Moffitt Cancer Center Logo
 

Santo V. Nicosia, MD

Where You Are:
Santo V. Nicosia, MD

Office  (813) 745-8450

Education And Training
  • Fellow, University of Pennsylvania School of Medicine, 1973 - Reproductive Biology
  • Resident, Catholic University Hospitals, Roma, Italy, 1972 - OB/GYN
  • Resident, Michael Reese Hospital and Medical Center, 1972 - Anatomic Pathology
  • MS, University of Illinois, Medical Center, 1971 - Pathology
  • MD, Catholic University of Sacred Heart School of Medicine and Surgery, Roma, Italy, 1967


Ovarian cancer is the fifth most frequent malignancy in U.S. women and the fourth leading cause of death. Approximately 80-85% of human ovarian neoplasms arise from the ovarian surface epithelium (OSE). The phenotype most frequently observed in such neoplasms is characterized by epithelium-lined fibrovascular structures or papillae. The mechanisms regulating papillogenesis in normal, reactive, and neoplastic human OSE are poorly understood and are currently under investigation by the Ovarian Epithelial Cancer Pathobiology Program under the direction of Dr. Nicosia. Dr. Nicosia and his colleagues have shown that estrogens and repetitive ovulation markedly stimulate papillogenesis in animal models, leading to development of an ovarian surface morphology similar to that seen in low-malignant-potential human serous neoplasms. Papillae are more frequent in human OSE brushings obtained after ovulation or from women with dysfunctional hormonal conditions. Estrogen- and ovulation-stimulated OSE cell growth and papillogenesis are most likely mediated by stromal factors, including morphogenetic and angiogenic cytokines and growth factors.

The research in Dr. Nicosia's laboratory has shown that level of bioactive VEGF is dramatically elevated in the cyst fluid of human OSE cancers. A recently completed study indicates that the seriousness of clinical status correlates significantly with plasma and/or urinary levels of VEGF, hepatocyte growth factor endostatin and angiostatin, and suggests that these cytokines may play an important role in development and progression of human OSE cancers. The researchers are currently manipulating tridimensional assays of angiogenesis to enhance interaction of human OSE cells with sprouting capillaries and to investigate gene and cytokine expression during papillogenesis.

Using DNA microarray a complex and diverse pattern of up- and down-regulated genes has been observed in papillary ferous human ovarian neoplasms. Utilizing a combined gene discovery and cytokine profiling approach, studies in Dr. Nicosia's laboratory are testing the hypothesis that transformation of human OSE from a two-dimensional monolayer to a hierarchical three-dimensional papillary configuration is related to expression of unique repertoires of gene and gene products, including morphogenetic cytokines. Identification of such unique genes and gene products and related mechanisms of action will likely provide molecular tools to better understand, and therefore interfere therapeutically with, the fundamental process of papillogenesis in human OSE cancers.

  • Lee JH, Cragun D, Thompson Z, Coppola D, Nicosia SV, Akbari M, Zhang S, McLaughlin J, Narod S, Schildkraut J, Sellers TA, Pal T. Association Between IHC and MSI Testing to Identify Mismatch Repair-Deficient Patients with Ovarian Cancer. Genet Test Mol Biomarkers. 2014 Apr;18(4):229-235. Pubmedid: 24592941.
  • Malaney P, Nicosia SV, Davé V. One mouse, one patient paradigm: New avatars of personalized cancer therapy. Cancer Lett. 2014 Mar;344(1):1-12. Pubmedid: 24157811.
  • Williams KA, Zhang M, Xiang S, Hu C, Wu JY, Zhang S, Ryan M, Cox AD, Der CJ, Fang B, Koomen J, Haura E, Bepler G, Nicosia SV, Matthias P, Wang C, Bai W, Zhang X. Extracellular signal-regulated kinase (ERK) phosphorylates histone deacetylase 6 (HDAC6) at serine 1035 to stimulate cell migration. J Biol Chem. 2013 Nov;288(46):33156-33170. Pubmedid: 24089523. Pmcid: PMC3829163.
  • Shan L, Chen YA, Davis L, Han G, Zhu W, Molina AD, Arango H, Lapolla JP, Hoffman MS, Sellers T, Kirby T, Nicosia SV, Sutphen R. Measurement of phospholipids may improve diagnostic accuracy in ovarian cancer. PLoS One. 2013 Apr;7(10):e46846. Pubmedid: 23082132. Pmcid: PMC3474784.
  • Wang L, Xiang S, Williams KA, Dong H, Bai W, Nicosia SV, Khochbin S, Bepler G, Zhang X. Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells. PLoS One. 2013 Feb;7(9):e44265. Pubmedid: 22957056. Pmcid: PMC3434198.
  • Pal T, Akbari MR, Sun P, Lee JH, Fulp J, Thompson Z, Coppola D, Nicosia S, Sellers TA, McLaughlin J, Risch HA, Rosen B, Shaw P, Schildkraut J, Narod SA. Frequency of mutations in mismatch repair genes in a population-based study of women with ovarian cancer. Br J Cancer. 2012 Nov;107(10):1783-1790. Pubmedid: 23047549. Pmcid: PMC3493867.
  • Coppola D, Nicosia SV, Doty A, Sellers TA, Lee JH, Fulp J, Thompson Z, Galeb S, McLaughlin J, Narod SA, Schildkraut J, Pal T. Uncertainty in the utility of immunohistochemistry in mismatch repair protein expression in epithelial ovarian cancer. Anticancer Res. 2012 Nov;32(11):4963-4969. Pubmedid: 23155266. Pmcid: PMC3919039.
