SSTR2 CAR-T: Somatostatin Receptor 2 Targeting CAR-T Cells for Neuroendocrine Tumors

S100A9: CD33/IgG1 Chimera Antibody Trap to Neutralize S100A9 to Treat MDS

Copyright: Energize:mBC is a Web-based Program to Treat Fatigue in Metastatic Breast Cancer Patients

Software: Cancer BERT Network (caBERTnet): A Question-and-Answer System to Extract Data from Free-Text Pathology Reports

Software: Negative Information Storage Model for Genomic Data

HDAC6: Method of Using Histone Deacetylase 6 Inhibition for Enhancing T cell Function During Anti-Tumor Response and Tumor-Peptide Vaccination

Software: Real-time Visualization Software Enables Surgeons to “see-through” the patient and remove tumors more effectively

Life Science Tool: Diazirine Reagents as Single and Double Nitrogen Transfer Reagents for Decarboxylative Amination

HDAC: Method of Using Histone Deacetylase as a Modulator of PDL1 Expression and Activity

Live Cell RNA Probe: First-in-class Live Cell RNA Probe to Detect Subcellular Localization

TILs: TILs modified with CAR constructs result in CAR-TILs for Cancer Therapy

NKG2D ligands: NKG2D Chimeric Antigen Receptor CAR-T Cells for Acute Myeloid Leukemia Immunotherapy

Suicide Switch: CAR-T cells can be Designed to Self-Destruct if Patient shows signs of Toxicity including graft-vs.-host-disease, cytokine release syndrome (CRS), and neurotoxicty

Inflammasome: Method of Using Small-molecule Pyrin-domain Targeted NLRP3 Inflammasome Inhibitors to Neutralize Pyroptotic Cell Death Contributing to MDS Pathogenesis

TLR9 Ligand Trap: TLR9-IgG4 Fusion Protein to Neutralize Innate Immune Activation and Chronic Inflammation Contributing to MDS Pathogenesis

TILs: Method of Using a Demethylating Agent to Enhance STING Expression and TIL Anti-Tumor Activity in Melanoma

aAPC: Artificial Antigen-Presenting Cells with Heparin-Binding Domain and Protein L for Producing CAR-T Cells

Glioma Stem Cell Targeting CAR-T Cell Constructs with Phage Display Derived Peptide Oligomers

B-RAF: Combination Therapy of TILs and BRAF Inhibitors to Treat BRAF Inhibitor-Resistant Metastatic Melanoma

TILs: Enhancing the anti-tumor immunity of TILs by inhibiting Sirt2

Brain Mets: Lung Cancer Brain Metastases Targeting CAR-T Cell Constructs with Phage Display Derived Peptide Oligomers

Antibodies: Fully Human anti-PD1 Antibodies

NKG2D-Ligand: Enhancing Carcinoma Infiltration by NKG2D-Ligand Targeted CAR-T Cells by Co-Expression of the Chemokine Receptor CX3CR1

GPC3: Enhancing Carcinoma Infiltration by Anti-GPC3 Targeted CAR-T Cells by Co-Expression of the Chemokine Receptor CX3CR1

aAPC: Artificial Antigen-Presenting Cells Expressing NKG2D Ligands for Producing anti-NKG2D CAR-T Cells

18MB072 Method of Using anti-CD277 Antibodies to Treat Cancer

Antibodies: Fully Human anti-LAG3 Antibodies

A Single Customizable and Adaptive Ventilator Device to Treat Multiple Patients

Med Device: An Improved Pigtail Drainage Catheter for Percutaneous Fluid Aspiration

Molecular Imaging Probe: Breast Cancer-Targeted Probe Set for Improved Detection of Lymph Node Metastases

Med Device: An Improved Stylet for Endotracheal Tube Placement

Med Device: Drug Infusion 'The Snowflake' Device for Treatment of Brain Cancer

Med Device: Biopsy Needle with Internal Ridges that Lead to a Higher Tissue Specimen Retrieval Rate

