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Nazanin Khakpour, MD, FACS

Specialty: Surgery
Program: Breast Oncology

Call 1-888-MOFFITT

Call 1-888-MOFFITT

Locations: Moffitt McKinley Outpatient Center

Cancer Types Treated: Inflammatory Breast Cancer , Invasive Ductal Carcinoma , Triple Negative Breast Cancer , Breast Cancer, Ductal Carcinoma In Situ

Dr. Khakpour is a surgical oncologist in the Department of Breast Oncology at Moffitt Cancer Center. In addition to treating patients, she directs the Breast Fellowship Program, helping train the next generation of physicians pursuing advanced training in oncology.  She also serves as an instructor and mentor for medical students and resident physicians.  As treatment for breast cancer becomes more complex and differentiated by tumor type, Dr. Khakpour believes it is essential for physicians to be well trained in all aspects of this multifaceted disease. Dr. Khakpour enjoys helping women understand the many treatment options that are available to them and making sure they are aware of the value of obtaining a second opinion. At Moffitt, each patient’s care plan is reviewed by a highly expert team of physicians with extensive, focused training in their area of specialty, giving them additional insights and knowledge to help make the best decision for that individual. Dr. Khakpour’s research interests include investigating disease recurrence after lumpectomy with the goal of identifying the most appropriate patients for breast conservation surgery.  She is a member of the Breast Cancer Screening Committee for the National Comprehensive Care Network and the Scientific Review Panel for the National Institutes of Health. Dr. Khakpour speaks Spanish, French and Farsi.

Education & Training

Board Certification:

  • Surgery


  • University of Texas MD Anderson Cancer Center - Breast Surgical Oncology


  • Baylor College of Medicine - General Surgery
  • Baylor College of Medicine - General Surgery

Medical School:

  • Emory University School of Medicine - MD
Participating Trials

A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy
Condition: Breast
Intervention: Not Applicable

An Open-Label, Single-Arm, Phase 2 Study Of Avb-620 In Women With Primary, Nonrecurrent Breast Cancer Undergoing Surgery
Condition: Breast
Intervention: AVB-620

A Phase II Study of Preoperative Stereotactic Ablative Body Radiotherapy (SABR) for Early-Stage Breast Cancer: Introduction of a Novel Form of Accelerated Partial Breast Radiotherapy
Condition: Breast
Intervention: Not Applicable

If you believe you are eligible for one of these trials or studies, please call
813-745-6100 or toll-free 1-800-679-0775.


