Cancer Control Journal

This peer-reviewed journal contains articles on the spectrum of actions and approaches needed to reduce the impact of human malignancy.

July 2014 | Volume 21, Number 3

Clinical and Translational Research


Vol. 21, No. 3, July 2014 – Clinical and Translational Research (Full Issue PDF file: 3.4 MB)


Clinical Trials and Drug Development (PDF file: 63KB)
Amit Mahipal, MD


Risks and Benefits of Phase 1 Clinical Trial Participation (PDF file: 182 KB)
Amit Mahipal, MD, and Danny Nguyen, MD

Phase 1 Trial Design: Is 3 + 3 the Best? (PDF file: 656 KB)
Aaron R. Hansen, MBBS, Donna M. Graham, MBBCh, Gregory R. Pond, PhD, and Lillian L. Siu, MD

Participation of the Elderly Population in Clinical Trials: Barriers and Solutions  (PDF file: 188 KB)
Aaron C. Denson, MD, and Amit Mahipal, MD

Studying Cancer Treatment in the Elderly Patient Population (PDF file: 201 KB)
Lodovico Balducci, MD
BRAF Mutations: Signaling, Epidemiology, and Clinical Experience in Multiple Malignancies (PDF file: 517 KB)
Richard D. Hall, MD, and Ragini R. Kudchadkar, MD
PD-1 Pathway Inhibitors: Changing the Landscape of Cancer Immunotherapy (PDF file: 186 KB)
Dawn E. Dolan, PharmD, and Shilpa Gupta, MD


Ten Best Readings Relating to Clinical and Translational Research  (PDF file: 71 KB)

Translational Medicine Simplified: AKT Goes Cycling  (PDF file: 107 KB)
Kiran N. Mahajan, PhD, and Nupam P. Mahajan, PhD

Special Report: Novel Pancreatic Cancer Vaccines Could Unleash the Army Within  (PDF file: 183 KB)
Gregory M. Springett, MD, PhD

Pathology Report: Histopathological and Immunophenotypical Features of Intestinal-Type Adenocarcinoma of the Gallbladder and its Precursors  (PDF file: 215KB)
Yan You, MD, Katherine Bui, Marilyn M. Bui, MD, PhD, Mokenge Malafa, MD, and Domenico Coppola, MD

Case Report: Follicular Lymphoma With Progression to Diffuse Large B-Cell Lymphoma and Concurrent CD5-Negative Mantle Cell Lymphoma-3 Entities in a Lymph Node  (PDF file: 313 KB)
Janese A. Trimaldi, MD, Jeremy W. Bowers, MD, Celeste Bello, MD, and Elizabeth M. Sagatys, MD

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About the art in this issue:

Henry Domke, MD, is an artist who creates nature art for hospitals. He took a nontraditional path to get where he is today. While still in high school, Domke enrolled in art school but decided to pursue medicine instead, and he worked as a family physician in Jefferson City, Missouri, for 25 years.

By the mid-1990s, his enduring passion for art led him to formalize his art training. He studied independently with Annette Weintraub, an art professor at City College in New York, and William Hawk, a painting professor at the University of Missouri-Columbia. Hawk convinced him to enter the university’s graduate arts program, where he studied from 1998 to 2001 while he temporarily reduced his hours at his medical practice.

Another defining factor in Domke’s life is the Prairie Garden Trust, a 600-acre property that he has lived on since 1981. It is a nature restoration project begun by his parents in central Missouri, and much of his art is based on images taken there.

Recently he has been expanding beyond his backyard to find inspiration and has photographs from coast to coast. In addition to local wildflowers and wildlife, his collection includes coastal landscapes, mountainous terrains, desert scenes, and sea shells.

His life had come full circle and he said goodbye to medicine in 2007 and pursued art full time. Today he tries to find beauty in the ordinary and create images that inspire and heal.

For further information or to contact the artist, visit or

Cherokee View_0376K.

Table of Contents: 
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Nautilus Spiral_4592. 
Cut Nautilus Shell_4499. 
Toohey Lake Panorama_0104K (detail).