Susan Elizabeth Minton, DO

Translational research investigating novel molecular markers for breast cancer. Her work also focuses on clinical translational neoadjuvant treatment trials for high-risk breast cancer.

• Phillips KM, McGinty HL, Gonzalez BD, Jim HS, Small BJ, Minton S, Andrykowski MA, Jacobsen PB. Factors associated with breast cancer worry 3 years after completion of adjuvant treatment. Psychooncology. 2013 Apr;22(4):936-939. Pubmedid: 22419546. Pmcid: PMC3392435.
• Silva AS, Kam Y, Khin ZP, Minton SE, Gillies RJ, Gatenby RA. Evolutionary approaches to prolong progression-free survival in breast cancer. Cancer Res. 2012 Dec;72(24):6362-6370. Pubmedid: 23066036. Pmcid: PMC3525750.
• Jim HS, Small BJ, Minton S, Andrykowski M, Jacobsen PB. History of major depressive disorder prospectively predicts worse quality of life in women with breast cancer. Ann Behav Med. 2012 Jun;43(3):402-408. Pubmedid: 22167580. Pmcid: PMC3424106.
• Munster PN, Moore AP, Ismail-Khan R, Cox CE, Lacevic M, Gross-King M, Xu P, Carter WB, Minton SE. Randomized trial using gonadotropin-releasing hormone agonist triptorelin for the preservation of ovarian function during (neo)adjuvant chemotherapy for breast cancer. J Clin Oncol. 2012 Feb;30(5):533-538. Pubmedid: 22231041. Pmcid: PMC3295555.
• Bardhan P, Bui MM, Minton S, Loftus L, Carter WB, Laronga C, Ismail-Khan R. HER2-positive male breast cancer with thyroid cancer: an institutional report and review of literature. Ann Clin Lab Sci. 2012;42(2):135-139. Pubmedid: 22585608.
• Haviland R, Eschrich S, Bloom G, Ma Y, Minton S, Jove R, Cress WD. Necdin, a Negative Growth Regulator, Is a Novel STAT3 Target Gene Down-Regulated in Human Cancer. PLoS One. 2011 Oct;6(10):e24923. Pubmedid: 22046235.
• Kiluk JV, Lee MC, Park CK, Meade T, Minton S, Harris E, Kim J, Laronga C. Male Breast Cancer: Management and Follow-up Recommendations. Breast J. 2011 Sep;17(5):503-509. Pubmedid: 21883641.
• Munster PN, Thurn KT, Thomas S, Raha P, Lacevic M, Miller A, Melisko M, Ismail-Khan R, Rugo H, Moasser M, Minton SE. A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer. Br J Cancer. 2011 Jun;104(12):1828-1835. Pubmedid: 21559012. Pmcid: PMC3111195.
• Faul LA, Jim HS, Minton S, Fishman M, Tanvetyanon T, Jacobsen PB. Relationship of exercise to quality of life in cancer patients beginning chemotherapy. J Pain Symptom Manage. 2011 May;41(5):859-869. Pubmedid: 21330097.
• Robert NJ, Saleh MN, Paul D, Generali D, Gressot L, Copur MS, Brufsky AM, Minton SE, Giguere JK, Smith JW, Richards PD, Gernhardt D, Huang X, Liau KF, Kern KA, Davis J. Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: a phase III, randomized, open-label trial. Clin Breast Cancer. 2011 Apr;11(2):82-92. Pubmedid: 21569994.
• Munster P, Marchion D, Bicaku E, Lacevic M, Kim J, Centeno B, Daud A, Neuger A, Minton S, Sullivan D. Clinical and Biological Effects of Valproic Acid as a Histone Deacetylase Inhibitor on Tumor and Surrogate Tissues: Phase I/II Trial of Valproic acid and Epirubicin/FEC. Clin Cancer Res. 2009 Apr;15(7):2488-2496. Pubmedid: 19318486.
• Moulder S, Valkov N, Neuger A, Choi J, Lee JH, Minton S, Munster P, Gump J, Lacevic M, Lush R, Sullivan D. Phase 2 study of gemcitabine and irinotecan in metastatic breast cancer with correlatives to determine topoisomerase I localization as a predictor of response. Cancer. 2008 Nov;113(10):2646-2654. Pubmedid: 18823053.
• Münster P, Marchion D, Bicaku E, Schmitt M, Lee JH, DeConti R, Simon G, Fishman M, Minton S, Garrett C, Chiappori A, Lush R, Sullivan D, Daud A. Phase I trial of histone deacetylase inhibition by valproic acid followed by the topoisomerase II inhibitor epirubicin in advanced solid tumors: a clinical and translational study. J Clin Oncol. 2007 May;25(15):1979-1985. Pubmedid: 17513804.