Molecular Imaging Probe: Fluorescent and MRI Targeted Probes for the Melanocortin Receptor 1 on Melanomas, and Micelle Complexes for Drug Delivery

Med Device: Expandable Intervertebral Cage for Spinal Fusion

Germfree System: Equipment to Maintain Germfree and Gnotobiotic Mice

miRNA Diagnostic: miRNA Signature for Non-invasive Early Detection of Malignancy in IPMN

Methylation Status Diagnostic: Diagnostic to Predict Response to Immunotherapy

Protein Biomarker: Diagnostic to Determine which Low-Risk MDS Patients to Treat with Lenalidomide to Restore Sensitivity to Erythropoietin

miRNA Diagnostic: MicroRNA Signature to Predict Progression of Barrett’s Esophagus to Esophageal Dysplasia or Adenocarcinoma

Genetic Biomarker: PTEN Loss of Expression as a Biomarker Response to GGTI-2418 Treatment

Molecular Imaging Probe: Novel IDO1-Targeting Cancer Diagnostic PET Imaging Agent

Genetic Signature: Gene Signature to Distinguish between Metastatic Urothelial Carcinoma and Squamous Cell Carcinoma (Primary Lung and Metastatic Head & Neck)

Protein Biomarker: Method for Measuring MRE11 in Muscle –Invasive Bladder Cancer to Predict Chemoradiation Response Using AQUA

Molecular Imaging: Predicting Response to Adjuvant Ipilimumab Treatment in Melanoma Using a Novel Algorithm to Analyze Nitric Oxide Levels in Peripheral Blood Immune Cells

CMG Helicase: Novel Replicative CMG Helicase Inhibitors (CMGi) to Treat Solid Tumors

Novel BRD4/JAK2 Dual Inhibitor Cancer Therapeutics

β-catenin/TCF: Small Molecule Peptidomimetic Inhibitors of the Interaction of β-catenin and T-cell Factor

β-catenin/BCL9: Novel Small Molecules that Inhibit the β-catenin/BCL9 Interaction in Breast Cancer

CDK12/CDK13: Novel Small Molecule Dual Inhibitors for CDK12/CDK13 for the Treatment of Triple Negative Breast Cancer

ACK1: Small molecule ACK1 Inhibitors for the Treatment of Castrate Resistant Prostate Cancer

β-catenin/TCF: Small Molecule Inhibitors of the Interaction of β-catenin and T-cell Factor

Actinium Dotatate: Novel Atinum Dotatate Compounds with Low Toxicity and High Efficacy

TAF1: Novel TAF1 Inhibitors for the Treatment of Cancer

Software: A Quantitative Framework to Identify Radiation Targets for Cancer Treatment that Synergize with Immunotherapy

Software: Decision Support Tool for Oncology Treatment using Mathematical Simulations

Math Model: Predict Patient-Specific Radiotherapy Responses Using a Proliferation Saturation Index in an Adaptive Bayesian Approach

Math Model: Methods for the Treatment of Prostate Cancer Using Intermittent Adaptive Therapy

Software: A Pathologist Tool for Alignment of Serial Whole Slide Histology Images

Inflammasome: Stapled Peptides NLRP3 Inflammasome Inhibitors to Neutralize Pyroptotic Cell Death Contributing to MDS Pathogenesis

CLEC12A: Novel CLEC12A scFv Targeting CAR-T cells for Acute Myeloid Leukemia Immunotherapy

TILs: Simple and Rapid Method for Culture of TILs from Melanoma Tumor Fragments or Core Needle Biopsies of Solid Tumors

CD99: Novel CD99 scFv Targeting CAR-T cells for Acute Myeloid Leukemia Immunotherapy

IL-13Rα2: Targeting Chimeric Antigen Receptor Expressing T cell (CAR-T) for Melanoma Immunotherapy

