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Julie Yin Djeu, PhD

Where You Are:
Julie Yin Djeu, PhD

Senior Member

"Natural killer (NK) cells are key players in innate immunity and are responsible for early defense against intracellular bacteria, viruses, and tumors."

Office  (813) 745-3041

Education And Training
  • Fellow, FDA/Center for Biologics, Res., & Evaluation, 1980 - Division of Virology
  • PhD, George Washington University, 1973 - Microbiology
  • BA, Columbia University, 1967 - Biology


Natural killer (NK) cells are key players in innate immunity and are responsible for early defense against intracellular bacteria, viruses, and tumors. They function by recognition and lysis of infected cells or abnormal cells that have undergone transformation. Recognition involves at least three families of receptors unrelated to the T-cell receptor, NKG2, KIR, and NCR, which recognize classic MHC Class I molecules or stress response MHC I proteins, such as MICA/MICB, as well as microbial antigens. How lysis takes place upon receptor/ligand recognition is still unresolved, however.

All NK antigen receptors defined thus far have no intrinsic kinase activity and require linkage with adaptor proteins, such as DAP10 and DAP12, to trigger signal cascades that drive the lytic process. Recently, the researchers of Dr. Djeu's laboratory identified a specific Syk-PI3K-Rac-PAK-MEK-ERK signal cascade triggered by target ligation in human NK cells that mobilizes lytic granules to the site of contact of target cells. The membrane-proximal signals that lead to this pathway are now being investigated. The hypothesis is that both DAP 10 and DAP12 are linked to this pathway, and that DAP 10 enters via its PI3K binding site and DAP12 via its ITAM association with Syk. How these two adaptors become phosphorylated to create binding sites for PI3K and Syk is unknown, however. On the basis of data suggesting that separate Src kinases, such as Fyn, Lck, and Lyn, may be involved, the researchers are attempting to define the mechanism of these Src kinases in the early events of signal transduction leading to PI3K or Syk activation that triggers lysis in NK cells. Furthermore, they are defining the NK receptors that are responsible for the constitutive activation of lytic function in the NK cells of patients with large granular lymphocyte leukemia.

Another key mechanism by which NK cells bridge innate immunity to adaptive immunity is by production of cytokines. The researchers in our laboratory are in the process of defining whether certain NK receptors are associated with release of T helper 1-type cytokines while others might preferentially induce T helper 2-type cytokines from NK cells.

  • Donatelli SS, Zhou JM, Gilvary DL, Eksioglu EA, Chen X, Cress WD, Haura EB, Schabath MB, Coppola D, Wei S, Djeu JY. TGF-β-inducible microRNA-183 silences tumor-associated natural killer cells. Proc Natl Acad Sci U S A. 2014 Mar;111(11):4203-4208. Pubmedid: 24586048. Pmcid: PMC3964044.
  • Kong W, He L, Richards EJ, Challa S, Xu CX, Permuth-Wey J, Lancaster JM, Coppola D, Sellers TA, Djeu JY, Cheng JQ. Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer. Oncogene. 2014 Feb;33(6):679-689. Pubmedid: 23353819. Pmcid: PMC3925335.
  • Chen X, Eksioglu EA, Zhou J, Zhang L, Djeu J, Fortenbery N, Epling-Burnette P, Van Bijnen S, Dolstra H, Cannon J, Youn JI, Donatelli SS, Qin D, De Witte T, Tao J, Wang H, Cheng P, Gabrilovich DI, List A, Wei S. Induction of myelodysplasia by myeloid-derived suppressor cells. J Clin Invest. 2013 Nov;123(11):4595-4611. Pubmedid: 24216507. Pmcid: PMC3809779.
  • Groer MW, El-Badri N, Djeu J, Williams SN, Kane B, Szekeres K. Suppression of Natural Killer Cell Cytotoxicity in Postpartum Women: Time Course and Potential Mechanisms. Biol Res Nurs. 2013 Aug. Pubmedid: 23956351.
