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Mark L. McLaughlin, PhD

Where You Are:
Mark L. McLaughlin, PhD

Senior Member

Office  (813) 974-0014

Education And Training
  • Postdoctoral Fellow, Ohio State University, 1986 - Synthetic Organic Chemistry
  • Postdoctoral Fellow, Rice University, 1985 - Physical Organic Chemistry
  • PhD, Georgia Institute of Technology, 1983 - Organic Chemistry
  • BS, Christian Brothers College, Memphis TN, 1979


The McLaughlin group focuses on the de novo design and synthesis of molecules designed to inhibit alpha-helix-like and beta-sheet-like protein-protein interactions.  Our lab has used several different repetitive scaffolds to structurally mimic the i, i + 4, and i + 7 side chains of an alpha-helix to develop more drug-like protein-protein interaction inhibitors.

  • Gebhard AW, Jain P, Nair RR, Emmons MF, Argilagos RF, Koomen JM, McLaughlin ML, Hazlehurst LA. MTI-101 (Cyclized HYD1) Binds a CD44 Containing Complex and Induces Necrotic Cell Death in Multiple Myeloma. Mol Cancer Ther. 2013 Nov;12(11):2446-2458. Pubmedid: 24048737.
  • Drake BL, Morris JL, McLaughlin ML, Fronczek FR, Watkins SF. Tetra-methyl anthracene-2,3,6,7-tetra-carboxyl-ate-tetra-methyl 9,10-dihydro-9,10-dioxoanthracene-2,3,6,7-tetra-carboxyl-ate (1/1). Acta Crystallogr Sect E Struct Rep Online. 2012 Aug;68(Pt 8):o2540-o2541. Pubmedid: 22904973. Pmcid: PMC3414986.
  • McLaughlin M, Belyk KM, Qian G, Reamer RA, Chen CY. Synthesis of α-Hydroxyacetophenones. J Org Chem. 2012 Jun;77(11):5144-5148. Pubmedid: 22568765.
  • Emmons MF, Gebhard AW, Nair RR, Baz R, McLaughlin ML, Cress AE, Hazlehurst LA. Acquisition of resistance toward HYD1 correlates with a reduction in cleaved α4 integrin expression and a compromised CAM-DR phenotype. Mol Cancer Ther. 2012 May;10(12):2257-2266. Pubmedid: 21980133. Pmcid: PMC3237739.
  • Zhong YL, Gauthier DR, Shi YJ, McLaughlin M, Chung JY, Dagneau P, Marcune B, Krska SW, Ball RG, Reamer RA, Yasuda N. Synthesis of antifungal glucan synthase inhibitors from enfumafungin. J Org Chem. 2012 Apr;77(7):3297-3310. Pubmedid: 22423625.
  • Cutler CS, Chanda N, Shukla R, Sisay N, Cantorias M, Zambre A, McLaughlin M, Kelsey J, Upenandran A, Robertson D, Deutscher S, Kannan R, Katti K. Nanoparticles and phage display selected peptides for imaging and therapy of cancer. Recent Results Cancer Res. 2012;194:133-147. Pubmedid: 22918758.
  • Phelan WA, Ngu-Schwemlein M, Fronczek FR, McLaughlin ML, Watkins SF. 1,2-Dihydro-9H-carbazole-4(3H)-thione. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr;67(Pt 4):o757. Pubmedid: 21754054. Pmcid: PMC3099987.
  • Anderson L, Zhou M, Sharma V, McLaughlin JM, Santiago DN, Fronczek FR, Guida WC, McLaughlin ML. Facile iterative synthesis of 2,5-terpyrimidinylenes as nonpeptidic alpha-helical mimics. J Org Chem. 2010 Jun;75(12):4288-4291. Pubmedid: 20469918. Pmcid: PMC2901110.
  • Sharma V, McLaughlin ML. Efficient assembly of 2,5,6-substituted pyrimidines via MgI(2)-mediated Morita-Baylis-Hillman reaction. J Comb Chem. 2010 May;12(3):327-331. Pubmedid: 20218627. Pmcid: PMC2919067.
  • Fronczek CF, Kil H, McLaughlin ML, Fronczek FR. (S)-(Z)-Methyl 2-[2,3-bis-(benzyl-oxy-carbon-yl)guanidino]-4-methyl-penta-no-ate. Acta Crystallogr Sect E Struct Rep Online. 2010;67(Pt 1):o27-o28. Pubmedid: 21522740. Pmcid: PMC3050400.
  • Lawrence HR, Li Z, Yip ML, Sung SS, Lawrence NJ, McLaughlin ML, McManus GJ, Zaworotko MJ, Sebti SM, Chen J, Guida WC. Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking. Bioorg Med Chem Lett. 2009 Oct;19(14):3756-3759. Pubmedid: 19457663. Pmcid: PMC2754843.
