Alphabetical list of MAX2 score

Alphabetical list of MAX2 score. Primary CSF prophylaxis decreases MAX 2 by 0.06, unless included mandatorily in the regimen design. Doses are in mg/m2 unless specified otherwise.


If the MAX2 of the chemotherapy is <0.20 and the patient had no 1st cycle neutropenia, then the risk of G4 neutropenia in the subsequent cycles is <5%, and the risk of febrile neutropenia <1.5%. Ref: Janssen-Heijnen et al., Crit Rev Oncol Hematol, e-pub Aug 2, 2010. Pubmed ID: 20685130

Regimen

MAX2

5FU/LV qw 6/8 (Roswell Park)

0.183

5-FU/LV q4-5w (Mayo)

0.166

5FU/LV qw 6/8 (Roswell Park)+ bevacizumab

0.168

AC

0.223

CAF

0.291

Capecitabine 2500

0.121

Carboplatin/gemcitabine AUC 4-6/1g q3w

0.135

Carboplatin/pemetrexed

0.089

Carboplatin/paclitaxel (6/200)

0.149

Carboplatin/docetaxel (5-6/75)

0.249

CHOP

0.341

Cisplatin/docetaxel 75/75

0.251

Cisplatin/etoposide 75-80/100 q3w

0.337

Cisplatin/gemcitabine d1,8,15 q4w

0.285

Cisplatin/gemcitabine d1,8 q3w

0.117

Cisplatin/irinotecan q3w

0.262

Cisplatin/pemetrexed

0.079

Cisplatin/paclitaxel 75/135-24h

0.477

CMF po

0.207

Dacarbazine

0.064

Docetaxel 75 q3w

0.253

Docetaxel 100 q3w

0.398

Docetaxel weekly

0.041

Doxorubicine 60

0.181

Doxorubicine 75

0.408

ECF

0.149

Fludarabine

0.138

FOLFIRI

0.075

FOLFOX 4

0.119

FOLFOX 6

0.172

Gemcitabine 1g 3/4 weeks

0.077

Gemcitabine 1.25g 3/4 weeks

0.076

Gemcitabine 1g 7/8 then 3/4 weeks

0.11

Gemcitabine FDR 1.5g 3/4 weeks

0.193

Gemcitabine/irinotecan

0.125

Gemcitabine/pemetrexed d8

0.239

Irinotecan q3w

0.226

PEG doxorubicin (Doxil) 50 q4w

0.089

Pemetrexed

0.042

Paclitaxel 175 q3w

0.3

Paclitaxel 200 q3w

0.239

Paclitaxel 80 weekly

0.08

Topotecan IV

0.346

Topotecan oral

0.221

Topotecan weekly

0.124

XELOX

0.134