Colon Cancer Clinical Trials

Researcher performing colon cancer research in a lab

Colon cancer clinical trials provide patients with opportunities to access novel treatments before they are made available for use in other settings. Each trial is individualized based on a number of variables and overseen by a team of oncologists and research specialists. Generally speaking, these studies are performed to determine whether a new therapy is more effective than a standard one, what sort of side effects a treatment might produce, how well a therapy works with others or what type of patients are most likely to benefit from a new treatment.

The clinical trials program at Moffitt Cancer Center has provided countless patients with the ability to be among the first to benefit from new therapies as soon as they become available. It has also provided our oncologists with a better understanding of the condition in general, which we use to improve treatment for all patients.

Through past colon cancer clinical trials, researchers have determined:

  • Which chemotherapy medications are most effective for the different types and stages of colon cancer
  • How targeted therapies (medications that interfere with the growth of cancer cells while leaving healthy cells unaffected) can be used along with or in place of chemotherapy
  • The most effective surgical techniques for removing a tumor from the delicate tissues of the colon
  • The best ways to enhance long-term quality of life for colon cancer patients and survivors
  • Ways to improve colon cancer screening and early detection processes

In recognition of our commitment to advancing colon cancer research and treatment strategies, Moffitt has been recognized as a Comprehensive Cancer Center by the National Cancer Institute. We are the only such center based in Florida.

If you are considering a clinical trial, our clinical trial navigators can help you find a study that meets your needs. For more information about the colon cancer clinical trials we are currently conducting, call 1-813-745-6100 or 1-800-679-0775 (toll-free) or submit a clinical trials inquiry form. No referral is required.


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Open Clinical Trials:

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A Randomized Phase 3 Study of the Efficacy and Safety of Glufosfamide Compared with Fluorouracil (5-FU) in Patients with Metastatic Pancreatic Adenocarcinoma Previously Treated with Gemcitabine

Disease Site: Colon, Liver, Lung, Other Endocrine System, Pancreas, Small Intestine, Stomach

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Phase I/II Trial of Pre-Operative Image Guided Intensity Modulated Proton Radiation Therapy (IMPT) or Photon (IMRT) with Simultaneously Integrated Boost to the High Margin for Retroperitoneal Sarcomas

Disease Site: Anal, Colon, Kidney, Other genitourinary, Pancreas, Rectum, Sarcoma

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A Phase 1/2 Study of Regn7075 (Egfrxcd28 Costimulatory Bispecific Antibody) in Combination with Cemiplimab in Patients with Advanced Solid Tumors

Disease Site: Anus, Breast, Cervix, Colon, Esophagus, Kidney, Lip, Oral Cavity and Pharynx, Lung, Other Digestive Organ, Other Female Genital, Other Male Genital, Other Skin, Other Urinary, Pancreas, Prostate, Stomach

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A First-in-Human, Two-Part, Open-Label, Clinical Study to Assess the Safety, Tolerability and Activity of Intravenous Doses of ICT01 as Monotherapy and in Combination with an Immune Checkpoint Inhibitor, in Patients with Advanced-Stage, Relapsed/Refractory Cancer (EVICTION Study)

Disease Site: Any Site, Breast, Colon, Larynx, Leukemia, other, Lip, Oral Cavity and Pharynx, Lung, Melanoma, skin, Ovary, Prostate, Stomach, Urinary Bladder

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A Phase I/Ib Global, Multicenter, Open-Label Umbrella Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients with Metastatic Colorectal Cancer (Intrinsic)

Disease Site: Colon

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Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)

Disease Site: Colon

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A Dose-Escalation and Expansion Study of the Safety and Efficacy of XL092 in Combination with Immuno-Oncology Agents in Subjects with Unresectable Advanced or Metastatic Solid Tumors

Disease Site: Breast, Colon, Prostate, Urinary Bladder

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Phase 2, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Topically Administered LUT014 in Metastatic Colorectal Cancer Patients with EGFR Inhibitor Induced Acneiform Lesions Protocol

Disease Site: Colon

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STRONG-PD: Support Through Remote Observation And Nutrition Guidance (STRONG) Program For Cancer Patients With Peritoneal Disease

Disease Site: Colon, Other Digestive Organ

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A Pre-Pilot of a Survivor-Personalized Colorectal Cancer Screening Education Intervention for Adult First-Degree Relatives

Disease Site: Colon, Rectum

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Transdisciplinary Research in Colorectal Cancer: The ColoCare Study

Disease Site: Colorectal, Colon, Rectum

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BASECAMP-1: An Observational Study Obtaining Solid Tumor Tissue from Subjects with Primary Surgical Resection and Leukapheresis for CAR T-Cell Therapy Manufacturing

Disease Site: Breast, Colon, Esophagus, Lip, Oral Cavity and Pharynx, Lung, Ovary, Pancreas, Rectum, Stomach

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Pilot to Create and Refine eHealth Genetic Education for Early-Onset Colorectal Cancer Patients (Nest-CRC Pilot)

Disease Site: Colon, Rectum

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