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A Modular Phase 2a Multicentre Open-Label Study to Investigate DNA-damage Response Agents (or Combinations) in Patients With Advanced Cancer Whose Tumours Contain Molecular Alterations (PLANETTE)
The study is investigating efficacy, safety and tolerability of DNA-damage Response Agents (or Combinations), in participants with advanced/metastatic solid malignancies whose tumour contain molecular alterations.
1. To obtain a preliminary assessment of the efficacy of study intervention as assessed by response rate. 2. To obtain a preliminary assessment of further efficacy endpoints with study intervention. 3. To assess the safety and tolerability profile of study intervention.