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Phase I Study of Pre-operative Capecitabine and Lenvatinib with External Radiation Therapy in Locally Advanced Rectal Adenocarcinoma
This research study is designed to see if Capecitabine and Lenvatinib in combination with external radiation therapy are effective in treating locally advanced rectal adenocarcinoma in patients who have not yet had surgery, and what the best dosage is.
Primary Objective: - To determine the maximally tolerated dose of lenvatinib when delivered concurrently with capecitibine and external beam radiation in patients with locally advanced rectal adenocarcinoma. Secondary Objectives: - To determine the pathologic response rate after pre-operative therapy and surgery. - To further define safety profile of the combination.