  • Henderson-Jackson EB, Nasir A, Chen DT, Nandyala P, Djeu J, Strosberg J, Kvols L, Coppola D. Cytoplasmic Clusterin Expression Correlates With Pancreatic Neuroendocrine Tumor Size and Pathological Stage. Pancreas. 2013 Aug;42(6):967-970. Pubmedid: 23770713.
  • Wei S, Chen X, McGraw K, Zhang L, Komrokji R, Clark J, Caceres G, Billingsley D, Sokol L, Lancet J, Fortenbery N, Zhou J, Eksioglu EA, Sallman D, Wang H, Epling-Burnette PK, Djeu J, Sekeres M, Maciejewski JP, List A. Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic syndrome with chromosome 5q deletion. Oncogene. 2013 Feb;32(9):1110-1120. Pubmedid: 22525275. Pmcid: PMC3751397.
  • Kumar NB, Dhurandhar M, Aggarwal B, Anant S, Daniel K, Deng G, Djeu J, Dou J, Hawk E, Jayaram B, Jia L, Joshi R, Kararala M, Karunagaran D, Kucuk O, Kumar L, Malafa M, Samathanam GJ, Sarkar F, Siddiqi M, Singh RP, Srivastava A, White JD. Proceedings of the Indo-U.S. bilateral workshop on accelerating botanicals/biologics agent development research for cancer chemoprevention, treatment, and survival. Cancer Med. 2013 Feb;2(1):108-115. Pubmedid: 24279005.
  • Lengacher CA, Kip KE, Post-White J, Fitzgerald S, Newton C, Barta M, Jacobsen PB, Shelton MM, Moscoso M, Johnson-Mallard V, Harris E, Loftus L, Cox C, Le N, Goodman M, Djeu J, Widen RH, Bercu BB, Klein TW. Lymphocyte Recovery After Breast Cancer Treatment and Mindfulness-Based Stress Reduction (MBSR) Therapy. Biol Res Nurs. 2013 Jan;15(1):37-47. Pubmedid: 22084404.
  • Bai F, Villagra AV, Zou J, Painter JS, Connolly K, Blaskovich MA, Sokol L, Sebti S, Djeu JY, Loughran TP, Wei S, Sotomayor E, Epling-Burnette P. Tipifarnib-mediated suppression of T-bet-dependent signaling pathways. Cancer Immunol Immunother. 2012 Apr;61(4):523-533. Pubmedid: 21983879.
  • Djeu J, Wei S. Chemoimmunomodulation of MDSCs as a novel strategy for cancer therapy. Oncoimmunology. 2012 Jan;1(1):121-122. Pubmedid: 22720231. Pmcid: PMC3376962.
  • Zhou J, Eksioglu EA, Fortenbery NR, Chen X, Wang H, Epling-Burnette PK, Djeu JY, Wei S. Bone marrow mononuclear cells up-regulate toll-like receptor expression and produce inflammatory mediators in response to cigarette smoke extract. PLoS One. 2011 Dec;6(6):e21173. Pubmedid: 21738617. Pmcid: PMC3126797.
  • Zhou J, Wu J, Chen X, Fortenbery N, Eksioglu E, Kodumudi KN, Epling-Burnette PK, Dong J, Djeu JY, Wei S. Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions. Int Immunopharmacol. 2011 Jul;11(7):890-898. Pubmedid: 21244860. Pmcid: PMC3109231.
  • Smith MA, Maurin M, Cho HI, Becknell B, Freud AG, Yu J, Wei S, Djeu J, Celis E, Caligiuri MA, Wright KL. PRDM1/Blimp-1 controls effector cytokine production in human NK cells. J Immunol. 2010 Nov;185(10):6058-6067. Pubmedid: 20944005. Pmcid: PMC3864810.
  • Kodumudi KN, Woan K, Gilvary DL, Sahakian E, Wei S, Djeu JY. A novel chemoimmunomodulating property of docetaxel: suppression of myeloid-derived suppressor cells in tumor bearers. Clin Cancer Res. 2010 Sep;16(18):4583-4594. Pubmedid: 20702612. Pmcid: PMC3874864.
  • Zhong B, Sallman DA, Gilvary DL, Pernazza D, Sahakian E, Fritz D, Cheng JQ, Trougakos I, Wei S, Djeu JY. Induction of clusterin by AKT--role in cytoprotection against docetaxel in prostate tumor cells. Mol Cancer Ther. 2010 Jun;9(6):1831-1841. Pubmedid: 20501799. Pmcid: PMC3874868.
