Roman Manetsch, PhD

Where You Are:
Roman Manetsch, PhD

"The Manetsch lab research interests embody a well-balanced blend of organic and biological chemistry, addressing modern aspects of medicinal chemistry."

Office  (813) 974-7306

Education And Training
  • Fellow, Scripps Research Institute, 2005
  • Fellow, Swiss National Science Foundation, 2004
  • Fellow, Novartis Foundation, 2003
  • Fellow, Swiss National Science Foundation, 2003
  • PhD, University of Basel (Basel Switzerland), 2002 - Department of Chemistry

The Manetsch lab research interests represent a well-balanced blend of organic and biological chemistry, addressing in particular modern aspects of medicinal chemistry. The conducted research includes development of drug discovery applications deviating from conventional lead discovery methodologies, drug discovery and optimization via target-guided synthesis applications, development of specific protein labeling tools and their application for the discovery of novel biological targets.

  • Mahajan S, Manetsch R, Merkler DJ, Stevens SM. Synthesis and evaluation of a novel adenosine-ribose probe for global-scale profiling of nucleoside and nucleotide-binding proteins. PLoS One. 2015;10(2):e0115644. Pubmedid: 25671571. Pmcid: PMC4324776.
  • Monastyrskyi A, Kyle DE, Manetsch R. 4(1H)-Pyridone and 4(1H)-Quinolone Derivatives as Antimalarials with Erythrocytic, Exoerythrocytic, and Transmission Blocking Activities. Curr Top Med Chem. 2014 Sep;14(14):1693-1705. Pubmedid: 25116582.
  • Campbell CO, Santiago DN, Guida WC, Manetsch R, Adams JH. In silico characterization of an atypical MAPK phosphatase of Plasmodium falciparum as a suitable target for drug discovery. Chem Biol Drug Des. 2014 Aug;84(2):158-168. Pubmedid: 24605883.
  • Van Horn K, Burda WN, Fleeman R, Shaw LN, Manetsch R. Antibacterial activity of a series of N2,N4-disubstituted quinazoline-2,4-diamines. J Med Chem. 2014 Apr;57(7):3075-3093. Pubmedid: 24625106.
  • Sáenz FE, Lacrue AN, Cross RM, Maignan JR, Udenze KO, Manetsch R, Kyle DE. 4-(1H)-Quinolones and 1,2,3,4-Tetrahydroacridin-9(10H)-Ones Prevent the Transmission of Plasmodium falciparum to Anopheles freeborni. Antimicrob Agents Chemother. 2013 Dec;57(12):6187-6195. Pubmedid: 24080648.
  • Nilsen A, Lacrue AN, White KL, Forquer IP, Cross RM, Marfurt J, Mather MW, Delves MJ, Shackleford DM, Saenz FE, Morrisey JM, Steuten J, Mutka T, Li Y, Wirjanata G, Ryan E, Duffy S, Kelly JX, Sebayang BF, Zeeman AM, Noviyanti R, Sinden RE, Kocken CH, Price RN, Avery VM, Angulo-Barturen I, Jiménez-Díaz MB, Ferrer S, Herreros E, Sanz LM, Gamo FJ, Bathurst I, Burrows JN, Siegl P, Guy RK, Winter RW, Vaidya AB, Charman SA, Kyle DE, Manetsch R, Riscoe MK. Quinolone-3-diarylethers: a new class of antimalarial drug. Sci Transl Med. 2013 Mar;5(177):177ra37. Pubmedid: 23515079. Pmcid: PMC4227885.
  • Kulkarni SS, Hu X, Manetsch R. A simple base-mediated amidation of aldehydes with azides. Chem Commun (Camb). 2013 Jan;49(12):1193-1195. Pubmedid: 23287824.
  • Lacrue AN, Sáenz FE, Cross RM, Udenze KO, Monastyrskyi A, Stein S, Mutka TS, Manetsch R, Kyle DE. 4(1H)-Quinolones with liver stage activity against Plasmodium berghei. Antimicrob Agents Chemother. 2013 Jan;57(1):417-424. Pubmedid: 23129047. Pmcid: PMC3535941.
  • Nacheva KP, Maza WA, Myers DZ, Fronczek FR, Larsen RW, Manetsch R. Fluorescent properties and resonance energy transfer of 3,4-bis(2,4-difluorophenyl)-maleimide. Org Biomol Chem. 2012 Sep;10(38):7840-7846. Pubmedid: 22930038.
