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Hepatobiliary Tumors

Moffitt Cancer Center's hepatobiliary team provides patients access to the latest treatments across surgical, medical and radiation oncology through a multidisciplinary management approach. Over the last several years, the Hepatobiliary Section has developed and strengthened the center’s hepatobiliary expertise.

The program maximizes the ability to provide curative treatments and optimize the delivery of care for each and every patient, including a special focus on the geriatric population. At Moffitt, it is our priority to evaluate every patient in the most comprehensive and efficient way possible. Every patient’s case is presented in our Multidisciplinary Hepatobiliary Tumor Board Conference, ensuring one-stop input from all specialties to establish the best diagnostic and management strategy for each individual patient. Patients are then seen by all involved specialties during one visit, reducing the need for multiple visits, additional travel, and expediting treatment initiation.

The hepatobiliary team at Moffitt sees and treats a high volume of a variety of liver-related diagnoses from across Florida. Additionally we have a close collaboration and well established patient flow process with Tampa General Hospital's organ transplantation team for those patients who would benefit from transplant.

The hepatobiliary malignancies section is one part of Moffitt’s GI Oncology Program. Every member of the integrated GI Oncology team at Moffitt has extensive sub-specialty experience in treating patients with the variety of GI cancers and can handle advanced cases.

Diagnoses Treated

• Liver lesions, masses and/or tumors - benign and premalignant conditions including but not limited to:
– Hemangiomas
– Focal nodular hyperplasia (FNH)
– Adenomas
• Liver cysts – benign, premalignant & malignant including:
– Biliary cysts
– Polycystic liver disease
– Parasitic (echinococcal) cysts
– Cystadenoma (mucinous neoplasm)
– Cystadenocarcinomas (mucinous carcinoma)
• Liver cancer – hepatocellular carcinoma, cholangiocarcinoma, others
• Liver metastasis – colorectal, neuroendocrine, renal cell, melanoma, among others
• Gallbladder cancer and premalignant lesions (polyps, calcified gallbladder, others)
• Hilar cholangiocarcinoma (Klatskin tumor)
• Extrahepatic cholangiocarcinoma of the bile ducts
• Bile duct strictures, bile duct cysts (choledochal cysts)

Treatments & Services

• Minor and major liver resection (hepatectomy) - open surgery and minimally invasive
– Combined simultaneous resections (liver and other organs)
– Percutaneous, laparoscopic and open liver ablation (primary and metastatic tumors)
– Cholecystectomy and radical cholecystectomy
– Biliary tract, bile duct, and hepatic duct resection, including biliary tract reconstruction for biliary strictures and tumors
– Novel surgical procedures - staged hepatectomies (bilobar tumors), ALPPS surgery, others
• Preoperative portal vein embolization and neoadjuvant therapies, to increase the resectability of tumors otherwise not amenable for surgery
• Chemotherapy
– Clinical trials with chemotherapy and other novel treatments – Phase I, II, III trials
• External beam radiation and stereotactic radiation (SBRT)
• Transarterial radiation therapy: radioembolization with yttrium-90
• Transarterial treatment of liver tumors: bland embolization (TAE), chemoembolization
• Irreversible electroporation (IRE)
• Diagnostic and therapeutic endoscopic procedures including:
– ERCP/cholangioscopy
– Stent placement
– EUS +/- biopsies
• Hepatitis B & C treatment
• Cirrhosis management