  • Kasiappan R, Shen Z, Tse AK, Jinwal U, Tang J, Lungchukiet P, Sun Y, Kruk P, Nicosia SV, Zhang X, Bai W. 1,25-Dihydroxyvitamin D3 suppresses telomerase expression and human cancer growth through microRNA-498. J Biol Chem. 2012 Nov;287(49):41297-41309. Pubmedid: 23055531. Pmcid: PMC3510828.
  • Xu CX, Xu M, Tan L, Yang H, Permuth-Wey J, Kruk PA, Wenham RM, Nicosia SV, Lancaster JM, Sellers TA, Cheng JQ. MicroRNA miR-214 regulates ovarian cancer cell stemness by targeting p53/Nanog. J Biol Chem. 2012 Oct;287(42):34970-34978. Pubmedid: 22927443. Pmcid: PMC3471722.
  • Yang Y, Tse AK, Li P, Ma Q, Xiang S, Nicosia SV, Seto E, Zhang X, Bai W. Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation. Oncogene. 2011 Jul;30(19):2207-2218. Pubmedid: 21242980. Pmcid: PMC3093431.
  • Khoor A, Byrd-Gloster AL, Nicosia SV. Expression of thyroid transcription factor-1 in malignant pleural effusions. Pathol Oncol Res. 2011 Jun;17(2):263-267. Pubmedid: 20848248.
  • Shen Z, Zhang X, Tang J, Kasiappan R, Jinwal U, Li P, Hann S, Nicosia SV, Wu J, Zhang X, Bai W. The coupling of epidermal growth factor receptor down regulation by 1alpha,25-dihydroxyvitamin D3 to the hormone-induced cell cycle arrest at the G1-S checkpoint in ovarian cancer cells. Mol Cell Endocrinol. 2011 May;338(1-2):58-67. Pubmedid: 21458521. Pmcid: PMC3089697.
  • Drenberg CD, Saunders BO, Wilbanks GD, Chen R, Nicosia RF, Kruk PA, Nicosia SV. Urinary angiostatin levels are elevated in patients with epithelial ovarian cancer. Gynecol Oncol. 2010 Apr;117(1):117-124. Pubmedid: 20071014.
  • Zhang Y, Dong H, Li Z, Xiang S, Zhu Y, Zhang M, Liu J, Bai W, Nicosia SV, Chen J. Bing De Ling, a Chinese herbal formula, inhibits cancer cells growth via p53. Front Biosci (Elite Ed). 2010 Jan;2:221-230. Pubmedid: 20036872.
  • Guo JP, Shu SK, He L, Lee YC, Kruk PA, Grenman S, Nicosia SV, Mor G, Schell MJ, Coppola D, Cheng JQ. Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer. Am J Pathol. 2009 Jul;175(1):324-333. Pubmedid: 19497997. Pmcid: PMC2708818.
  • Fu W, Ma Q, Chen L, Li P, Zhang M, Ramamoorthy S, Nawaz Z, Shimojima T, Wang H, Yang Y, Shen Z, Zhang Y, Zhang X, Nicosia SV, Zhang Y, Pledger JW, Chen J, Bai W. MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. J Biol Chem. 2009 May;284(21):13987-14000. Pubmedid: 19321440. Pmcid: PMC2682847.
  • Ma Q, Fu W, Li P, Nicosia SV, Jenster G, Zhang X, Bai W. FoxO1 mediates PTEN suppression of androgen receptor N- and C-terminal interactions and coactivator recruitment. Mol Endocrinol. 2009 Feb;23(2):213-225. Pubmedid: 19074551. Pmcid: PMC2646622.
  • Zhang Y, Zhang M, Dong H, Yong S, Li X, Olashaw N, Kruk PA, Cheng JQ, Bai W, Chen J, Nicosia SV, Zhang X. Deacetylation of cortactin by SIRT1 promotes cell migration. Oncogene. 2009 Jan;28(3):445-460. Pubmedid: 18850005.
  • Anderson NS, Bermudez Y, Badgwell D, Chen R, Nicosia SV, Bast RC, Kruk PA. Urinary levels of Bcl-2 are elevated in ovarian cancer patients. Gynecol Oncol. 2009 Jan;112(1):60-67. Pubmedid: 19007973. Pmcid: PMC3729448.
  • Permuth-Wey J, Boulware D, Valkov N, Livingston S, Nicosia S, Lee JH, Sutphen R, Schildkraut J, Narod S, Parker A, Coppola D, Sellers T, Pal T. Sampling strategies for tissue microarrays to evaluate biomarkers in ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):28-34. Pubmedid: 19124477. Pmcid: PMC2664171.
  • Anderson NS, Turner L, Livingston S, Chen R, Nicosia SV, Kruk PA. Bcl-2 expression is altered with ovarian tumor progression: an immunohistochemical evaluation. J Ovarian Res. 2009;2:16. Pubmedid: 19852858. Pmcid: PMC2774291.
  • Drenberg CD, Livingston S, Chen R, Kruk PA, Nicosia SV. Expression of Semaphorin 3F and Its Receptors in Epithelial Ovarian Cancer, Fallopian Tubes, and Secondary Mullerian Tissues. Obstet Gynecol Int. 2009;2009:730739-. Pubmedid: 20041133. Pmcid: PMC2796214.
  • Yang H, Kong W, He L, Zhao JJ, O'Donnell JD, Wang J, Wenham RM, Coppola D, Kruk PA, Nicosia SV, Cheng JQ. MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. Cancer Res. 2008 Jan;68(2):425-433. Pubmedid: 18199536.
