Sheng Wei, MD

Where You Are:
Sheng Wei, MD

Associate Member

Office  (813) 745-3934

Education And Training
  • Postdoctoral Fellow, University of South Florida, 1992 - Immunology , Tianjin Medical University, Tianjin, China, 1987 - Immunology
  • MD, Tianjin Medical University, Tianjin, China, 1981

Innate immune responses against infections provide a first line of host defense that occurs rapidly and is aimed at a wide range of pathogens. Activation of innate responses involves the coordinated actions of several cell types, including neutrophils, monocytes, and natural killers cells. Neutrophils are key to controlling infectious diseases, which can be deadly in cancer patients. Chemotherapy-induced myelosuppression can cause severe neutropenia. There is evidence to indicate that increasing the number of circulating neutrophils or enhancing neutrophil function may be useful for cancer patients with neutropenia. Research in my laboratory has focused on improving the functional status of neutrophils and analyzing human neutrophil activation and signaling pathways that control the neutrophil's biological functions.

By use of biological, biochemical, and gene manipulation methods, we have identified a key signaling pathway vital in normal cell function. This key signaling pathway involves mitogen-activated protein kinase (MAPK)/extracellular signal-related kinase (ERK) in neutrophils for inhibition of Candida albicans growth. Contact with C albicans triggered MAPK activation and fungicidal activity, while blocking MAPK activation, either by pharmacologic reagent PD098059 or by dominant-negative MAPK expression via vaccinia viral delivery, suppressed antimicrobial activity. Rac and Cdc42, but not Ras or Rho, were responsible for this MAPK activation, indicating that Rac/Cdc42-dependent activation of MAPK is a critical event in the immediate phagocytic response of neutrophils to microbial challenge.

Our lab is also investigating large granulocytic lymphocyte (LGL) leukemia, a syndrome of increased numbers of circulating LGLs associated with chronic neutropenia as well as other systemic symptoms. LGL leukemia is commonly associated with anemia, neutropenia, rheumatoid arthritis, and occasionally idiopathic primary pulmonary hypertension. We have generated data suggesting that perforin proteins and granzymes released from natural killer cells isolated from LGL leukemia patients significantly contribute to elevated autoimmunity and induce vascular endothelial cell death, which is capable of causing local tissue damage and chronic vascular cell injury. The lab is examining the signaling mechanism that activates perforin and granzyme release upon cell-target contact, and is attempting to provide the critical biological, biochemical, and molecular information necessary to support future design of small molecule inhibitors to reduce autoimmune reaction-mediated self-tissue damage.

  • Yang L, Qian Y, Eksioglu E, Epling-Burnette PK, Wei S. The inflammatory microenvironment in MDS. Cell Mol Life Sci. 2015 May;72(10):1959-1966. Pubmedid: 25662443.
  • Schinke C, Giricz O, Li W, Shastri A, Gordon S, Barreryo L, Bhagat T, Bhattacharyya S, Ramachandra N, Bartenstein M, Pellagatti A, Boultwood J, Wickrema A, Yu Y, Will B, Wei S, Steidl U, Verma A. IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells. Blood. 2015 May;125(20):3144-3152. Pubmedid: 25810490. Pmcid: PMC4432009.
  • McGraw KL, Zhang LM, Rollison DE, Basiorka AA, Fulp W, Rawal B, Jerez A, Billingsley DL, Lin HY, Kurtin SE, Yoder S, Zhang Y, Guinta K, Mallo M, Solé F, Calasanz MJ, Cervera J, Such E, González T, Nevill TJ, Haferlach T, Smith AE, Kulasekararaj A, Mufti G, Karsan A, Maciejewski JP, Sokol L, Epling-Burnette PK, Wei S, List AF. The relationship of TP53 R72P polymorphism to disease outcome and TP53 mutation in myelodysplastic syndromes. Blood Cancer J. 2015 Mar;5:e291. Pubmedid: 25768405. Pmcid: PMC4382654.