  • Groer M, El-Badri N, Djeu J, Harrington M, Van Eepoel J. Suppression of natural killer cell cytotoxicity in postpartum women. Am J Reprod Immunol. 2010 Mar;63(3):209-213. Pubmedid: 20055786. Pmcid: PMC2861128.
  • Wei S, Chen X, Rocha K, Epling-Burnette PK, Djeu JY, Liu Q, Byrd J, Sokol L, Lawrence N, Pireddu R, Dewald G, Williams A, Maciejewski J, List A. A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide. Proc Natl Acad Sci U S A. 2009 Aug;106(31):12974-12979. Pubmedid: 19470455. Pmcid: PMC2722346.
  • Chen X, Bai F, Sokol L, Zhou J, Ren A, Painter JS, Liu J, Sallman DA, Chen YA, Yoder JA, Djeu JY, Loughran TP, Epling-Burnette PK, Wei S. A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia. Blood. 2009 Apr;113(14):3226-3234. Pubmedid: 19075187. Pmcid: PMC2665892.
  • Mohapatra S, Chu B, Zhao X, Djeu J, Cheng JQ, Pledger WJ. Apoptosis of metastatic prostate cancer cells by a combination of cyclin-dependent kinase and AKT inhibitors. Int J Biochem Cell Biol. 2009 Mar;41(3):595-602. Pubmedid: 18708158.
  • Trougakos IP, Djeu JY, Gonos ES, Boothman DA. Advances and challenges in basic and translational research on clusterin. Cancer Res. 2009 Jan;69(2):403-406. Pubmedid: 19147550. Pmcid: PMC2848483.
  • Djeu JY, Wei S. Clusterin and chemoresistance. Adv Cancer Res. 2009;105:77-92. Pubmedid: 19879424. Pmcid: PMC3889866.
  • Epling-Burnette PK, Sokol L, Chen X, Bai F, Zhou J, Blaskovich MA, Zou J, Painter JS, Edwards TD, Moscinski L, Yoder JA, Djeu JY, Sebti S, Loughran TP, Wei S. Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling. Blood. 2008 Dec;112(12):4694-4698. Pubmedid: 18791165. Pmcid: PMC2597136.
  • Sellers TA, Vierkant RA, Djeu J, Celis E, Wang AH, Kumar N, Cerhan JR. Unpasteurized milk consumption and subsequent risk of cancer. Cancer Causes Control. 2008 Oct;19(8):805-811. Pubmedid: 18344007. Pmcid: PMC2575230.
  • Coppola D, Oliveri C, Sayegh Z, Boulware D, Takahashi Y, Pow-Sang J, Djeu JY, Wang HG. Bax-interacting factor-1 expression in prostate cancer. Clin Genitourin Cancer. 2008 Sep;6(2):117-121. Pubmedid: 18824435. Pmcid: PMC2626142.
  • Lengacher C, Bennett M, Gonzalez L, Gilvary D, Cox C, Cantor A, Jacobsen PB, Yang C, Djeu J. Immune responses to guided imagery during breast cancer treatment. Biol Res Nurs. 2008 Jan;9(3):205-214. Pubmedid: 18077773.
  • Liang Y, Liu C, Djeu JY, Zhong B, Peters T, Scharffetter-Kochanek K, Anasetti C, Yu XZ. Beta2 integrins separates graft-versus-host disease and graft-versus-leukemia effects. Blood. 2008 Jan;111(2):954-962. Pubmedid: 17928532.
  • Wei S, Zhou JM, Chen X, Shah RN, Liu J, Orcutt TM, Traver D, Djeu JY, Litman GW, Yoder JA. The zebrafish activating immune receptor Nitr9 signals via Dap12. Immunogenetics. 2007 Dec;59(10):813-821. Pubmedid: 17891481. Pmcid: PMC3709248.