  • Yang Y, Fu W, Chen J, Olashaw N, Zhang X, Nicosia SV, Bhalla K, Bai W. SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat Cell Biol. 2008 Jan;9(11):1253-1262. Pubmedid: 17934453. Pmcid: PMC3201724.
  • Bermudez Y, Yang H, Saunders BO, Cheng JQ, Nicosia SV, Kruk PA. VEGF- and LPA-induced telomerase in human ovarian cancer cells is Sp1-dependent. Gynecol Oncol. 2007 Sep;106(3):526-537. Pubmedid: 17559911.
  • Garbuzova-Davis S, Haller E, Saporta S, Kolomey I, Nicosia S, Sanberg P. Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS. Brain Res. 2007 Jul;1157C:126-137. Pubmedid: 17512910.
  • Yang L, Sun M, Sun XM, Cheng GZ, Nicosia SV, Cheng JQ. Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212. J Biol Chem. 2007 Apr;282(15):10981-10987. Pubmedid: 17311912.
  • Lee H, Kim D, Dan HC, Wu EL, Gritsko TM, Cao C, Nicosia SV, Golemis EA, Liu W, Coppola D, Brem SS, Testa JR, Cheng JQ. Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein. Mol Cell Biol. 2007 Mar;27(6):2103-2119. Pubmedid: 17210637. Pmcid: PMC1820506.
  • Bao J, Cao C, Zhang X, Jiang F, Nicosia SV, Bai W. Suppression of beta-amyloid precursor protein signaling into the nucleus by estrogens mediated through complex formation between the estrogen receptor and Fe65. Mol Cell Biol. 2007 Feb;27(4):1321-1333. Pubmedid: 17130235. Pmcid: PMC1800721.
  • Yang H, He L, Kruk P, Nicosia SV, Cheng JQ. Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian cancer cells. Int J Cancer. 2006 Nov;119(10):2304-2312. Pubmedid: 16894566.
  • Zhang X, Nicosia SV, Bai W. Vitamin D receptor is a novel drug target for ovarian cancer treatment. Curr Cancer Drug Targets. 2006 May;6(3):229-244. Pubmedid: 16712459.
  • Cox C, White L, Allred N, Meyers M, Dickson D, Dupont E, Cantor A, Ly Q, Dessureault S, King J, Nicosia S, Vrcel V, Diaz N. Survival outcomes in node-negative breast cancer patients evaluated with complete axillary node dissection versus sentinel lymph node biopsy. Ann Surg Oncol. 2006 May;13(5):708-711. Pubmedid: 16538416.
  • Pal T, Permuth-Wey J, Betts JA, Krischer JP, Fiorica J, Arango H, LaPolla J, Hoffman M, Martino MA, Wakeley K, Wilbanks G, Nicosia S, Cantor A, Sutphen R. BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases. Cancer. 2005 Dec;104(12):2807-2816. Pubmedid: 16284991.
  • Cheng JQ, Lindsley CW, Cheng GZ, Yang H, Nicosia SV. The Akt/PKB pathway: molecular target for cancer drug discovery. Oncogene. 2005 Nov;24(50):7482-7492. Pubmedid: 16288295.
  • Park S, Kim D, Kaneko S, Szewczyk KM, Nicosia SV, Yu H, Jove R, Cheng JQ. Molecular cloning and characterization of the human AKT1 promoter uncovers its up-regulation by the Src/Stat3 pathway. J Biol Chem. 2005 Nov;280(47):38932-38941. Pubmedid: 16174774.
  • Zhang X, Li P, Bao J, Nicosia SV, Wang H, Enkemann SA, Bai W. Suppression of death receptor-mediated apoptosis by 1,25-dihydroxyvitamin D3 revealed by microarray analysis. J Biol Chem. 2005 Oct;280(42):35458-35468. Pubmedid: 16093247. Pmcid: PMC3249976.
  • Reed J, Hakam A, Nicosia S, Coppola D. Significance of Fas receptor protein expression in epithelial ovarian cancer. Hum Pathol. 2005 Oct;36(9):971-976. Pubmedid: 16153459.
  • Yuan ZQ, Kim D, Kaneko S, Sussman M, Bokoch GM, Kruh GD, Nicosia SV, Testa JR, Cheng JQ. ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival. J Biol Chem. 2005 Jun;280(22):21483-21490. Pubmedid: 15784622.
  • Yang Y, Hou H, Haller EM, Nicosia SV, Bai W. Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. EMBO J. 2005 Mar;24(5):1021-1032. Pubmedid: 15692560. Pmcid: PMC554122.
  • Cox C, Centeno B, Dickson D, Clark J, Nicosia S, Dupont E, Greenberg H, Stowell N, White L, Patel J, Furman B, Cantor A, Hakam A, Ahmad N, Diaz N, King J. Accuracy of intraoperative imprint cytology for sentinel lymph node evaluation in the treatment of breast carcinoma. Cancer. 2005 Feb;105(1):13-20. Pubmedid: 15605359.
  • Zhang X, Jiang F, Li P, Li C, Ma Q, Nicosia SV, Bai W. Growth suppression of ovarian cancer xenografts in nude mice by vitamin D analogue EB1089. Clin Cancer Res. 2005 Jan;11(1):323-328. Pubmedid: 15671562.
  • Kim D, Dan HC, Park S, Yang L, Liu Q, Kaneko S, Ning J, He L, Yang H, Sun M, Nicosia SV, Cheng JQ. AKT/PKB signaling mechanisms in cancer and chemoresistance. Front Biosci. 2005 Jan;10:975-987. Pubmedid: 15569636.