  • Chen X, Eksioglu EA, Carter JD, Fortenbery N, Donatelli SS, Zhou J, Liu J, Yang L, Gilvary D, Djeu J, Wei S. Inactivation of DAP12 in PMN Inhibits TREM1-Mediated Activation in Rheumatoid Arthritis. PLoS One. 2015;10(2):e0115116. Pubmedid: 25642940. Pmcid: PMC4313943.
  • Sallman DA, Wei S, List A. PP2A: The Achilles Heal in MDS with 5q Deletion. Front Oncol. 2014 OCT;4:264. Pubmedid: 25295231. Pmcid: PMC4172014.
  • Donatelli SS, Zhou JM, Gilvary DL, Eksioglu EA, Chen X, Cress WD, Haura EB, Schabath MB, Coppola D, Wei S, Djeu JY. TGF-β-inducible microRNA-183 silences tumor-associated natural killer cells. Proc Natl Acad Sci U S A. 2014 Mar;111(11):4203-4208. Pubmedid: 24586048. Pmcid: PMC3964044.
  • McGraw KL, Basiorka AA, Johnson JO, Clark J, Caceres G, Padron E, Heaton R, Ozawa Y, Wei S, Sokol L, List AF. Lenalidomide induces lipid raft assembly to enhance erythropoietin receptor signaling in myelodysplastic syndrome progenitors. PLoS One. 2014;9(12):e114249. Pubmedid: 25469886. Pmcid: PMC4254997.
  • Yang L, Eksioglu EA, Wei S. hTERT deficiency in naïve T cells affects lymphocyte homeostasis in myelodysplastic syndrome patients. Oncoimmunology. 2013 Nov;2(11):e26329. Pubmedid: 24386611.
  • Chen X, Eksioglu EA, Zhou J, Zhang L, Djeu J, Fortenbery N, Epling-Burnette P, Van Bijnen S, Dolstra H, Cannon J, Youn JI, Donatelli SS, Qin D, De Witte T, Tao J, Wang H, Cheng P, Gabrilovich DI, List A, Wei S. Induction of myelodysplasia by myeloid-derived suppressor cells. J Clin Invest. 2013 Nov;123(11):4595-4611. Pubmedid: 24216507. Pmcid: PMC3809779.
  • Caceres G, McGraw K, Yip BH, Pellagatti A, Johnson J, Zhang L, Liu K, Zhang LM, Fulp WJ, Lee JH, Al Ali NH, Basiorka A, Smith LJ, Daugherty FJ, Littleton N, Wells RA, Sokol L, Wei S, Komrokji RS, Boultwood J, List AF. TP53 suppression promotes erythropoiesis in del(5q) MDS, suggesting a targeted therapeutic strategy in lenalidomide-resistant patients. Proc Natl Acad Sci U S A. 2013 Oct;110(40):16127-16132. Pubmedid: 24043769. Pmcid: PMC3791697.
  • Mailloux AW, Zhang L, Moscinski L, Bennett JM, Yang L, Yoder SJ, Bloom G, Wei C, Wei S, Sokol L, Loughran TP, Epling-Burnette PK. Fibrosis and subsequent cytopenias are associated with basic fibroblast growth factor-deficient pluripotent mesenchymal stromal cells in large granular lymphocyte leukemia. J Immunol. 2013 Oct;191(7):3578-3593. Pubmedid: 24014875. Pmcid: PMC4346227.
  • Zhang Y, Zhang L, Jin X, Zhao H, Hao X, Peker D, Wei S, Sokol L, Moscinski L. Bone marrow involvement as initial presentation of CD8 cytotoxic peripheral T-cell lymphoma with CD20 coexpression and relatively indolent clinical course. Leuk Lymphoma. 2013 May;54(5):1113-1116. Pubmedid: 23035635.
  • Yang L, Mailloux A, Rollison DE, Painter JS, Maciejewski J, Paquette RL, Loughran TP, McGraw K, Makishima H, Radhakrishnan R, Wei S, Ren X, Komrokji R, List AF, Epling-Burnette PK. Naive T-cells in myelodysplastic syndrome display intrinsic human telomerase reverse transcriptase (hTERT) deficiency. Leukemia. 2013 Apr;27(4):897-906. Pubmedid: 23072779. Pmcid: PMC4346223.
