Clinical Trial 19119

Cancer Type: Malignant Hematology
Interventions:Jakafi (Ruxolitinib); Methylprednisolone; Ruxolitinib; prednisone

Study Type: Treatment
Phase of Study: Phase II


    Study Title

    A Single-Cohort, Phase 2 Study of Ruxolitinib in Combination With Corticosteroids for the Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease


    The purpose of the Study is to find out if taking ruxolitinib in combination with corticosteroids is safe and effective in participants with Grades II to IV steroid-refractory acute graft-versus-host disease (GVHD).


    Primary Objective: Assess the efficacy of ruxolitinib in combination with corticosteroids in subjects with Grade II to IV steroid-refractory acute graft-versus-host disease (GVHD). Secondary Objectives: Assess additional response and longer-term efficacy outcomes in the study population. Assess the incidence and severity of adverse events (AEs) and serious adverse events (SAEs). Evaluate the pharmacokinetics of ruxolitinib when administered in combination with corticosteroids.

    Inclusion Criteria

  • Have undergone first allogeneic hematopoietic stem cell transplantation (allo-HSCT) from any donor source using bone marrow, peripheral blood stem cells, or cord blood for hematologic malignancies. Recipients of nonmyeloablative and myeloablative conditioning regimens are eligible.
  • Clinically suspected Grades II to IV acute GVHD as per MAGIC guidelines, occurring after allo-HSCT with any conditioning regimen and any anti-GVHD prophylactic program.
  • Potential participants with steroid-refractory acute GVHD, defined as any of the following: 1.) Progressive GVHD (i.e., increase in stage in any organ system or any new organ involvement) after 3 days of primary treatment with methylprednisolone ≥ 2 mg/kg per day (or equivalent). 2.) GVHD that has not improved (i.e., decrease in stage in at least 1 involved organ system) after 7 days of primary treatment with methylprednisolone ≥ 2 mg/kg per day (or equivalent). 3.) Previously began corticosteroid therapy at a lower dose (at least 1 mg/kg per day methylprednisolone) but develop new GVHD in another organ system. 4.) Cannot tolerate a corticosteroid taper, that is, begin corticosteroids at 2.0 mg/kg per day, demonstrate response, but progress before a 50% decrease from the initial starting dose of corticosteroids is achieved.
  • Evidence of myeloid engraftment (e.g., absolute neutrophil count ≥ 0.5 × 10^9/L for 3 consecutive days if ablative therapy was previously used). Use of growth factor supplementation is allowed.

  • Exclusion Criteria

  • Has received more than 1 allogeneic hematopoietic stem cell transplantation (allo-HSCT).
  • Has received more than 1 systemic treatment in addition to corticosteroids for acute GVHD.
  • Presence of GVHD overlap syndrome as per National Institutes of Health (NIH) guidelines.
  • Presence of an active uncontrolled infection. An active uncontrolled infection is defined as hemodynamic instability attributable to sepsis or new symptoms, worsening physical signs, or radiographic findings attributable to infection. Persisting fever without signs or symptoms will not be interpreted as an active uncontrolled infection.
  • Known human immunodeficiency virus infection.
  • Active hepatitis B virus (HBV) or hepatitis C virus infection that requires treatment or at risk for HBV reactivation. Subjects whose immune status is unknown or uncertain must have results confirming immune status before enrollment.
  • Serum creatinine > 2.0 mg/dL or creatinine clearance > Evidence of relapsed primary disease, or have been treated for relapse after the allo-HSCT was performed.
  • Unresolved toxicity or complications (other than acute GVHD) due to previous allo-HSCT.
  • Any corticosteroid therapy for indications other than GVHD at doses of methylprednisolone or equivalent > 1 mg/kg per day within 7 days of enrollment.
  • Severe organ dysfunction unrelated to underlying GVHD, including: 1.) Cholestatic disorders or unresolved veno-occlusive disease of the liver (defined as persistent bilirubin abnormalities not attributable to GVHD and ongoing organ dysfunction). 2.) Clinically significant or uncontrolled cardiac disease including unstable angina, acute myocardial infarction within 6 months from Day 1 of study drug administration, New York Heart Association Class III or IV congestive heart failure, circulatory collapse requiring vasopressor or inotropic support, or arrhythmia that requires therapy. 3.) Clinically significant respiratory disease that requires mechanical ventilation support or 50% oxygen.
  • Currently breast feeding.
  • Received Janus kinase (JAK) inhibitor therapy after allo-HSCT for any indication. Treatment with a JAK inhibitor before allo-HSCT is permitted.
  • Treatment with any other investigational agent, device, or procedure, within 21 days (or 5 half-lives, whichever is greater) of enrollment. Patients participating in a GVHD prophylaxis study or conditioning regimen should be discussed with the sponsor's medical monitor before enrollment.
  • Any condition that would, in the investigator's judgment, interfere with full participation in the study, including administration of study drug and attending required study visits; pose a significant risk to the participant; or interfere with interpretation of study data.
  • Known allergies, hypersensitivity, or intolerance to any of the study medications, excipients, or similar compounds.