Depending on the biological context manipulation of the activity of individual members of the E2F family may promote proliferation, may induce growth arrest or may drive programmed cell death. Our laboratory is focused on understanding the structure, function and regulation of the E2F family expecting that this information will provide a greater understanding of cancer biology and will inform improved cancer therapeutic approaches.
One area of focus in our lab is to understand a variety of negative feedback loops that retrain E2F1’s death-inducing activity and thus limit chemotherapeutic efficacy of many drugs. A second area of focus is the identification, development and characterization of novel small molecules that target various steps of the E2F pathway. And finally, we seek to understand the mechanism that regulate the expression and biological activity of E2F4 a pro-survival member of the E2F family who’s depletion can significantly increase the efficacy of number of stand chemotherapeutic drugs.