Clinical Trials Search
Clinical Trial 20042
Cancer Type: Malignant Hematology
Study Type: Treatment
NCT#: NCT04620681
Phase: Phase I/II
Prinicipal Investigator: Hany Elmariah
Study Title
CD8 Depleted, Non-Engrafting, HLA Mismatched Unrelated Donor Lymphocyte Infusion in Patients with MDS and Secondary AML
Summary
The purpose of the study is to determine the safety of an investigational treatment for myelodysplastic syndrome (MDS) after the first therapy (such as azacitidine or decitabine) stops working or after progression of MDS to acute myeloid leukemia (AML).
Objective
1. Determine the maximum tolerated dose (MTD) of CD8-depleted non-engrafting human leukocyte antigen (HLA) mismatched unrelated donor lymphocyte infusion (NE-DLI) in patients with myeloid malignancies. 2. Estimate the response rate to therapy with CD8-depleted NE-DLI in patients with myelodysplastic syndrome (MDS) who have failed therapy with hypomethylating agents (HMAs) or untreated patients with acute myeloid leukemia (AML) secondary to an antecedent hematologic disease (sAML).
Therapies
Medications
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