Dr. Sellers’ research program seeks to integrate a basic science background in nutrition and genetics with observational research methods to try to understand questions like these why less than 20% of cigarette smokers develop lung cancer and why a proven effective cancer treatment is beneficial to only a subset of patients. His studies are based on genetic analysis of germline DNA with increasing incorporation of acquired (somatic) events. The primary focus of his research is ovarian cancer, which is a devastating disease with no clear warning signs and high mortality rates. Dr. Sellers also has active collaborations that involve cancers of the breast, lung and prostate. The underlying theme is identifying inter-individual differences in cancer susceptibility and using that to inform approaches to cancer prevention, early detection and precision medicine to enhance outcomes after diagnosis.Critical to the success of this effort is team science, necessitating collaborations with geneticists, pathologists, biostatisticians, biomedical informaticists and clinicians. The Moffitt environment enables that to happen naturally.