Moffitt logo
    Search

    Choose a type to search within:

    All Doctors Clinical Trials Researchers
    search icon
    • Schedule
      New Patients
       
      Referring Physicians
    • Locations
      Magnolia
       
      McKinley
       
      Wesley Chapel
       
      International Plaza
       
      Moffitt at Memorial
       
      Fowler
       
      Telecomm/Intellicenter
    • Find a Doctor
    • MyMoffitt Portal
      Log In
       
      Enroll
    • Donate
    • 1-888-663-3488
    • image Search
    • Cancer Types & Treatments
        Cancers We Treat
      • Adrenal
      • Anal
      • Appendiceal (Appendix)
      • Astrocytoma
      • Basal Cell Carcinoma
      • Bladder
      • Bone Metastasis
      • Brain
      • Brain Tumor
      • Breast
      • Cervical
      • Cholangiocarcinoma (Bile Duct )
      • Colon
      • Colorectal
      • Cutaneous T-Cell Lymphoma
      • Ductal Carcinoma In Situ
      • Endometrial (Uterine)
      • Esophageal
      • Gallbladder
      • Gastrointestinal Carcinoid Tumor
      • GIST (Gastrointestinal Stromal Tumor)
      • Glioblastoma
      • Head and Neck
      • HER2 Positive Breast
      • Hodgkin Lymphoma
      • Inflammatory Breast
      • Invasive Ductal Carcinoma
      • Kidney (Renal Cell)
      • Leukemia
      • Liver (Hepatocellular)
      • Lung
      • Lymphomas (Hodgkin and Non-Hodgkin)
      • Melanoma
      • Meningioma
      • Merkel Cell Carcinoma
      • Mesothelioma
      • Metastatic Breast
      • Multiple Myeloma-Plasma Cell Tumor
      • Myelodysplastic Syndromes (MDS)
      • Neuroendocrine Tumor
      • Neurofibromatosis
      • Non-Hodgkin Lymphoma
      • Oral Cavity (Mouth)
      • Oral Cavity or Throat
      • Osteosarcoma
      • Ovarian
      • Pancoast Tumor
      • Pancreatic
      • Penile
      • Pituitary Adenoma
      • Prostate
      • Rectal
      • Sarcoma
      • Skin (Nonmelanoma)
      • Skull Base Tumors
      • Small Intestine
      • Spinal Tumor
      • Squamous Cell Carcinoma
      • Stomach (Gastric)
      • Testicular
      • Throat
      • Thymoma
      • Thyroid
      • Tongue
      • Tracheal
      • Triple Negative Breast
      • Vaginal
      • Vulvar
        Cancer Diagnostics and Treatments
      • Blood & Bone Marrow Transplant
      • Cardio-Oncology
      • Chemotherapy
      • Clinical Pathways
      • Clinical Trials
      • Endoscopic Procedures
      • Fertility Preservation
      • Gynecologic Oncology
      • Immunotherapy
      • Interventional Pain Management
      • Interventional Radiology
      • Personalized Medicine
      • Pharmacy
      • Radiation Therapy
      • Rehabilitation Services
      • Supportive Care Medicine
      • Surgical Care
      • Systemic Therapy
      • Targeted Therapy
      • Tumor Board
        Diagnostic Services
      • Radiology – Diagnostic Imaging and Interventional Radiology
      • Genetic Counseling and Genetic Testing
      • Pathology
      • Labwork and Bloodwork
      • Cancer Screenings
    • Patients & Families
        Patients and Families Resources Overview
      • International Referral Services
      • Moffitt Virtual Visits
      • Taking Care of Your Health
        Preparing For Your Appointment
      • Scheduling Your Appointment
      • MyMoffitt Patient Portal
      • Patient and Family Orientation
      • Patient Rights and Responsibilities
      • Medical Records
      • Traveling for Cancer Treatment
        Insurance & Financial Information
      • Insurance Coverage
      • Health Exchange
      • Medicare Coverage
      • Copay Assistance Program
      • Financial Assistance
      • Financial Information
      • Obtain a Cost Estimate
      • Understanding Your Bill
      • Frequently Asked Questions
        Programs & Support Services
        Patient and Family-Centered Care
        Cancer Survivorship
        Caregivers and Families
    • For Healthcare Professionals
        For Healthcare Professionals Overview
      • Clinical Perspectives
        Programs & Services
      • Adolescent & Young Adult (AYA)
      • Anesthesiology
      • BMT and Cellular Immunotherapy
      • Breast Oncology
      • Cardio-Oncology
      • Cutaneous Oncology
      • Diagnostic Imaging and Interventional Radiology
