Melanoma CoE News

  • In a new study published in EBioMedicine, researchers with Moffitt Cancer Center’s Donald A. Adam Melanoma and Skin Cancer Center of Excellence reveal that differences at the single-cell level can predict responses to initial BRAF inhibitor therapy, and that leveraging these differences may improve patient outcomes. Full Story
  • Using a combination of novel genetic tools, the Tsai and Brown labs are studying how clones of keratinocytes exposed to UV radiation expand and contract over time, forming the basis for skin cancer. Full Story
  • Researchers have discovered a mechanism by which melanoma cells become resistant to the commonly used drugs that target the BRAF protein and its signaling pathway. Full Story
  • Researchers in the Melanoma and Skin Cancer Center of Excellence have discovered a signaling pathway between cytokines and BRAF that promotes tumor growth. Full Story
  • Researchers in the Melanoma and Skin Cancer Center of Excellence are working to change the prognosis for patients with metastatic uveal melanoma. They have identified a new drug combination that is effective against metastatic uveal melanoma cells in preclinical studies. Their findings were published in Clinical Cancer Research. Full story