Moffitt Researchers Help Lead International Efforts That Find New Genetic Links To Ovarian Cancer

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ABC Action News story: Genetic links found to ovarian cancer

Eighteen Moffitt researchers, including Center Director Thomas A. Sellers, PhD, MPH, discovered four new regions of the genome that influence the risk for developing ovarian cancer. Ovarian cancer is the fifth leading cause of cancer death among women and accounts for 3 percent of all female cancers. Although mutations in the BRCA1 and BRCA2 genes remain the strongest genetic risk factors for ovarian cancer, these new findings taken with previously identified common genetic variants account for approximately 4 percent of the inherited component of this disease.

The two Moffitt-led studies were part of a coordinated series of 13 publications that resulted from collaborations involving researchers from around the world who are part of the Collaborative Oncological Gene-environment Study. This is the largest study of its kind to investigate the genetic basis of hormone-related cancers (ovarian, breast and prostate) by looking at DNA sequences of more than 250,000 individuals.


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