Clinical Trials Search
Clinical Trial 17263
Interventions:FK506 (Tacrolimus); Rapamune (Sirolimus); Rapamycin (Sirolimus); Sirolimus; Tacrolimus
Study Type: Prevention
Phase of Study: Phase I
- Joseph Pidala
Phase I Trial of ex-vivo Expanded Donor Regulatory T Cells for Prevention of Acute Graft-Versus-Host Disease
Clinical trial of allospecific regulatory t cells (Tregs) for prevention of acute graft-versus-host disease (GVHD) in human leukocyte antigen (HLA) identical sibling transplants.
The primary objective of this trial is to evaluate the safety of sirolimus based immune suppression and ex-vivo expanded donor regulatory T cells for the prevention of acute graft-versus-host disease following allogeneic hematopoietic cell transplantation. Secondary objectives will monitor Treg repopulation, longevity, and antigen-specific suppressive function after HCT in vivo.