TILs: The Use of Fucose to Increase TILs for the Immunotherapy of Melanoma

CD3-CD28: Bispecific Antibody for the Generation of CAR-T cells for Cancer Immunotherapy

CD33: CAR-T Cell Constructs that Recognize CD33 for the Treatment of Acute Myeloid Leukemia

CD123: CAR-T Cell Constructs that Recognize CD123 for the Treatment of Acute Myeloid Leukemia

Fucose Increases Tumor Cell HLA-DRB1 Expression Increasing CD4+ T-cell Activation with Synergistic Tumor Killing Activity with anti-PD1 Checkpoint Inhibitors

N-Terminal Mutant PGC-1α Overexpression Enhances Metabolic Fitness Reducing CAR-T Exhaustion while Maintaining Proliferative Capacity

EGFR, MUC1: Bispecific CAR-T Cell constructs (chimeric antigen receptors) that Recognize EGFR and MUC1 for the Treatment of Lung Cancer

T-bet: T-bet Transcription Factor Armed CAR-T Cells Maintain Memory Phenotypes and Rescue CD4 Cells Leading to Increased Persistence

Bispecific T-Cell Engagers: B Cells Engineered to Express Bispecific T-Cell Engagers Result in Longer Half Lives

NOTCH: Enhancing the Efficacy of Adoptive T-cell Immunotherapy Using Novel Notch Ligands

Antibodies: Fully Human anti-TSPAN7 Antibodies

Antibodies: Fully Human anti-BDNF Antibodies

Med Device: Improved Endotracheal Tube to Prevent Intubation-Related Complications Related to Airway Edema (Swelling)

Med Device: Improved Enteral Feeding Tube and Retention Disc to Reduce Dislodgement, Infection and Complications

KRAS: Platform Technology: Dimeric IgA Therapeutic Antibody for Intra-Tumoral Targeting of Mutant KRAS

CAR-T: CAR-T Constructs with NKG2D Receptor Signaling Domains

TILs: aAPCs that expresses an anti-CD3 scFv transmembrane to determine the cytotoxicity of TILs

MDSC: Method of using Oral-L-Fucose to reduce immunosuppressive effect of Myeloid Derived Suppressor Cells (MDSCs)

Human ITAM Mutated Variants For Better Intracellular Signaling Domains For Gamma-Delta CAR T-Cell Activation

DC Vaccine: Enriching Monocyte Derived Dendritic Cells to Create DC Vaccine based Immunotherapy Using L-Fucose

CLEC12A: Novel CLEC12A scFv Targeting CAR-T cells for Acute Myeloid Leukemia Immunotherapy

miRNA Diagnostic: Blood Based microRNA Assay to Detect Malignant Intraductal Papillary Mucinous Neoplasms (IPMNs)

Molecular Imaging: Monoacylated TLR2 Ligand Fluorescent Probe for Detecti

Molecular Imaging: Novel Imaging Software Diagnostic to Determine Survival in Glioblastoma Multiforme

Genetic Signature: Gene Signature to Distinguish Lung Squamous Cell Carcinoma from Metastatic Head & Neck Squamous Cell Carcinoma

Protein Biomarker: Diagnostic for Progression of MDS to AML Using PD-1 or PD-L1 Expression

Molecular Imaging Probe: In vivo Positron Emission Tomography-Based Perfusion/Blood Pool Imaging Using Labeled Erythrocytes

Genetic Signature: Microarray-based Gene Expression Profiling to Predict Tumor Sensitivity to Radiotherapy

Diagnostic: Intracellular S100A9 Alone or NLRP3 Inflammasome Activation as MDS Biomarkers

Diagnostic: S100A9 Serum Concentration Levels Predict Lenalidomide Response Duration

Diagnostic for Predicting Response to Therapies in Multiple Myeloma

Companion Diagnostic to Predict Response to Immunotherapy Based on the Methylation Status

