Susan Elizabeth Minton, DO

Where You Are:
Susan Elizabeth Minton, DO

Associate Member

Office  (813) 745-8410

Education And Training
  • Fellow, University of South Florida, 1996 - Hematology & Oncology
  • Resident, University of Florida Health Science Center of Jacksonville, 1993 - Internal Medicine
  • Intern, Sun Coast Hospital, 1990
  • DO, University of Medicine & Dentistry of New Jersey, 1989
  • BS, Cook College, Rutgers University, New Brunswick, New Jersey, 1984 - Food Science

Translational research investigating novel molecular markers for breast cancer. Her work also focuses on clinical translational neoadjuvant treatment trials for high-risk breast cancer.

  • Kam Y, Das T, Tian H, Foroutan P, Ruiz E, Martinez G, Minton S, Gillies RJ, Gatenby RA. Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges". Int J Cancer. 2015 Feb;136(4):E188-E196. Pubmedid: 25156304. Pmcid: PMC4262548.
  • DeMichele A, Yee D, Berry DA, Albain KS, Benz CC, Boughey J, Buxton M, Chia SK, Chien AJ, Chui SY, Clark A, Edmiston K, Elias A, Forero-Torres A, Haddad TC, Haley B, Haluska P, Hylton NM, Isaacs C, Kaplan H, Korde LA, Leyland-Jones B, Liu MC, Melisko M, Minton SE, Moulder S, Nanda R, Olopade OI, Paoloni M, Park JW, Parker BA, Perlmutter J, Petricoin E, Rugo HS, Symmans WF, Tripathy D, van 't Veer LJ, Viscusi RK, Wallace A, Wolf D, Yau C, Esserman LJ. The Neoadjuvant Model is Still the Future for Drug Development in Breast Cancer. Clin Cancer Res. 2015 Feb. Pubmedid: 25712686.
  • Jacobsen PB, Muchnick S, Marcus S, Amheiser P, Reiersen P, Gonzalez B, Gomez M, Jim HS, Thompson LM, Minton S, Bower J. Pilot study of Iyengar yoga for management of aromatase inhibitor-associated arthralgia in women with breast cancer. Psychooncology. 2015 Jan. Pubmedid: 25631519.
  • Zheng XQ, Guo JP, Yang H, Kanai M, He LL, Li YY, Koomen JM, Minton S, Gao M, Ren XB, Coppola D, Cheng JQ. Aurora-A is a determinant of tamoxifen sensitivity through phosphorylation of ERα in breast cancer. Oncogene. 2014 Oct;33(42):4985-4996. Pubmedid: 24166501. Pmcid: PMC4002670.
  • Soliman HH, Jackson E, Neuger T, Dees EC, Harvey RD, Han H, Ismail-Khan R, Minton S, Vahanian NN, Link C, Sullivan DM, Antonia S. A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors. Oncotarget. 2014 Sep;5(18):8136-8146. Pubmedid: 25327557.
  • Molife LR, Yan L, Vitfell-Rasmussen J, Zernhelt AM, Sullivan DM, Cassier PA, Chen E, Biondo A, Tetteh E, Siu LL, Patnaik A, Papadopoulos KP, de Bono JS, Tolcher AW, Minton S. Phase 1 trial of the oral AKT inhibitor MK-2206 plus carboplatin/paclitaxel, docetaxel, or erlotinib in patients with advanced solid tumors. J Hematol Oncol. 2014 Sep;7:1. Pubmedid: 24387695. Pmcid: PMC3884022.
  • Kam Y, Das T, Minton S, Gatenby RA. Evolutionary strategy for systemic therapy of metastatic breast cancer: balancing response with suppression of resistance. Womens Health (Lond Engl). 2014 Jul;10(4):423-430. Pubmedid: 25259902. Pmcid: PMC4258899.
  • Phillips KM, McGinty HL, Gonzalez BD, Jim HS, Small BJ, Minton S, Andrykowski MA, Jacobsen PB. Factors associated with breast cancer worry 3 years after completion of adjuvant treatment. Psychooncology. 2013 Apr;22(4):936-939. Pubmedid: 22419546. Pmcid: PMC3392435.
  • Silva AS, Kam Y, Khin ZP, Minton SE, Gillies RJ, Gatenby RA. Evolutionary approaches to prolong progression-free survival in breast cancer. Cancer Res. 2012 Dec;72(24):6362-6370. Pubmedid: 23066036. Pmcid: PMC3525750.