  • Sanft T, Denlinger CS, Armenian S, Baker KS, Broderick G, Demark-Wahnefried W, Friedman DL, Goldman M, Hudson M, Khakpour N, Koura D, Lally RM, Langbaum TS, McDonough AL, Melisko M, Mooney K, Moore HCF, Moslehi JJ, O'Connor T, Overholser L, Paskett ED, Peterson L, Pirl W, Rodriguez MA, Ruddy KJ, Smith S, Syrjala KL, Tevaarwerk A, Urba SG, Zee P, McMillian NR, Freedman-Cass DA. NCCN Guidelines Insights: Survivorship, Version 2.2019. J Natl Compr Canc Ne. 2019 Jul;17(7):784-794. Pubmedid: 31319383.
  • Kuritzky A, Walheim L, Khakpour N. Cancer identified in accessory breast tissue within the mid axilla. Breast J. 2018 May;24(3):414-415. Pubmedid: 29063657.
  • Mills MN, Yang GQ, Oliver DE, Liveringhouse CL, Ahmed KA, Orman AG, Laronga C, Hoover SJ, Khakpour N, Costa RLB, Diaz R. Histologic heterogeneity of triple negative breast cancer: A National Cancer Centre Database analysis. Eur J Cancer. 2018 Jul;98:48-58. Pubmedid: 29870876.
  • Denlinger CS, Sanft T, Baker KS, Baxi S, Broderick G, Demark-Wahnefried W, Friedman DL, Goldman M, Hudson M, Khakpour N, King A, Koura D, Kvale E, Lally RM, Langbaum TS, Melisko M, Montoya JG, Mooney K, Moslehi JJ, O'Connor T, Overholser L, Paskett ED, Peppercorn J, Rodriguez MA, Ruddy KJ, Silverman P, Smith S, Syrjala KL, Tevaarwerk A, Urba SG, Wakabayashi MT, Zee P, Freedman-Cass DA, McMillian NR. Survivorship, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Ne. 2017 Sep;15(9):1140-1163. Pubmedid: 28874599. Pmcid: PMC5865602.
  • Mattingly AE, Ma Z, Smith PD, Kiluk JV, Khakpour N, Hoover SJ, Laronga C, Lee MC. Early Postoperative Complications after Oncoplastic Reduction. South Med J. 2017 Oct;110(10):660-666. Pubmedid: 28973708.
  • Mattingly AE, Mooney B, Lin HY, Kiluk JV, Khakpour N, Hoover SJ, Laronga C, Lee MC. Magnetic Resonance Imaging for Axillary Breast Cancer Metastasis in the Neoadjuvant Setting: A Prospective Study. Clin Breast Cancer. 2017 Jun;17(3):180-187. Pubmedid: 27956116.
  • Prabhakaran S, Elston JB, Lleshi A, Kumar A, Sun W, Khakpour N, Dayicioglu D. Single Institution Review of Patients With Prior Breast Augmentation Undergoing Breast Conservation Therapy for Breast Cancer. Ann Plast Surg. 2017 Jun;78(6S Suppl 5):S289-S291. Pubmedid: 28328631.
  • Mellon EA, Orman A, Joya LE, Montejo ME, Laronga C, Hoover SJ, Lee MC, Khakpour N, Kubal PF, Diaz R. Frequency of whole breast radiation therapy after intraoperative radiation therapy due to criteria identified by lumpectomy. Brachytherapy. 2017 Jul;16(1):174-180. Pubmedid: 27816540.
  • González SJ, Mooney B, Lin HY, Zhao X, Kiluk JV, Khakpour N, Laronga C, Lee MC. 2-D and 3-D Ultrasound for Tumor Volume Analysis: A Prospective Study. Ultrasound Med Biol. 2017 Apr;43(4):775-781. Pubmedid: 28187928.
  • Dayicioglu D, Tugertimur B, Munzenmaier K, Khan M, Smith P, Murr M, Kumar A, Khakpour N. Outcomes of Breast Reconstruction After Mastectomy Using Deep Inferior Epigastric Perforator Flap After Massive Weight Loss. Ann Plast Surg. 2016 Jun;76 Suppl 4:S286-S289. Pubmedid: 26808755.
  • Parabkaharan S, Melody M, Trotta R, Lleshi A, Sun W, Smith PD, Khakpour N, Dayicioglu D. Comparison of Reconstructive Outcomes in Breast Cancer Patients With Preexisting Subpectoral Implants: Implant-Sparing Mastectomy With Delayed Implant Exchange Versus Immediate Tissue Expander Reconstruction. Ann Plast Surg. 2016 Jun;76 Suppl 4:S332-S335. Pubmedid: 27187252.
  • Dayicioglu D, Tugertimur B, Zemina K, Dallarosa J, Killebrew S, Wilson A, Atisha D, Khakpour N. Vertical Mastectomy Incision in Implant Breast Reconstruction After Skin Sparing Mastectomy: Advantages and Outcomes. Ann Plast Surg. 2016 Jun;76 Suppl 4:S290-S294. Pubmedid: 27187251.