  • Kumar AB, Anderson JM, Melendez AL, Manetsch R. Synthesis and structure-activity relationship studies of 1,3-disubstituted 2-propanols as BACE-1 inhibitors. Bioorg Med Chem Lett. 2012 Jul;22(14):4740-4744. Pubmedid: 22727644.
  • Namelikonda NK, Manetsch R. Sulfo-click reaction via in situ generated thioacids and its application in kinetic target-guided synthesis. Chem Commun (Camb). 2012 Feb;48(10):1526-1528. Pubmedid: 21892513.
  • Cross RM, Namelikonda NK, Mutka TS, Luong L, Kyle DE, Manetsch R. Synthesis, antimalarial activity, and structure-activity relationship of 7-(2-phenoxyethoxy)-4(1H)-quinolones. J Med Chem. 2011 Dec;54(24):8321-8327. Pubmedid: 22111907.
  • Kumar AB, Anderson JM, Manetsch R. Design, synthesis and photoactivation studies of fluorous photolabels. Org Biomol Chem. 2011 Sep;9(18):6284-6292. Pubmedid: 21785789.
  • Cross RM, Maignan JR, Mutka TS, Luong L, Sargent J, Kyle DE, Manetsch R. Optimization of 1,2,3,4-tetrahydroacridin-9(10H)-ones as antimalarials utilizing structure-activity and structure-property relationships. J Med Chem. 2011 Jul;54(13):4399-4426. Pubmedid: 21630666.
  • Kulkarni SS, Hu X, Doi K, Wang HG, Manetsch R. Screening of protein-protein interaction modulators via sulfo-click kinetic target-guided synthesis. Acs Chem Biol. 2011 Jul;6(7):724-732. Pubmedid: 21506574. Pmcid: PMC3151735.
  • Cross RM, Manetsch R. Divergent route to access structurally diverse 4-quinolones via mono or sequential cross-couplings. J Org Chem. 2010 Dec;75(24):8654-8657. Pubmedid: 21082793.
  • Cross RM, Monastyrskyi A, Mutka TS, Burrows JN, Kyle DE, Manetsch R. Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity. J Med Chem. 2010 Oct;53(19):7076-7094. Pubmedid: 20828199.
  • Hu X, Manetsch R. Kinetic target-guided synthesis. Chem Soc Rev. 2010 Apr;39(4):1316-1324. Pubmedid: 20309488.
  • Hu X, Sun J, Wang HG, Manetsch R. Bcl-XL-templated assembly of its own protein-protein interaction modulator from fragments decorated with thio acids and sulfonyl azides. J Am Chem Soc. 2008 Dec;130(42):13820-13821. Pubmedid: 18811158. Pmcid: PMC2574679.
  • Radić Z, Manetsch R, Fournier D, Sharpless KB, Taylor P. Probing gorge dimensions of cholinesterases by freeze-frame click chemistry. Chem Biol Interact. 2008 Sep;175(1-3):161-165. Pubmedid: 18555981. Pmcid: PMC2585062.
  • Sharpless KB, Manetsch R. In situ click chemistry: a powerful means for lead discovery. Expert Opin Drug Discov. 2006 Nov;1(6):525-538. Pubmedid: 23506064.
  • Radic Z, Manetsch R, Krasinski A, Raushel J, Yamauchi J, Garcia C, Kolb H, Sharpless K, Taylor P. Molecular basis of interactions of cholinesterases with tight binding inhibitors. Chem Biol Interact. 2005 Dec;157-158:133-141. Pubmedid: 16289416.
  • Krasinski A, Radic Z, Manetsch R, Raushel J, Taylor P, Sharpless K, KolbHC. In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors. J Am Chem Soc. 2005 May;127(18):6686-6692. Pubmedid: 15869290.
  • Zheng L, Manetsch R, Woggon W, Baumann U, Reymond J. Mechanistic study of proton transfer and hysteresis in catalytic antibody 16E7 by site-directed mutagenesis and homology modeling. Bioorg Med Chem. 2005 Feb;13(4):1021-1029. Pubmedid: 15670909.
  • Manetsch R, Zheng L, Reymond M, Woggon W, Reymond J. A catalytic antibody against a tocopherol cyclase inhibitor. Chemistry. 2004 May;10(10):2487-2506. Pubmedid: 15146522.
  • Manetsch R, Krasinski A, Radic Z, Raushel J, Taylor P, Sharpless K, KolbHC. In situ click chemistry: enzyme inhibitors made to their own specifications. J Am Chem Soc. 2004;126(40):12809-12818. Pubmedid: 15469276.
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