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Clinical Trial 19720

Cancer Type: Malignant Hematology
Study Type: Treatment
NCT#: NCT03568461

Phase: Phase II
Prinicipal Investigator:

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Study Title

A Phase II, Single Arm, Multicenter Open Label Trial to Determine the Efficacy and Safety of Tisagenlecleucel (CTL019) In Adult Patients with Refractory or Relapsed Follicular Lymphoma


This study is to determine the efficacy and safety of tisagenlecleucel in adult patients with refractory or relapsed follicular lymphoma


Evaluate the efficacy of tisagenlecleucel therapy as measured by complete response rate determined by Independent Review Committee in the full analysis set based on Lugano 2014 classification response criteria




Tisagenlecleucel ()

Inclusion Criteria

  • Refractory or relapsed Follicular Lymphoma (Grade 1, 2, 3A)
  • Radiographically measurable disease at screening
  • Other criteria may apply

  • Exclusion Criteria

  • Evidence of histologic transformation
  • Follicular Lymphoma Grade 3B
  • Prior anti-CD19 therapy
  • Prior gene therapy
  • Prior adoptive T cell therapy
  • Prior allogeneic hematopoietic stem cell transplant
  • Active CNS involvement by malignancy
  • Other criteria may apply

  • If you are interested in learning more about clinical trials, our clinical trial navigators can discuss your options and recommend opportunities that may be suitable for you. Call 813-745-6100 or 1-800-679-0775 (toll-free) or submit a clinical trials inquiry form.