IRE-1: Novel Small Molecule Inhibitors of IRE-1 for the Treatment of B-cell Cancer

Liquid Biopsy: Liquid Biopsy Based PCR Assay to Predict Drug Resistant in Prostate Cancer

Liquid Biopsy: Liquid Biopsy Assay for Pan-cancer Early Detection Using Cell-free DNA Methylation

STAT3: Novel Small Molecule STAT3 Inhibitor for Cancer Treatment

Molecular Imaging Agent: A Novel Fluorescence Molecular Imaging Agent for Intraoperative Margin Assessment in Breast Cancer

Liquid Biopsy: Saliva Based Liquid Biopsy Assay for Oropharyngeal Cancer

Protein Diagnostic: Diagnostic to detect Leptomeningeal Disease

HPV E1: Novel Use for Aminocoumarins as HPV Helicase E1 Inhibitors to Treat Cancer

YAP1/OCT4: Small Molecule Inhibitors of the Protein Protein Interaction of YAP1 and OCT4 to Treat Cancer

β-Catenin/BCL-9: Acyl sulfonamide-containing Small Molecules that Inhibit the β-catenin/BCL9 Protein-Protein Interaction

Small Molecule Inhibitor: 3-(4-fluorophenyl)-N-phenylbenzamide Small-Molecule Inhibitors of the β-Catenin/BCL9 Protein-Protein Interaction

p53: Combination Therapy of Hypothermia and Chemotherapy to Treat Temperature Sensitive p53 Mutant Tumors

TROLLS: Inhibition Of TAp63 Regulated Oncogenic Long Noncoding RNAs (TROLLs) for the Treatment Of Cancer

Antibodies: Novel Targeted Nanobodies Against HPV E6/E7 to treat HPV Related Cancers

BRD4 JAK2: Sultam (cyclic sulfonamide) BRD4 JAK2 Inhibitors to Treat Myelofibrosis

TAF1: Novel TAF1 PROTACS for the Treatment of Cancer

Machine Learning: A Rapid and Non-invasive Lung Cancer Diagnostic to Predict PD-L1 Status Using Deep Learning Radiomics

Adaptive Radiotherapy: Machine Learning Based App to Optimize Adaptive Radiotherapy Treatment Regimen

Software: Deep Neural Network to Locate and Label Brain Tumors Enables Surgeons to Remove Tumors More Effectively

Software: An Automated Mammographic Density Measure for Improved Breast Cancer Screening

Software: BMT Research Analysis Information Network (BRAIN)

Math Model: A Diagnostic that Predicts Efficacy and Progression Free Survival in CAR-T Treated Patients

Math Model: A Radiomics Based Diagnostic to Predict Treatment Outcomes in Lung Cancer

Math Model: A Diagnostic that Predicts Treatment Outcome and Personalize CAR-T Therapies

Math Model: A Diagnostic for Lesion Heterogeneity Classification for Informed Treatment Decision

TIM3 Ligand Trap: TIM-3-IgG4 Fusion Protein for the Treatment of Anemia in Low- or Intermediate (Int)-risk MDS Patients

Cancer Vaccine: Full-Length Variant Survivin Vaccine Potentiates Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma

TAG72-CD3: Bispecific T-Cell Engager for Targeted Cancer Immunotherapy

TLR9: Targeting Chimeric Antigen Receptor-Expressing T cell (CAR-T) for MDS and AML Immunotherapy

AaPC: Artificial Antigen-Presenting Cells for Expanding TILs and MILs in Cancer Immunotherapy

aAPC: Artificial Antigen-Presenting Cells expressing CD3, CD28 and a Heparin-Binding Domain for Producing CAR-Ts

TAG72: CAR-T Cell constructs (chimeric antigen receptors) that Recognize TAG72

TLS: Method of Using Chitosan Hydrogels with Chemokine-Releasing Microparticles or Stromal Cells to Bioengineer Tertiary Lymphoid Structures to Enhance the Immune System for Cancer Therapy

