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Contribution of Sleep Disruption and Physical Inactivity to Fatigue In Survivors of Allogeneic Hematopoietic Cell Transplant
While relationships between self-reports of sleep, activity, and fatigue are well characterized, relationships between objectively measured sleep and activity with self-reported fatigue are not well understood. Moreover, even less is known about the impact of daily sleep and activity on daily fatigue. Given these key unanswered questions, the proposed study will characterize fatigue among allogeneic HCT patients and investigate relationships of sleep and sedentary behavior with fatigue. The study participants will include adults who underwent an allogeneic HCT at Moffitt Cancer Center for treatment of a hematologic disease.
Aim 1: To characterize the prevalence and daily variability of fatigue among allogeneic HCT survivors. Aim 2: To investigate the relative contribution of aggregated daily fatigue and summary fatigue to aggregated sleep disruption. Aim 3: To investigate the relative contribution of aggregated daily fatigue and summary fatigue to aggregated sedentary behavior. Aim 4: To explore whether sleep disruption during the previous night and sedentary behavior during the day are related to evening reports of fatigue.