  • Prabhakaran S, Melody M, Trotta R, Lleshi A, Sun W, Smith PD, Khakpour N, Dayicioglu D. Comparison of Reconstructive Outcomes in Breast Cancer Patients With Preexisting Subpectoral Implants: Implant-Sparing Mastectomy With Delayed Implant Exchange Versus Immediate Tissue Expander Reconstruction. Ann Plast Surg. 2016 Jun;76 Suppl 4:S332-S335. Pubmedid: 27755066.
  • Acs G, Khakpour N, Kiluk J, Lee MC, Laronga C. The presence of extensive retraction clefts in invasive breast carcinomas correlates with lymphatic invasion and nodal metastasis and predicts poor outcome: a prospective validation study of 2742 consecutive cases. Am J Surg Pathol. 2015 Mar;39(3):325-337. Pubmedid: 25353283.
  • Reyna C, Kiluk JV, Frelick A, Khakpour N, Laronga C, Lee MC. Impact of axillary ultrasound (AUS) on axillary dissection in breast conserving surgery (BCS). J Surg Oncol. 2015 Jun;111(7):813-818. Pubmedid: 25753101.
  • Roetzheim RG, Lee JH, Fulp W, Matos Gomez E, Clayton E, Tollin S, Khakpour N, Laronga C, Lee MC, Kiluk JV. Acceptance and adherence to chemoprevention among women at increased risk of breast cancer. Breast. 2015 Feb;24(1):51-56. Pubmedid: 25491191. Pmcid: PMC4503358.
  • Reyna C, Lee MC, Frelick A, Khakpour N, Laronga C, Kiluk JV. Axillary burden of disease following false-negative preoperative axillary evaluation. Am J Surg. 2014 Oct;208(4):577-581. Pubmedid: 25118162.
  • Kiluk JV, Prowler V, Lee MC, Khakpour N, Laronga C, Cox CE. Contralateral axillary nodal involvement from invasive breast cancer. Breast. 2014 Jun;23(3):291-294. Pubmedid: 24709584.
  • Goble RN, Drukteinis JS, Lee MC, Khakpour N, Kiluk JV, Laronga C. Early experience with ultrasound features after intrabeam intraoperative radiation for early stage breast cancer. J Surg Oncol. 2014 Jun;109(8):751-755. Pubmedid: 24862923.
  • Prowler VL, Joh JE, Acs G, Kiluk JV, Laronga C, Khakpour N, Lee MC. Surgical excision of pure flat epithelial atypia identified on core needle breast biopsy. Breast. 2014 Aug;23(4):352-356. Pubmedid: 24518220.
  • Williams M, Eatrides J, Kim J, Talwar H, Esposito N, Szabunio M, Ismail-Khan R, Kiluk J, Lee M, Laronga C, Khakpour N. Comparison of breast magnetic resonance imaging clinical tumor size with pathologic tumor size in patients status post-neoadjuvant chemotherapy. Am J Surg. 2013 Oct;206(4):567-573. Pubmedid: 23809673.
  • Joh JE, Esposito NN, Kiluk JV, Laronga C, Khakpour N, Soliman H, Catherine Lee M. Pathologic tumor response of invasive lobular carcinoma to neo-adjuvant chemotherapy. Breast J. 2013 Apr;18(6):569-574. Pubmedid: 23034096.
  • Walsh N, Kiluk JV, Sun W, Khakpour N, Laronga C, Lee MC. Ipsilateral nodal recurrence after axillary dissection for breast cancer. J Surg Res. 2012 Sep;177(1):81-86. Pubmedid: 22498028.
  • Kaur P, Santillan AA, McGuire K, Turaga KK, Shamehdi C, Meade T, Ramos D, Mathias M, Parbhoo J, Davis M, Khakpour N, King J, Balducci L, Cox CE. The surgical treatment of breast cancer in the elderly: a single institution comparative review of 5235 patients with 1028 patients ≥70 years. Breast J. 2012 Sep;18(5):428-435. Pubmedid: 22957995.
  • Turaga KK, Chau A, Eatrides JM, Kiluk JV, Khakpour N, Laronga C, Lee MC. Selective application of routine preoperative axillary ultrasonography reduces costs for invasive breast cancers. Oncologist. 2012 Jan;16(7):942-948. Pubmedid: 21572122. Pmcid: PMC3228129.
  • Joh JE, Han G, Kiluk JV, Laronga C, Khakpour N, Lee MC. Indications for axillary ultrasound use in breast cancer patients. Clin Breast Cancer. 2012 Dec;12(6):433-437. Pubmedid: 23062709.
  • Pimiento JM, Lee MC, Esposito NN, Kiluk JV, Khakpour N, Carter WB, Han G, Laronga C. Role of axillary staging in women diagnosed with ductal carcinoma in situ with microinvasion. J Oncol Pract. 2011 Sep;7(5):309-313. Pubmedid: 22211128. Pmcid: PMC3170064.
