lovrenert K, Watson DC, Zhang D, Kay K, Lee J, Lauko A, Johnson S, Lo A, Silver DJ, McGraw M, Grabowski MM, Mohammadi AM, Veglia F, Fan Y, Vogelbaum MA, Scacheri PC. Distinct Cell Adhesion Signature Defines Glioblastoma Myeloid-Derived Suppressor Cell Subsets. Cancer Res. 2022 Nov.82(22):4274-4287. Pubmedid: 36126163. Pmcid: PMC9664137.
  • Salvagno C, Mandula JK, Rodriguez PC, Cubillos-Ruiz JR. Decoding endoplasmic reticulum stress signals in cancer cells and antitumor immunity. Trends Cancer. 2022 Nov.8(11):930-943. Pubmedid: 35817701. Pmcid: PMC9588488.
  • Conejo-Garcia JR, Guevara-Patino JA. Barriers and Opportunities for CAR T-Cell Targeting of Solid Tumors. Immunol Invest. 2022 Nov.51(8):2215-2225. Pubmedid: 35797428. Pmcid: PMC9795814.
  • Kwiatkowski AJ, Helm EY, Stewart JM, Drashansky TT, Cho JJ, Avram D, Keselowsky BG. Treatment with an antigen-specific dual microparticle system reverses advanced multiple sclerosis in mice. Proc Natl Acad Sci U S A. 2022 Oct.119(43):e2205417119. Pubmedid: 36256820. Pmcid: PMC9618088.
  • Li J, Ruffell B. Cytokines drive prostate cancer lineage plasticity. Immunity. 2022 Oct.55(10):1761-1763. Pubmedid: 36223725.
  • Gupta PK, Allocco JB, Fraipont JM, McKeague ML, Wang P, Andrade MS, McIntosh C, Chen L, Wang Y, Li Y, Andrade J, Conejo-Garcia JR, Chong AS, Alegre ML. Reduced Satb1 expression predisposes CD4+ T conventional cells to Treg suppression and promotes transplant survival. Proc Natl Acad Sci U S A. 2022 Oct.119(40). Pubmedid: 36161903. Pmcid: PMC9546564.
  • Mandula JK, Chang S, Mohamed E, Jimenez R, Sierra-Mondragon RA, Chang DC, Obermayer AN, Moran-Segura CM, Das S, Vazquez-Martinez JA, Prieto K, Chen A, Smalley KSM, Czerniecki B, Forsyth P, Koya RC, Ruffell B, Cubillos-Ruiz JR, Munn DH, Shaw TI, Conejo-Garcia JR, Rodriguez PC. Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses. Cancer Cell. 2022 Oct.40(10):1145-1160.e9. Pubmedid: 36150390. Pmcid: PMC9561067.
  • Hesterberg RS, Liu M, Elmarsafawi AG, Koomen JM, Welsh EA, Hesterberg SG, Ranatunga S, Yang C, Li W, Lawrence HR, Rodriguez PC, Berglund AE, Cleveland JL. TCR-Independent Metabolic Reprogramming Precedes Lymphoma-Driven Changes in T-cell Fate. Cancer Immunol Res. 2022 Oct.10(10):1263-1279. Pubmedid: 35969234. Pmcid: PMC9662872.
  • Law V, Chen Z, Vena F, Smalley I, Macaulay R, Evernden BR, Tran N, Pina Y, Puskas J, Caceres G, Bayle S, Johnson J, Liu JKC, Etame A, Vogelbaum M, Rodriguez P, Duckett D, Czerniecki B, Chen A, Smalley KSM, Forsyth PA. A preclinical model of patient-derived cerebrospinal fluid circulating tumor cells for experimental therapeutics in leptomeningeal disease from melanoma. Neurooncol. 2022 Oct.24(10):1673-1686. Pubmedid: 35213727. Pmcid: PMC9527526.
  • Anadon CM, Zhang C, Wang X, Cen L, Conejo-Garcia JR, Yu X. Protocol for the isolation of CD8+ tumor-infiltrating lymphocytes from human tumors and their characterization by single-cell immune profiling and multiome. STAR Protoc. 2022 Sep.3(3):101649. Pubmedid: 36065294. Pmcid: PMC9440482.
