Robert J. Gillies, PhD

The work of Dr. Gillies has impacted all 3 aims of the ET program, with the majority focused on Aim 1: Define & characterize deregulated pathways with therapeutic relevance in subsets of human cancers. Work in this area has examined two different pathways: 1) cell surface proteins that can be targeted by imaging or therapy, and 2) energy metabolic pathways and their sequelae. Dr. Gillies and colleagues have identified targetable cell surface receptors in pancreatic, melanoma and breast cancers.  For agents designed to be applied locally, Dr. Gillies and colleagues have looked for single protein targets that are expressed in the cancer or pre-cancer, that are not expressed in normal not adjacent-normal tissues.  These can be targeted with homomultivalent ligands (hoMVLs) coupled to dyes or nanoparticles.  For agents designed to be applied systemically, they have interrogated the gene expression arrays looking for combinations of cell surface receptors that can be targeted with heteromultivalent ligands (htMVLs).  Recently, Dr. Gillies and colleagues have identified both hoMVL and htMVL targets in pancreatic cancers and melanomas, and have identified hoMVL targets for breast cancer in lymph nodes.

• Martinez GV, Navath S, Sewda K, Rao V, Foroutan P, Alleti R, Moberg VE, Ahad AM, Coppola D, Lloyd MC, Gillies RJ, Morse DL, Mash EA. Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract. Bioorg Med Chem Lett. 2013 Apr;23(7):2061-2064. Pubmedid: 23481651.
• Brabez N, Nguyen KL, Saunders K, Lacy R, Xu L, Gillies RJ, Lynch RM, Chassaing G, Lavielle S, Hruby VJ. Synthesis and evaluation of cholecystokinin trimers: A multivalent approach to pancreatic cancer detection and treatment. Bioorg Med Chem Lett. 2013 Apr;23(8):2422-2425. Pubmedid: 23489620.
• Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH. A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep. 2013 Apr;3:1449. Pubmedid: 23618955.
• Gu Y, Kumar V, Hall LO, Goldgof DB, Li CY, Korn R, Bendtsen C, Velazquez ER, Dekker A, Aerts H, Lambin P, Li X, Tian J, Gatenby RA, Gillies RJ. Automated Delineation of Lung Tumors from CT Images Using a Single Click Ensemble Segmentation Approach. Pattern Recognit. 2013 Mar;46(3):692-702. Pubmedid: 23459617.
• Kumar V, Nath K, Berman CG, Kim J, Tanvetyanon T, Chiappori AA, Gatenby RA, Gillies RJ, Eikman EA. Variance of SUVs for FDG-PET/CT is Greater in Clinical Practice Than Under Ideal Study Settings. Clin Nucl Med. 2013 Mar;38(3):175-182. Pubmedid: 23354032.
• Estrella V, Chen T, Lloyd M, Wojtkowiak J, Cornnell HH, Ibrahim-Hashim A, Bailey K, Balagurunathan Y, Rothberg JM, Sloane BF, Johnson J, Gatenby RA, Gillies RJ. Acidity generated by the tumor microenvironment drives local invasion. Cancer Res. 2013 Mar;73(5):1524-1535. Pubmedid: 23288510. Pmcid: PMC3594450.
• Kreahling JM, Foroutan P, Reed D, Martinez G, Razabdouski T, Bui MM, Raghavan M, Letson D, Gillies RJ, Altiok S. Wee1 Inhibition by MK-1775 Leads to Tumor Inhibition and Enhances Efficacy of Gemcitabine in Human Sarcomas. PLoS One. 2013;8(3):e57523. Pubmedid: 23520471.
• Martinez-Zaguilan R, Tompkins LS, Gillies RJ, Lynch RM. Simultaneous analysis of intracellular pH and Ca²? from cell populations. Methods Mol Biol. 2013;937:253-271. Pubmedid: 23007592.
• Xu L, Josan JS, Vagner J, Caplan MR, Hruby VJ, Mash EA, Lynch RM, Morse DL, Gillies RJ. Heterobivalent ligands target cell-surface receptor combinations in vivo. Proc Natl Acad Sci U S A. 2012 Dec;109(52):21295-21300. Pubmedid: 23236171. Pmcid: PMC3535626.
• Silva AS, Kam Y, Khin ZP, Minton SE, Gillies RJ, Gatenby RA. Evolutionary approaches to prolong progression-free survival in breast cancer. Cancer Res. 2012 Dec;72(24):6362-6370. Pubmedid: 23066036. Pmcid: PMC3525750.
• Chinnaiyan P, Kensicki E, Bloom G, Prabhu A, Sarcar B, Kahali S, Eschrich S, Qu X, Forsyth P, Gillies R. The metabolomic signature of malignant glioma reflects accelerated anabolic metabolism. Cancer Res. 2012 Nov;72(22):5878-5888. Pubmedid: 23026133.
• Rios Velazquez E, Aerts HJ, Gu Y, Goldgof DB, De Ruysscher D, Dekker A, Korn R, Gillies RJ, Lambin P. A semiautomatic CT-based ensemble segmentation of lung tumors: Comparison with oncologists' delineations and with the surgical specimen. Radiother Oncol. 2012 Nov;105(2):167-173. Pubmedid: 23157978.
• Kumar V, Gu Y, Basu S, Berglund A, Eschrich SA, Schabath MB, Forster K, Aerts HJ, Dekker A, Fenstermacher D, Goldgof DB, Hall LO, Lambin P, Balagurunathan Y, Gatenby RA, Gillies RJ. Radiomics: the process and the challenges. Magn Reson Imaging. 2012 Nov;30(9):1234-1248. Pubmedid: 22898692. Pmcid: PMC3563280.
• Stephen RM, Pagel MD, Brown K, Baker AF, Meuillet EJ, Gillies RJ. Monitoring the development of xenograft triple-negative breast cancer models using diffusion-weighted magnetic resonance imaging. Exp Biol Med (Maywood). 2012 Nov;237(11):1273-1280. Pubmedid: 23239438.
• Wojtkowiak JW, Gillies RJ. Autophagy on Acid. Autophagy. 2012 Nov;8(11):1688-1689. Pubmedid: 22874557.
• Cárdenas-Rodríguez J, Li Y, Galons JP, Cornnell H, Gillies RJ, Pagel MD, Baker AF. Imaging biomarkers to monitor response to the hypoxia-activated prodrug TH-302 in the MiaPaCa2 flank xenograft model. Magn Reson Imaging. 2012 Sep;30(7):1002-1009. Pubmedid: 22554971. Pmcid: PMC3402593.
• Wojtkowiak JW, Rothberg JM, Kumar V, Schramm KJ, Haller E, Proemsey JB, Lloyd MC, Sloane BF, Gillies RJ. Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments. Cancer Res. 2012 Aug;72(16):3938-3947. Pubmedid: 22719070.
• Ibrahim-Hashim A, Cornnell HH, Abrahams D, Lloyd M, Bui M, Gillies RJ, Gatenby RA. Systemic Buffers Inhibit Carcinogenesis in TRAMP Mice. J Urol. 2012 Aug;188(2):624-631. Pubmedid: 22704445.
• Gillies RJ, Verduzco D, Gatenby RA. Evolutionary dynamics of carcinogenesis and why targeted therapy does not work. Nat Rev Cancer. 2012 Jul;12(7):487-493. Pubmedid: 22695393.
