Clinical Trial 21561

Study Title

Assessment of Chimerism and Relapse Post-Bone Marrow / Hematopoietic Cell Transplant (HCT) using ALLOHEME Test (ACROBAT)

Summary

This observational cohort study will evaluate the correlation of chimerism status detected by a highly sensitive AlloHeme method with post-transplant relapse in patients with acute leukemias and MDS receiving allo-HCT

Objective

Primary Objective To determine the association between an iMC detected by AlloHeme and post-transplant relapse in patients with AML, MDS, or ALL. Secondary Objectives To determine the association between longitudinal measurement of mixed- chimerism (MC) detected by AlloHeme and post-transplant relapse in patients with AML, MDS, or ALL. To determine the association of microchimerism detected by AlloHeme on post-transplant relapse in patients with AML, MDS, or ALL. To determine the association between an iMC detected by AlloHeme and disease-free survival post-transplant in patients with AML, MDS, or ALL. To determine the correlation of donor chimerism quantitatively detected by AlloHeme and post-transplant measurable residual disease (MRD) in patients with AML, MDS, or ALL. To compare the performance of post-transplant chimerism measured by Alloheme versus STR-PCR method for post-transplant relapse prediction in patients with AML, MDS, or ALL.