  • Celias DP, de Mingo Pulido Á, Ruffell B. Detection of exogenous DNA uptake by murine dendritic cells. STAR Protoc. 2022 Sep.3(3):101464. Pubmedid: 35719726. Pmcid: PMC9204794.
  • Conejo-Garcia JR, Curiel TJ. Belly Fat Weakens Immune Fitness. Cancer Discov. 2022 Aug.12(8):1841-1843. Pubmedid: 35929132.
  • Mullinax JE, Pilon-Thomas S. Adoptive Cell Therapy for Advanced Solid Tumors. Cancer J. 2022 Jul.28(4):255-256. Pubmedid: 35880933.
  • Bustos X, Snedal S, Tordesillas L, Pelle E, Abate-Daga D. γδ T Cell-Based Adoptive Cell Therapies Against Solid Epithelial Tumors. Cancer J. 2022 Jul.28(4):270-277. Pubmedid: 35880936. Pmcid: PMC9335899.
  • Alkhouli MA, Bazargan S, Pilon-Thomas S, Poch M, Chahoud J. Current State of Cell Therapies for Genitourinary Malignancies. Cancer J. 2022 Jul.28(4):294-300. Pubmedid: 35880939.
  • Hensel J, Metts J, Gupta A, Ladle BH, Pilon-Thomas S, Mullinax J. Adoptive Cellular Therapy for Pediatric Solid Tumors: Beyond Chimeric Antigen Receptor-T Cell Therapy. Cancer J. 2022 Jul.28(4):322-327. Pubmedid: 35880942.
  • Bekker RA, Zahid MU, Binning JM, Spring BQ, Hwu P, Pilon-Thomas S, Enderling H. Rethinking the immunotherapy numbers game. J Immunother Cancer. 2022 Jul.10(7). Pubmedid: 35793871. Pmcid: PMC9260835.
  • Ming Q, Celias DP, Wu C, Cole AR, Singh S, Mason C, Dong S, Tran TH, Amarasinghe GK, Ruffell B, Luca VC. LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition. Nat Immunol. 2022 Jul.23(7):1031-1041. Pubmedid: 35761082.
  • Martin AL, Anadon CM, Biswas S, Mine JA, Handley KF, Payne KK, Mandal G, Chaurio RA, Powers JJ, Sprenger KB, Rigolizzo KE, Innamarato P, Harro CM, Mehta S, Perez BA, Wenham RM, Conejo-Garcia JR. Olfactory Receptor OR2H1 Is an Effective Target for CAR T Cells in Human Epithelial Tumors. Mol Cancer Ther. 2022 Jul.21(7):1184-1194. Pubmedid: 35499393. Pmcid: PMC9256805.
  • Daniel Grass G, Alfonso JCL, Welsh E, Ahmed KA, Teer JK, Pilon-Thomas S, Harrison LB, Cleveland JL, Mulé JJ, Eschrich SA, Enderling H, Torres-Roca JF. The Radiosensitivity Index Gene Signature Identifies Distinct Tumor Immune Microenvironment Characteristics Associated With Susceptibility to Radiation Therapy. Int J Radiat Oncol Biol Phys. 2022 Jul.113(3):635-647. Pubmedid: 35289298. Pmcid: PMC9250625.
  • Conejo-Garcia JR, Innamarato P. γδ T cells share the spotlight in cancer. Nat Cancer. 2022 Jun.3(6):657-658. Pubmedid: 35764741.
  • Mandriani B, Pellè E, Mannavola F, Palazzo A, Marsano RM, Ingravallo G, Cazzato G, Ramello MC, Porta C, Strosberg J, Abate-Daga D, Cives M. Development of anti-somatostatin receptors CAR T cells for treatment of neuroendocrine tumors. J Immunother Cancer. 2022 Jun.10(6). Pubmedid: 35764366. Pmcid: PMC9240886.