  • Wei S, Chen X, McGraw K, Zhang L, Komrokji R, Clark J, Caceres G, Billingsley D, Sokol L, Lancet J, Fortenbery N, Zhou J, Eksioglu EA, Sallman D, Wang H, Epling-Burnette PK, Djeu J, Sekeres M, Maciejewski JP, List A. Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic syndrome with chromosome 5q deletion. Oncogene. 2013 Feb;32(9):1110-1120. Pubmedid: 22525275. Pmcid: PMC3751397.
  • Epling-Burnette PK, McDaniel J, Wei S, List AF. Emerging immunosuppressive drugs in myelodysplastic syndromes. Expert Opin Emerg Drugs. 2012 Dec;17(4):519-541. Pubmedid: 23163589.
  • Bai F, Villagra AV, Zou J, Painter JS, Connolly K, Blaskovich MA, Sokol L, Sebti S, Djeu JY, Loughran TP, Wei S, Sotomayor E, Epling-Burnette P. Tipifarnib-mediated suppression of T-bet-dependent signaling pathways. Cancer Immunol Immun. 2012 Apr;61(4):523-533. Pubmedid: 21983879.
  • Djeu J, Wei S. Chemoimmunomodulation of MDSCs as a novel strategy for cancer therapy. Oncoimmunology. 2012 Jan;1(1):121-122. Pubmedid: 22720231. Pmcid: PMC3376962.
  • Zhou J, Eksioglu EA, Fortenbery NR, Chen X, Wang H, Epling-Burnette PK, Djeu JY, Wei S. Bone marrow mononuclear cells up-regulate toll-like receptor expression and produce inflammatory mediators in response to cigarette smoke extract. PLoS One. 2011 Dec;6(6):e21173. Pubmedid: 21738617. Pmcid: PMC3126797.
  • Yin M, Wei S, Wei Q. Vitamin D Receptor Genetic Polymorphisms and Prostate Cancer Risk: A Meta-analysis of 36 Published Studies. Int J Clin Exp Med. 2011 Jul;2(2):159-175. Pubmedid: 19684888. Pmcid: PMC2719705.
  • Zhou J, Wu J, Chen X, Fortenbery N, Eksioglu E, Kodumudi KN, Epling-Burnette PK, Dong J, Djeu JY, Wei S. Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions. Int Immunopharmacol. 2011 Jul;11(7):890-898. Pubmedid: 21244860. Pmcid: PMC3109231.
  • Smith MA, Wright G, Wu J, Tailor P, Ozato K, Chen X, Wei S, Piskurich JF, Ting JP, Wright KL. Positive regulatory domain I (PRDM1) and IRF8/PU.1 counter-regulate MHC class II transactivator (CIITA) expression during dendritic cell maturation. J Biol Chem. 2011 Mar;286(10):7893-7904. Pubmedid: 21216962. Pmcid: PMC3048676.
  • Smith MA, Maurin M, Cho HI, Becknell B, Freud AG, Yu J, Wei S, Djeu J, Celis E, Caligiuri MA, Wright KL. PRDM1/Blimp-1 controls effector cytokine production in human NK cells. J Immunol. 2010 Nov;185(10):6058-6067. Pubmedid: 20944005. Pmcid: PMC3864810.
  • Liu Z, Li G, Wei S, Niu J, El-Naggar AK, Sturgis EM, Wei Q. Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck. Cancer. 2010 Oct;116(20):4753-4760. Pubmedid: 20549817. Pmcid: PMC3030480.
  • Kodumudi KN, Woan K, Gilvary DL, Sahakian E, Wei S, Djeu JY. A novel chemoimmunomodulating property of docetaxel: suppression of myeloid-derived suppressor cells in tumor bearers. Clin Cancer Res. 2010 Sep;16(18):4583-4594. Pubmedid: 20702612. Pmcid: PMC3874864.