  • Liu Q, Kaneko S, Yang L, Feldman RI, Nicosia SV, Chen J, Cheng JQ. Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. J Biol Chem. 2004 Dec;279(50):52175-52182. Pubmedid: 15469940.
  • Jiang F, Bao J, Li P, Nicosia S, Bai W. Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down-regulation of telomerase. J Biol Chem. 2004 Dec;279(51):53213-53221. Pubmedid: 15485861.
  • Weinberg ES, Dickson D, White L, Ahmad N, Patel J, Hakam A, Nicosia S, Dupont E, Furman B, Centeno B, Cox C. Cytokeratin staining for intraoperative evaluation of sentinel lymph nodes in patients with invasive lobular carcinoma. Am J Surg. 2004 Oct;188(4):419-422. Pubmedid: 15474439.
  • Yang L, Dan HC, Sun M, Liu Q, Sun XM, Feldman RI, Hamilton AD, Polokoff M, Nicosia SV, Herlyn M, Sebti SM, Cheng JQ. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer Res. 2004 Jul;64(13):4394-4399. Pubmedid: 15231645.
  • Li P, Li C, Zhao X, Zhang X, Nicosia SV, Bai W. p27(Kip1) stabilization and G(1) arrest by 1,25-dihydroxyvitamin D(3) in ovarian cancer cells mediated through down-regulation of cyclin E/cyclin-dependent kinase 2 and Skp1-Cullin-F-box protein/Skp2 ubiquitin ligase. J Biol Chem. 2004 Jun;279(24):25260-25267. Pubmedid: 15075339.
  • Dan HC, Sun M, Kaneko S, Feldman RI, Nicosia SV, Wang HG, Tsang BK, Cheng JQ. Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). J Biol Chem. 2004 Feb;279(7):5405-5412. Pubmedid: 14645242.
  • Yang H, Ou CC, Feldman RI, Nicosia SV, Kruk PA, Cheng JQ. Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cells. Cancer Res. 2004 Jan;64(2):463-467. Pubmedid: 14744757.
  • Dan HC, Jiang K, Coppola D, Hamilton A, Nicosia SV, Sebti SM, Cheng JQ. Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis. Oncogene. 2004 Jan;23(3):706-715. Pubmedid: 14737105.
  • Nicosia S, Wilbanks G, Saunders B, Mayer J, Cardosi R, Kruk P, Cheng J, Bai W, Coppola D, Fiorica J. Cytology of human ovarian surface epithelial brushings. Cancer Cytopathol. 2004;102(1):1-10. Pubmedid: 14968412.
  • Weinberg E, Cox C, Dupont E, White L, Ebert M, Greenberg H, Diaz N, Vercel V, Centeno B, Cantor A, Nicosia S. Local recurrence in lumpectomy patients after imprint cytology margin evaluation. Am J Surg. 2004;188(4):349-354. Pubmedid: 15474425.
  • Diaz N, Cox C, Ebert M, Clark J, Vrcel V, Stowell N, Sharma A, Jakub J, Cantor A, Centeno B, Dupont E, Muro-Cacho C, Nicosia S. Benign Mechanical Transport of Breast Epithelial Cells to Sentinel Lymph Nodes. Am J Surg Pathol. 2004;28(12):1641-1645. Pubmedid: 15577685.
  • Jiang F, Li P, Fornace A, Nicosia S, Bai W. G2/M arrest by 1,25-dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer. J Biol Chem. 2003 Nov;278(48):48030-48040. Pubmedid: 14506229.
  • Sun M, Yang L, Feldman RI, Sun XM, Bhalla KN, Jove R, Nicosia SV, Cheng JQ. Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85alpha, androgen receptor, and Src. J Biol Chem. 2003 Oct;278(44):42992-43000. Pubmedid: 12933816.
  • Yuan ZQ, Feldman RI, Sussman GE, Coppola D, Nicosia SV, Cheng JQ. AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance. J Biol Chem. 2003 Jun;278(26):23432-23440. Pubmedid: 12697749.
  • Gritsko TM, Coppola D, Paciga JE, Yang L, Sun M, Shelley SA, Fiorica JV, Nicosia SV, Cheng JQ. Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer. Clin Cancer Res. 2003 Apr;9(4):1420-1426. Pubmedid: 12684414.
  • Nicosia S, Bai W, Cheng J, Coppola D, Kruk P. Oncogenic pathways implicated in ovarian epithelial cancer. Hematol Oncol Clin North Am. 2003;17(4):927-943. Pubmedid: 12959183.
  • Jiang F, Saunders B, Haller E, Livingston S, Nicosia S, Bai W. Conditionally immortal ovarian cell lines for investigating the influence of ovarian stroma on the estrogen sensitivity and tumorigenicity of ovarian surface epithelial cells. In Vitro Cell Dev Biol Anim. 2003;39(7):304-312. Pubmedid: 12964904.
  • Tsibris J, Maas S, Segars J, Nicosia S, Enkemann S, O'Brien W, Spellacy W. New potential regulators of uterine leiomyomata from DNA arrays: the ionotropic glutamate receptor GluR2. Biochem Biophys Res Commun. 2003;312(1):249-254. Pubmedid: 14630051.
  • Wright T, Holinka C, Ferenczy A, Gatsonis C, Mutter G, Nicosia S, Richart R. Estradiol-induced hyperplasia in endometrial biopsies from women on hormone replacement therapy. Am J Surg Pathol. 2002 Oct;26(10):1269-1275. Pubmedid: 12360041.