  • Sallman DA, Chen X, Zhong B, Gilvary DL, Zhou J, Wei S, Djeu JY. Clusterin mediates TRAIL resistance in prostate tumor cells. Mol Cancer Ther. 2007 Nov;6(11):2938-2947. Pubmedid: 18025278.
  • Burnette PK, Bai F, Painter JS, Rollison DE, Salih HR, Krusch M, ZouJ, Ku E, Zhong B, Boulware D, Moscinski L, Wei S, Djeu JY, List AF. Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors. Blood. 2007 Jun;109(11):4816-4824. Pubmedid: 17341666.
  • Herber DL, Nagaraj S, Djeu JY, Gabrilovich DI. Mechanism and therapeutic reversal of immune suppression in cancer. Cancer Res. 2007 Jun;67(11):5067-5069. Pubmedid: 17545581. Pmcid: PMC1976287.
  • Patterson S, Wei S, Chen X, Sallman D, Gilvary D, Zhong B, Pow-Sang J, Yeatman T, Djeu J. Novel role of Stat1 in the development of docetaxel resistance in prostate tumor cells. Oncogene. 2006 Nov;25(45):6113-6122. Pubmedid: 16652143.
  • Pilon-Thomas S, Li W, Briggs J, Djeu J, Mule J, Riker A. Immunostimulatory Effects of CpG-ODN Upon Dendritic Cell-Based Immunotherapy in a Murine Melanoma Model. J Immunother. 2006 Jul;29(4):381-387. Pubmedid: 16799333.
  • Panagos P, Dobrinski K, Chen X, Grant A, Traver D, Djeu J, Wei S, Yoder JA. Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish. Immunogenetics. 2006 Feb;58(1):31-40. Pubmedid: 16467987.
  • Burdelya L, Kujawski M, Niu G, Zhong B, Wang T, Zhang S, Kortylewski M, Shain K, Kay H, Djeu J, Dalton W, Pardoll D, Wei S, Yu H. Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects. J Immunol. 2005 Apr;174(7):3925-3931. Pubmedid: 15778348. Pmcid: PMC2632804.
  • Shurin G, Tourkova I, Chatta G, Schmidt G, Wei S, Djeu J, Shurin M. Small rho GTPases regulate antigen presentation in dendritic cells. J Immunol. 2005 Mar;174(6):3394-3400. Pubmedid: 15749872.
  • Guo F, Sigua C, Bali P, George P, Fiskus W, Scuto A, Annavarapu S, Mouttaki A, Sondarva G, Wei S, Wu J, Djeu J, Bhalla K. Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells. Blood. 2005 Feb;105(3):1246-1255. Pubmedid: 15388581.
  • Yoder JA, Litman RT, Mueller MG, Desai S, Dobrinski KP, Montgomery JS, Buzzeo MP, Ota T, Amemiya CT, Trede NS, Wei S, Djeu JY, Humphray S, Jekosch K, Hernandez Prada JA, Ostrov DA, Litman GW. Resolution of the novel immune-type receptor gene cluster in zebrafish. Proc Natl Acad Sci U S A. 2004 Dec;101(44):15706-15711. Pubmedid: 15496470. Pmcid: PMC524843.
  • Epling-Burnette PK, Bai F, Wei S, Painter JS, Olashaw N, Hamilton A, Sebti S, Djeu JY, Loughran TP. ERK couples chronic survival of NK cells to constitutively activated Ras in lymphoproliferative disease of granular lymphocytes (LDGL). Oncogene. 2004 Dec;23(57):9220-9229. Pubmedid: 15516985.
  • Jiang K, Sun J, Cheng J, Djeu JY, Wei S, Sebti S. Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis. Mol Cell Biol. 2004 Jun;24(12):5565-5576. Pubmedid: 15169915. Pmcid: PMC419878.
  • Epling-Burnette P, Painter J, Bai F, Wei S, Djeu J, LoughranTP. Dysregulated NK receptor expression in patients with lymphoproliferative disease of granular lymphocytes. Blood. 2004;103(9):3431-3439. Pubmedid: 14726391.
  • Mohapatra S, Chu B, Wei S, Djeu J, Epling-Burnette PK, Loughran T, Jove R, Pledger WJ. Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2. Cancer Res. 2003 Dec;63(23):8523-8530. Pubmedid: 14679020.