  • Zhong B, Sallman DA, Gilvary DL, Pernazza D, Sahakian E, Fritz D, Cheng JQ, Trougakos I, Wei S, Djeu JY. Induction of clusterin by AKT--role in cytoprotection against docetaxel in prostate tumor cells. Mol Cancer Ther. 2010 Jun;9(6):1831-1841. Pubmedid: 20501799. Pmcid: PMC3874868.
  • Kryczek I, Banerjee M, Cheng P, Vatan L, Szeliga W, Wei S, Huang E, Finlayson E, Simeone D, Welling TH, Chang A, Coukos G, Liu R, Zou W. Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood. 2009 Sep;114(6):1141-1149. Pubmedid: 19470694. Pmcid: PMC2723011.
  • Wei S, Chen X, Rocha K, Epling-Burnette PK, Djeu JY, Liu Q, Byrd J, Sokol L, Lawrence N, Pireddu R, Dewald G, Williams A, Maciejewski J, List A. A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide. Proc Natl Acad Sci U S A. 2009 Aug;106(31):12974-12979. Pubmedid: 19470455. Pmcid: PMC2722346.
  • Zou JX, Rollison DE, Boulware D, Chen DT, Sloand EM, Pfannes LV, Goronzy JJ, Bai F, Painter JS, Wei S, Cosgrove D, List AF, Epling-Burnette PK. Altered naive and memory CD4+ T-cell homeostasis and immunosenescence characterize younger patients with myelodysplastic syndrome. Leukemia. 2009 Jul;23(7):1288-1296. Pubmedid: 19282834. Pmcid: PMC3252820.
  • Chen X, Bai F, Sokol L, Zhou J, Ren A, Painter JS, Liu J, Sallman DA, Chen YA, Yoder JA, Djeu JY, Loughran TP, Epling-Burnette PK, Wei S. A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia. Blood. 2009 Apr;113(14):3226-3234. Pubmedid: 19075187. Pmcid: PMC2665892.
  • Kazemfar K, Chen R, Nicholson K, Coppola D, Zhou JM, Chen X, Wei S, Blanck G. Combined IL-8 and TGF-beta blockade efficiently prevents neutrophil infiltrates into an A549-cell tumor. Immunol Lett. 2009 Jan;122(1):25-29. Pubmedid: 19056425.
  • Djeu JY, Wei S. Clusterin and chemoresistance. Adv Cancer Res. 2009;105:77-92. Pubmedid: 19879424. Pmcid: PMC3889866.
  • Epling-Burnette PK, Sokol L, Chen X, Bai F, Zhou J, Blaskovich MA, Zou J, Painter JS, Edwards TD, Moscinski L, Yoder JA, Djeu JY, Sebti S, Loughran TP, Wei S. Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling. Blood. 2008 Dec;112(12):4694-4698. Pubmedid: 18791165. Pmcid: PMC2597136.
  • Yang J, Epling-Burnette PK, Painter JS, Zou J, Bai F, Wei S, Loughran TP. Antigen activation and impaired Fas-induced death-inducing signaling complex formation in T-large-granular lymphocyte leukemia. Blood. 2008 Feb;111(3):1610-1616. Pubmedid: 17993614. Pmcid: PMC2214759.
  • Wei S, Zhou JM, Chen X, Shah RN, Liu J, Orcutt TM, Traver D, Djeu JY, Litman GW, Yoder JA. The zebrafish activating immune receptor Nitr9 signals via Dap12. Immunogenetics. 2007 Dec;59(10):813-821. Pubmedid: 17891481. Pmcid: PMC3709248.
  • Sallman DA, Chen X, Zhong B, Gilvary DL, Zhou J, Wei S, Djeu JY. Clusterin mediates TRAIL resistance in prostate tumor cells. Mol Cancer Ther. 2007 Nov;6(11):2938-2947. Pubmedid: 18025278.
  • Burnette PK, Bai F, Painter JS, Rollison DE, Salih HR, Krusch M, ZouJ, Ku E, Zhong B, Boulware D, Moscinski L, Wei S, Djeu JY, List AF. Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors. Blood. 2007 Jun;109(11):4816-4824. Pubmedid: 17341666.