  • Kazi A, Lawrence H, Guida WC, McLaughlin ML, Springett GM, Berndt N, Yip RM, Sebti SM. Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells. Cell Cycle. 2009 Aug;8(12):1940-1951. Pubmedid: 19471122. Pmcid: PMC2892826.
  • Xu Y, McLaughlin M, Chen CY, Reamer RA, Dormer PG, Davies IW. A general method for the synthesis of 3,5-diarylcyclopentenones via friedel-crafts acylation of vinyl chlorides. J Org Chem. 2009 Jul;74(14):5100-5103. Pubmedid: 19485346.
  • Anderson L, Topper M, Jain P, McIntosh E, McLaughlin ML. Synthesis of N-Boc protected hydrazine diacids as key structural units for the formation of alpha-helix mimics. Adv Exp Med Biol. 2009;611:211-212. Pubmedid: 19400164.
  • Yi SW, Jain P, Ajmera M, Kaulagari SR, Topper M, Anderson L, McLaughlin ML. Cysteine based PNA (CPNA): design and synthesis of novel CPNA monomers. Adv Exp Med Biol. 2009;611:553-554. Pubmedid: 19400310.
  • Mokdad A, Belof J, Yi S, Shuler S, McLaughlin M, Space B, Larsen R. Photophysical studies of the trans to cis isomerization of the push-pull molecule: 1-(pyridin-4-yl)-2-(N-methylpyrrol-2-yl)ethene (mepepy). J Phys Chem A. 2008 Sep;112(36):8310-8315. Pubmedid: 18700732.
  • Talele TT, McLaughlin ML. Molecular docking/dynamics studies of Aurora A kinase inhibitors. J Mol Graph Model. 2008 Jun;26(8):1213-1222. Pubmedid: 18096419.
  • Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, Yip ML, Jove R, McLaughlin MM, Lawrence NJ, Sebti SM, Turkson J. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci U S A. 2007 May;104(18):7391-7396. Pubmedid: 17463090. Pmcid: PMC1863497.
  • Weiss S, McIntyre N, McLaughlin M, Merkler D. The development of molecular clamps as drugs. Drug Discov Today. 2006 Aug;11(17-18):819-824. Pubmedid: 16935750.
  • McLaughlin M, Palucki M, Davies IW. Efficient access to cyclic ureas via Pd-catalyzed cyclization. Org Lett. 2006 Jul;8(15):3311-3314. Pubmedid: 16836393.
  • McLaughlin M. Suzuki-Miyaura cross-coupling of benzylic phosphates with arylboronic acids. Org Lett. 2005 Oct;7(22):4875-4878. Pubmedid: 16235911.
  • Gennaccaro A, McLaughlin M, Quintero-Betancourt W, Huffman D, Rose J. Infectious Cryptosporidium parvum oocysts in final reclaimed effluent. Appl Environ Microbiol. 2003;69(8):4983-4984. Pubmedid: 12902296.
  • Liu B, Thalji RK, Adams PD, Fronczek FR, McLaughlin ML, Barkley MD. Fluorescence of cis-1-amino-2-(3-indolyl)cyclohexane-1-carboxylic acid: a single tryptophan chi(1) rotamer model. J Am Chem Soc. 2002 Nov;124(44):13329-13338. Pubmedid: 12405862.
  • Adams P, Chen Y, Ma K, Zagorski M, Sonnichsen F, McLaughlin M, BarkleyMD. Intramolecular quenching of tryptophan fluorescence by the peptide bond in cyclic hexapeptides. J Am Chem Soc. 2002 Aug;124(31):9278-9286. Pubmedid: 12149035.
  • McLaughlin M, Hale R, Ellston D, Gaudet S, Lue R, Viel A. The distribution and function of alternatively spliced insertions in hDlg. J Biol Chem. 2002;277:6406-6412. Pubmedid: 11723125.
  • Hellberg M, McLaughlin M, Sharif N, DeSantis L, Dean T, Kyba E, Bishop J, Klimko P, Zinke P, Selliah R, Barnes G, DeFaller J, Kothe A, Landry T, SullivanE, Andrew R, Davis A, Silver L, Bergamini M, Robertson S, Weiner A, Sallee V. Identification and Characterization of the Ocular Hypotensive Efficacy ofTravoprost, a Potent and Selective FP Prostaglandin Receptor Agonist, andAL-6598, a DP Prostaglandin Receptor Agonist. Surv Ophthalmol. 2002;47 Suppl 1:S13-S13. Pubmedid: 12204698.