  • Jiang K, Zhong B, Ritchey C, Gilvary DL, Hong-Geller E, Wei S, Djeu JY. Regulation of Akt-dependent cell survival by Syk and Rac. Blood. 2003 Jan;101(1):236-244. Pubmedid: 12393431.
  • Huang M, Dorsey JF, Epling-Burnette PK, Nimmanapalli R, Landowski TH, Mora LB, Niu G, Sinibaldi D, Bai F, Kraker A, Yu H, Moscinski L, Wei S, Djeu J, Dalton WS, Bhalla K, Loughran TP, Wu J, Jove R. Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells. Oncogene. 2002 Dec;21(57):8804-8816. Pubmedid: 12483533.
  • Jiang K, Zhong B, Gilvary DL, Corliss BC, Vivier E, Hong-Geller E, Wei S, Djeu JY. Syk regulation of phosphoinositide 3-kinase-dependent NK cell function. J Immunol. 2002 Apr;168(7):3155-3164. Pubmedid: 11907067.
  • Cunnick JM, Meng S, Ren Y, Desponts C, Wang HG, Djeu JY, Wu J. Regulation of the mitogen-activated protein kinase signaling pathway by SHP2. J Biol Chem. 2002 Mar;277(11):9498-9504. Pubmedid: 11779868.
  • Djeu J, Jiang K, Wei S. A view to a kill: signals triggering cytotoxicity. Clin Cancer Res. 2002;8(3):636-640. Pubmedid: 11895890.
  • Liu J, Wei S, Lamy T, Yongxiang L, Epling-Burnette P, Djeu J, Loughran T. Blockade of Fas-dependent apoptosis by soluble Fas in LGL leukemia. Blood. 2002;100(4):1449-1453. Pubmedid: 12149230.
  • Yoder JA, Mueller MG, Wei S, Corliss BC, Prather DM, Willis T, Litman RT, Djeu JY, Litman GW. Immune-type receptor genes in zebrafish share genetic and functional properties with genes encoded by the mammalian leukocyte receptor cluster. Proc Natl Acad Sci U S A. 2001 Jun;98(12):6771-6776. Pubmedid: 11381126. Pmcid: PMC34428.
  • Epling-Burnette PK, Zhong B, Bai F, Jiang K, Bailey RD, Garcia R, Jove R, Djeu JY, Loughran TP, Wei S. Cooperative regulation of Mcl-1 by Janus kinase/stat and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed apoptosis in human neutrophils. J Immunol. 2001 Jun;166(12):7486-7495. Pubmedid: 11390502.
  • Monson N, Fenske T, Wei S, Okragly A, de Jong J, Haak-Frendscho M, O'Shea J, Djeu J, Sondel P. A p74 common gamma receptor chain isoform facilitates IL-2 and IL-15 responses by the myelomonocytic cell line Tf-1beta2. J Leukoc Biol. 2001;69(3):419-419. Pubmedid: 11261789.
  • Jiang K, Zhong B, Gilvary D, Corliss B, Hong-Geller E, Wei S, Djeu J. Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. Nat Immunol. 2000 Nov;1(5):419-425. Pubmedid: 11062502.
  • Wei S, Liu JH, Epling-Burnette PK, Jiang K, Zhong B, Elkabani ME, Pearson EW, Djeu JY. IL-2 induces the association of IL-2Rbeta, lyn, and MAP kinase ERK-1 in human neutrophils. Immunobiology. 2000 Nov;202(4):363-382. Pubmedid: 11131153.
  • Wei S, Gilvary D, Corliss B, Sebti S, Sun J, Straus D, Leibson P, Trapain J, Hamilton A, Weber M, Djeu J. Direct tumor lysis by NK cells uses a Ras-independent mitogen-activated protein kinase signal pathway. J Immunol. 2000 Oct;165(7):3811-3819. Pubmedid: 11034387.
  • Liu J, Wei S, Lamy T, Loughran, Jr. T, Epling-Burnette P, Starkebaum G, Djeu J. Chronic neutropenia mediated by fas ligand. Blood. 2000;95(10):3219-3222. Pubmedid: 10807792.