  • Patterson S, Wei S, Chen X, Sallman D, Gilvary D, Zhong B, Pow-Sang J, Yeatman T, Djeu J. Novel role of Stat1 in the development of docetaxel resistance in prostate tumor cells. Oncogene. 2006 Nov;25(45):6113-6122. Pubmedid: 16652143.
  • Panagos P, Dobrinski K, Chen X, Grant A, Traver D, Djeu J, Wei S, Yoder JA. Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish. Immunogenetics. 2006 Feb;58(1):31-40. Pubmedid: 16467987.
  • Kortylewski M, Kujawski M, Wang T, Wei S, Zhang S, Pilon-Thomas S, Niu G, Kay H, Mulé J, Kerr WG, Jove R, Pardoll D, Yu H. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med. 2005 Dec;11(12):1314-1321. Pubmedid: 16288283.
  • Burdelya L, Kujawski M, Niu G, Zhong B, Wang T, Zhang S, Kortylewski M, Shain K, Kay H, Djeu J, Dalton W, Pardoll D, Wei S, Yu H. Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects. J Immunol. 2005 Apr;174(7):3925-3931. Pubmedid: 15778348. Pmcid: PMC2632804.
  • Shurin G, Tourkova I, Chatta G, Schmidt G, Wei S, Djeu J, Shurin M. Small rho GTPases regulate antigen presentation in dendritic cells. J Immunol. 2005 Mar;174(6):3394-3400. Pubmedid: 15749872.
  • Guo F, Sigua C, Bali P, George P, Fiskus W, Scuto A, Annavarapu S, Mouttaki A, Sondarva G, Wei S, Wu J, Djeu J, Bhalla K. Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells. Blood. 2005 Feb;105(3):1246-1255. Pubmedid: 15388581.
  • Epling-Burnette PK, Bai F, Wei S, Painter JS, Olashaw N, Hamilton A, Sebti S, Djeu JY, Loughran TP. ERK couples chronic survival of NK cells to constitutively activated Ras in lymphoproliferative disease of granular lymphocytes (LDGL). Oncogene. 2004 Dec;23(57):9220-9229. Pubmedid: 15516985.
  • Yoder JA, Litman RT, Mueller MG, Desai S, Dobrinski KP, Montgomery JS, Buzzeo MP, Ota T, Amemiya CT, Trede NS, Wei S, Djeu JY, Humphray S, Jekosch K, Hernandez Prada JA, Ostrov DA, Litman GW. Resolution of the novel immune-type receptor gene cluster in zebrafish. Proc Natl Acad Sci U S A. 2004 Dec;101(44):15706-15711. Pubmedid: 15496470. Pmcid: PMC524843.
  • Jiang K, Sun J, Cheng J, Djeu JY, Wei S, Sebti S. Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis. Mol Cell Biol. 2004 Jun;24(12):5565-5576. Pubmedid: 15169915. Pmcid: PMC419878.
  • Epling-Burnette P, Painter J, Bai F, Wei S, Djeu J, LoughranTP. Dysregulated NK receptor expression in patients with lymphoproliferative disease of granular lymphocytes. Blood. 2004 May;103(9):3431-3439. Pubmedid: 14726391.
  • Mohapatra S, Chu B, Wei S, Djeu J, Epling-Burnette PK, Loughran T, Jove R, Pledger WJ. Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2. Cancer Res. 2003 Dec;63(23):8523-8530. Pubmedid: 14679020.
  • Zhong B, Jiang K, Gilvary DL, Epling-Burnette PK, Ritchey C, Liu J, Jackson RJ, Hong-Geller E, Wei S. Human neutrophils utilize a Rac/Cdc42-dependent MAPK pathway to direct intracellular granule mobilization toward ingested microbial pathogens. Blood. 2003 Jun;101(8):3240-3248. Pubmedid: 12511425.
  • Jiang K, Zhong B, Ritchey C, Gilvary DL, Hong-Geller E, Wei S, Djeu JY. Regulation of Akt-dependent cell survival by Syk and Rac. Blood. 2003 Jan;101(1):236-244. Pubmedid: 12393431.