• D'Silva L, Pola A, Dutta P, Martinez GV, Sprenger P, Gillies RJ, Kuchel PW, Sendhil Velan S. Slow relaxation of longitudinal multispin orders in weakly and strongly coupled two-spin systems. Magn Reson Chem. 2012 Jun;50(6):443-448. Pubmedid: 22552892.
• Lambin P, Rios-Velazquez E, Leijenaar R, Carvalho S, van Stiphout RG, Granton P, Zegers CM, Gillies R, Boellard R, Dekker A, Aerts HJ. Radiomics: extracting more information from medical images using advanced feature analysis. Eur J Cancer. 2012 Mar;48(4):441-446. Pubmedid: 22257792.
• Martin NK, Robey IF, Gaffney EA, Gillies RJ, Gatenby RA, Maini PK. Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study. Br J Cancer. 2012 Mar;106(7):1280-1287. Pubmedid: 22382688. Pmcid: PMC3314784.
• Gillies RJ, Gelovani J. The World Molecular Imaging Society (WMIS). Mol Imaging Biol. 2012 Feb;14(1):1-3. Pubmedid: 22203242.
• Ribeiro MdLC, Silva AS, Bailey KM, Kumar NB, Sellers TA, Gatenby RA, Arig IH, Gillies RJ. Buffer therapy for cancer. J Nutr Food Sci. 2012 Jan;1-7.
• Tafreshi NK, Bui MM, Bishop K, Lloyd MC, Enkemann SA, Lopez AS, Abrahams D, Carter WB, Vagner J, Gobmyer SR, Gillies RJ, Morse DL. Noninvasive Detection of Breast Cancer Lymph Node Metastasis Using Carbonic Anhydrases IX and XII Targeted Imaging Probes. Clin Cancer Res. 2012 Jan;18(1):207-219. Pubmedid: 22016510.
• Bailey KM, Wojtkowiak JW, Hashim AI, Gillies RJ. Targeting the metabolic microenvironment of tumors. Adv Pharmacol. 2012;65:63-107. Pubmedid: 22959024.
• Cunningham J, Estrella V, Lloyd M, Gillies R, Frieden BR, Gatenby R. Intracellular electric field and pH optimize protein localization and movement. PLoS One. 2012;7(5):e36894. Pubmedid: 22623963. Pmcid: PMC3356409.
• Yamazato M, Ferreira AJ, Yamazato Y, Diez-Freire C, Yuan L, Gillies R, Raizada MK. Gene transfer of angiotensin-converting enzyme 2 in the nucleus tractus solitarius improves baroreceptor heart rate reflex in spontaneously hypertensive rats. J Renin Angiotensin Aldosterone Syst. 2011 Dec;12(4):456-461. Pubmedid: 21719524. Pmcid: PMC3375591.
• Barkey NM, Tafreshi NK, Josan JS, De Silva CR, Sill KN, Hruby VJ, Gillies RJ, Morse DL, Vagner J. Development of melanoma-targeted polymer micelles by conjugation of a melanocortin 1 receptor (MC1R) specific ligand. J Med Chem. 2011 Dec;54(23):8078-8084. Pubmedid: 22011200. Pmcid: PMC3302579.
• Martinez GV, Zhang X, García-Martín ML, Morse DL, Woods M, Sherry AD, Gillies RJ. Imaging the extracellular pH of tumors by MRI after injection of a single cocktail of T1 and T2 contrast agents. NMR Biomed. 2011 Dec;24(10):1380-1391. Pubmedid: 21604311.
• Ibrahim Hashim A, Cornnell HH, Coelho Ribeiro Mde L, Abrahams D, Cunningham J, Lloyd M, Martinez GV, Gatenby RA, Gillies RJ. Reduction of metastasis using a non-volatile buffer. Clin Exp Metastasis. 2011 Dec;28(8):841-849. Pubmedid: 21861189. Pmcid: PMC3213349.
• Wojtkowiak JW, Verduzco D, Schramm KJ, Gillies RJ. Drug resistance and cellular adaptation to tumor acidic pH microenvironment. Mol Pharm. 2011 Dec;8(6):2032-2038. Pubmedid: 21981633. Pmcid: PMC3230683.
• Rao V, Alleti R, Xu L, Tafreshi NK, Morse DL, Gillies RJ, Mash EA. A sucrose-derived scaffold for multimerization of bioactive peptides. Bioorg Med Chem. 2011 Nov;19(21):6474-6482. Pubmedid: 21940174. Pmcid: PMC3197697.
• Brabez N, Lynch RM, Xu L, Gillies RJ, Chassaing G, Lavielle S, Hruby VJ. Design, synthesis, and biological studies of efficient multivalent melanotropin ligands: tools toward melanoma diagnosis and treatment. J Med Chem. 2011 Oct;54(20):7375-7384. Pubmedid: 21928837. Pmcid: PMC3521580.
• Gatenby RA, Gillies RJ. Integrated imaging of cancer metabolism. Acad Radiol. 2011 Aug;18(8):929-931. Pubmedid: 21718952.
• Hashim AI, Zhang X, Wojtkowiak JW, Martinez GV, Gillies RJ. Imaging pH and metastasis. NMR Biomed. 2011 Jul;24(6):582-591. Pubmedid: 21387439.
• Josan JS, Handl HL, Sankaranarayanan R, Xu L, Lynch RM, Vagner J, Mash EA, Hruby VJ, Gillies RJ. Cell-specific targeting by heterobivalent ligands. Bioconjug Chem. 2011 Jul;22(7):1270-1278. Pubmedid: 21639139. Pmcid: PMC3381984.
• Huynh AS, Abrahams DF, Torres MS, Baldwin MK, Gillies RJ, Morse DL. Development of an orthotopic human pancreatic cancer xenograft model using ultrasound guided injection of cells. PLoS One. 2011 May;6(5):e20330. Pubmedid: 21647423. Pmcid: PMC3103544.
• Perfahl H, Byrne HM, Chen T, Estrella V, Alarcón T, Lapin A, Gatenby RA, Gillies RJ, Lloyd MC, Maini PK, Reuss M, Owen MR. Multiscale modelling of vascular tumour growth in 3D: the roles of domain size and boundary conditions. PLoS One. 2011 Apr;6(4):e14790. Pubmedid: 21533234. Pmcid: PMC3076378.
• Gatenby RA, Gillies RJ, Brown JS. Of cancer and cave fish. Nat Rev Cancer. 2011 Apr;11(4):237-238. Pubmedid: 21548400.
• Martin NK, Gaffney EA, Gatenby RA, Gillies RJ, Robey IF, Maini PK. A mathematical model of tumour and blood pHe regulation: The HCO3-/CO2 buffering system. Math Biosci. 2011 Mar;230(1):1-11. Pubmedid: 21167185. Pmcid: PMC3045481.
• Tafreshi NK, Enkemann SA, Bui MM, Lloyd MC, Abrahams D, Huynh AS, Kim J, Grobmyer SR, Carter WB, Vagner J, Gillies RJ, Morse DL. A mammaglobin-A targeting agent for noninvasive detection of breast cancer metastasis in lymph nodes. Cancer Res. 2011 Feb;71(3):1050-1059. Pubmedid: 21169406.
• Alleti R, Rao V, Xu L, Gillies RJ, Mash EA. A solanesol-derived scaffold for multimerization of bioactive peptides. J Org Chem. 2010 Sep;75(17):5895-5903. Pubmedid: 20701315. Pmcid: PMC2929268.
