YAP1/OCT4: Small Molecule Inhibitors of the Protein-protein Interaction of YAP1 and OCT4 to Treat Cancer

Disruption of the OCT4-YAP1 interaction suppresses Sox2 expression as well as certain metabolic genes, preventing the self-renewal of stem-like cells thus preventing tumor initiation, progression, drug resistance and metastasis. Highly potent and selective disruptors of the Oct4-YAP1 interaction were identified by researchers here at Moffitt. These compounds can be developed into anti-cancer therapies for lung cancer and possibly other malignancies.

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