  • Huang M, Dorsey JF, Epling-Burnette PK, Nimmanapalli R, Landowski TH, Mora LB, Niu G, Sinibaldi D, Bai F, Kraker A, Yu H, Moscinski L, Wei S, Djeu J, Dalton WS, Bhalla K, Loughran TP, Wu J, Jove R. Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells. Oncogene. 2002 Dec;21(57):8804-8816. Pubmedid: 12483533.
  • Jiang K, Zhong B, Gilvary DL, Corliss BC, Vivier E, Hong-Geller E, Wei S, Djeu JY. Syk regulation of phosphoinositide 3-kinase-dependent NK cell function. J Immunol. 2002 Apr;168(7):3155-3164. Pubmedid: 11907067.
  • Zhong B, Liu JH, Gilvary DL, Jiang K, Kasuga M, Ritchey CA, Trapani JA, Wei S. Functional role of phosphatidylinositol 3-kinase in direct tumor lysis by human natural killer cells. Immunobiology. 2002 Mar;205(1):74-94. Pubmedid: 11999346.
  • Djeu J, Jiang K, Wei S. A view to a kill: signals triggering cytotoxicity. Clin Cancer Res. 2002;8(3):636-640. Pubmedid: 11895890.
  • Liu J, Wei S, Lamy T, Yongxiang L, Epling-Burnette P, Djeu J, Loughran T. Blockade of Fas-dependent apoptosis by soluble Fas in LGL leukemia. Blood. 2002;100(4):1449-1453. Pubmedid: 12149230.
  • Epling-Burnette PK, Zhong B, Bai F, Jiang K, Bailey RD, Garcia R, Jove R, Djeu JY, Loughran TP, Wei S. Cooperative regulation of Mcl-1 by Janus kinase/stat and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed apoptosis in human neutrophils. J Immunol. 2001 Jun;166(12):7486-7495. Pubmedid: 11390502.
  • Yoder JA, Mueller MG, Wei S, Corliss BC, Prather DM, Willis T, Litman RT, Djeu JY, Litman GW. Immune-type receptor genes in zebrafish share genetic and functional properties with genes encoded by the mammalian leukocyte receptor cluster. Proc Natl Acad Sci U S A. 2001 Jun;98(12):6771-6776. Pubmedid: 11381126. Pmcid: PMC34428.
  • Monson N, Fenske T, Wei S, Okragly A, de Jong J, Haak-Frendscho M, O'Shea J, Djeu J, Sondel P. A p74 common gamma receptor chain isoform facilitates IL-2 and IL-15 responses by the myelomonocytic cell line Tf-1beta2. J Leukoc Biol. 2001;69(3):419-419. Pubmedid: 11261789.
  • Jiang K, Zhong B, Gilvary D, Corliss B, Hong-Geller E, Wei S, Djeu J. Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. Nat Immunol. 2000 Nov;1(5):419-425. Pubmedid: 11062502.
  • Wei S, Liu JH, Epling-Burnette PK, Jiang K, Zhong B, Elkabani ME, Pearson EW, Djeu JY. IL-2 induces the association of IL-2Rbeta, lyn, and MAP kinase ERK-1 in human neutrophils. Immunobiology. 2000 Nov;202(4):363-382. Pubmedid: 11131153.
  • Wei S, Gilvary D, Corliss B, Sebti S, Sun J, Straus D, Leibson P, Trapain J, Hamilton A, Weber M, Djeu J. Direct tumor lysis by NK cells uses a Ras-independent mitogen-activated protein kinase signal pathway. J Immunol. 2000 Oct;165(7):3811-3819. Pubmedid: 11034387.
  • Zhang H, Wei S, Sun J, Coppola D, Zhong B, Wu G, Goodwin B, Sebti S, Djeu JY, Blanck G. Retinoblastoma protein activation of interleukin 8 expression inhibits tumor cell survival in nude mice. Cell Growth Differ. 2000;11(12):635-639. Pubmedid: 11149598.