      • Endocrine Oncology
      • Gastrointestinal Oncology
      • Genetic Counseling
      • Genitourinary Oncology
      • Gynecologic Oncology
      • Head and Neck Oncology
      • Immunotherapy
      • Malignant Hematology
      • Moffitt Malignant Hematology & Cellular Therapy at Memorial Healthcare System
      • Neuro-Oncology
      • Pathology
      • Pharmacy
      • Radiation Oncology
      • Sarcoma
      • Screening & Prevention
      • Senior Adult Oncology
      • Supportive Care Medicine
      • Thoracic Oncology
        Physician Relations
        Continuing Education
      • Provider Conferences
      • Moffitt Grand Rounds
      • Multidisciplinary Programs
    • Research
        Research Overview
        CCSG Programs
      • Cancer Biology and Evolution
      • Cancer Epidemiology
      • Health Outcomes & Behavior
      • Immuno-Oncology
      • Molecular Medicine
        Divisions and Departments
      • Biostatistics and Bioinformatics
      • Cancer Epidemiology
      • Drug Discovery
      • Health Outcomes and Behavior
      • Immunology
      • Integrated Mathematical Oncology
      • Machine Learning
      • Metabolism and Physiology
      • Molecular Oncology
      • Tumor Biology
        Centers and Institutes
      • Institutes
      • Centers of Excellence
        Shared Resources
      • Analytic Microscopy
      • Biostatistics and Bioinformatics
      • Cancer Pharmacokinetics and Pharmacodynamics
      • Cell Therapies
      • Chemical Biology
      • Collaborative Data Services
      • Flow Cytometry
      • Gene Targeting
      • Molecular Genomics
      • Participant Research, Interventions, and Measurement Core (PRISM)
      • Proteomics and Metabolomics
      • Quantitative Imaging Core
      • Small Animal Imaging Lab
      • Tissue
        Research Education and Training
      • Office of Postdoctoral Affairs
      • Office of Graduate Affairs
      • Office of Undergraduate and Visiting Scholar Affairs
      • What We Provide
        Community Outreach, Engagement, and Equity
      • About Us
      • Catchment Area Cancer Data
      • Moffitt Outreach in the Community
      • Research in the Community
      • Education and Outreach Resources
      • Get Involved
        Innovation and Industry Alliances
      • Available Technologies
      • Business of Biotech
      • Events
      • Internship Programs
      • Technology And Innovation Fund
      • Contact Us
    • Training & Education
        Training and Education Overview
      • Moffitt Innovators of Tomorrow Symposium
        Medical Education
      • Program Staff/Contact Us
      • Our Training Programs
      • Salary and Benefits
        Research Education and Training
      • Office of Postdoctoral Affairs
      • Office of Graduate Affairs
      • Office of Undergraduate and Visiting Scholar Affairs
      • What We Provide
      • Where Are They Now
        Nursing Education
      • Oncology Nurse Residency Program
      • Ambulatory Care Oncology Nurse Residency Program
      • Registered Nurse
      • Nurse Anesthetist
      • Nurse Practitioner
        Health Professional Education
        Continuing Education
        Other Educational Programs
    • Give
        Give Overview
        Ways to Give
      • Cash, Stock or Other Assets
      • Planned Giving
      • Philanthropic Foundation Giving
      • Corporate Partnership
      • Employer Matching Gifts
      • Endowment Gifts
      • Other Ways to Donate
        Get Involved
      • Become a Member
      • Join a Community Partner Event
      • Volunteer Your Time
      • Miles for Moffitt
      • Magnolia
      • Mission Possible Sarasota Luncheon
      • Discovery Series Webinars
        Why Give?
      • About the Moffitt Foundation
      • FAQ
      • Financials and Stewardship
      • Contact the Foundation
      • You Can Make a Difference
      • 2021 Annual Foundation Impact Report
    1. Home
    2. Newsroom
    3. Press Release Archive
    4. 2015
    5. Moffitt Cancer Center Researchers Report that MEDI4736 Combined with Tremelimumab Results in Acceptable Toxicity, Clinical Activity in Non-Small Cell Lung Cancer Patients
    • click to share
      Facebook
      Twitter
      Linkedin
      Pinterest
      Email
    • click to print