  • Jim HS, Small BJ, Minton S, Andrykowski M, Jacobsen PB. History of major depressive disorder prospectively predicts worse quality of life in women with breast cancer. Ann Behav Med. 2012 Jun;43(3):402-408. Pubmedid: 22167580. Pmcid: PMC3424106.
  • Haviland R, Eschrich S, Bloom G, Ma Y, Minton S, Jove R, Cress WD. Necdin, a negative growth regulator, is a novel STAT3 target gene down-regulated in human cancer. PLoS One. 2012 Mar;6(10):e24923. Pubmedid: 22046235. Pmcid: PMC3203112.
  • Munster PN, Moore AP, Ismail-Khan R, Cox CE, Lacevic M, Gross-King M, Xu P, Carter WB, Minton SE. Randomized trial using gonadotropin-releasing hormone agonist triptorelin for the preservation of ovarian function during (neo)adjuvant chemotherapy for breast cancer. J Clin Oncol. 2012 Feb;30(5):533-538. Pubmedid: 22231041. Pmcid: PMC3295555.
  • Bardhan P, Bui MM, Minton S, Loftus L, Carter WB, Laronga C, Ismail-Khan R. HER2-positive male breast cancer with thyroid cancer: an institutional report and review of literature. Ann Clin Lab Sci. 2012;42(2):135-139. Pubmedid: 22585608.
  • Robert NJ, Saleh MN, Paul D, Generali D, Gressot L, Copur MS, Brufsky AM, Minton SE, Giguere JK, Smith JW, Richards PD, Gernhardt D, Huang X, Liau KF, Kern KA, Davis J. Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: a phase III, randomized, open-label trial. Clin Breast Cancer. 2011 Sep;11(2):82-92. Pubmedid: 21569994.
  • Kiluk JV, Lee MC, Park CK, Meade T, Minton S, Harris E, Kim J, Laronga C. Male Breast Cancer: Management and Follow-up Recommendations. Breast J. 2011 Sep;17(5):503-509. Pubmedid: 21883641.
  • Munster PN, Thurn KT, Thomas S, Raha P, Lacevic M, Miller A, Melisko M, Ismail-Khan R, Rugo H, Moasser M, Minton SE. A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer. Brit J Cancer. 2011 Jun;104(12):1828-1835. Pubmedid: 21559012. Pmcid: PMC3111195.
  • Faul LA, Jim HS, Minton S, Fishman M, Tanvetyanon T, Jacobsen PB. Relationship of exercise to quality of life in cancer patients beginning chemotherapy. J Pain Symptom Manage. 2011 May;41(5):859-869. Pubmedid: 21330097. Pmcid: PMC3779914.
  • Munster P, Marchion D, Bicaku E, Lacevic M, Kim J, Centeno B, Daud A, Neuger A, Minton S, Sullivan D. Clinical and biological effects of valproic acid as a histone deacetylase inhibitor on tumor and surrogate tissues: phase I/II trial of valproic acid and epirubicin/FEC. Clin Cancer Res. 2009 Apr;15(7):2488-2496. Pubmedid: 19318486.
  • Moulder S, Valkov N, Neuger A, Choi J, Lee JH, Minton S, Munster P, Gump J, Lacevic M, Lush R, Sullivan D. Phase 2 study of gemcitabine and irinotecan in metastatic breast cancer with correlatives to determine topoisomerase I localization as a predictor of response. Cancer. 2008 Nov;113(10):2646-2654. Pubmedid: 18823053.
  • Münster P, Marchion D, Bicaku E, Schmitt M, Lee JH, DeConti R, Simon G, Fishman M, Minton S, Garrett C, Chiappori A, Lush R, Sullivan D, Daud A. Phase I trial of histone deacetylase inhibition by valproic acid followed by the topoisomerase II inhibitor epirubicin in advanced solid tumors: a clinical and translational study. J Clin Oncol. 2007 May;25(15):1979-1985. Pubmedid: 17513804.
  • Munster P, Britten C, Mita M, Gelmon K, Minton S, Moulder S, Slamon D, Guo F, Letrent S, Denis L, Tolcher A. First Study of the Safety, Tolerability, and Pharmacokinetics of CP-724,714 in Patients with Advanced Malignant Solid HER2-Expressing Tumors. Clin Cancer Res. 2007 Feb;13(4):1238-1245. Pubmedid: 173.
