Post translational modifications, such as phosphorylation and acetylation, play important roles in a variety of cellular processes. Alterations of these modifications may lead to human diseases including cancer. Our lab is interested in how these posttranslational modifications, particularly acetylation, influence biological functions such as gene expression, cell motility etc., in normal and aberrant settings. Our ultimate goal is to apply our knowledge to cure human diseases.
Our lab is interested in studying the roles of HDAC6 and cortactin, a novel HDAC6 substrate in human cancers, particularly in ovarian and breast cancers. Our previous investigation showed that HDAC6 and cortactin are associated with cell migration. We will further determine whether HDAC6 and cortactin, especially the deacetylated form of cortactin, are involved in ovarian and breast cancer metastasis.