  • Zhang H, Wei S, Sun J, Coppola D, Zhong B, Wu G, Goodwin B, Sebti S, Djeu JY, Blanck G. Retinoblastoma protein activation of interleukin 8 expression inhibits tumor cell survival in nude mice. Cell Growth Differ. 2000;11(12):635-639. Pubmedid: 11149598.
  • Turkson J, Bowman T, Adnane J, Zhang Y, Djeu JY, Sekharam M, Frank DA, Holzman LB, Wu J, Sebti S, Jove R. Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein. Mol Cell Biol. 1999 Nov;19(11):7519-7528. Pubmedid: 10523640. Pmcid: PMC84756.
  • Zhang H, Shephard AT, Eason DD, Wei S, Diaz JI, Djeu JY, Wu GD, Blanck G. Retinoblastoma protein expression leads to reduced Oct-1 DNA binding activity and enhances interleukin-8 expression. Cell Growth Differ. 1999 Jul;10(7):457-465. Pubmedid: 10437913.
  • Liu J, Wei S, Burnette P, Gamero A, Ussery D, Djeu J. Functional association of TGF-beta receptor II with cyclin B. Oncogene. 1999;18(1):269-275. Pubmedid: 9926943.
  • Wei S, Gamero A, Liu J, Daulton A, Valkov N, Trapani J, Larner A, Weber M, Djeu J. Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: identification of perforin and granzyme B mobilization by functional ERK2. J Exp Med. 1998 Jun;187(11):1753-1765. Pubmedid: 9607917. Pmcid: PMC2212310.
  • Lengacher C, Bennett M, Gonzalez L, Cox C, Reintgen D, Cantor A, Djeu J. Review of literature: Psychoneuroimmunology, immune system link: stress, depression, health behaviors and breast cancer. Alternative Health Pract. 1998;4:95-107. Pubmedid: noPMID.
  • DeCesare S, Gamero A, Becker J, Barton D, Bomalaski J, Fiorica J, Arango H, Hoffman M, Djeu J. Identification of the inhibitory p40 subunit of interleukin 12 from the ascites fluid of patients with advanced carcinoma of the ovary. Int J Gynecol Cancer. 1998;8:133-137. Pubmedid: noPMID.
  • Sweeney J, Rosemary A, Wei S, Djeu J. Intact autocrine activation and cytokine production by PMNs from injured adults with elevated Candida antigen titres. Injury. 1998;29:35-35. Pubmedid: 9659479.
  • Lengacher C, Bennett M, Gonzalez L, Cox C, Reintgen D, Cantor A, Djeu J. Psychoneuroimmunology, immune system link, stress, depression,health behaviors and breast cancer. Alternative Health Care. 1998;4(2):95-108. Pubmedid: noPMID.
  • Pericle F, Burnette P, Podack E, Wei S, Djeu J. CD4-CD40L interactions provide "third-party" costimulation for T cell response against B7-1 transfected human breast tumor cells. J Leukoc Biol. 1997;61:201-208. Pubmedid: 9021926.
  • Rosemurgy, II A, Zervos J, Sweeney J, Djeu J. Candida antigen titre dilution and death after injury. Br J Su. 1997;84:771-771. Pubmedid: 9189082.
  • Wei S, Liu JH, Epling-Burnette PK, Gamero AM, Ussery D, Pearson EW, Elkabani ME, Diaz JI, Djeu JY. Critical role of Lyn kinase in inhibition of neutrophil apoptosis by granulocyte-macrophage colony-stimulating factor. J Immunol. 1996 Dec;157(11):5155-5162. Pubmedid: 8943427.
  • Sweeney JF, Greene JN, Hiemenz JW, Wei S, Rosemurgy AS, Djeu J. Identification of an amphotericin B resistant strain of Candida albicans using a rapid 3H-glucose incorporation microassay. J Infect. 1996 Nov;33(3):221-226. Pubmedid: 8945714 .
  • Sweeney JF, Greene JN, Hiemenz JW, Wei S, Rosemurgy AS, Djeu JY. Identification of an amphotericin B resistant strain of Candida albicans using a rapid 3H-glucose incorporation microassay. J Infection. 1996 Nov;33(3):221-226. Pubmedid: 8945714.
