Peter G. Medveczky, MD

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Peter G. Medveczky, MD

Office  (813) 974-2372

Education And Training
  • MD, Semmetlweis Medical School, 1970 - Infectious Diseases

The Kaposi's sarcoma-associated herpesvirus (KSHV) is implicated as a causative agent in skin malignancies and some lymphomas. Dr. Medveczky and his colleagues are studying KSHV and a related monkey tumor virus, Herpesvirus saimiri (HVS). KSHV and HVS share genes that are suspected to have roles in immortalization.

The first goal of Dr. Medveczky's current research is to identify essential genetic elements and genes of KSHV and HVS required for latent episomal replication of the viral genome in tumor cells. They identified a viral protein, latency-associated nuclear antigen (LANA), that is required for this process. LANA is a specific DNA-binding protein and interacts with the terminal repeats of the KSHV and HVS genomes. LANA and the repeats are essential and sufficient for maintenance of the viral genome in tumor cells.

The second focus of Dr. Medveczky's studies on HVS is a specific viral gene (TIP) that is essential for malignant transformation. TIP binds and activates a T cell-specific protein kinase, Lck. Activation of Lck leads to induction of STAT transcription factors and activation of downstream genes. Dr. Medvecsky and his colleagues showed that activation of STATs by Lck occurs in the absence of Jak kinases. This area of investigation is important because STATs are induced in human lymphomas and in many other cancers. Therefore, the HVS model provides a unique opportunity to study the roles of Lck and STATs in oncogenic transformation. This system also could be used as an animal model to evaluate drugs designed against Lck and STATs.

Third, Dr. Medveczky's laboratory described that THC, the active compound in marijuana blocks reactivation and replication of oncogenic herpesviruses. Experiments are under way to thest the hypothesis that endogenous cannabinoids may regulate viral latency and reactivation.