• Morse DL, Gillies RJ. Molecular imaging and targeted therapies. Biochem Pharmacol. 2010 Sep;80(5):731-738. Pubmedid: 20399197. Pmcid: PMC2925390.
• Morse DL, Balagurunathan Y, Hostetter G, Trissal M, Tafreshi NK, Burke N, Lloyd M, Enkemann S, Coppola D, Hruby VJ, Gillies RJ, Han H. Identification of novel pancreatic adenocarcinoma cell-surface targets by gene expression profiling and tissue microarray. Biochem Pharmacol. 2010 Sep;80(5):748-754. Pubmedid: 20510208. Pmcid: PMC2914681.
• Zhang X, Lin Y, Gillies RJ. Tumor pH and its measurement. J Nucl Med. 2010 Aug;51(8):1167-1170. Pubmedid: 20660380.
• Gatenby RA, Gillies RJ, Brown JS. Evolutionary dynamics of cancer prevention. Nat Rev Cancer. 2010 Aug;10(8):526-527. Pubmedid: 21137109.
• Lee YS, Fernandes S, Kulkarani V, Mayorov A, Davis P, Ma SW, Brown K, Gillies RJ, Lai J, Porreca F, Hruby VJ. Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain. Bioorg Med Chem Lett. 2010 Jul;20(14):4080-4084. Pubmedid: 20547453. Pmcid: PMC2917332.
• Gillies RJ, Anderson AR, Gatenby RA, Morse DL. The biology underlying molecular imaging in oncology: from genome to anatome and back again. Clin Radiol. 2010 Jul;65(7):517-521. Pubmedid: 20541651.
• Xu L, Vagner J, Alleti R, Rao V, Jagadish B, Morse DL, Hruby VJ, Gillies RJ, Mash EA. Synthesis and characterization of a Eu-DTPA-PEGO-MSH(4) derivative for evaluation of binding of multivalent molecules to melanocortin receptors. Bioorg Med Chem Lett. 2010 Apr;20(8):2489-2492. Pubmedid: 20304640. Pmcid: PMC2857964.
• De Silva CR, Vagner J, Lynch R, Gillies RJ, Hruby VJ. Optimization of time-resolved fluorescence assay for detection of europium-tetraazacyclododecyltetraacetic acid-labeled ligand-receptor interactions. Anal Biochem. 2010 Mar;398(1):15-23. Pubmedid: 19852924. Pmcid: PMC2830854.
• Silva AS, Gatenby RA, Gillies RJ, Yunes JA. A quantitative theoretical model for the development of malignancy in ductal carcinoma in situ. J Theor Biol. 2010 Feb;262(4):601-613. Pubmedid: 19887072.
• Morse DL, Hostetter G, Balagurunathan Y, Gillies RJ, Han H. Identification of pancreatic cancer-specific cell-surface markers for development of targeting ligands. Methods Mol Biol. 2010;624:195-210. Pubmedid: 20217597.
• Rosca EV, Gillies RJ, Caplan MR. Glioblastoma targeting via integrins is concentration dependent. Biotechnol Bioeng. 2009 Oct;104(2):408-417. Pubmedid: 19575417. Pmcid: PMC2791716.
• Lee HK, Smith MD, Smith BJ, Grussendorf J, Xu L, Gillies RJ, White HS, Bulaj G. Anticonvulsant Met-enkephalin analogues containing backbone spacers reveal alternative non-opioid signaling in the brain. ACS Chem Biol. 2009 Aug;4(8):659-671. Pubmedid: 19634861.
• Xu L, Vagner J, Josan J, Lynch RM, Morse DL, Baggett B, Han H, Mash EA, Hruby VJ, Gillies RJ. Enhanced targeting with heterobivalent ligands. Mol Cancer Ther. 2009 Aug;8(8):2356-2365. Pubmedid: 19671749.
• De Leon-Rodriguez LM, Lubag AJ, Malloy CR, Martinez GV, Gillies RJ, Sherry AD. Responsive MRI agents for sensing metabolism in vivo. Acc Chem Res. 2009 Jul;42(7):948-957. Pubmedid: 19265438. Pmcid: PMC2713815.
• Josan JS, Morse DL, Xu L, Trissal M, Baggett B, Davis P, Vagner J, Gillies RJ, Hruby VJ. Solid-phase synthetic strategy and bioevaluation of a labeled delta-opioid receptor ligand Dmt-Tic-Lys for in vivo imaging. Org Lett. 2009 Jun;11(12):2479-2482. Pubmedid: 19445485. Pmcid: PMC2756606.
• Gatenby RA, Silva AS, Gillies RJ, Frieden BR. Adaptive therapy. Cancer Res. 2009 Jun;69(11):4894-4903. Pubmedid: 19487300.
• Silva AS, Yunes JA, Gillies RJ, Gatenby RA. The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. Cancer Res. 2009 Mar;69(6):2677-2684. Pubmedid: 19276380.
• Robey IF, Baggett BK, Kirkpatrick ND, Roe DJ, Dosescu J, Sloane BF, Hashim AI, Morse DL, Raghunand N, Gatenby RA, Gillies RJ. Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res. 2009 Mar;69(6):2260-2268. Pubmedid: 19276390. Pmcid: PMC2834485.
• Morse DL, Carroll D, Day S, Gray H, Sadarangani P, Murthi S, Job C, Baggett B, Raghunand N, Gillies RJ. Characterization of breast cancers and therapy response by MRS and quantitative gene expression profiling in the choline pathway. NMR Biomed. 2009 Jan;22(1):114-127. Pubmedid: 19016452.
• Josan JS, Vagner J, Handl HL, Sankaranarayanan R, Gillies RJ, Hruby VJ. Solid-Phase Synthesis of Heterobivalent Ligands Targeted to Melanocortin and Cholecystokinin Receptors. Int J Pept Res Ther. 2008 Dec;14(4):293-300. Pubmedid: 19714261. Pmcid: PMC2732021.
• Jennings D, Raghunand N, Gillies R. Imaging hemodynamics. Cancer Metastasis Rev. 2008 Dec;27(4):589-613. Pubmedid: 18506397.
• Fang JS, Gillies RD, Gatenby RA. Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression. Semin Cancer Biol. 2008 Oct;18(5):330-337. Pubmedid: 18455429. Pmcid: PMC2953714.
• Lope-Piedrafita S, Garcia-Martin ML, Galons JP, Gillies RJ, Trouard TP. Longitudinal diffusion tensor imaging in a rat brain glioma model. NMR Biomed. 2008 Oct;21(8):799-808. Pubmedid: 18470959. Pmcid: PMC2857329.
• Balagurunathan Y, Morse DL, Hostetter G, Shanmugam V, Stafford P, Shack S, Pearson J, Trissal M, Demeure MJ, Von Hoff DD, Hruby VJ, Gillies RJ, Han H. Gene expression profiling-based identification of cell-surface targets for developing multimeric ligands in pancreatic cancer. Mol Cancer Ther. 2008 Sep;7(9):3071-3080. Pubmedid: 18765825. Pmcid: PMC2567866.
• Robey IF, Stephen RM, Brown KS, Baggett BK, Gatenby RA, Gillies RJ. Regulation of the Warburg effect in early-passage breast cancer cells. Neoplasia. 2008 Aug;10(8):745-756. Pubmedid: 18670636.
• Gillies R, Robey I, Gatenby R. Causes and consequences of increased glucose metabolism of cancers. J Nucl Med. 2008 Jun;49:24S-42S. Pubmedid: 18523064.