CD33 CD123: Novel Bispecific CD33 CD123 scFv CAR-T Cells for Acute Myeloid Leukemia Immunotherapy

PERK, IRE1: Method of Enhancing Immunotherapy Using ER Stress Pathway Inhibitors

CAR-T: D99/CLEC12A AND gated Bispecific CAR-T for the Treatment of AML

Olfactory Receptor Targeting Chimeric Antigen Receptor Expressing T cell (CAR-T) for Solid Tumors

Mutated Estrogen Receptor Neoantigen Peptide-Pulsed Type I Dendritic Cell (DC1) Vaccine Therapy to Treat Metastatic ER-positive Breast Cancer

Bispecific Gamma Delta CAR-T Cells that Recognize CD33, CD123 and NKG2D Ligands for the Treatment of Acute Myeloid Leukemia

Single-domain antibodies (nanobodies) targeting the notch ligand DLL4 to Disrupt the interaction of DLL4 and Notch1 for GVHD

TILs: 12 Chemokine Gene Expression Signature to Increase the Efficacy of Manufacturing Tumor Infiltrating Lymphocytes

HER-2: Combination Therapy of a HER2-DC1 Dendritic Cell Cancer Vaccine and a Probiotic

Imaging: Digital Pathology Tool to Grade Breast Cancer Histological Images

Genetic Signature: Gene Expression Signature to Determine the Benefit of Adjuvant Chemotherapy in Early Stage Non-Small Cell Lung Cancer

Molecular Imaging Probe: Synthetic Fluorescent Probe for Improved Detection and Tumor Removal in Pancreatic Cancer Patients

Molecular Imaging Probe: A Novel 18F Scaffold for Preparing Targeted PET Imaging Probess

Multiplex Diagnostic: in Multiple Myeloma Using Detection of Minimal Residual Disease RNA Sequencing and Mass Spectrometry

Protein Diagnostic: New Receptor Tyrosine Kinase Assay for Patient Treatment Selection Based on Protein-Protein Bindi

Genetic Signature: Gene Signature Predicts Recurrence and Benefit From Adjuvant Chemotherapy in Colorectal Cancer

Protein Diagnostic: Phosphorylated STAT3 Protein as a Novel Biomarker of Graft Versus Host Disease

Molecular Imaging Probe: Surrogate Markers for Colon Adenoma and Adenocarcinoma

XBP-1: XBP-1 Inhibitor B-I09 for the Treatment of Acute GVHD and Solid Organ Rejection

WEE1: Small Molecule WEE1 Inhibitor (WEIN-159) that Inhibits WEE1 Phosphorylation of H2B but Not Cdc2 to Treat Can

Ras: Small Molecules that Inhibit Mutant KRAS

β-catenin/BCL-9: Small Molecules that Inhibit the β-catenin/BCL9 Interaction

Ras/Raf: Stapled Peptides as Inhibitors of Mutant KRAS

Ubiquitin Bispecific Antibody: Antibodies that Bring the E3 Ubiquitin Ligase into Close Proximity to Receptors to Induce the Receptor’s Degradation

HDAC, BTK: Method of Using HDAC Inhibitors, Alone or in Combination with BTK Inhibitors, for Treating Non-Hodgkin’s Lymphoma (NHL)

HDAC, BTK: Method of Using HDAC Inhibitors, Alone or in Combination with BTK Inhibitors, for Treating Chronic Lymphocytic Leukemia (CLL)

Aurora/JAK2: Dual JAK2 and Aurora A Kinase Inhibitor for GVHD Prophylaxis

Immunomodulatory: Cereblon Degrading Molecules for the Treatment of Small Cell Lung Carcinoma and Melanoma

ULK3: ULK3 Inhibitors for the Treatment of Multiple Myeloma