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Clinical Trial 20748

Cancer Type: Breast
Study Type: Treatment
NCT#: NCT04461600

Phase: Phase II
Prinicipal Investigator: Aixa Soyano Muller

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Overview

Study Title

TENACITY- A Phase 2, Multicenter, Open-Label, Single-arm Study of AL101 Monotherapy in Patients with Notch-activated Triple Negative Breast Cancer

Summary

This study is designed to evaluate the efficacy and safety of AL101 monotherapy in subjects with Notch-activated recurrent or metastatic TNBC; Notch activation will be determined by a Next Generation Sequencing (NGS) test.

Objective

Primary Objective: To evaluate the efficacy of AL101 monotherapy in subjects with Notch-activated recurrent or metastatic TNBC

Treatments

Therapies

Medications

AL101 (); BMS-906024 (AL101)

Inclusion Criteria

Inclusion Criteria:

  • Male of female subjects who are at least 18 years of age (inclusive) at the time of signing the Informed Consent Form (ICF).
  • Have at least one measurable lesion per RECIST v1.1.
  • Have formalin-fixed paraffin-embedded (FFPE) tissue available from a metastatic lesion; a tumor block or 25 unstained slides from an archived (within 2 years) or fresh tumor samples (core or punch needle biopsy) are acceptable.
  • Documented tumor progression following no more than 3 lines of systemic chemotherapy, PARP inhibitor therapy or immunotherapy for metastatic disease, as appropriate. Of note, neoadjuvant and adjuvant therapy will not count as prior lines of therapy.
  • Histologically confirmed diagnosis of inoperable locally advanced or metastatic TNBC defined as ER and progesterone receptor staining > Documented Notch activation from tumor biopsy results from within the last 2 years from a commercially available NGS assay, LDT or other validated IUO clinical trial assay.
  • Women of childbearing potential (WOCBP) must have a negative serum or urine pregnancy test.
  • Other criteria may apply

  • Exclusion Criteria

    Exclusion Criteria:

  • A known additional malignancy that is progressing or requires active treatment that is considered medically active and may interfere in the ability to detect responses in this subject. Exceptions include basal cell carcinoma of the skin, squamous cell carcinoma of the skin that have undergone potentially curative therapy or in situ cervical cancer.
  • Breast Cancer that, in the opinion of the investigator, is considered amenable to potentially curative treatment.
  • Symptomatic central nervous system (CNS) metastases.
  • Current or recent (within 2 months of IP administration) gastrointestinal (GI) disease or disorders that increase the risk of diarrhea, such as inflammatory bowel disease and Crohn's disease.
  • Developed immune-mediated colitis with immunotherapy unless resolved to G1 or lower and without requirement of steroid treatment for at least 14 days prior to first dose of IP.
  • Peripheral neuropathy Grade 2 for at least 14 days prior to first dose of IP.
  • Evidence of uncontrolled, active infection, requiring systemic anti-bacterial, anti-viral or anti-fungal therapy ≤7 days prior to administration of IP such as known active infection with hepatitis B, hepatitis C, or human immunodeficiency virus (HIV).
  • Unstable or severe uncontrolled medical condition (e.g., unstable cardiac or pulmonary function or uncontrolled diabetes) or any important medical illness or abnormal laboratory finding that would, in the investigator's judgment, increase the risk to the subject associated with his or her participation in the study.
  • Eastern Cooperative Oncology Group (ECOG) performance status greater than or equal to 2
  • Abnormal organ and marrow function as defined per protocol.
  • Myocardial infarction within 6 months prior to enrollment or has New York Heart Association (NYHA) Class III or IV heart failure, uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities.
  • Mean QT interval corrected for heart rate using Fridericia's formula (QTcF) less than or equal to 480 msec
  • Completed palliative radiation therapy > Prior treatment with gamma secretase inhibitors.
  • Last chemotherapy, biologic, or investigational therapy agent at least 4 weeks or 5 half-lives (whichever is shorter) prior to initiating IP; at least 6 weeks if the last regimen included BCNU or mitomycin C. Prior treatment with investigational monoclonal antibody will be reviewed case-by-case by the Sponsor.
  • Receiving chronic systemic steroid therapy (in dosing exceeding 10 mg/day of prednisone or equivalent) or any other form of immunosuppressive therapy within 7 days prior to the first dose of IP. The use of physiologic doses of corticosteroids may be approved after consultation with the Sponsor.
  • Use of strong inhibitors of CYP3A4 within 1 week or 5 half-lives (whichever is longer) or strong inducers of CYP3A4 within 2 weeks or 5 half-lives (whichever is longer).
  • Other exclusions may apply

  • If you are interested in learning more about clinical trials, our clinical trial navigators can discuss your options and recommend opportunities that may be suitable for you. Call 813-745-6100 or 1-800-679-0775 (toll-free) or submit a clinical trials inquiry form.