  • Liu J, Wei S, Lamy T, Loughran, Jr. T, Epling-Burnette P, Starkebaum G, Djeu J. Chronic neutropenia mediated by fas ligand. Blood. 2000;95(10):3219-3222. Pubmedid: 10807792.
  • Zhang H, Shephard AT, Eason DD, Wei S, Diaz JI, Djeu JY, Wu GD, Blanck G. Retinoblastoma protein expression leads to reduced Oct-1 DNA binding activity and enhances interleukin-8 expression. Cell Growth Differ. 1999 Jul;10(7):457-465. Pubmedid: 10437913.
  • Liu J, Wei S, Burnette P, Gamero A, Ussery D, Djeu J. Functional association of TGF-beta receptor II with cyclin B. Oncogene. 1999;18(1):269-275. Pubmedid: 9926943.
  • Wei S, Gamero A, Liu J, Daulton A, Valkov N, Trapani J, Larner A, Weber M, Djeu J. Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: identification of perforin and granzyme B mobilization by functional ERK2. J Exp Med. 1998 Jun;187(11):1753-1765. Pubmedid: 9607917. Pmcid: PMC2212310.
  • Sweeney J, Rosemary A, Wei S, Djeu J. Intact autocrine activation and cytokine production by PMNs from injured adults with elevated Candida antigen titres. Injury. 1998;29:35-35. Pubmedid: 9659479.
  • Pericle F, Burnette P, Podack E, Wei S, Djeu J. CD4-CD40L interactions provide "third-party" costimulation for T cell response against B7-1 transfected human breast tumor cells. J Leukoc Biol. 1997;61:201-208. Pubmedid: 9021926.
  • Wei S, Liu JH, Epling-Burnette PK, Gamero AM, Ussery D, Pearson EW, Elkabani ME, Diaz JI, Djeu JY. Critical role of Lyn kinase in inhibition of neutrophil apoptosis by granulocyte-macrophage colony-stimulating factor. J Immunol. 1996 Dec;157(11):5155-5162. Pubmedid: 8943427.
  • Sweeney JF, Greene JN, Hiemenz JW, Wei S, Rosemurgy AS, Djeu J. Identification of an amphotericin B resistant strain of Candida albicans using a rapid 3H-glucose incorporation microassay. J Infect. 1996 Nov;33(3):221-226. Pubmedid: 8945714 .
  • Blanchard D, Wei S, Duan C, Pericle F, Diaz J, Djeu J. Role of extracellular adenosine triphosphate in the cytotoxic T-lymphocyte-mediated lysis of antigen presenting cells. Blood. 1995 Jun;85(11):3173-3182. Pubmedid: 7538819.
  • Epling-Burnette P, Wei S, Liu J, Pericle F, Ussery D, Russell S, Leonard W, Djeu J. Expression of interleukin-2 receptor gamma on human monocytes: characterization of lineage specific post-translational modifications. Eur J Immunol. 1995 Jan;25(1):291-294. Pubmedid: 7843245.
  • Sweeney JF, Rosemurgy AS, Wei S, Djeu JY. Candida antigen titer is a marker of neutrophil dysfunction after severe injury. J Trauma. 1994 Jun;36(6):797-802. Pubmedid: 8015000.
  • Djeu J, Wei S, Blanchard D. Regulation of monocytes by IL-2-activated killer cells. Immunol Ser. 1994;61:75-75.
  • Liu J, Wei S, Ussery D, Epling-Burnette P, Leonard W, Djeu J. Expression of IL-2R-gamma chain in human neutrophils. Blood. 1994;84:3870-3870.
  • Liu J, Wei S, Blanchard D, Djeu J. Restoration of lytic function in a human natural killer cell line by gene transfection. Cell Immunol. 1994;156:24-24.
  • Sweeney J, Rosemurgy II A, Wei S, Djeu J. Candida antigen titer is a marker of neutrophil dysfunction after severe injury. J Trauma. 1994;36:797-797.