  • Dan HC, Sun M, Yang L, Feldman RI, Sui XM, Ou CC, Nellist M, Yeung RS, Halley DJ, Nicosia SV, Pledger WJ, Cheng JQ. Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. J Biol Chem. 2002 Sep;277(38):35364-35370. Pubmedid: 12167664.
  • Yuan ZQ, Feldman RI, Sun M, Olashaw NE, Coppola D, Sussman GE, Shelley SA, Nicosia SV, Cheng JQ. Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells. J Biol Chem. 2002 Aug;277(33):29973-29982. Pubmedid: 12048203.
  • Kaneko S, Feldman RI, Yu L, Wu Z, Gritsko T, Shelley SA, Nicosia SV, Nobori T, Cheng JQ. Positive feedback regulation between Akt2 and MyoD during muscle differentiation. Cloning of Akt2 promoter. J Biol Chem. 2002 Jun;277(26):23230-23235. Pubmedid: 11948187.
  • Ravasi S, Capra V, Panigalli T, Rovati G, Nicosia S. Pharmacological differences among CysLT(1) receptor antagonists with respect toLTC(4) and LTD(4) in human lung parenchyma. Biochem Pharmacol. 2002;63:1537-1546. Pubmedid: 11996896.
  • Buccellati C, Ciceri P, Ballerio R, Casagrande C, Folco G, Nicosia S. Evaluation of the effects of anti-thromboxane agents in platelet-vessel wallinteraction. Eur J Pharmacol. 2002;443:133-141. Pubmedid: 12044803.
  • Sun M, Paciga JE, Feldman RI, Yuan Z, Coppola D, Lu YY, Shelley SA, Nicosia SV, Cheng JQ. Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K. Cancer Res. 2001 Aug;61(16):5985-5991. Pubmedid: 11507039.
  • Naidu K, Tang J, Naidu K, Prockop L, Nicosia S, Coppola D. Antiproliferative and apoptotic effect of ascorbyl stearate in human glioblastoma multiforme cells: modulation of insulin-like growth factor-I receptor (IGF-IR) expression. J Neurooncol. 2001 Aug;54(1):15-22. Pubmedid: 11763418.
  • Sun M, Wang G, Paciga JE, Feldman RI, Yuan ZQ, Ma XL, Shelley SA, Jove R, Tsichlis PN, Nicosia SV, Cheng JQ. AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. Am J Pathol. 2001 Aug;159(2):431-437. Pubmedid: 11485901. Pmcid: PMC1850562.
  • Li P, Nicosia SV, Bai W. Antagonism between PTEN/MMAC1/TEP-1 and androgen receptor in growth and apoptosis of prostatic cancer cells. J Biol Chem. 2001 Jun;276(23):20444-20450. Pubmedid: 11278645.
  • Lee H, Jiang F, Wang Q, Nicosia SV, Yang J, Su B, Bai W. MEKK1 activation of human estrogen receptor alpha and stimulation of the agonistic activity of 4-hydroxytamoxifen in endometrial and ovarian cancer cells. Mol Endocrinol. 2000 Nov;14(11):1882-1896. Pubmedid: 11075819.
  • Yuan ZQ, Sun M, Feldman RI, Wang G, Ma X, Jiang C, Coppola D, Nicosia SV, Cheng JQ. Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer. Oncogene. 2000 May;19(19):2324-2330. Pubmedid: 10822383.
  • Jiang K, Coppola D, Crespo NC, Nicosia SV, Hamilton AD, Sebti SM, Cheng JQ. The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis. Mol Cell Biol. 2000 Jan;20(1):139-148. Pubmedid: 10594016. Pmcid: PMC85069.
  • Bai W, Oliveros-Saunders B, Wang Q, Acevedo-Duncan M, Nicosia S. Estrogen stimulation of ovarian surface epithelial cell proliferation. In Vitro Cell Dev Biol Anim. 2000;36(10):657-666. Pubmedid: 11229598.
  • Adnane J, Jackson R, Nicosia S, Cantor A, Pledger W, Sebti S. Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model. Oncogene. 2000;19(47):5338-5347. Pubmedid: 11103935.
  • Diaz J, Mora L, Austin P, Muro-Cacho C, Cantor A, Nicosia S, Pow-Sang J. Predictability of PSA failure in prostate cancer by computerized cytometric assessment of tumoral cell proliferation. Urology. 1999;53(5):931-938. Pubmedid: 10223486.
  • Mora L, Diaz J, Cantor A, Nicosia S. Differential diagnosis of endometrial hyperplasia and carcinoma by computerized image cytometry of cell proliferation, apoptosis and Bcl-2 expression. Ann Clin Lab Sci. 1999;29(4):308-315. Pubmedid: 10528831.
  • Hazelton D, Bland K, Nicosia R, Copeland E, Nicosia S. Vascular endothelial growth factor levels in ovarian cyst fluid correlate with malignancy. Clin Cancer Res. 1999;5(4):823-829. Pubmedid: 10213218.
  • Cavanagh D, Fiorica JV, Hoffman MS, Durfee J, Nicosia SV. Adenocarcinoma of the endometrium: an institutional review. Cancer Control. 1999;6(4):354-360. Pubmedid: 10758567.
  • Hakam A, Yeatman T, Lu L, Mora L, Marcet J, Nicosia S, Karl R, Coppola D. Expression of insulin-like growth factor-1 receptor in human colorectal cancer. Hum Pathol. 1999;30(10):1128-1133. Pubmedid: 10534157.
  • Coppola D, Saunders B, Fu L, Mao W, Nicosia S. The insulin-like growth factor 1 receptor induces transformation and tumorigenicity of ovarian mesothelial cells and down-regulates their Fas-receptor expression. Cancer Res. 1999;59(13):3264-3270. Pubmedid: 10397275.