• Borden MA, Zhang H, Gillies RJ, Dayton PA, Ferrara KW. A stimulus-responsive contrast agent for ultrasound molecular imaging. Biomaterials. 2008 Feb;29(5):597-606. Pubmedid: 17977595. Pmcid: PMC2266628.
• Gatenby R, Gillies R. A microenvironmental model of carcinogenesis. Nat Rev Cancer. 2008 Jan;8(1):56-61. Pubmedid: 18059462.
• Black KC, Kirkpatrick ND, Troutman TS, Xu L, Vagner J, Gillies RJ, Barton JK, Utzinger U, Romanowski M. Gold nanorods targeted to delta opioid receptor: plasmon-resonant contrast and photothermal agents. Mol Imaging. 2008 Jan;7(1):50-57. Pubmedid: 18384724.
• Vagner J, Xu L, Handl HL, Josan JS, Morse DL, Mash EA, Gillies RJ, Hruby VJ. Heterobivalent ligands crosslink multiple cell-surface receptors: the human melanocortin-4 and delta-opioid receptors. Angew Chem Int Ed Engl. 2008;47(9):1685-1688. Pubmedid: 18205159. Pmcid: PMC2716288.
• Moellering R, Black K, Krishnamurty C, Baggett B, Stafford P, Rain M, Gatenby R, Gillies R. Acid treatment of melanoma cells selects for invasive phenotypes. Clin Exp Metastasis. 2008;25(4):411-425. Pubmedid: 18301995.
• Ackerstaff E, Artemov D, Gillies RJ, Bhujwalla ZM. Hypoxia and the presence of human vascular endothelial cells affect prostate cancer cell invasion and metabolism. Neoplasia. 2007 Dec;9(12):1138-1151. Pubmedid: 18084621.
• Rosca EV, Stukel JM, Gillies RJ, Vagner J, Caplan MR. Specificity and mobility of biomacromolecular, multivalent constructs for cellular targeting. Biomacromolecules. 2007 Dec;8(12):3830-3835. Pubmedid: 18039007.
• Morse D, Galons J, Payne C, Jennings D, Day S, Xia G, Gillies R. MRI-measured water mobility increases in response to chemotherapy via multiple cell-death mechanisms. Nmr Biomed. 2007 Oct;20(6):602-614. Pubmedid: 17265424.
• Gatenby R, Smallbone K, Maini P, Rose F, Averill J, Nagle R, Worrall L, Gillies R. Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer. Br J Cancer. 2007 Sep;97(5):646-653. Pubmedid: 17687336.
• Morse D, Raghunand N, Sadarangani P, Murthi S, Job C, Day S, Howison C, Gillies R. Response of choline metabolites to docetaxel therapy is quantified in vivo by localized (31)P MRS of human breast cancer xenografts and in vitro by high-resolution (31)P NMR spectroscopy of cell extracts. Magn Reson Med. 2007 Aug;58(2):270-280. Pubmedid: 17654590.
• Borden M, Caskey C, Little E, Gillies R, Ferrara K. DNA and polylysine adsorption and multilayer construction onto cationic lipid-coated microbubbles. Langmuir. 2007 Aug;23(18):9401-9408. Pubmedid: 17665937.
• Gillies R, Gatenby R. Hypoxia and adaptive landscapes in the evolution of carcinogenesis. Cancer Metastasis Rev. 2007 Jun;26(2):311-317. Pubmedid: 17404691.
• Gillies R, Gatenby R. Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis. J Bioenerg Biomembr. 2007 Jun;39(3):251-257. Pubmedid: 17624581.
• Jagadish B, Sankaranarayanan R, Xu L, Richards R, Vagner J, Hruby VJ, Gillies RJ, Mash EA. Squalene-derived flexible linkers for bioactive peptides. Bioorg Med Chem Lett. 2007 Jun;17(12):3310-3313. Pubmedid: 17448660. Pmcid: PMC2033335.
• Stephen RM, Gillies RJ. Promise and progress for functional and molecular imaging of response to targeted therapies. Pharm Res. 2007 Jun;24(6):1172-1185. Pubmedid: 17385018.
• Bowen ME, Monguchi Y, Sankaranarayanan R, Vagner J, Begay LJ, Xu L, Jagadish B, Hruby VJ, Gillies RJ, Mash EA. Design, synthesis, and validation of a branched flexible linker for bioactive peptides. J Org Chem. 2007 Mar;72(5):1675-1680. Pubmedid: 17279799. Pmcid: PMC3538035.
• Smallbone K, Gatenby R, Gillies R, Maini P, Gavaghan D. Metabolic changes during carcinogenesis: potential impact on invasiveness. J Theor Biol. 2007 Feb;244(4):703-713. Pubmedid: 17055536.
• Gatenby R, Gillies R. Glycolysis in cancer: a potential target for therapy. Int J Biochem Cell Biol. 2007;39(7-8):1358-1366. Pubmedid: 17499003.
• Sloane B, Gillies R, Mohla S, Sogn J, Menkens A, Sullivan D. I2 imaging: cancer biology and the tumor microenvironment. Cancer Res. 2006 Dec;66(23):11097-11099. Pubmedid: 17114235.
• Vagner J, Handl HL, Monguchi Y, Jana U, Begay LJ, Mash EA, Hruby VJ, Gillies RJ. Rigid linkers for bioactive peptides. Bioconjug Chem. 2006 Nov;17(6):1545-1550. Pubmedid: 17105235. Pmcid: PMC2743982.
• Tatum J, Kelloff G, Gillies R, Arbeit J, Brown J, Chao K, Chapman J, Eckelman W, Fyles A, Giaccia A, Hill R, Koch C, Krishna M, Krohn K, LewisJS, Mason R, Melillo G, Padhani A, Powis G, Rajendran J, Reba R, Robinson S, Sullivan D. Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol. 2006 Oct;82(10):699-757. Pubmedid: 17118889.
• Raghunand N, Jagadish B, Trouard TP, Galons JP, Gillies RJ, Mash EA. Redox-sensitive contrast agents for MRI based on reversible binding of thiols to serum albumin. Magn Reson Med. 2006 Jun;55(6):1272-1280. Pubmedid: 16700014. Pmcid: PMC1808246.
• Gatenby R, Gawlinski E, Gmitro A, Kaylor B, Gillies R. Acid-mediated tumor invasion: a multidisciplinary study. Cancer Res. 2006 May;66(10):5216-5223. Pubmedid: 16707446.
• Borden M, Martinez G, Ricker J, Tsvetkova N, Longo M, Gillies R, DaytonPA, Ferrara K. Lateral phase separation in lipid-coated microbubbles. Langmuir. 2006 Apr;22(9):4291-4297. Pubmedid: 16618177.
• Garcia-Martin M, Martinez G, Raghunand N, Sherry A, Zhang S, Gillies R. High resolution pH(e) imaging of rat glioma using pH-dependent relaxivity. Magn Reson Med. 2006 Feb;55(2):309-315. Pubmedid: 16402385.
• Jordan B, Black K, Robey I, Runquist M, Powis G, Gillies R. Metabolite changes in HT-29 xenograft tumors following HIF-1alpha inhibition with PX-478 as studied by MR spectroscopy in vivo and ex vivo. Nmr Biomed. 2005 Nov;18(7):430-439. Pubmedid: 16206237.