• Munster P, Britten C, Mita M, Gelmon K, Minton S, Moulder S, Slamon D, Guo F, Letrent S, Denis L, Tolcher A. First Study of the Safety, Tolerability, and Pharmacokinetics of CP-724,714 in Patients with Advanced Malignant Solid HER2-Expressing Tumors. Clin Cancer Res. 2007 Feb;13(4):1238-1245. Pubmedid: 173.
• Munster PN, Britten CD, Mita M, Gelmon K, Minton SE, Moulder S, Slamon DJ, Guo F, Letrent SP, Denis L, Tolcher AW. First study of the safety, tolerability, and pharmacokinetics of CP-724,714 in patients with advanced malignant solid HER2-expressing tumors. Clin Cancer Res. 2007 Feb;13(4):1238-1245. Pubmedid: 17317835.
• Cox C, Cox J, White L, Stowell N, Clark J, Allred N, Meyers M, Dupont E, Furman B, Minton S. Sentinel node biopsy before neoadjuvant chemotherapy for determining axillary status and treatment prognosis in locally advanced breast cancer. Ann Surg Oncol. 2006 Apr;13(4):483-490. Pubmedid: 16523361.
• Diaz N, Minton S, Cox C, Bowman T, Gritsko T, Garcia R, Eweis I, Wloch M, Livingston S, Seijo E, Cantor A, Lee JH, Beam CA, Sullivan D, Jove R, Muro-Cacho CA. Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression. Clin Cancer Res. 2006 Jan;12(1):20-28. Pubmedid: 16397019.
• Gritsko T, Williams A, Turkson J, Kaneko S, Bowman T, Huang M, Nam S, Eweis I, Diaz N, Sullivan D, Yoder S, Enkemann S, Eschrich S, Lee JH, Beam CA, Cheng J, Minton S, Muro-Cacho CA, Jove R. Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clin Cancer Res. 2006 Jan;12(1):11-19. Pubmedid: 16397018.
• Kumar N, Allen K, Riccardi D, Bercu B, Cantor A, Minton S, Balducci L, Jacobsen P. Fatigue, weight gain, lethargy and amenorrhea in breast cancer patients on chemotherapy: is subclinical hypothyroidism the culprit. Breast Cancer Res Treat. 2004;83(2):149-159. Pubmedid: 14997046.
• Minton S, Munster P. Chemotherapy-induced amenorrhea and fertility in women undergoing adjuvant treatment for breast cancer. Cancer Control. 2002;9(6):466-472. Pubmedid: 12514564.
• Weitzner M, Moncello J, Jacobsen P, Minton S. A pilot trial of paroxetine for the treatment of hot flashes and associated symptoms in women with breast cancer. J Pain Symptom Manage. 2002;23(4):337-345. Pubmedid: 11997203.
• Minton S, Munster P. Chemotherapy-induced amenorrhea and fertility in women undergoing adjuvant treatment for breast cancer. Cancer Control. 2002;9(6):466-471. Pubmedid: 12514564.
• Garcia R, Bowman T, Niu G, Minton S, Muro-Cacho C, Cox C, Kraker A, Levitzki A, Parsons S, Jove R, Falcone R, Fairclough R, Yu H, Laudano A, Gazit A. Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene. 2001;20(20):2499-2513. Pubmedid: 11420660.
• Minton S. Chemoprevention of breast cancer in the older patient. Hematol Oncol Clin North Am. 2000;14(1):113-129. Pubmedid: 10680075.
• Minton S. Breast cancer treatment: prospects for the future. Cancer Control. 1999;6:215-217. Pubmedid: 10758551.
• Minton S. New hormonal therapies for breast cancer. Cancer Control. 1999;6(3):247-255. Pubmedid: 10758554.
• Sutphen R, Diamond T, Minton S, Peacocke M, Root A. Severe Lhermitte-Duclos disease with unique germline mutation of PTEN. Am J Med Genet. 1999;82(4):290-293. Pubmedid: 10051160.
• Lyman G, Kuderer N, Lyman S, Debus M, Minton S, Balducci L, Horton J, Reintgen D, Cox C. 1997;181a.
• Lyman G, Kuderer N, Lyman S, Debus M, Minton S, Balducci L, Horton J, Reintgen D, Cox C. Menopausal status and the impact of early recurrence on breast cancer survival. Cancer Control. 1997;4(4):335-341. Pubmedid: 10763039.
• Minton S, Shaw G. Chemoprevention of cancer in the elderly. In: Balducci L, Lyman G, Ershler W, et al, eds. Comprehensive Geriatric Oncology. Harwood Academic Publishers; 1998;307-324.