  • Coppola D, Catalano E, Nicosia S. Significance of p53 and Bcl-2 protein expression in human breast ductal carcinoma. Cancer Control. 1999;6(2):181-187. Pubmedid: 10758547.
  • Porter K, Tsibris J, Porter G, Fuchs-Young R, Nicosia S, O'Brien W, Spellacy W. Effects of raloxifene in a guinea pig model for leiomyomas. Am J Obstet Gynecol. 1998 Nov;179(5):1283-1287. Pubmedid: 9822517.
  • Liu AX, Testa JR, Hamilton TC, Jove R, Nicosia SV, Cheng JQ. AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells. Cancer Res. 1998 Jul;58(14):2973-2977. Pubmedid: 9679957.
  • Cox C, Pendas S, Ku N, Reintgen D, Greenberg H, Nicosia S. Local recurrence of breast cancer after cytological evaluation of lumpectomy margins. Am Surg. 1998;64(6):533-538. Pubmedid: 9619174.
  • Coppola D, Hyacinthe M, Fu L, Cantor A, Karl R, Marcet J, Cooper D, Nicosia S, Cooper H. CD44V6 expression in human colorectal carcinoma. Hum Pathol. 1998;29(6):627-635. Pubmedid: 9635685.
  • Coppola D, Fu L, Nicosia S, Kounelis S, Jones M. Prognostic significance of p53, Bcl-2, Vimentin and S100 protein-positive Langerhans cells in endometrial carcinoma. Hum Pathol. 1998;29:455-462. Pubmedid: 9596268.
  • Cowper S, Fiorica J, Nicosia S, Coppola D. Papillary squamous cell carcinoma of the vagina. Cancer Control. 1998;5(2):179-183. Pubmedid: 10761029.
  • Garcia E, Sandin R, Greene J, Baekey P, Walling A, Letson G, Choy J, Nicosia S, Moscinski L. Infections of the leg which mimic malignancy. Infect Med. 1998;15(8):557-567. Pubmedid: noPMID.
  • Cowper S, Fiorica J, Nicosia S, Coppola D. Benign breast disorders: first rule out cancer. Cancer Control. 1998;31(7):140-154.
  • Cox CE, Hyacinthe M, Gonzalez RJ, Ku NN, Greenberg H, Reintgen D, Lyman G, Nicosia SV. Cytologic evaluation of lumpectomy margins in patients with ductal carcinoma in-situ: clinical outcome. Ann Surg Oncol. 1997 Dec;4(8):644-649. Pubmedid: 9416412.
  • Ku NN, Mela N, Cox CE, Reintgen DS, Nicosia SV. Diagnostic pitfalls in aspiration biopsy cytology of papillary breast lesions. Cancer Control. 1997;4(5):451-457. Pubmedid: 10763054.
  • Coppola D, Catalano E, Nicosia S. Transforming growth factor-alpha and c-erbB-2 oncogene products in ovarian epithelial tumors. Int J Surgical Pathol. 1997;4(3):129-136. Pubmedid: noPMID.
  • Reintgen D, Joseph E, Lyman G, Yeatman T, Balducci L, Ku N, Berman C, Shons A, Wells K, Horton J, Greenberg H, Nicosia S, Clark R, Shivers S, Li W, Wang X, Cantor A, Cox C. The role of selective lymphadenectomy in breast cancer. Cancer Control. 1997;4(3):211-219. Pubmedid: 10763020.
  • Pinelli D, Fiorica J, Roberts W, Hoffman M, Nicosia S, Cavanagh D. Chemotherapy plus sequential hormonal therapy for advanced and recurrent endometrial carcinoma: a phase II study. Gynecol Oncol. 1996 Mar;60(3):462-467. Pubmedid: 8774658.
  • Pierro E, Nicosia S, Saunders B, Fultz C, Nicosia R, Mancuso S. Influence of growth factors on proliferation and morphogenesis of ovarian mesothelial cells in vitro. Biol Reprod. 1996;54:660-669. Pubmedid: 8835389.
  • Coppola D, Catalano E, Clark M, Cantor A, Nicosia S. P53 protein expression in human ductal breast carcinoma and medullary variant. Int J Surgical Pathol. 1996;3:169-174.
  • Nicosia S. Ovarian and peritonal borderline neoplasm: histopathology, diganostic pitfalls and prognostication. Cancer Control. 1996;3:58-65. Pubmedid: 10825277.
  • Albertini J, Lyman G, Cox C, Yeatman T, Balducci L, Ku N, Shivers S, Berman C, Wells K, Rapaport D, Shons A, Horton J, Greenberg H, Nicosia S, Clark R, Cantor A, Reintgen D. Lymphatic mapping and sentinel node biopsy in the patient with breast cancer. Jama. 1996;276(22):1818-1822. Pubmedid: 8946902.
  • Mora L, Nicosia S, Pow-Sang J, Ku N, Diaz J, Lockhart J, Einstein, Jr. A. Ancillary techniques in the follow-up of trasitional cell carcinoma: a comparision of cytology, histology and DNA image analysis cytometry in 91 patients. J Urol. 1996;156:49-55. Pubmedid: 8648836.
  • Diaz J, Nicosia S, Szakacs J, Pow-Sang J, Saba H. Metastatic Seminoma Simulating Malignant lymphoma in an HIV infected hemophiliac. Leuk Lymphoma. 1996;23:165-171. Pubmedid: 9021701.