  • Pimiento JM, Gadgil PV, Santillan AA, Lee MC, Esposito NN, Kiluk JV, Khakpour N, Hartley TL, Yeh IT, Laronga C. Phyllodes tumors: race-related differences. J Am Coll Surg. 2011 Oct;213(4):537-542. Pubmedid: 21856184.
  • Nasir A, Chen DT, Gruidl M, Henderson-Jackson EB, Venkataramu C, McCarthy SM, McBride HL, Harris E, Khakpour N, Yeatman TJ. Novel molecular markers of malignancy in histologically normal and benign breast. Patholog Res Int. 2011 Nov;2011:489064. Pubmedid: 21785684. Pmcid: PMC3140260.
  • Lee MC, Eatrides J, Chau A, Han G, Kiluk JV, Khakpour N, Cox CE, Carter WB, Laronga C. Consequences of axillary ultrasound in patients with T2 or greater invasive breast cancers. Ann Surg Oncol. 2011 Jan;18(1):72-77. Pubmedid: 20585876.
  • Kiluk JV, Khakpour N, Lee MC, Lowe J, Harris E, Szabunio M, Laronga C. Management of abnormal Rotter's lymph nodes identified on preoperative breast magnetic resonance imaging. Am Surg. 2011 Jan;77(1):E10-E12. Pubmedid: 21396292.
  • Mohiuddin MM, Zhang B, Tkaczuk K, Khakpour N. Upright, standing technique for breast radiation treatment in the morbidly-obese patient. Breast J. 2010 Jul;16(4):448-450. Pubmedid: 20522098.
  • Riddle ND, Yamauchi H, Caracciolo JT, Cheong D, Khakpour N, Bui MM. Giant cell tumor of the anterior rib masquerading as a breast mass: a case report and review of current literature. Cases J. 2010 Feb;3:51. Pubmedid: 20205847. Pmcid: PMC2825505.
  • McGuire KP, Eisen S, Rodriguez A, Meade T, Cox CE, Khakpour N. Factors associated with improved outcome after surgery in metastatic breast cancer patients. Am J Surg. 2009 Oct;198(4):511-515. Pubmedid: 19800458.
  • Bevers TB, Anderson BO, Bonaccio E, Buys S, Buys S, Daly MB, Dempsey PJ, Farrar WB, Fleming I, Garber JE, Harris RE, Heerdt AS, Helvie M, Huff JG, Khakpour N, Khan SA, Krontiras H, Lyman G, Rafferty E, Shaw S, Smith ML, Tsangaris TN, Williams C, Yaneeklov T. NCCN clinical practice guidelines in oncology: breast cancer screening and diagnosis. J Natl Compr Canc Ne. 2009 Nov;7(10):1060-1096. Pubmedid: 19930975.
  • Marulanda G, Mont M, Lucci A, Letson G, Khakpour N. Orthopedic surgery implications of breast cancer. Expert Rev Anticancer Ther. 2008 Jun;8(6):949-956. Pubmedid: 18533804.
  • Chumsri S, Phatak P, Edelman MJ, Khakpour N, Hamburger AW, Burger AM. Cancer stem cells and individualized therapy. Cancer Genomics Proteomics. 2007;4(3):165-174. Pubmedid: 17878520.
  • Boughey J, Khakpour N, Meric-Bernstam F, Ross M, Kuerer H, Singletary S, Babiera G, Arun B, Hunt K, Bedrosian I. Selective use of sentinel lymph node surgery during prophylactic mastectomy. Cancer. 2006 Oct;107(7):1440-1447. Pubmedid: 16955504.
  • Khakpour N, Zager J, Yen T, Stephens T, Kuerer H, Singletary E, Ross M, Hunt K, Babiera G. The role of ultrasound in the surgical management of patients diagnosed with ductal carcinoma in situ of the breast. Breast J. 2006 May;12(3):212-215. Pubmedid: 16684318.
  • Royak-Schaler R, DeYoung C, Khakpour N, Ross D, Tkaczuk K, Gadalla S. Readers respond to "balancing evidence-based medicine and cultural competence in the quest to end healthcare disparities". MedGenMed. 2006;8(3):73. Pubmedid: 17415934. Pmcid: PMC1781273.
  • Khakpour N, Hunt K, Kuerer H, Yi M, Meric-Bernstam F, Ross M, Lucci A. Sentinel lymph node dissection provides axillary control equal to complete axillary node dissection in breast cancer patients with lobular histology and a negative sentinel node. Am J Surg. 2005 Oct;190(4):598-601. Pubmedid: 16164930.
  • Chatterjee A, Dayicioglu D, Khakpour N, Czerniecki BJ. Oncoplastic Surgery: Keeping It Simple With 5 Essential Volume Displacement Techniques for Breast Conservation in a Patient With Moderate- to Large-Sized Breasts. Cancer Control. 24(4):1073274817729043. Pubmedid: 28975837. Pmcid: PMC5937235.