  • Munster PN, Britten CD, Mita M, Gelmon K, Minton SE, Moulder S, Slamon DJ, Guo F, Letrent SP, Denis L, Tolcher AW. First study of the safety, tolerability, and pharmacokinetics of CP-724,714 in patients with advanced malignant solid HER2-expressing tumors. Clin Cancer Res. 2007 Feb;13(4):1238-1245. Pubmedid: 17317835.
  • Cox C, Cox J, White L, Stowell N, Clark J, Allred N, Meyers M, Dupont E, Furman B, Minton S. Sentinel node biopsy before neoadjuvant chemotherapy for determining axillary status and treatment prognosis in locally advanced breast cancer. Ann Surg Oncol. 2006 Apr;13(4):483-490. Pubmedid: 16523361.
  • Diaz N, Minton S, Cox C, Bowman T, Gritsko T, Garcia R, Eweis I, Wloch M, Livingston S, Seijo E, Cantor A, Lee JH, Beam CA, Sullivan D, Jove R, Muro-Cacho CA. Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression. Clin Cancer Res. 2006 Jan;12(1):20-28. Pubmedid: 16397019.
  • Gritsko T, Williams A, Turkson J, Kaneko S, Bowman T, Huang M, Nam S, Eweis I, Diaz N, Sullivan D, Yoder S, Enkemann S, Eschrich S, Lee JH, Beam CA, Cheng J, Minton S, Muro-Cacho CA, Jove R. Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clin Cancer Res. 2006 Jan;12(1):11-19. Pubmedid: 16397018.
  • Kumar N, Allen K, Riccardi D, Bercu B, Cantor A, Minton S, Balducci L, Jacobsen P. Fatigue, weight gain, lethargy and amenorrhea in breast cancer patients on chemotherapy: is subclinical hypothyroidism the culprit?. Breast Cancer Res Treat. 2004 Jan;83(2):149-159. Pubmedid: 14997046.
  • Weitzner M, Moncello J, Jacobsen P, Minton S. A pilot trial of paroxetine for the treatment of hot flashes and associated symptoms in women with breast cancer. J Pain Symptom Manag. 2002 Apr;23(4):337-345. Pubmedid: 11997203.
  • Minton S, Munster P. Chemotherapy-induced amenorrhea and fertility in women undergoing adjuvant treatment for breast cancer. Cancer Control. 2002;9(6):466-471. Pubmedid: 12514564.
  • Minton S, Munster P. Chemotherapy-induced amenorrhea and fertility in women undergoing adjuvant treatment for breast cancer. Cancer Control. 2002;9(6):466-472. Pubmedid: 12514564.
  • Garcia R, Bowman T, Niu G, Minton S, Muro-Cacho C, Cox C, Kraker A, Levitzki A, Parsons S, Jove R, Falcone R, Fairclough R, Yu H, Laudano A, Gazit A. Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene. 2001;20(20):2499-2513. Pubmedid: 11420660.
  • Minton S. Chemoprevention of breast cancer in the older patient. Hematol Oncol Clin North Am. 2000 Feb;14(1):113-130. Pubmedid: 10680075.
  • Minton S. New hormonal therapies for breast cancer. Cancer Control. 1999;6(3):247-255. Pubmedid: 10758554.
  • Sutphen R, Diamond T, Minton S, Peacocke M, Root A. Severe Lhermitte-Duclos disease with unique germline mutation of PTEN. Am J Med Genet. 1999;82(4):290-293. Pubmedid: 10051160.
  • Minton S. Breast cancer treatment: prospects for the future. Cancer Control. 1999;6:215-217. Pubmedid: 10758551.
  • Lyman G, Kuderer N, Lyman S, Debus M, Minton S, Balducci L, Horton J, Reintgen D, Cox C. 1997;181a.
  • Lyman G, Kuderer N, Lyman S, Debus M, Minton S, Balducci L, Horton J, Reintgen D, Cox C. Menopausal status and the impact of early recurrence on breast cancer survival. Cancer Control. 1997;4(4):335-341. Pubmedid: 10763039.
  • Minton S, Shaw G. Chemoprevention of cancer in the elderly. In: Balducci L, Lyman G, Ershler W, et al, eds. Comprehensive Geriatric Oncology. Harwood Academic Publishers; 1998;307-324.
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