  • Porter KB, Tsibris JC, Nicosia SV, Murphy JM, O'Brien WF, Rao PS, Spellacy WN. Estrogen-induced guinea pig model for uterine leiomyomas: do the ovaries protect?. Biol Reprod. 1995 Apr;52(4):824-832. Pubmedid: 7780004.
  • Nicosia S, Diaz J, Nicosia J, Saunders R, Muro-Cacho C. Cell proliferation and apoptosis during development and aging of the rabbit corpus luteum. Ann Clin Lab Sc. 1995;2:143-157. Pubmedid: 7785964.
  • Diaz J, Nicosia S, Szakacs J, Pow-Sang J, Saba H. Metastatic seminoma simulating malignant lymphoma in an HIV infected hemophiliac. Leuk Lymphoma. 1995;18:179-184. Pubmedid: noPMID.
  • Nicosia S, Diaz J, Nicosia J, Saunders R, Muro-Cacho C. Cell proliferation and apoptosis during development and aging of the rabbit corpus luteum. Ann Clin Lab Sci. 1995;2:143-157. Pubmedid: 7785964.
  • Giacomini G, Nicosia S, Saunders B, Fultz C, Sun X, Jasonni V. Ovarian mesothelial and extramesothelial cells in interactive culture. Vitro Cell Dev Biol. 1995;31:300-309. Pubmedid: 7795849.
  • Nicosia S, Sowinski J. Cytological analysis of the urn cell complex of sipunculus nudus (linnaeus) before and after serum-induced mucus release. Biol Bull. 1995;188:267-280. Pubmedid: 7612718.
  • Morgan M, Nicosia S, Shabaik A, Ku N, Szakacs J, Reintgen D, Cox C. Aspiration biopsy cytology of argyrophilic carcinoma (carcinoid tumor) of the breast. Cancer Control. 1995;2:245-249. Pubmedid: 10887036.
  • Cox C, Reintgen D, Nicosia S, Ku N, Baekey P, Carey L. Analysis of residual cancer after diagnostic breast biopsy: an argument for fine needle aspiration biopsy. Ann Surg Oncol. 1995;2(3):201-206. Pubmedid: 7641015.
  • Barton D, Blanchard D, Wells A, Nicosia S, Roberts W, Cavanagh D, Djeu J. Expression of IL-2 receptor alpha mRNA and protein in advanced epithelial ovarian cancer. Anticancer Res. 1994;14:761-761.
  • Ku N, Mela N, Fiorica J, Cox C, Reintgen D, Greenberg H, Clark R, Nicosia S. Role of fine needle aspiration cytology after lumpectomy. Acta Cytol. 1994;38(6):927-932.
  • Nicosia R, Nicosia S, Smith M. Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-2 promote rate aortic angiogenesis. Am J Pathol. 1994;145:1023-1029.
  • Norman Jr. J, Franz M, Schiro R, Nicosia S, Docs J, Fabri P, Gower R. Functional glucocorticoid receptor modulates pancreatic carcinoma through an autocrine loop. J Surg Res. 1994;57:1-6.
  • Nicosia S. Role of fine needle aspiration biopsy cytology in gynecologic oncology. Cancer Control. 1994;1:160-165.
  • Ku N, Nicosia S, Reintgen D, Cox C. Role of cytopathology in the management of breast cancer. Cancer Control. 1994;1(4):402-408.
  • Ku N, Cox C, Reintgen D, Greenberg H, Nicosia S. Local recurrence after cytologic evaluation of lumpectony margins: a follow-up study of 520 breast cancers. Lab Invest. 1994;70:17a-17a.
  • Gleeson NC, Nicosia SV, Mark JE, Hoffman MS, Cavanagh D. Abdominal wall metastases from ovarian cancer after laparoscopy. Am J Obstet Gynecol. 1993 Sep;169(3):522-523. Pubmedid: 8018126.
  • Setraloam S, Saunders B, Nicosia S. Growth stimulation of ovarian and extraovarian mesothelial cells by corpus luteum extract. In Vitro Cell Dev Biol. 1993;30:879-883.
  • Reintgen D, Cox C, Greenberg H, Baekey P, Nicosia S, Berman C, Clark R, Lyman G. The medical legal implications of following mammographic breast masses. Am Surg. 1993;59(2):99-105.
  • Cox C, Greenberg H, Fleisher D, Clark R, Nicosia S, Berman C, Ku N, Fiorica J, Reintgen D. Natural history and clinical evaluation of the lumpectomy scar. Am Surg. 1993;59:55-59.
  • Townsend P, Schapira D, Nicosia S, Kuzela D, Kavanagh J. Evaluation of a frozen section protocol in endometrial carcinoma. Int J Gynecol Oncol. 1993;2:663-667.
  • Shabaik A, Pow-Sang J, Lockhart J, Nicosia S. Role of DNA image cytometry in the follow-up of patients with urinary tract transitional cell carcinoma. Acta Cytol. 1993;15(2):115-123. Pubmedid: 8318126.
  • Reintgen D, Berman C, Cox C, Baekey P, Nicosia S, Greenberg H, Bush C, Lyman G, Clark R. The anatomy of missed breast cancers. Surg Oncol. 1993;2:65-75.
  • Nicosia S, Williams J, Horowitz S, Ku N, Shabaik A, Mela N, Reintgen D, Cox C. Fine needle aspiration biopsy of palpable breast lesions: review and statistical analysis of 1,875 cases. Surg Oncol. 1993;2(3):145-160.
  • Barton D, Blanchard D, Michelini-Norris B, Nicosia S, Cavanagh D, Djeu J. High serum and ascitic soluble IL2 receptor alpha levels in advanced epithelial ovarian cancer. Blood. 1993;81:424-424.