• Morse D, Gray H, Payne C, Gillies R. Docetaxel induces cell death through mitotic catastrophe in human breast cancer cells. Mol Cancer Ther. 2005 Oct;4(10):1495-1504. Pubmedid: 16227398.
• Handl H, Vagner J, Yamamura H, Hruby V, Gillies R. Development of a lanthanide-based assay for detection of receptor-ligand interactions at the delta-opioid receptor. Anal Biochem. 2005 Aug;343(2):299-307. Pubmedid: 16004955.
• Galons J, Lope-Piedrafita S, Divijak J, Corum C, Gillies R, Trouard T. Uncovering of intracellular water in cultured cells. Magn Reson Med. 2005 Jul;54(1):79-86. Pubmedid: 15968680.
• Morse D, Carroll D, Weberg L, Borgstrom M, Ranger-Moore J, Gillies R. Determining suitable internal standards for mRNA quantification of increasing cancer progression in human breast cells by real-time reverse transcriptase polymerase chain reaction. Anal Biochem. 2005 Jul;342(1):69-77. Pubmedid: 15958182.
• Handl H, Gillies R. Lanthanide-based luminescent assays for ligand-receptor interactions. Life Sci. 2005 Jun;77(4):361-371. Pubmedid: 15894006.
• Jordan BF, Runquist M, Raghunand N, Baker A, Williams R, Kirkpatrick L, Powis G, Gillies RJ. Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478. Neoplasia. 2005 May;7(5):475-485. Pubmedid: 15967100. Pmcid: PMC1501160.
• Robey IF, Lien AD, Welsh SJ, Baggett BK, Gillies RJ. Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors. Neoplasia. 2005 Apr;7(4):324-330. Pubmedid: 15967109.
• Gillies RJ, Hoffman JM, Lam KS, Menkens AE, Piwnica-Worms DR, Sullivan DC, Weissleder R. Meeting report: high-throughput technologies for in vivo imaging agents. Mol Imaging. 2005 Apr;4(2):98-103. Pubmedid: 16105507.
• Gillies RJ, Morse DL. In vivo magnetic resonance spectroscopy in cancer. Annu Rev Biomed Eng. 2005;7:287-326. Pubmedid: 16004573.
• Handl H, Vagner J, Han H, Mash E, Hruby V, Gillies R. Hitting multiple targets with multimeric ligands. Expert Opin Ther Targets. 2004 Dec;8(6):565-586. Pubmedid: 15584863.
• Baggett B, Roy R, Momen S, Morgan S, Tisi L, Morse D, Gillies RJ. Thermostability of firefly luciferases affects efficiency of detection by in vivo bioluminescence. Mol Imaging. 2004 Oct;3(4):324-332. Pubmedid: 15802049.
• Handl H, Vagner J, Yamamura H, Hruby V, Gillies R. Lanthanide-based time-resolved fluorescence of in cyto ligand-receptor interactions. Anal Biochem. 2004 Jul;330(2):242-250. Pubmedid: 15203329.
• Vagner J, Handl H, Gillies R, Hruby V. Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: homooligomers of alpha-MSH. Bioorg Med Chem Lett. 2004 Jan;14(1):211-215. Pubmedid: 14684330.
• Bascunan-Castillo E, Erickson R, Howison C, Hunter R, Heidenreich R, Hicks C, Trouard T, Gillies R. Tamoxifen and vitamin E treatments delay symptoms in the mouse model of Niemann-Pick C. J Appl Genet. 2004;45(4):461-467. Pubmedid: 15523158.
• Lukasik V, Gillies R. Animal anaesthesia for in vivo magnetic resonance. Nmr Biomed. 2003 Dec;16(8):459-467. Pubmedid: 14696002.
• Raghunand N, Mahoney B, Gillies R. Tumor acidity, ion trapping and chemotherapeutics: pH-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents. Biochem Pharmacol. 2003 Oct;66(7):1219-1229. Pubmedid: 14505801.
• Mahoney B, Raghunand N, Baggett B, Gillies R. Tumor acidity, ion trapping and chemotherapeutics: Acid pH affects the distribution of chemotherapeutic agents in vitro. Biochem Pharmacol. 2003 Oct;66(7):1207-1218. Pubmedid: 14505800.
• Guo J, Erickson R, Trouard T, Galons J, Gillies R. Magnetization transfer contrast imaging in Niemann pick type C mouse liver. J Magn Reson Imaging. 2003 Sep;18(3):321-327. Pubmedid: 12938127.
• Gillies R, Hruby V. Expression-driven reverse engineering of targeted imaging and therapeutic agents. Expert Opin Ther Targets. 2003 Apr;7(2):137-139. Pubmedid: 12667092.
• Gillies R. Noninvasive imaging of anticancer therapy. Mol Cancer Ther. 2003 Mar;2(3):333-334. Pubmedid: 12657728.
• Schornack PA, Gillies RJ. Contributions of cell metabolism and H+ diffusion to the acidic pH of tumors. Neoplasia. 2003 Mar;5(2):135-145. Pubmedid: 12659686.
• Raghunand N, Howison C, Sherry A, Zhang S, Gillies R. Renal and systemic pH imaging by contrast-enhanced MRI. Magn Reson Med. 2003 Feb;49(2):249-257. Pubmedid: 12541244.
• Raghunand N, Gatenby R, Gillies R. Microenvironmenalamd cellular consequences of altered blood flow in tumours. Br J Radiol. 2003;76:S11-S22. Pubmedid: 15456710.
• Gillies R, Raghunand N, Karczmar G, Bhujwalla Z. MRI of the tumor microenvironment. J Magn Reson Imaging. 2002 Oct;16(4):430-450. Pubmedid: 12353258.
• Raghunand N, Zhang S, Sherry A, Gillies R. In vivo magnetic resonance imaging of tissue pH using a novel pH-sensitive contrast agent, GdDOTA-4AmP. Acad Radiol. 2002 Aug;9:S481-S483. Pubmedid: 12188315.
• Jennings D, Hatton B, Guo J, Galons J, Trouard T, Raghunand N, Marshall J, Gillies R. Early response of prostate carcinoma xenografts to docetaxel chemotherapy monitored with diffusion MRI. Neoplasia. 2002 May;4(3):255-262. Pubmedid: 11988845.
• Bhujwalla Z, Artemov D, Ballesteros P, Cerdan S, Gillies R, Solaiyappan M. Combined vascular and extracellular pH imaging of solid tumors. Nmr Biomed. 2002 Apr;15(2):114-119. Pubmedid: 11870907.
• Gillies R. In vivo molecular imaging. J Cell Biochem Suppl. 2002;39:231-238. Pubmedid: 12552622.
• Raghunand N, Mahoney B, van Sluis R, Baggett B, Gillies R. Acute metabolic alkalosis enhances response of C3H mouse mammary tumors to the weak base mitoxantrone. Neoplasia. 2001 May;3(3):227-235. Pubmedid: 11494116.
• Gillies R. Causes and consequences of hypoxia and acidity in tumors--Novartis Foundation symposium. Trends Mol Med. 2001 Feb;7(2):47-49. Pubmedid: 11330256.
• Raghunand N, Gillies R. pH and chemotherapy. Novartis Found Symp. 2001;240:199-211. Pubmedid: 11727930.
• Gillies R. The tumour microenvironment: causes and consequences of hypoxia and acidity. Novartis Found Symp. 2001;240:1-6. Pubmedid: 11727923.
