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Clinical Trial 20866

Cancer Type: Genitourinary
Study Type: Treatment
NCT#: NCT03606174

Phase: Phase II
Prinicipal Investigator: Rohit Jain

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or 1-800-679-0775 Learn More
Overview

Study Title

A Phase 2 Study of Sitravatinib in Combination with PD-(L)1 Checkpoint Inhibitor Regimens in Patients with Advanced or Metastatic Urothelial Carcinoma

Summary

The study will evaluate the clinical activity of PD-(L)1 Checkpoint Inhibitor regimens in combination with the investigational agent sitravatinib in patients with advanced or metastatic urothelial carcinoma.

Objective

- To evaluate the clinical activity of sitravatinib in combination with PD-(L)1 checkpoint inhibitor regimens in patients with advanced or metastatic urothelial carcinoma

Treatments

Therapies

Medications

BMS-936558 (Nivolumab); Enfortumab Vedotin (Padcev); Nivolumab (Opdivo); Pembrolizumab (Keytruda); Sitravatinib ()

Inclusion Criteria

  • Diagnosis of urothelial carcinoma
  • Adequate bone marrow and organ function

  • Exclusion Criteria

  • Uncontrolled tumor in the brain
  • Unacceptable toxicity with prior checkpoint inhibitor
  • Impaired heart function

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