  • Ablashi D, Agut H, Alvarez-Lafuente R, Clark DA, Dewhurst S, Diluca D, Flamand L, Frenkel N, Gallo R, Gompels UA, Höllsberg P, Jacobson S, Luppi M, Lusso P, Malnati M, Medveczky P, Mori Y, Pellett PE, Pritchett JC, Yamanishi K, Yoshikawa T. Classification of HHV-6A and HHV-6B as distinct viruses. Arch Virol. 2014 May;159(5):863-870. Pubmedid: 24193951.
  • Pantry SN, Medveczky MM, Arbuckle JH, Luka J, Montoya JG, Hu J, Renne R, Peterson D, Pritchett JC, Ablashi DV, Medveczky PG. Persistent human herpesvirus-6 infection in patients with an inherited form of the virus. J Med Virol. 2013 Nov;85(11):1940-1946. Pubmedid: 23893753. Pmcid: PMC3779660.
  • Arbuckle JH, Pantry SN, Medveczky MM, Prichett J, Loomis KS, Ablashi D, Medveczky PG. Mapping the telomere integrated genome of human herpesvirus 6A and 6B. Virology. 2013 Jul;442(1):3-11. Pubmedid: 23648233. Pmcid: PMC3696530.
  • Cheema A, Katta J, Velez AP, Medveczky M, Medveczky P, Quilitz R, Blue BJ, Vincent AL, Sandin RL, Greene JN. Encephalitis and inherited HHV-6: encephalitis case report. Infect Dis Clin Prac. 2012 Nov;20(6):419-421.
  • Montoya JG, Neely MN, Gupta S, Lunn MR, Loomis KS, Pritchett JC, Polsky B, Medveczky PG. Antiviral therapy of two patients with chromosomally-integrated human herpesvirus-6A presenting with cognitive dysfunction. J Clin Virol. 2012 Sep;55(1):40-45. Pubmedid: 22770640.
  • Pellett PE, Ablashi DV, Ambros PF, Agut H, Caserta MT, Descamps V, Flamand L, Gautheret-Dejean A, Hall CB, Kamble RT, Kuehl U, Lassner D, Lautenschlager I, Loomis KS, Luppi M, Lusso P, Medveczky PG, Montoya JG, Mori Y, Ogata M, Pritchett JC, Rogez S, Seto E, Ward KN, Yoshikawa T, Razonable RR. Chromosomally integrated human herpesvirus 6: questions and answers. Rev Med Virol. 2012 May;22(3):144-155. Pubmedid: 22052666. Pmcid: PMC3498727.
  • Arbuckle JH, Medveczky PG. The molecular biology of human herpesvirus-6 latency and telomere integration. Microbes Infect. 2011 Aug;13(8-9):731-741. Pubmedid: 21458587. Pmcid: PMC3130849.
  • Flamand L, Komaroff AL, Arbuckle JH, Medveczky PG, Ablashi DV. Review, part 1: Human herpesvirus-6-basic biology, diagnostic testing, and antiviral efficacy. J Med Virol. 2010 Sep;82(9):1560-1568. Pubmedid: 20648610.
  • Arbuckle JH, Medveczky MM, Luka J, Hadley SH, Luegmayr A, Ablashi D, Lund TC, Tolar J, De Meirleir K, Montoya JG, Komaroff AL, Ambros PF, Medveczky PG. The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro. Proc Natl Acad Sci U S A. 2010 Mar;107(12):5563-5568. Pubmedid: 20212114. Pmcid: PMC2851814.
  • Bedoya F, Medveczky MM, Lund TC, Perl A, Horvath J, Jett SD, Medveczky PG. Identification of mitochondrial genome concatemers in AIDS-associated lymphomas and lymphoid cell lines. Leuk Res. 2009 Sep;33(11):1499-1504. Pubmedid: 19362738. Pmcid: PMC2730422.
  • Pantry SN, Medveczky PG. Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus replication. Semin Cancer Biol. 2009 Jun;19(3):153-157. Pubmedid: 19429478. Pmcid: PMC2753186.
  • Medveczky P, Szmola R, Sahin-Tóth M. Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregation. Biochem J. 2009 Jun;420(2):335-343. Pubmedid: 19254208. Pmcid: PMC2750038.
  • Bedoya F, Medveczky PG. Formation of Mitochondrial Genome Concatemers as an Alternative Mechanism Promoting Oncogenic Transformation of Lymphoid Cells. Biosci Hypotheses. 2009 Jan;2(5):310-312. Pubmedid: 20046889.
  • Gombos L, Kardos J, Patthy A, Medveczky P, Szilágyi L, Málnási-Csizmadia A, Gráf L. Probing conformational plasticity of the activation domain of trypsin: the role of glycine hinges. Biochemistry-Us. 2008 Feb;47(6):1675-1684. Pubmedid: 18193894.
  • Focher F, Lossani A, Verri A, Spadari S, Maioli A, Gambino JJ, Wright GE, Eberle R, Black DH, Medveczky P, Medveczky M, Shugar D. Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides. Antimicrob Agents Chemother. 2007 Jun;51(6):2028-2034. Pubmedid: 17438061. Pmcid: PMC1891389.