  • Sun T, Van Hoek A, Huang Y, Bouley R, McLaughlin M, Brown D. Aquaporin-2 localization in clathrin-coated pits: inhibition of endocytosis bydominant-negative dynamin. Am J Physiol Renal Physiol. 2002;282:F998-1011. Pubmedid: 11997316.
  • McLaughlin M, Hunter D, Thomson C, Yool D, Kirkham D, Freer A, Griffiths I. Evidence for possible interactions between PLP and DM20 within the myelinsheath. Glia. 2002;39:31-36. Pubmedid: 12112373.
  • Zhu Y, Xu G, Patel A, McLaughlin M, Silverman C, Knecht K, Sweitzer S, LiX, McDonnell P, Mirabile R, Zimmerman D, Boyce R, Tierney L, Hu E, Livi G, WolfB, Abdel-Meguid S, Rose G, Aurora R, Hensley P, Briggs M, Young P. Cloning, Expression, and Initial Characterization of a Novel Cytokine-like GeneFamily. Genomics. 2002;80:144-144. Pubmedid: 12160727.
  • Chun T, Justement J, Pandya P, Hallahan C, McLaughlin M, Liu S, EhlerLA, Kovacs C, Fauci A. Relationship between the size of the human immunodeficiency virus type 1 (HIV-1)reservoir in peripheral blood CD4+ T cells and CD4+:CD8+ T cell ratios inaviremic HIV-1-infected individuals receiving long-term highly activeantiretroviral therapy. J Infect Dis. 2002;185:1672-1676. Pubmedid: 12023777.
  • Yool D, Montague P, McLaughlin M, McCulloch M, Edgar J, Nave K, DaviesRW, Griffiths I, McCallion A. Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform. Glia. 2002;39:256-267. Pubmedid: 12203392.
  • Yokum T, Hammer R, McLaughlin M, Elzer P. Peptides with indirect in vivo activity against an intracellular pathogen: selective lysis of infected macrophages. J Pept Res. 2002;59(1):9-17. Pubmedid: 11906603.
  • Yuan H, Takeuchi E, Taylor G, McLaughlin M, Brown D, Salant D. Nephrin dissociates from actin, and its expression is reduced in earlyexperimental membranous nephropathy. J Am Soc Nephrol. 2002;13:946-956. Pubmedid: 11912254.
  • Sodha M, McLaughlin M, Williams G, Dhillon S. Nurses' confidence and pharmacological knowledge: a study. Br J Community Nurs. 2002;7:309-315. Pubmedid: 12066065.
  • Fu Y, Hammarström LG, Miller TJ, Fronczek FR, McLaughlin ML, Hammer RP. Sterically hindered C(alpha, alpha)-disubstituted alpha-amino acids: synthesis from alpha-nitroacetate and incorporation into peptides. J Org Chem. 2001 Oct;66(21):7118-7124. Pubmedid: 11597239.
  • Williamson S, McLaughlin M, Paul J. Interaction of the PhiHSIC virus with its host: lysogeny or pseudolysogeny. Appl Environ Microbiol. 2001;67(4):1682-1688. Pubmedid: 11282621.
  • McDaniel L, Griffin D, Crespo-Gomez J, McLaughlin M, Paul J. Evaluation of marine bacterial lysogens for development of a marine prophage induction assay. Mar Biotechnol (Ny). 2001;3:528-535. Pubmedid: 14961325.
  • Hammarström LG, Zhang T, Giraldés J, McLaughlin ML, Billodeaux DR, Fronczek FR. Two N-ortho-nitrobenzenesulfonyl alpha,alpha-disubstituted amino acid adducts. Acta Crystallogr C. 2000 Dec;56(Pt 12):1484-1486. Pubmedid: 11118999.
  • Javadpour MM, Juban MM, Lo WC, Bishop SM, Alberty JB, Cowell SM, Becker CL, McLaughlin ML. De novo antimicrobial peptides with low mammalian cell toxicity. J Med Chem. 1996 Aug;39(16):3107-3113. Pubmedid: 8759631.
  • McLaughlin ML, McBride DE, Perrone RD. Secondary hyperaldosteronism stimulates acidification in rat distal colon. Pflugers Arch. 1990 Aug;416(6):639-645. Pubmedid: 2174145.
  • Perrone RD, McLaughlin ML. Cyst function in polycystic kidney disease: nongradient cysts. Clin Nephrol. 1989 Sep;32(3):113-118. Pubmedid: 2791361.
  • Diamond JR, McLaughlin ML. Urinary parameters to assess renal function. Clin Lab Med. 1988 Sep;8(3):493-505. Pubmedid: 3048855.
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