    Moffitt Cancer Center Researchers Report that MEDI4736 Combined with Tremelimumab Results in Acceptable Toxicity, Clinical Activity in Non-Small Cell Lung Cancer Patients

    May 30, 2015

    TAMPA, Fla. – Advanced non-small cell lung cancer (NSCLC) patients have few effective treatment options and low 5-year survival rates. The checkpoint inhibitors MEDI4736 and tremelimumab have both demonstrated acceptable safety and potential efficacy when used as single-agents in several different types of cancer. Scott J. Antonia, M.D., Ph.D., chair of the Thoracic Oncology Department at Moffitt Cancer Center will be presenting data from a phase 1b dose-escalation and expansion study of MEDI4736 combined with tremelimumab at the 2015 American Society of Clinical Oncology Annual Meeting in Chicago.  

    MEDI4736 is a monoclonal antibody that targets the programmed cell death-1 ligand (PD-L1) expressed on tumor cells, and tremelimumab is a monoclonal antibody that inhibits cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) found on T cells.  Activation of both PD-L1 and CTLA-4 pathways blocks the immune system and inhibits the generation of an immune response.  Tumor cells take advantage of this physiological process to avoid immune detection and cell death.  Inhibiting these proteins with MEDI4736 and tremelimumab restimulates the immune system to detect and destroy tumor cells.

    The Moffitt team and their collaborators report that MEDI4736 combined with tremelimumab resulted in manageable toxicity, with 64 percent of patients experiencing adverse events. Patients who were administered higher doses of tremelimumab with a constant dose of MEDI4736 experienced more frequent and severe toxicities. The most common overall drug-related adverse events were fatigue (26 percent), diarrhea (21 percent), and increased amylase (13 percent). Thirty-one percent of patients had one or more grade 3/4 drug-related adverse event, with the most frequent being diarrhea (8 percent) and colitis (7 percent).  

    Results demonstrate that the combination of MEDI4736 and tremelimumab has clinical activity in NSCLC patients, including in patients who lack tumor expression of PD-L1. Out of 31 evaluable patients, 8 patients achieved a partial response and 11 patients had stable disease, while 3 out of 10 patients with PD-L1 negative tumors had a partial response.  

    The maximum-tolerated dose has yet to be defined and recruitment to the study is ongoing. Trial results to date will be presented during a poster discussion session on Saturday, May 30, 3-4:15 p.m. in room S406 and during the poster session from 8-11:30 a.m. in S Hall A.

    About Moffitt Cancer Center
    Located in Tampa, Moffitt is one of only 41 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt’s excellence in research, its contributions to clinical trials, prevention and cancer control. Moffitt is the top-ranked cancer hospital in the Southeast and has been listed in U.S. News & World Report as one of the “Best Hospitals” for cancer care since 1999. With more than 4,500 employees, Moffitt has an economic impact in Florida of nearly $1.6 billion. For more information, visit MOFFITT.org, and follow the Moffitt momentum on Facebook, Twitter and YouTube.

    ###

    Twitter

    Tweets by MoffittNews
    footer logo
    • BROWSE
      • Cancer Types & Treatments
      • Careers
      • Clinical Trials
      • Diagnostic Services
      • Education & Training
      • Locations
      • Patients & Families
      • Research
    • ABOUT
      • About Moffitt
      • Available Technologies
      • Calendar of Events
      • Clinical Perspectives
      • Community Benefit
      • Diversity
      • Endeavor
      • Newsroom
      • Our Outcomes
      • Partnerships
      • Taking Care of Your Health
    • ACTION
      • Appointments
      • Find a Doctor
      • Patient Portal
      • Refer a Patient
      • Referring Provider Portal
      • Staff Login
      • Staff Access
      • Volunteer
      • Ways to Give
    Call Today 1-888-663-3488
    Link to FaceBook
    Facebook
    Link to Twitter
    Twitter
    Link to Instagram
    Instagram
    Link to YouTube
    YouTube
    nci designated comprehensive cancer center award
    nccn award
    magnet recognized award
    diversity inc award
    • Site Map
    • Privacy Policy
    • Terms & Conditions
    • Unsubscribe
    • State Nonprofit Disclosures
    • Donor Privacy
    • Notice of Privacy Practices
    • Visitor Policy
    ©Copyright 2023 Moffitt Cancer Center
    ✕

    Request an Appointment at Moffitt Cancer Center

    Please call 1-888-663-3488 for support from a Moffitt representative. New Patients and Healthcare Professionals can submit an online form by selecting the appropriate button below. Existing patients can call 1-888-663-3488. Click here for a current list of insurances accepted at Moffitt.

    NEW PATIENTS To request a new patient appointment, please fill out the online form or call 1-888-663-3488.

    REFERRING PHYSICIANS Providers and medical staff can refer patients by submitting our online referral form.

    Moffit now offers Virtual Visits for patients. If you are eligible for a virtual appointment, our scheduling team will discuss this option further with you.


    Moffitt Cancer Center is committed to the health and safety of our patients and their families. For more information on how we’re protecting our new and existing patients, visit our COVID-19 Info Hub

    ✕

    Access Your Portal

    For Patients

    A secure website for patients to access their medical care at Moffitt.

    PATIENT PORTAL LOGIN

    For Physicians

    An online resource for referring physicians and their staff.

    PROVIDER PORTAL LOGIN

    For Moffitt Staff

    For Moffitt faculty & staff members to access MoffittNet applications.

    STAFF PORTAL LOGIN

    ✕

    Call: 1-888-663-3488

    Call: 1-888-663-3488

    Our patient services specialists can assist you with scheduling an appointment, questions about medical records, insurance, billing and more.

    Patient Appointment Center Hours: 7 a.m. to 7 p.m. Monday - Friday; 8 a.m. to noon Saturday