  • Medveczky P, Antal J, Patthy A, Kékesi K, Juhász G, Szilágyi L, Gráf L. Myelin basic protein, an autoantigen in multiple sclerosis, is selectively processed by human trypsin 4. FEBS Lett. 2006 Jan;580(2):545-552. Pubmedid: 16412431.
  • Medveczky MM, Sherwood TA, Klein TW, Friedman H, Medveczky PG. Delta-9 tetrahydrocannabinol (THC) inhibits lytic replication of gamma oncogenic herpesviruses in vitro. BMC Med. 2004 Sep;2:34. Pubmedid: 15369590. Pmcid: PMC521080.
  • Fejer G, Medveczky M, Horvath E, Lane B, Chang Y, Medveczky P. The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts preferentially with the terminal repeats of the genome in vivo and this complex is sufficient for episomal DNA replication. J Gen Virol. 2003 Jun;84(Pt 6):1451-1462. Pubmedid: 12771414.
  • Kjellen P, Amdjadi K, Lund TC, Medveczky PG, Sefton BM. The herpesvirus saimiri tip484 and tip488 proteins both stimulate lck tyrosine protein kinase activity in vivo and in vitro. Virology. 2002 Jun;297(2):281-288. Pubmedid: 12083826.
  • Collins C, Medveczky P. Genetic requirements for the episomal maintenance of oncogenic herpes virus genomes. Adv Cancer Res. 2002;84:155-174. Pubmedid: 11883526.
  • Collins C, Medveczky M, Lund T, Medveczky P. The terminal repeats and the latency associated nuclear antigen of herpesvirus saimiri are essential for episomal persistence of the viral genome. J Gen Virol. 2002;83(Pt9):2269-2278. Pubmedid: 12185282.
  • Zhang Y, Turkson J, Carter-Su C, Smithgall T, Levitzki A, Kraker A, Krolewski J, Medveczky P, Jove R. Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity. J Biol Chem. 2000;275(32):24935-24944. Pubmedid: 10823829.
  • Hartley D, Amdjadi K, Lund T, Medveczky P, Sefton B. Activation of the Lck tyrosine protein kinase by the Herpesvirus saimiri tip protein involves two binding interactions. Virology. 2000;276(2):339-348. Pubmedid: 11040125.
  • Lund T, Coleman C, Horvath E, Sefton B, Jove R, Medveczky M, Medveczky P. The Src-family kinase Lck can induce STAT3 phosphorylation and DNA binding activity. Cell Signal. 1999 Nov;11(11):789-796. Pubmedid: 10617281.
  • Lund TC, Prator PC, Medveczky MM, Medveczky PG. The Lck binding domain of herpesvirus saimiri tip-484 constitutively activates Lck and STAT3 in T cells. J Virol. 1999 Feb;73(2):1689-1694. Pubmedid: 9882381. Pmcid: PMC104000.
  • Lund T, Medveczky M, Medveczky P. Interferon-alpha induction of STATs1, -3 DNA binding and growth arrest is independent of Lck and active mitogen-activated kinase in T cells. Cell Immunol. 1999;192(2):133-139. Pubmedid: 10087181.
  • Hartley D, Hurley T, Hardwick J, Lund T, Medveczky P, Sefton B. Activation of the Lck tyrosine-protein kinase by the binding of the Tip protein of herpesvirus saimiri does not require tyrosine phosphorlylation of the Lck protein. J Biol Chem. 1999;274(29):20056-20059. Pubmedid: 10400611.
  • Muralidhar S, Pumfery A, Hassani M, Sadaie M, Kishishita M, Brady J, Doniger J, Medveczky P, Rosenthal L. Identification of kaposin (open reading frame K12) as a human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) transforming gene. J Virol. 1998;72(6):4980-4988. Pubmedid: 9573267.
  • Lund T, Garcia R, Medveczky M, Jove R, Medveczky P. Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56lck. J Virol. 1997 Sep;71(9):6677-6682. Pubmedid: 9261390. Pmcid: PMC191946.
  • Medveczky MM, Horvath E, Lund T, Medveczky PG. In vitro antiviral drug sensitivity of the Kaposi's sarcoma-associated herpesvirus. Aids. 1997 Sep;11(11):1327-1332. Pubmedid: 9302441.
  • Lund T, Medveczky M, Medveczky P. Herpesvirus saimiri Tip-484 membrane protein markedly increases p56lck activity in T cells. J Virol. 1997 Jan;71(1):378-382. Pubmedid: 8985360. Pmcid: PMC191061.
