COVID-19 UPDATE: Moffitt is offering third doses and vaccine booster shots. Learn More
Phase I Trial With Expansion Cohort Of DNA-PK Inhibition And IMRT In Cisplatin-Ineligible Patients With Stage 3-4 Local-Regionally Advanced Head And Neck Squamous Cell Carcinoma (HNSCC)
Primary Objective: To determine the recommended phase 2 dose (RP2D) of M3814 (peposertib) when given in combination with IMRT. Secondary Objectives: To evaluate the safety and tolerability of the combination of M3814 (peposertib) with radiotherapy. To estimate the rates of grade 3 or greater acute toxicities of the regimen. To estimate late toxicities of the regimen. To evaluate the clinical response rate, based on RECIST 1.1, at 3 months post completion of radiotherapy. To estimate 6 and 12-month progression-free survival (PFS) in the dose expansion cohort (DEC). To estimate 6 and 12-month overall survival (OS) in the DEC.
Chemotherapy (NOS); Radiotherapy
IGRT (); IMRT (); M3814 Peposertib ()
Back to top
Please call 1-888-663-3488 for support from a Moffitt representative. New Patients and Healthcare Professionals can submit an online form by selecting the appropriate buttonbelow. Existing patients can call 1-888-663-3488. Click here for a current list of insurances accepted at Moffitt.
NEW PATIENTS To request a new patient appointment, please fill out the online form or call 1-888-663-3488.
REFERRING PHYSICIANS Providers and medical staff can refer patients by submitting our online referral form.
Moffit now offers Virtual Visits for patients. If you are eligible for a virtual appointment, our scheduling team will discuss this option further with you.