  • Pericle F, Kirken R, Epling-Burnette P, Blanchard D, Djeu J. Direct killing of interleukin-2 transfected tumor cells by human neutrophils. Int J Cancer. 1996;66:367-373. Pubmedid: 8621259.
  • Tan J, Newton C, Djeu J, Gutsch D, Chang A, Yang N, Klein T, Yu H. Injection of complementary DNA encoding interleukin-12 inhibits tumor establishment at a distant site in a murine renal carcinoma model. Cancer Res. 1996;56:3399-3403. Pubmedid: 8758901.
  • Yeatman T, Duan C, Mao W, Karl R, Djeu J. Augmentation of carcinoembryonic antigen release from intact, viable tumor cells by a factor in human serum. Ann Surg Oncol. 1995 Jul;2(4):336-342. Pubmedid: 7552624.
  • Blanchard D, Wei S, Duan C, Pericle F, Diaz J, Djeu J. Role of extracellular adenosine triphosphate in the cytotoxic T-lymphocyte-mediated lysis of antigen presenting cells. Blood. 1995 Jun;85(11):3173-3182. Pubmedid: 7538819.
  • Blanchard D, Hoffman S, Djeu J. Inhibition of extracellular ATP-mediated lysis of human macrophages by calmodulin antagonists. J Cell Biochem. 1995 Mar;57(3):452-464. Pubmedid: 7768980.
  • Epling-Burnette P, Wei S, Liu J, Pericle F, Ussery D, Russell S, Leonard W, Djeu J. Expression of interleukin-2 receptor gamma on human monocytes: characterization of lineage-specific post-translational modifications. Eur J Immunol. 1995;25:291-294. Pubmedid: 7843245.
  • Garin EH, West L, Blanchard K, Matsushima K, Djeu JY. Effect of lymphokines on 35sulfate uptake by the glomerular basement membrane. Nephron. 1995;71(4):442-447. Pubmedid: 8587625.
  • Gamero A, Ussery D, Reintgen D, Djeu J. Interleukin 15 induction of lymphokine activated killer cell function against autologous tumor cells in melanoma patient lymphoctyes by a CD18 dependent, perforin-related mechanism. Cancer Res. 1995;55:4988-4994. Pubmedid: 7585540.
  • DeCesare S, Michelini-Norris B, Blanchard D, Barton D, Cavanagh D, Roberts W, Fiorica J, Hoffman M, Djeu J. Interleukin-12-mediated tumoricidal activity of patient lymphocytes in an autologous in vitro ovarian cancer assay system. Gynecol Oncol. 1995;57:86-95. Pubmedid: 7705706.
  • Michelini-Norris M, Blanchard D, Diaz J, Barton D, Roberts W, Djeu J. An alternative medium supplement for the culturing and growth of human peritoneal mesothelial cells. In Vitro Cell Dev Biol. 1995;31:487-491. Pubmedid: 8528494.
  • Wei S, Liu JH, Blanchard DK, Djeu JY. Induction of IL-8 gene expression in human polymorphonuclear neutrophils by recombinant IL-2. J Immunol. 1994 Apr;152(7):3630-3636. Pubmedid: 8144938.
  • Kusher DI, Dawson LO, Taylor AC, Djeu JY. Effect of the psychoactive metabolite of marijuana, delta 9-tetrahydrocannabinol (THC), on the synthesis of tumor necrosis factor by human large granular lymphocytes. Cell Immunol. 1994 Mar;154(1):99-108. Pubmedid: 8118892.
  • Sweeney JF, Rosemurgy AS, Wei S, Djeu JY. Elevated Candida antigen titers are associated with neutrophil dysfunction after injury. Clin Diagn Lab Immunol. 1994 Jan;1(1):111-114. Pubmedid: 7496911. Pmcid: PMC368206.
  • Sweeney J, Rosemurgy II A, Wei S, Djeu J. Candida antigen titer is a marker of neutrophil dysfunction after severe injury. J Trauma. 1994;36:797-797.
  • Rossi A, Pericle F, Rashleigh S, Janiec J, Djeu J. Lysis of neuroblastoma cell lines by human natural killer cells activated by IL-2 and IL-12. Blood. 1994;5:1323-1323.