  • Sweeney J, Rosemurgy II A, Wei S, Djeu J. Monocytes overcome lymphocyte dysfunction in injured adults with elevated Candida antigen titers. J Trauma. 1994;37:944-949.
  • Wei S, Liu J, Blanchard D, Djeu J. Induction of IL-8 gene expression in human polymorphonuclear neutrophils by recombinant IL-2. J Immunol. 1994;152:3630-3630.
  • Pericle F, Liu J, Diaz J, Blanchard D, Wei S, Forni G, Djeu J. Interleukin-2 prevention of apoptosis in human neutrophils. Eur J Immunol. 1994;24:440-440.
  • Sweeney J, Rosemurgy II A, Wei S, Djeu J. Elevated Candida antigen titers are associated with neutrophil dysfunction after injury. Clin Diagn Lab Immunol. 1994;1:111-111.
  • Djeu JY, Liu JH, Wei S, Rui H, Pearson CA, Leonard WJ, Blanchard DK. Function associated with IL-2 receptor-beta on human neutrophils. Mechanism of activation of antifungal activity against Candida albicans by IL-2. J Immunol. 1993 Feb;150(3):960-970. Pubmedid: 8380826.
  • Burnette P, Wei S, Blanchard D, Spranzi E, Djeu J. Co-induction of GM-CSF release and LAK susceptibility in monocytes by IL-2 via Il-2R(beta). Blood. 1993;81:3130-3130.
  • Wei S, Blanchard D, Liu J, Leonard W, Djeu J. Activation of tumor necrosis factor-(alpha) production from human neutrophils by IL-2 via Il-2R(beta)1. J Immunol. 1993;150(5):1979-1987.
  • Sweeney J, Rosemurgy II A, Wei S, Djeu J. Lymphocytes dysfunction in injured adults with elevated Candida antigen titers. Surgery. 1993;114:698-698.
  • Djeu J, Liu J, Wei S, Rui H, Pearson C, Leonard W, Blanchard D. Function associated with IL-2 receptor (beta) on human neutrophils: mechanism of activation of antifungal activity against candida albicans by IL-2. J Immunol. 1993;150:960-960.
  • Epling-Burnett P, Wei S, Blanchard D, Spranzi E, Djeu J. Coinduction of granulocyte-macrophage colony stimulating factor release and lymphokine-activated killer cell susceptibility in monocytes by interleukin-2 via interleukin-2 receptor-beta. Blood. 1993;81:3130-3130.
  • Rosemurgy II A, Sweeney J, Albrink M, Wei S, Djeu J. Implication of Candida antigens titers in injured adults. Contemp Surg. 1993;42:327-332.
  • Liu JH, Blanchard DK, Wei S, Djeu JY. Recombinant interleukin-8 induces changes in cytosolic Ca2+ in human neutrophils. J Infect Dis. 1992 Nov;166(5):1089-1096. Pubmedid: 1402020.
  • Wei S, Blanchard DK, McMillen S, Djeu JY. Lymphokine-activated killer cell regulation of T-cell-mediated immunity to Candida albicans. Infect Immun. 1992 Sep;60(9):3586-3595. Pubmedid: 1500166. Pmcid: PMC257365.
  • Wei S, Blanchard D, McMillen S, Djeu J. LAK regulation of T cell immunity to Candida albicans. Infect Immun. 1992;60:3586-3586.
  • Wei S, Serbousek D, McMillen S, Blanchard DK, Djeu JY. Suppression of human monocyte function against Candida albicans by autologous IL-2-induced lymphokine-activated killer cells. J Immunol. 1991 Jan;146(1):337-342. Pubmedid: 1898605.
  • Epling-Burnette PK, Garcia R, Catlet-Falcone R, Liu J, Gamero M, Yu L, Jove R, Djeu J, Wei S. Carboxy-terminal truncated STAT5 is induced by interleukin-2 and GM-CSF in human neutrophils. Cell Immunol. 217(1-2):1-11. Pubmedid: 12425996.
TOOLS:   Font Size small font resizer separator font resizer separator big font resizer
 |  Site Map  |  Privacy Policy  |  Terms and Conditions