Vrushank G. Dave, MS, PhD

Where You Are:
Vrushank G. Dave, MS, PhD

Office  (813) 974-0930

Education And Training
  • Postdoctoral Fellow, University of Cincinnati College of Medicine, 1996 - Cell and Molecular Biology
  • PhD, Jawaharlal Nehru University, 1994 - Biotechnology (Cell & Microbiology)
  • MSc, MS University, 1987 - Biotechnology (Cell & Microbiology)

As a molecular biologist with a keen interest in developing mouse models of solid cancers, my lab, over the last 5 years has generated lung-specific doxycycline inducible & conditional (Cre/loxP) mouse models to elucidate molecular mechanisms of aberrant transcription regulation & cell signaling events lung cancer. We are using systems biology approach mainly focusing to mechanistic understanding of initiation of lung cancer and Epithelail-Mesencymal Transitions (EMT) during the process of metastasis.

The PTEN and the LKB1 lung-specific conditional-deficiency models are also utilized to identify gene signatures of epithelial cell polarity (AJRCB 2008) & Epithelial-Mesenchymal Transition (EMT) regulated by miRNA and master transcription factors Snail, Slug, Twist ZEB1, ZEB2 etc.

We have also developed conditional mouse models for pVHL/HIFs & lung-specific CDC42-Flox mice to identify, enrich and study cancer and normal Stem cell properties

Other interests include Transcriptional regulatory networks in the lung mediated by Calcinurin/NFAT signaling (JBC 2004, JCI 2006) & Structure-function studies on Transcription factor-DNA & protein-protein interaction in specific gene regulation. (MCB 2000, MCB 2000, Biochemistry 2005 & JMB 2006)

  • Malaney P, Uversky VN, Davé V. Identification of intrinsically disordered regions in PTEN and delineation of its function via a network approach. Methods. 2015 May;77-78:69-74. Pubmedid: 25449897.
  • Kathiriya JJ, Pathak RR, Clayman E, Xue B, Uversky VN, Davé V. Presence and utility of intrinsically disordered regions in kinases. Mol Biosyst. 2014 Sep;10(11):2876-2888. Pubmedid: 25099472.
  • Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR. A unified nomenclature and amino acid numbering for human PTEN. Sci Signal. 2014 Jul;7(332):pe15. Pubmedid: 24985344. Pmcid: PMC4367864.
  • Malaney P, Nicosia SV, Davé V. One mouse, one patient paradigm: New avatars of personalized cancer therapy. Cancer Lett. 2014 Mar;344(1):1-12. Pubmedid: 24157811. Pmcid: PMC4092874.
  • Malaney P, Uversky VN, Davé V. The PTEN Long N-tail is intrinsically disordered: increased viability for PTEN therapy. Mol Biosyst. 2013 Oct;9(11):2877-2888. Pubmedid: 24056727.
  • Pathak RR, Grover A, Malaney P, Quarni W, Pandit A, Allen-Gipson D, Dave V. Loss of phosphatase and tensin homolog (PTEN) induces leptin-mediated leptin gene expression: feed-forward loop operating in the lung. J Biol Chem. 2013 Oct;288(41):29821-29835. Pubmedid: 23963458. Pmcid: PMC3795281.
  • Davé V, Wert SE, Tanner T, Thitoff AR, Loudy DE, Whitsett JA. Conditional deletion of Pten causes bronchiolar hyperplasia. Am J Respir Cell Mol Biol. 2008 Mar;38(3):337-345. Pubmedid: 17921358. Pmcid: PMC2258453.
  • Chaney BA, Clark-Baldwin K, Dave V, Ma J, Rance M. Solution structure of the K50 class homeodomain PITX2 bound to DNA and implications for mutations that cause Rieger syndrome. Biochemistry-Us. 2005 May;44(20):7497-7511. Pubmedid: 15895993.
TOOLS:   Font Size small font resizer separator font resizer separator big font resizer
 |  Site Map  |  Privacy Policy  |  Terms and Conditions