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Shilpa Gupta, MD

Where You Are:
Shilpa Gupta, MD

Assistant Member

Office  (813) 745-3973

Education And Training
  • Research Fellow, Thomas Jefferson University, 2011 - Genitourinary Oncology
  • Fellow, Thomas Jefferson University, 2010 - Hematology Oncology
  • Fellow, Medical College of Wisconsin, 2009 - Hematology Oncology
  • Fellow, Georgetown University, 2008 - Hematology Oncology
  • Resident, University of Connecticut, 2007 - Internal Medicine
  • Intern, University of Connecticut, 2005 - Internal Medicine
  • Fellow, Royal College of General Practitioners, UK, 2002 - Emergency Medicine
  • MBBS, Lady Hardinge Medical College, New Delhi, India, 2001


My research interests include developing novel therapeutics for treatment of genitourinary malignancies.  My translational research has been focused on testing small-molecule inhibitors targeting the Jak2/Stat5a/b signaling pathway in prostate cancer using ex-vivo preclinical model systems like human prostate cancer organ cultures. 

Our laboratory has shown that active Stat5a/b is critical for prostate cancer cell survival and growth and that the Jak2/Stat5a/b signaling pathway in prostate cancer plays a role in the progression of organ-confined prostate cancer to castration-resistant and/or disseminated disease.  The Jak2/Stat5a/b pathway provides various molecular targets for developing rational targeted therapeutics for prostate cancer and we have tested small-molecule inhibitors including Jak2 inhibitor and Stat5 inhibitor targeting this pathway with promising results.

I am interested in developing early phase clinical trials using novel targeted agents for genitourinary cancers with an emphasis on prostate and bladder cancer.

  • Baumgarten AS, Emtage JB, Wilder RB, Biagioli MC, Gupta S, Spiess PE. Intravesical Lipiodol Injection Technique for Image-guided Radiation Therapy for Bladder Cancer. Urology. 2014 Apr;83(4):946-950. Pubmedid: 24397940.
  • Motzer RJ, Jonasch E, Agarwal N, Beard C, Bhayani S, Bolger GB, Chang SS, Choueiri TK, Derweesh IH, Gupta S, Hancock SL, Kim JJ, Kuzel TM, Lam ET, Lau C, Levine EG, Lin DW, Margolin KA, Michaelson MD, Olencki T, Pili R, Plimack ER, Rampersaud EN, Redman BG, Ryan CJ, Sheinfeld J, Sircar K, Somer B, Wang J, Wilder RB, Dwyer MA, Kumar R. Kidney cancer, version 2.2014. J Natl Compr Canc Ne. 2014 Feb;12(2):175-182. Pubmedid: 24586079.
  • Mahipal A, Kothari N, Gupta S. Epidermal growth factor receptor inhibitors: coming of age. Cancer Control. 2014 Jan;21(1):74-79. Pubmedid: 24357745.
  • Gupta S, Spiess PE. The prospects of pazopanib in advanced renal cell carcinoma. Ther Adv Urol. 2013 Oct;5(5):223-232. Pubmedid: 24082917. Pmcid: PMC3763778.
  • Nevalainen MT, Gu L, Liao Z, Hoang DT, Dagvadorj A, Gupta S, Blackmon S, Ellsworth E, Talati P, Leiby B, Zinda M, Lallas CD, Trabulsi EJ, McCue PA, Gomella LG, Huszar D. Pharmacologic Inhibition of Jak2-Stat5 Signaling By Jak2 Inhibitor AZD1480 Potently Suppresses Growth of Both Primary and Castrate-Resistant Prostate Cancer. Clin Cancer Res. 2013 Oct;19(20):5658-5674. Pubmedid: 23942095.
  • Gupta S, Mahipal A. Role of systemic chemotherapy in urothelial urinary bladder cancer. Cancer Control. 2013 Jul;20(3):200-210. Pubmedid: 23811704.
  • Motzer RJ, Agarwal N, Beard C, Bhayani S, Bolger GB, Buyyounouski MK, Carducci MA, Chang SS, Choueiri TK, Gupta S, Hancock SL, Hudes GR, Jonasch E, Kuzel TM, Lau C, Levine EG, Lin DW, Margolin KA, Michaelson MD, Olencki T, Pili R, Ratliff TW, Redman BG, Robertson CN, Ryan CJ, Sheinfeld J, Wang J, Wilder RB. Testicular cancer. J Natl Compr Canc Netw. 2012 Apr;10(4):502-535. Pubmedid: 22491049.
  • Gupta S, Fishman M. Progress and contrasts of the development of tivozanib for therapy of kidney cancer. Expert Opin Pharmacother. 2011 Dec;12(18):2915-2922. Pubmedid: 22098229.
  • Gupta S, Carballido E, Fishman M. Sipuleucel-T for therapy of asymptomatic or minimally symptomatic, castrate-refractory prostate cancer: an update and perspective among other treatments. Onco Targets Ther. 2011 Nov;4:79-96. Pubmedid: 21792315. Pmcid: PMC3143908.
  • Gupta S, Gupta R, Singh S, Pant L. Solitary intrascrotal neurofibroma: A case diagnosed on aspiration cytology. Diagn Cytopathol. 2011 Nov;39(11):843-846. Pubmedid: 21994196.
  • Koptyra M, Gupta S, Talati P, Nevalainen MT. Signal transducer and activator of transcription 5a/b: biomarker and therapeutic target in prostate and breast cancer. Int J Biochem Cell Biol. 2011 Oct;43(10):1417-1421. Pubmedid: 21704724. Pmcid: PMC3163765.
  • Mahipal A, Gupta S. Small-cell carcinoma of the gallbladder: report of a case and literature review. Gastrointest Cancer Res. 2011 Jul;4(4):135-136. Pubmedid: 22368737. Pmcid: PMC3283103.
  • Dua V, Gupta S, Singh C. Evaluation of the nasolabial angle in the Indian population. Contemp Clin Dent. 2010 Apr;1(2):79-82. Pubmedid: 22114388. Pmcid: PMC3220091.
  • Gupta S, Mahipal A. A case of acquired hemophilia associated with bullous pemphigoid. Am J Hematol. 2007 Jun;82(6):502. Pubmedid: 17301969.
  • Gupta S, Mahipal A. Fatal pulmonary toxicity after a single dose of cyclophosphamide. Pharmacotherapy. 2007 Apr;27(4):616-618. Pubmedid: 17381391.
  • Weinberg B, Gupta S, Thomas MJ, Stern H. Pott's puffy tumor: Sonographic diagnosis. J Clin Ultrasound. 2005;33(6):305-307. Pubmedid: 16134159.
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