  • Wang X, Muzaffar J, Kirtane K, Song F, Johnson M, Schell MJ, Li J, Yoder SJ, Conejo-Garcia JR, Guevara-Patino JA, Bonomi M, Bhateja P, Rocco JW, Steuer CE, Saba NF, Chung CH. T cell repertoire in peripheral blood as a potential biomarker for predicting response to concurrent cetuximab and nivolumab in head and neck squamous cell carcinoma. J Immunother Cancer. 2022 Jun.10(6). Pubmedid: 35676062. Pmcid: PMC9185557.
  • Saad M, Lee SJ, Tan AC, El Naqa IM, Hodi FS, Butterfield LH, LaFramboise WA, Storkus W, Karunamurthy AD, Conejo-Garcia J, Hwu P, Streicher H, Sondak VK, Kirkwood JM, Tarhini AA. Enhanced immune activation within the tumor microenvironment and circulation of female high-risk melanoma patients and improved survival with adjuvant CTLA4 blockade compared to males. J Transl Med. 2022 Jun.20(1):253. Pubmedid: 35659704. Pmcid: PMC9164320.
  • Zhang T, Yin C, Fedorov A, Qiao L, Bao H, Beknazarov N, Wang S, Gautam A, Williams RM, Crawford JC, Peri S, Studitsky V, Beg AA, Thomas PG, Walkley C, Xu Y, Poptsova M, Herbert A, Balachandran S. ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis. Nature. 2022 Jun.606(7914):594-602. Pubmedid: 35614224. Pmcid: PMC9373927.
  • Mandula JK, Rodriguez PC. Tumor-directed dysregulation of erythroid progenitors drives immunosuppressive myeloid cells. Cancer Cell. 2022 Jun.40(6):597-599. Pubmedid: 35594864.
  • Bekker RA, Kim S, Pilon-Thomas S, Enderling H. Mathematical modeling of radiotherapy and its impact on tumor interactions with the immune system. Neoplasia. 2022 Jun.28:100796. Pubmedid: 35447601. Pmcid: PMC9043662.
  • Chiappori AA, Creelan B, Tanvetyanon T, Gray JE, Haura EB, Thapa R, Barlow ML, Chen Z, Chen DT, Beg AA, Boyle TA, Castro J, Morgan L, Morris E, Aregay M, Hurtado FK, Manenti L, Antonia S. Phase I Study of Taminadenant (PBF509/NIR178), an Adenosine 2A Receptor Antagonist, with or without Spartalizumab (PDR001), in Patients with Advanced Non-Small Cell Lung Cancer. Clin Cancer Res. 2022 Jun.28(11):2313-2320. Pubmedid: 35254415. Pmcid: PMC9167697.
  • Kornepati AVR, Boyd JT, Murray CE, Saifetyarova J, de la Peña Avalos B, Rogers CM, Bai H, Padron AS, Liao Y, Ontiveros C, Svatek RS, Hromas R, Li R, Hu Y, Conejo-Garcia JR, Vadlamudi RK, Zhao W, Dray E, Sung P, Curiel TJ. Tumor Intrinsic PD-L1 Promotes DNA Repair in Distinct Cancers and Suppresses PARP Inhibitor-Induced Synthetic Lethality. Cancer Res. 2022 Jun.82(11):2156-2170. Pubmedid: 35247877.
  • Cheng P, Chen X, Dalton R, Calescibetta A, So T, Gilvary D, Ward G, Smith V, Eckard S, Fox JA, Guenot J, Markowitz J, Cleveland JL, Wright KL, List AF, Wei S, Eksioglu EA. Immunodepletion of MDSC by AMV564, a novel bivalent, bispecific CD33/CD3 T cell engager, ex vivo in MDS and melanoma. Mol Ther. 2022 Jun.30(6):2315-2326. Pubmedid: 35150889. Pmcid: PMC9171150.
  • Noyes D, Bag A, Oseni S, Semidey-Hurtado J, Cen L, Sarnaik AA, Sondak VK, Adeegbe D. Tumor-associated Tregs obstruct antitumor immunity by promoting T cell dysfunction and restricting clonal diversity in tumor-infiltrating CD8+ T cells. J Immunother Cancer. 2022 May.10(5). Pubmedid: 35618289. Pmcid: PMC9125763.
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