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CLINICAL TRIAL 17425

Randomized Phase II/III Trial of Adjuvant Radiation Therapy with Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck

Disease Site: Larynx, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 18994

Phase II Randomized Trial of Radiotherapy with or without Cisplatin for Surgically Resected Squamous Cell Carcinoma of the Head and Neck (SCCHN) with TP53 Sequencing

Disease Site: Head & Neck, Larynx, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 19748

Phase II Randomized Trial of Radiotherapy with Concurrent and Adjuvant Pembrolizumab (Keytruda®) Versus Concurrent Chemotherapy in Patients with Advanced/Intermediate-Risk p16+ Head and Neck Squamous Cell Carcinoma (KEYCHAIN Trial)

Disease Site: Head & Neck, Squamous Cell Carcinoma (SCC), Lip, Oral Cavity and Pharynx, Other Skin

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CLINICAL TRIAL 20132

Phase 1/2 Dose-Escalation and Expansion Study of FLX475 Alone and in Combination with Pembrolizumab in Advanced Cancer

Disease Site: Any Site, Breast, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 20144

A Phase 1, First-in-Human, Open-Label, Dose Escalation and Expansion Study of CUE-101 Monotherapy in Second Line and CUE-101 Combination Therapy with Pembrolizumab in First Line Patients with HPV16+ Recurrent / Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)

Disease Site: Head & Neck, Larynx, Lip, Oral Cavity and Pharynx, Squamous Cell Carcinoma (SCC)

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CLINICAL TRIAL 20274

A Phase II/III Randomized Study of Maintenance Nivolumab versus Observation in Patients with Locally Advanced, Intermediate Risk HPV Positive OPCA

Disease Site: Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 20282

A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients with Early-Stage, P16 Positive, Non-Smoking Associated Oropharyngeal Cancer

Disease Site: Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 20285

A Multicenter Phase I/II Trial of a Novel MDM2 Inhibitor (APG-115) in P53 Wild-Type Salivary Gland Carcinoma

Disease Site: Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 20956

A Two-Part, Phase 1a/B, Open-Label, Multicenter Trial Evaluating Pharmacokinetics, Safety and Efficacy Of PF-07284890 (ARRY-461) In Participants With BRAF V600-Mutant Solid Tumors With And Without Brain Involvement

Disease Site: Any Site, Brain and Nervous System, Larynx, Lip, Oral Cavity and Pharynx, Lung, Melanoma, skin, Other Skin, Brain metastasis, Gliomas

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CLINICAL TRIAL 21026

A Phase II Study of Cemiplimab, an Anti-PD-1 Monoclonal Antibody, and ISA101b Vaccine in Patients with Recurrent/Metastatic HPV16 Positive Oropharyngeal Cancer who have Experienced Disease Progression with Prior Anti-PD-1 Therapy

Disease Site: Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 21077

A Phase 2 Study of ALX148 in Combination with Pembrolizumab in Patients with Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03)

Disease Site: Larynx, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 21078

A Phase 2 Study of ALX148 in Combination with Pembrolizumab and chemotherapy in Patients with Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-04)

Disease Site: Larynx, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 21116

Birinapant and Intensity Modulated Re-Irradiation Therapy (IMRRT) for Locoregionally Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC)

Disease Site: Larynx, Lip, Oral Cavity and Pharynx, Head & Neck, Squamous Cell Carcinoma (SCC)

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CLINICAL TRIAL 21131

A Phase II Randomized Trial of Adjuvant Therapy with Pembrolizumab After Resection of Recurrent/Second Primary Head and Neck Squamous Cell Carcinoma with High Risk Features

Disease Site: Larynx, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 21140

Phase I Trial With Expansion Cohort Of DNA-PK Inhibition And IMRT In Cisplatin-Ineligible Patients With Stage 3-4 Local-Regionally Advanced Head And Neck Squamous Cell Carcinoma (HNSCC)

Disease Site: Larynx, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 21163

A Phase 1/2 Study of Regn7075 (Egfrxcd28 Costimulatory Bispecific Antibody) in Combination with Cemiplimab in Patients with Advanced Solid Tumors

Disease Site: Anus, Breast, Cervix, Colon, Esophagus, Kidney, Lip, Oral Cavity and Pharynx, Lung, Other Digestive Organ, Other Female Genital, Other Male Genital, Other Skin, Other Urinary, Pancreas, Prostate, Stomach

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CLINICAL TRIAL 21180

A First-in-Human, Two-Part, Open-Label, Clinical Study to Assess the Safety, Tolerability and Activity of Intravenous Doses of ICT01 as Monotherapy and in Combination with an Immune Checkpoint Inhibitor, in Patients with Advanced-Stage, Relapsed/Refractory Cancer (EVICTION Study)

Disease Site: Any Site, Breast, Colon, Larynx, Leukemia, other, Lip, Oral Cavity and Pharynx, Lung, Melanoma, skin, Ovary, Prostate, Stomach, Urinary Bladder

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CLINICAL TRIAL 21282

The BURAN Study of Buparlisib (AN2025) In Combination with Paclitaxel Compared to Paclitaxel Alone, in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Disease Site: Larynx, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 21641

First-in-Human, Phase 1/1b, Open-label, Multicenter Study of Bifunctional EGFR/TGF_ Fusion Protein BCA101 Alone and in Combination with Pembrolizumab in Patients With EGFR-Driven Advanced Solid Tumors

Disease Site: Larynx, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 21657

Randomized Phase II/III Trial of Radiation with High-Dose Cisplatin (100 mg/m2) Every Three Weeks Versus Radiation with Low-Dose Weekly Cisplatin (40 mg/m2) for Patients with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN)

Disease Site: Larynx, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 21150

Effect of Prolonged Nightly Fasting (PNF) on Immunotherapy Treatment Outcomes in Patients with Advanced Head and Neck Cancer (HNSCC)-Role of Gut Microbiome

Disease Site: Larynx, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 20337

Nine-valent HPV Vaccine to Prevent Persistent Oral HPV Infection in Men Living with HIV

Disease Site: Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 17716

A Biomarker-related Approach to Screening for HPV-related Oropharyngeal Cancer

Disease Site: Larynx, Throat, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 20819

Adaptation of an HPV education resource to promote HPV vaccination among Latino Young Men who Have Sex with Men in Puerto Rico and Florida (Proyecto Hombres Previniendo el VPH (Proyecto HPV)

Disease Site: Anus, Cervix, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 21589

BASECAMP-1: An Observational Study Obtaining Solid Tumor Tissue from Subjects with Primary Surgical Resection and Leukapheresis for CAR T-Cell Therapy Manufacturing

Disease Site: Breast, Colon, Esophagus, Lip, Oral Cavity and Pharynx, Lung, Ovary, Pancreas, Rectum, Stomach

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