  • Barton D, Blanchard D, Michelini Norris B, Roberts W, Hoffman M, Fiorica J, Nicosia S, Cavanagh D, Djeu J. Serum soluble interleukin-2 receptor alpha levels in patients with gynecologic cancers: early effect of surgery. Am J Reprod Immunol. 1993;30:202-206.
  • Shabaik A, Cox C, Clark R, Reintgen D, Humphrey E, Nicosia S. Imprint cytology of needle-localized breast lesions. Acta Cytol. 1993;37(1):10-15. Pubmedid: 8434486.
  • Gleeson N, Nicosia S, Hoffman M, Cavanagh D. Abdominal wall metastases from ovarian cancer following laparoscopy. Report of two cases. Am J Obstet Gynecol. 1993;169:522-523.
  • Mourad W, Erkman-Balis B, Livingstone S, Nicosia S, Rowlands D. The argyrophilic nucleolar organizer region in breast carcinoma: correlation with DNA, flow cytometry, histopathology and lymph node status. Cancer. 1992;69:1739-1744.
  • Yeko T, Nicosia S, Maroulis G, Bardawil W, Dawood M. Histology of medluteal corpus luteum and peri-implantation endrometrium from clomiphene citrate-induced cycles. Fertil Steril. 1992;57:28-32.
  • Cox C, Reintgen D, Greenberg H, Baekey P, Nicosia S, Clark R. Indications for lumpectomy and radiation therapy versus mastectomy for intraductal breast carcinoma. Breast Cancer Res Treat. 1992;23(162):126-126.
  • Heal A, Tyson I, Greenberg H, Roberts W, Nicosia S, Berman C, Silbiger M. Pharmacokinetics, dosimetry and clinical evaluation of 131-I-HMFG1 MoAb in the therapy of colorectal and ovarian carcinoma. Antibody Immunoconjugates Radiopharm. 1992;5:1-12.
  • Ku N, Cox C, Reintgen D, Greenberg H, Nicosia S. The cytologic evaluation of breast lumpectomy margin. Arch Cytol. 1991;35:417-421.
  • Nicosia SV. Pathology of the oviducts and embryonal remnants. Obstet Gynecol Annu. 1985;14:382-410. Pubmedid: 3920592.
  • Chilton BS, Nicosia SV, Sowinski JM, Wolf DP. Isolation and characterization of rabbit endocervical cells. J Cell Biol. 1980 Jul;86(1):172-180. Pubmedid: 7191424. Pmcid: PMC2110667.
  • Maroulis G, Nicosia S. Aspiration cytology in reproductive-assisted technologies. In: Selvaggi S, ed. Guidelines to Clinical Aspiration Biopsy: Female Pelvic Organs. Baltimore, MD: Williams And Wilkins; 1997;35-46.
  • Naidu K, Fang Q, Naidu K, Cheng J, Nicosia S, Coppola D. P53 enhances ascorbyl stearate-induced G2/M arrest of human ovarian cancer cells. Anticancer Res. 27(6B):3927-3934. Pubmedid: 18225552.
  • Nicosia S, Ku N, Giacomini G, Pierro E, Mayer J, Nicosia R. Ovarian mesothelium (surface epithelium) in normal, pathological and experimental conditions. In: Motta P, ed. Recent advances in microscopy of cells. Rome. Piccin Press; 1997;509-517.
  • Nicosia S, Nicosia L. Clinical and laboratory technologies. In: Selvaggi S, ed. Guides to clinical aspiration biopsy: female pelvic organs. Baltimore. Williams Wilkins; 1997;5-33.
  • Cox C, Ku N, Joseph E, Reintgen D, Greenberg H, Nicosia S. Intraoperative imprint cytology. In: Bland K, Copeland E, eds. The Second Edition on the Breast: Comprehensive Management of Benign and Malignant Diseases. Philadelphia, PA: WB Saunders Publishing Co; 1998;1118-1129.
  • Cox C, Ku N, Joseph E, Reintgen D, Greenberg H, Nicosia S. Intraoperative imprint cytology. In: Bland K, Copeland E, eds. The second edition on the breast: comprehensive management of benign and malignant diseases. WB Saunders; 1998;1118-1129.
  • Fang Q, Naidu KA, Naidu KA, Zhao H, Sun M, Dan HC, Nasir A, Kaiser HE, Cheng JQ, Nicosia SV, Coppola D. Ascorbyl stearate inhibits cell proliferation and tumor growth in human ovarian carcinoma cells by targeting the PI3K/AKT pathway. Anticancer Res. 26(1A):203-209. Pubmedid: 16475700.
  • Nicosia S, Nicosia R, Saunders B, Sun X, Pierro E, Mancuso S. Control of papillogenesis in benign and malignant ovarian mesothelium. In: Strauss J, Fujimoto S, Hsueh A, Strauss J, et al, eds. New achievments in research of ovarian function. Ares Serono Symposia; 1995;333-343.
  • Nicosia SV, Mikhail G. Cumuli oophori in tissue culture: hormone production, ultrastructure, and morphometry of early luteinization. Fertil Steril. 1975 May;26(5):427-448. Pubmedid: 1168590.
  • Nicosia SV. Luteinization of rabbit preovulatory granulosa cells cultured in vitro in presence of follicular oocytes. I. Growth characteristics and progestin biosynthesis. Fertil Steril. 1972 Nov;23(11):791-801. Pubmedid: 4563146.
TOOLS:   Font Size small font resizer separator font resizer separator big font resizer