• Bhujwalla Z, Artemov D, Aboagye E, Ackerstaff E, Gillies R, Natarajan K, Solaiyappan M. The physiological environment in cancer vascularization, invasion and metastasis. Novartis Found Symp. 2001;240:23-45. Pubmedid: 11727932.
• Gillies R, Lynch R. Frontiers in the measurement of cell and tissue pH. Novartis Found Symp. 2001;240:7-22. Pubmedid: 11727938.
• Pilatus U, Ackerstaff E, Artemov D, Mori N, Gillies R, Bhujwalla Z. Imaging prostate cancer invasion with multi-nuclear magnetic resonance methods: the Metabolic Boyden Chamber. Neoplasia. 2000 May;2(3):273-279. Pubmedid: 10935513.
• Raghunand N, Gillies R. pH and drug resistance in tumors. Drug Resist Updat. 2000 Feb;3(1):39-47. Pubmedid: 11498364.
• Evelhoch JL, Gillies RJ, Karczmar GS, Koutcher JA, Maxwell RJ, Nalcioglu O, Raghunand N, Ronen SM, Ross BD, Swartz HM. Applications of magnetic resonance in model systems: cancer therapeutics. Neoplasia. 2000 Jan-Apr;2(1-2):152-165. Pubmedid: 10933074. Pmcid: PMC1531871.
• Gillies R, Bhujwalla Z, Evelhoch J, Garwood M, Neeman M, Robinson S, SotakCH, Van Der Sanden B. Applications of magnetic resonance in model systems: tumor biology and physiology. Neoplasia. 2000 Jan;2(1-2):139-151. Pubmedid: 10933073.
• Gillies R, Schornack P, Secomb T, Raghunand N. Causes and effects of heterogeneous perfusion in tumors. Neoplasia. 1999 Aug;1(3):197-207. Pubmedid: 10935474.
• Galons J, Altbach M, Paine-Murrieta G, Taylor C, Gillies R. Early increases in breast tumor xenograft water mobility in response to paclitaxel therapy detected by non-invasive diffusion magnetic resonance imaging. Neoplasia. 1999 Jun;1(2):113-117. Pubmedid: 10933044.
• Raghunand N, He X, van Sluis R, Mahoney B, Baggett B, Taylor C, Paine-Murrieta G, Roe D, Bhujwalla Z, Gillies R. Enhancement of chemotherapy by manipulation of tumour pH. Br J Cancer. 1999 Jun;80(7):1005-1011. Pubmedid: 10362108.
• Bhujwalla Z, Aboagye E, Gillies R, Chacko V, Mendola C, Backer J. Nm23-transfected MDA-MB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH: a 31P nuclear magnetic resonance study in vivo and in vitro. Magn Reson Med. 1999 May;41(5):897-903. Pubmedid: 10332871.
• Raghunand N, Martinez-Zaguilan R, Wright S, Gillies R. pH and drug resistance: Turnover of acidic vesicles and resistance to weakly basic chemotherapeutic drugs. Biochem Pharmacol. 1999 May;57(9):1047-1058. Pubmedid: 10796075.
• van Sluis R, Bhujwalla Z, Raghunand N, Ballesteros P, Alvarez J, Cerd?!n S, Galons J, Gillies R. In vivo imaging of extracellular pH using 1H MRSI. Magn Reson Med. 1999 Apr;41(4):743-750. Pubmedid: 10332850.
• Gillies R. Angiostatin's partners. Science. 1999 Apr;284(5413):434-434. Pubmedid: 10232986.
• Martinez-Zaguilan R, Tompkins L, Gillies R, Lynch R. Simultaneous analysis of intracellular pH and Ca2+ from cell populations. Methods Mol Biol. 1999;114:287-306. Pubmedid: 10081026.
• Bhujwalla ZM, McCoy CL, Glickson JD, Gillies RJ, Stubbs M. Estimations of intra- and extracellular volume and pH by 31P magnetic resonance spectroscopy: effect of therapy on RIF-1 tumours. Br J Cancer. 1998 Sep;78(5):606-611. Pubmedid: 9744499. Pmcid: PMC2063062.
• Bhujwalla Z, McCoy C, Glickson J, Gillies R, Stubbs M. Estimations of intra- and extracellular volume and pH by 31P magnetic resonance spectroscopy: effect of therapy on RIF-1 tumours. Br J Cancer. 1998 Sep;78(5):606-611. Pubmedid: 9744499 .
• Martínez-Zaguilán R, Martinez GM, Gomez A, Hendrix MJ, Gillies RJ. Distinct regulation of pHin and [Ca2+]in in human melanoma cells with different metastatic potential. J Cell Physiol. 1998 Jul;176(1):196-205. Pubmedid: 9618159.
• Martinez-Zaguilan R, Martinez G, Gomez A, Hendrix M, Gillies R. Distinct regulation of pHin and [Ca2+]in in human melanoma cells with different metastatic potential. J Cell Physiol. 1998 Jul;176(1):196-205. Pubmedid: 9618159 .
• Xie X, Gillies R, Gerner E. Characterization of a diamine exporter in Chinese hamster ovary cells and identification of specific polyamine substrates. J Biol Chem. 1997 Aug;272(33):20484-20489. Pubmedid: 9252359 .
• Aiken N, Gillies R. Phosphomonoester metabolism as a function of cell proliferative status and exogenous precursors. Anticancer Res. 1996 May;16(3B):1393-1397. Pubmedid: 8694507 .
• Martinez-Zaguilan R, Seftor E, Seftor R, Chu Y, Gillies R, Hendrix M. Acidic pH enhances the invasive behavior of human melanoma cells. Clin Exp Metastasis. 1996 Mar;14(2):176-186. Pubmedid: 8605731 .
• Lien Y, Wang X, Gillies R, Martinez-Zaguilan R. Modulation of intracellular Ca2+ by glucose in MDCK cells: role of endoplasmic reticulum Ca(2+)-ATPase. Am J Physiol. 1995 Apr;268(4 Pt 2):F671-F679. Pubmedid: 7733324 .
• Lien YH, Wang X, Gillies RJ, Martinez-Zaguilan R. Modulation of intracellular Ca2+ by glucose in MDCK cells: role of endoplasmic reticulum Ca(2+)-ATPase. Am J Physiol. 1995 Apr;268(4 Pt 2):F671-F679. Pubmedid: 7733324.
• Galons J, Job C, Gillies R. Increase of GPC levels in cultured mammalian cells during acidosis: A 31P MR spectroscopy study using a continuous bioreactor system. Magn Reson Med. 1995 Mar;33(3):422-426. Pubmedid: 7760711 .
• Martinez-Zaguilan R, Wegner J, Gillies R, Hoyer P. Differential regulation of Ca2+ homeostasis in ovine large and small luteal cells. Endocrinology. 1994 Nov;135(5):2099-2108. Pubmedid: 7956933 .
• Martínez-Zaguilán R, Wegner JA, Gillies RJ, Hoyer PB. Differential regulation of Ca2+ homeostasis in ovine large and small luteal cells. Endocrinology. 1994 Nov;135(5):2099-2108. Pubmedid: 7956933.
• Gunn J, Martinez-Zaguilan R, Wald-Hopkins S, Woolridge D, Gillies R. NIH3T3 cells transfected with the yeast H(+)-ATPase have altered rates of protein turnover. Arch Biochem Biophys. 1994 Nov;314(2):268-275. Pubmedid: 7979364 .
