Clinical Trial 18626

Cancer Type: Malignant Hematology
Interventions:carfilzomib (Kyprolis)

Study Type: Treatment
Phase of Study: Phase II
Investigators:

  • Joseph Pidala

Overview

Study Title

Carfilzomib for Treatment of Chronic Graft vs. Host Disease

Summary

The purpose of this research study is to see if Carfilzomib is helpful in the treatment of chronic graft-versus-host disease (GVHD). The study will enroll people who have active chronic GVHD despite at least one prior chronic GVHD treatment. The study will also examine how chronic GVHD affects quality of life and symptoms, and will explore the impact of this treatment on the immune system.

Objective

Primary Objective: Determine the proportion of subjects with treatment failure by 6 months after carfilzomib treatment for chronic GVHD. Secondary Objectives: 1. Determine 3 month overall (complete + partial), and complete response rate. 2. Determine 6 month overall (complete + partial), and complete response rate. 3. Report overall survival, non-relapse mortality, primary malignancy relapse, failure-free survival, treatment success, and discontinuation of immune-suppressive therapy at 6 months and 1 year. 4. Examine functional outcome (2-minute walk test) and patient-reported outcomes (Lee Chronic GVHD Symptom Scale, quality of life (SF-36, FACT-BMT), Human Activity Profile (HAP)) at study enrollment, 6 months and 1 year. 5. Study biologic effects of proteasome inhibition.

Inclusion Criteria

  • Diagnosis of chronic graft-versus-host disease (GVHD according to National Institutes of Health (NIH) Consensus Criteria. May have either classic chronic GVHD or overlap subtype of chronic GVHD.
  • Failure of at least one prior line of systemic immune suppressive therapy for management of chronic GVHD.
  • Potential participant underwent transplantation at least 3 months prior to enrollment.
  • Anticipated life expectancy >= 6 months.
  • Alanine aminotransferase (ALT) => Bilirubin => Absolute neutrophil count (ANC) >= 1.0 × 10^9/L.
  • Hemoglobin >= 8 g/dL.
  • Platelet count >= 50 × 10^9/L.
  • Creatinine clearance (CrCl) >= 15 mL/minute, either measured or calculated.
  • Signed informed consent in accordance with federal, local, and institutional guidelines.
  • Females of childbearing potential (FCBP) must agree to a pregnancy test at study enrollment and to practice contraception during the study.
  • Males must agree to practice contraception during the study.

  • Exclusion Criteria

  • Evidence of recurrent or progressive underlying malignant disease.
  • Women who are pregnant or lactating.
  • Surgery within 21 days prior to enrollment. Does not include placement of venous access device, bone marrow biopsy, GVHD diagnostic biopsy, or other routine procedures in chronic GVHD or post-transplantation care.
  • Uncontrolled infection within 14 days prior to enrollment. Infection treated with appropriate antimicrobial therapy and without signs of progression/treatment failure does not constitute an exclusion criterion.
  • Documented human immunodeficiency virus (HIV) infection.
  • Active hepatitis B or C infection.
  • Documented unstable angina or myocardial infarction within 6 months prior to enrollment, New York Heart Association (NYHA) class III or IV heart failure, uncontrolled angina, severe uncontrolled ventricular arrhythmias, sick sinus syndrome, or electrocardiographic evidence of acute ischemia or grade 3 conduction system abnormalities (unless subject has a pacemaker), left ventricular ejection fraction (LVEF) > Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to enrollment. Sustained systolic blood pressure > 160 or diastolic blood pressure > 100 despite medical therapy; sustained blood sugar > 300 despite medical therapy. Chronic hypertension or diabetes on appropriate medical therapy does not constitute an exclusion criterion.
  • Non-hematologic malignancy within the past 3 years with the exception of: Adequately treated basal cell carcinoma, squamous cell skin cancer, or thyroid cancer; Carcinoma in situ of the cervix or breast; Prostate cancer of Gleason grade 6 or less with stable prostate-specific antigen levels; Cancer considered cured by surgical resection or unlikely to impact survival during the duration of the study.
  • Significant neuropathy per Common Terminology Criteria for Adverse Events (CTCAE) version (ver.) 4.03 or current version (grade 3 and above, or grade 2 with pain) within 14 days prior to enrollment.
  • History of allergy to Captisol (a cyclodextrin derivative used to solubilize carfilzomib).
  • Contraindication to all available herpes simplex virus (HSV)/varicella prophylactic antiviral drugs.
  • Pleural effusions requiring thoracentesis, or ascites requiring paracentesis, within 14 days prior to enrollment.
  • Any other clinically significant medical or psychological disease or condition that, in the investigator's opinion, may interfere with protocol adherence or a subject's ability to give informed consent.
  • New systemic immune suppressive agent added for the treatment of chronic GVHD within 2 weeks prior to enrollment.
  • Treatment with a non-Food and Drug Administration (FDA) approved drug in the previous 4 weeks.