  • Nagy K, Horvath K, Medveczky M, Szabo Z, Toth A, Szende B, Yangco B, Medveczky P. Human herpesvirus 8 DNA is present in visceral kaposi's sarcoma of AIDS and other immunocompromised individuals in Hungary. Cancer Control. 1997;4:522-556. Pubmedid: 10763005.
  • Kung S, Medveczky P. Identification of a herpesvirus Saimiri cis-acting DNA fragment that permits stable replication of episomes in transformed T cells. J Virol. 1996 Mar;70(3):1738-1744. Pubmedid: 8627695. Pmcid: PMC189998.
  • Lund T, Medveczky MM, Neame PJ, Medveczky PG. A herpesvirus saimiri membrane protein required for interleukin-2 independence forms a stable complex with p56lck. J Virol. 1996 Jan;70(1):600-606. Pubmedid: 8523578. Pmcid: PMC189852.
  • Kung S, Medveczky P. Identification of a Herpesvirus saimiri cis-acting DNA fragment that permits stable replication of episomes in transformed T cells. J Virol. 1996;70:1738-1744.
  • Williams L, Moscinski LC, Medveczky PG. Immunoglobulin germline mu transcripts in acute myelogenous leukemia cells vary in splicing pattern and are heterogeneous. Leukemia. 1995 Dec;9(12):2016-2022. Pubmedid: 8609711.
  • Lund T, Medveczky M, Geck P, Medveczky P. A herpesvirus saimiri protein required for interleukin-2 independence is associated with membranes of transformed T cells. J Virol. 1995 Jul;69(7):4495-4499. Pubmedid: 7769710. Pmcid: PMC189192.
  • Chou C, Medveczky M, Geck P, Vercelli D, Medveczky P. Expression of IL-2 and IL-4 in T lymphocytes transformed by herpesvirus saimiri. Virology. 1995 Apr;208(2):418-426. Pubmedid: 7747414.
  • Medveczky M, Yang T, Gambino J, Medveczky P, Wright G. Haloanilino derivatives of pyrimidines, purines, and purine nucleoside analogs: synthesis and activity against human cytomegalovirus. J Med Chem. 1995;38(10):1811-1819. Pubmedid: 7752205.
  • Crute J, Lehman I, Gambino T, Yang P, Medveczky P, Medveczky M, Khan N, Mulder C, Monroe J, Wright G. Inhibition of herpes simplex virus type I helicase-primase by dichloroanilino purines and pyrimidines. J Med Chem. 1995;38:1820-1825. Pubmedid: 7752206.
  • Chou C, Geck P, Medveczky M, Hernandez O, Medveczky P. Induction of a herpesvirus saimiri small RNA AU binding factor (AUBF70) activity and lymphokine mRNAs by T cell mitogens. Arch Virol. 1995;140(3):415-435. Pubmedid: 7733817.
  • Whitaker S, Geck P, Medveczky M, Cus J, Kung S, Lund T, Medveczky P. A polycistronic transcript in transformed cells encodes the dihydrogolate reductase of herpesvirus saimiri. Virus Genes. 1995;10:163-172. Pubmedid: 8560776.
  • Geck P, Whitaker SA, Medveczky MM, Last TJ, Medveczky PG. Small RNA expression from the oncogenic region of a highly oncogenic strain of herpesvirus saimiri. Virus Genes. 1994 Jan;8(1):25-34. Pubmedid: 8209420.
  • Geck P, Whitaker S, Medveczky M, Last T, Medveczky P. Small RNA expression from the oncogenic region of a highly oncogenic strain of Herpesvirus saimiri. Virus Genes. 1994;8(1):25-34.
  • Geck P, Medveczky M, Chou C, Brown A, Cus J, Medveczky P. Herpesvirus saimiri small RNA and interleukin-4 mRNA AUUUA repeats compete for sequence-specific factors including a novel 70K protein. J Gen Virol. 1994;75:2293-2301.
  • Medveczky M, Geck P, Medveczky P. Expression of the collagen-like putative oncoprotein of Herpesvirus Saimiri in transformed T cells. Virus Genes. 1993;7:349-365.
  • Medveczky P. Western blotting and polymerase chain reaction (PCR) for the diagnosis of HIV infection. J Fla Med Assoc. 1992;79:47-50.
  • Medveczky MM, Geck P, Clarke C, Byrnes J, Sullivan JL, Medveczky PG. Arrangement of repetitive sequences in the genome of herpesvirus Sylvilagus. J Virol. 1989 Feb;63(2):1010-1014. Pubmedid: 2911114. Pmcid: PMC247786.
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