• Gunn JM, Martinez-Zaguilan R, Wald-Hopkins S, Woolridge D, Gillies RJ. NIH3T3 cells transfected with the yeast H(+)-ATPase have altered rates of protein turnover. Arch Biochem Biophys. 1994 Nov;314(2):268-275. Pubmedid: 7979364.
• Wysynski A, Martinez-Zaguilan R, Alden C, Gandolfi A, Gillies R. Phenobarbital induces cytosolic acidification in an established liver epithelial cell line. Toxicol Lett. 1994 Nov;74(2):157-166. Pubmedid: 7940597 .
• Martinez G, Martinez-Zaguilan R, Gillies R. Effect of glucose on pHin and [Ca2+]in in NIH-3T3 cells transfected with the yeast P-type H(+)-ATPase. J Cell Physiol. 1994 Oct;161(1):129-141. Pubmedid: 7929598 .
• Martínez GM, Martínez-Zaguilán R, Gillies RJ. Effect of glucose on pHin and [Ca2+]in in NIH-3T3 cells transfected with the yeast P-type H(+)-ATPase. J Cell Physiol. 1994 Oct;161(1):129-141. Pubmedid: 7929598.
• Gillies RJ, Barry JA, Ross BD. In vitro and in vivo 13C and 31P NMR analyses of phosphocholine metabolism in rat glioma cells. Magn Reson Med. 1994 Sep;32(3):310-318. Pubmedid: 7984063.
• Gillies R, Barry J, Ross B. In vitro and in vivo 13C and 31P NMR analyses of phosphocholine metabolism in rat glioma cells. Magn Reson Med. 1994 Sep;32(3):310-318. Pubmedid: 7984063 .
• Lax D, Martínez-Zaguilán R, Gillies RJ. Furazolidone increases thapsigargin-sensitive Ca(2+)-ATPase in chick cardiac myocytes. Am J Physiol. 1994 Aug;267(2 Pt 2):H734-H741. Pubmedid: 8067429.
• Lax D, Martinez-Zaguilan R, Gillies R. Furazolidone increases thapsigargin-sensitive Ca(2+)-ATPase in chick cardiac myocytes. Am J Physiol. 1994 Aug;267(2 Pt 2):H734-H741. Pubmedid: 8067429 .
• Gillies RJ, Liu Z, Bhujwalla Z. 31P-MRS measurements of extracellular pH of tumors using 3-aminopropylphosphonate. Am J Physiol. 1994 Jul;267(1 Pt 1):C195-C203. Pubmedid: 8048479.
• Gillies R, Liu Z, Bhujwalla Z. 31P-MRS measurements of extracellular pH of tumors using 3-aminopropylphosphonate. Am J Physiol. 1994 Jul;267(1 Pt 1):C195-C203. Pubmedid: 8048479 .
• Peterson E, Martinez G, Martinez-Zaguilan R, Perona R, Gillies R. NIH 3T3 cells transfected with a yeast H(+)-ATPase have altered sensitivity to insulin, insulin growth factor-I, and platelet-derived growth factor-AA. J Cell Physiol. 1994 Jun;159(3):551-560. Pubmedid: 8188769 .
• Sanchez-Armass S, Martinez-Zaguilan R, Mart?-nez G, Gillies R. Regulation of pH in rat brain synaptosomes: Role of sodium, bicarbonate, and potassium. J Neurophysiol. 1994 Jun;71(6):2236-2248. Pubmedid: 7931513 .
• Martinez-Zaguilan R, Gillies R, Sanchez-Armass S. Regulation of pH in rat brain synaptosomes: Role of Cl-. J Neurophysiol. 1994 Jun;71(6):2249-2257. Pubmedid: 7931514 .
• Peterson EP, Martinez GM, Martinez-Zaguilan R, Perona R, Gillies RJ. NIH 3T3 cells transfected with a yeast H(+)-ATPase have altered sensitivity to insulin, insulin growth factor-I, and platelet-derived growth factor-AA. J Cell Physiol. 1994 Jun;159(3):551-560. Pubmedid: 8188769.
• Wegner JA, Martinez-Zaguilan R, Gillies RJ, Hoyer PB. Prostaglandin F2 alpha releases calcium from a thapsigargin-sensitive pool in ovine large luteal cells. Am J Physiol. 1994 Jan;266(1 Pt 1):E50-E56. Pubmedid: 8304445.
• Wegner J, Martinez-Zaguilan R, Gillies R, Hoyer P. Prostaglandin F2 alpha releases calcium from a thapsigargin-sensitive pool in ovine large luteal cells. Am J Physiol. 1994 Jan;266(1 Pt 1):E50-E56. Pubmedid: 8304445 .
• Martinez-Zaguilan R, Lynch R, Martinez G, Gillies R. Vacuolar-type H(+)-ATPases are functionally expressed in plasma membranes of human tumor cells. Am J Physiol. 1993 Oct;265(4 Pt 1):C1015-C1029. Pubmedid: 8238296 .
• Barry J, McGovern K, Lien Y, Ashmore B, Gillies R. Dimethyl methylphosphonate (DMMP): a 31P nuclear magnetic resonance spectroscopic probe of intracellular volume in mammalian cell cultures. Biochemistry. 1993 May;32(17):4665-4670. Pubmedid: 8485143 .
• Barry JA, McGovern KA, Lien YH, Ashmore B, Gillies RJ. Dimethyl methylphosphonate (DMMP): a 31P nuclear magnetic resonance spectroscopic probe of intracellular volume in mammalian cell cultures. Biochemistry. 1993 May;32(17):4665-4670. Pubmedid: 8485143.
• Gillies R, Galons J, McGovern K, Scherer P, Lien Y, Job C, Ratcliff R, Chapa F, Cerdan S, Dale B. Design and application of NMR-compatible bioreactor circuits for extended perfusion of high-density mammalian cell cultures. Nmr Biomed. 1993 Jan;6(1):95-104. Pubmedid: 8457432 .
• Martinez-Zaguilan R, Gillies R. A plasma membrane V-type H(+)-ATPase may contribute to elevated intracellular pH(pHin) in some human tumor cells. Ann N Y Acad Sci. 1992 Nov;671:478-480. Pubmedid: 1288345 .
• Lien Y, Zhou H, Job C, Barry J, Gillies R. In vivo 31P NMR study of early cellular responses to hyperosmotic shock in cultured glioma cells. Biochimie. 1992 Sep;74(9-10):931-939. Pubmedid: 1467347 .
• Gillies R. Nuclear magnetic resonance and its applications to physiological problems. Annu Rev Physiol. 1992;54:733-748. Pubmedid: 1562189 .
• Gillies R, Scherer P, Raghunand N, Okerlund L, Martinez-Zaguilan R, Hesterberg L, Dale B. Iteration of hybridoma growth and productivity in hollow fiber bioreactors using 31P NMR. Magn Reson Med. 1991 Mar;18(1):181-192. Pubmedid: 2062229 .
• Wegner J, Martinez-Zaguilan R, Gillies R, Hoyer P. Prostaglandin F2 alpha-induced calcium transient in ovine large luteal cells: Modulation of the transient and resting cytosolic free calcium alters progesterone secretion. Endocrinology. 1991 Feb;128(2):929-936. Pubmedid: 1899223 .
• Martinez-Zaguilan R, Martinez G, Lattanzio F, Gillies R. Simultaneous measurement of intracellular pH and Ca2+ using the fluorescence of SNARF-1 and fura-2. Am J Physiol. 1991 Feb;260(2 Pt 1):C297-C307. Pubmedid: 1996613 .
• Wegner JA, Martinez-Zaguilan R, Gillies RJ, Hoyer PB. Prostaglandin F2 alpha-induced calcium transient in ovine large luteal cells: II. Modulation of the transient and resting cytosolic free calcium alters progesterone secretion. Endocrinology. 1991 Feb;128(2):929-936. Pubmedid: 1899223.
• Gillies R, Martinez-Zaguilan R. Regulation of intracellular pH in BALB/c 3T3 cells: Bicarbonate raises pH via NaHCO3/HCl exchange and attenuates the activation of Na+/H+ exchange by serum. J Biol Chem. 1991 Jan;266(3):1551-1556. Pubmedid: 1846359 .
• Wegner J, Martinez-Zaguilan R, Wise M, Gillies R, Hoyer P. Prostaglandin F2 alpha-induced calcium transient in ovine large luteal cells: Alterations in cytosolic-free calcium levels and calcium flux. Endocrinology. 1990 Dec;127(6):3029-3037. Pubmedid: 2249641 .
• Gillies R, Martinez-Zaguilan R, Martinez G, Serrano R, Perona R. Tumorigenic 3T3 cells maintain an alkaline intracellular pH under physiological conditions. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7414-7418. Pubmedid: 2170979 .
• Martinez R, Gillies R. Dimethylsulfoxide modifies the sensitivity of BALB/c-3T3 cells to the activation of Na+/H+ exchange by phorbol esters. J Cell Physiol. 1989 Apr;139(1):131-135. Pubmedid: 2540208 .
• Gillies R, Martinez R, Sneider J, Hoyer P. Sphingosine inhibits phorbol 12-myristate 13-acetate-, but not serum-induced, activation of Na+/H+ exchange in mammalian cells. J Cell Physiol. 1989 Apr;139(1):125-130. Pubmedid: 2540207 .
• Martinez R, Gillies R, Giuliano K. Effect of serum on the intracellular pH of BALB/c-3T3 cells: serum deprivation causes changes in sensitivity of cells to serum. J Cell Physiol. 1988 Jul;136(1):154-160. Pubmedid: 2840441 .
• Lucas C, Gillies R, Olson J, Giuliano K, Martinez R, Sneider J. Intracellular acidification inhibits the proliferative response in BALB/c-3T3 cells. J Cell Physiol. 1988 Jul;136(1):161-167. Pubmedid: 3397393 .
• Giuliano K, Gillies R. Determination of intracellular pH of BALB/c-3T3 cells using the fluorescence of pyranine. Anal Biochem. 1987 Dec;167(2):362-371. Pubmedid: 2831755 .
• DeFronzo M, Gillies R. Characterization of methylphosphonate as a 31P NMR pH indicator. J Biol Chem. 1987 Aug;262(23):11032-11037. Pubmedid: 3611105 .
• Gillies R, Cook J, Fox M, Giuliano K. Flow cytometric analysis of intracellular pH in 3T3 cells. Am J Physiol. 1987 Jul;253(1 Pt 1):C121-C125. Pubmedid: 3605325 .
• Nelson T, Gillies R, Powell D, Schrader M, Manchester D, Pretorius D. High resolution proton NMR spectroscopy of human amniotic fluid. Prenat Diagn. 1987 Jun;7(5):363-372. Pubmedid: 3615362 .
• Gillies R, Didier N, Denton M. Determination of cell number in monolayer cultures. Anal Biochem. 1986 Nov;159(1):109-113. Pubmedid: 3812988 .
• Gillies R, Benoit A. NMR analysis of a cell division cycle mutant of Saccharomyces cerevisiae. Biochim Biophys Acta. 1983 Jun;762(3):466-470. Pubmedid: 6303444 .
• Findly R, Gillies R, Shulman R. In vivo phosphorus-31 nuclear magnetic resonance reveals lowered ATP during heat shock of Tetrahymena. Science. 1983 Mar;219(4589):1223-1225. Pubmedid: 6828852 .
• Gillies R, Ogino T, Shulman R, Ward D. 31P nuclear magnetic resonance evidence for the regulation of intracellular pH by Ehrlich ascites tumor cells. J Cell Biol. 1982 Oct;95(1):24-28. Pubmedid: 7142288 .
• Alger J, Sillerud L, Behar K, Gillies R, Shulman R, Gordon R, Shae D, Hanley P. In vivo carbon-13 nuclear magnetic resonance studies of mammals. Science. 1981 Nov;214(4521):660-662. Pubmedid: 7292005 .
• Gillies R, Rosenberg M, Deamer D. Carbon dioxide efflux accompanies release of fertilization acid from sea urchin eggs. J Cell Physiol. 1981 Aug;108(2):115-122. Pubmedid: 6790553 .
• Gillies R, Ugurbil K, den Hollander J, Shulman R. 31P NMR studies of intracellular pH and phosphate metabolism during cell division cycle of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1981 Apr;78(4):2125-2129. Pubmedid: 7017724 .
• Gillies RJ, Ugurbil K, den Hollander JA, Shulman RG. 31P NMR studies of intracellular pH and phosphate metabolism during cell division cycle of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1981 Apr;78(4):2125-2129. Pubmedid: 7017724. Pmcid: PMC319296.
• Gillies R, Deamer D. Endogenously produced CO2 induces stationary phase in Tetrahymena cultures. J Cell Physiol. 1980 Nov;105(2):221-225. Pubmedid: 6780574 .
• Dale B, Gillies R. Nuclear magnetic resonance spectroscopy of dense cell populations for metabolic studies and bioreactor engineering: a synergistic partnership. Biotechnology. 1991 Win;17:107-118. Pubmedid: 2049536 .
• Martinez-Zaguilan R, Tompkins L, Gillies R, Lynch R. Simultaneous analysis of intracellular pH and Ca2+ from cell populations. Methods Mol Biol. 2006 312;312:269-287. Pubmedid: 16422205.
• Handl HL, Sankaranarayanan R, Josan JS, Vagner J, Mash EA, Gillies RJ, Hruby VJ. Synthesis and evaluation of bivalent NDP-alpha-MSH(7) peptide ligands for binding to the human melanocortin receptor 4 (hMC4R). Bioconjug Chem. 18(4):1101-1109. Pubmedid: 17591746. Pmcid: PMC3538036.
• Gillies R, Deamer D. Intracellular pH changes during the ce;; cycle in Tetrahymena. J Cell Physiol. 1979 Jul;100(1):23-31. Pubmedid: 38259.
• Gillies R, Alger J, den Hollander J, Shulman R. Intracellular pH measured by NMR: methods and results. Kroc Found Ser. 1981 Win;15:79-104. Pubmedid: 7042927 .
• Theilmann RJ, Borders R, Trouard TP, Xia G, Outwater E, Ranger-Moore J, Gillies RJ, Stopeck A. Changes in water mobility measured by diffusion MRI predict response of metastatic breast cancer to chemotherapy. Neoplasia. 6(6):831-837. Pubmedid: 15720810. Pmcid: PMC1531687.
• Gillies R. Intracellular pH and proliferation in yeast, Tetrahymena and sea urchin eggs. Kroc Found Ser. 1981 Win;15:341-359. Pubmedid: 7042923 .
• Noble E, Gillies R, Vigran R, Mandel P. The modification of the ethanol withdrawal syndrome in rats by di-n-propylacetate. Psychopharmacologia. 1976 Mar;46(2):127-131. Pubmedid: 781711.