  • Pericle F, Liu J, Diaz J, Blanchard D, Wei S, Forni G, Djeu J. Interleukin-2 prevention of apoptosis in human neutrophils. Eur J Immunol. 1994;24:440-440.
  • Yeatman T, Mao W, Karl R, Djeu J. Phospholiase C-gamma is present on the surface of human colerectal cancer cells. Biochem Biophys Res Commun. 1994;201(2):1043-1049.
  • Sweeney J, Rosemurgy II A, Wei S, Djeu J. Elevated Candida antigen titers are associated with neutrophil dysfunction after injury. Clin Diagn Lab Immunol. 1994;1:111-111.
  • Djeu J, Wei S, Blanchard D. Regulation of monocytes by IL-2-activated killer cells. Immunol Ser. 1994;61:75-75.
  • Barton D, Blanchard D, Wells A, Nicosia S, Roberts W, Cavanagh D, Djeu J. Expression of IL-2 receptor alpha mRNA and protein in advanced epithelial ovarian cancer. Anticancer Res. 1994;14:761-761.
  • Liu J, Wei S, Blanchard D, Djeu J. Restoration of lytic function in a human natural killer cell line by gene transfection. Cell Immunol. 1994;156:24-24.
  • Sweeney J, Rosemurgy II A, Wei S, Djeu J. Monocytes overcome lymphocyte dysfunction in injured adults with elevated Candida antigen titers. J Trauma. 1994;37:944-949.
  • Wei S, Liu J, Blanchard D, Djeu J. Induction of IL-8 gene expression in human polymorphonuclear neutrophils by recombinant IL-2. J Immunol. 1994;152:3630-3630.
  • Liu J, Wei S, Ussery D, Epling-Burnette P, Leonard W, Djeu J. Expression of IL-2R-gamma chain in human neutrophils. Blood. 1994;84:3870-3870.
  • Kusher D, Dawson L, Taylor A, Djeu J. Effect of the psychoactive metabolite of marijuana, THC, on the synthesis of tumor necrosis factor by human large granular lymphocytes. Cell Immunol. 1994;154:99-99.
  • Yeatman T, Mao W, Karl R, Djeu J. Phospholipase C-gamma is present on the surface of human colorectal cancer cells. Biochem Biophys Res Commun. 1994;201(2):1043-1049.
  • Spranzi E, Djeu JY, Hoffman SL, Epling-Burnette PK, Blanchard DK. Lysis of human monocytic leukemia cells by extracellular adenosine triphosphate: mechanism and characterization of the adenosine triphosphate receptor. Blood. 1993 Sep;82(5):1578-1585. Pubmedid: 8364207.
  • Wei S, Blanchard DK, Liu JH, Leonard WJ, Djeu JY. Activation of tumor necrosis factor-alpha production from human neutrophils by IL-2 via IL-2-R beta. J Immunol. 1993 Mar;150(5):1979-1987. Pubmedid: 8436829.
  • Djeu JY, Liu JH, Wei S, Rui H, Pearson CA, Leonard WJ, Blanchard DK. Function associated with IL-2 receptor-beta on human neutrophils. Mechanism of activation of antifungal activity against Candida albicans by IL-2. J Immunol. 1993 Feb;150(3):960-970. Pubmedid: 8380826.
  • Barton D, Blanchard D, Michelini-Norris B, Nicosia S, Cavanagh D, Djeu J. High serum and ascitic soluble IL2 receptor alpha levels in advanced epithelial ovarian cancer. Blood. 1993;81:424-424.
  • Spranzi E, Djeu J, Hoffman S, Epling-Burnett P, Blanchard D. Lysis of human monocytic leukemia cells by extracellular adenosine triphosphate: mechanism and characterization of the adenosine triphosphate receptor. Blood. 1993;82:1578-1578.
  • Burnette P, Wei S, Blanchard D, Spranzi E, Djeu J. Co-induction of GM-CSF release and LAK susceptibility in monocytes by IL-2 via Il-2R(beta). Blood. 1993;81:3130-3130.
  • Rosemurgy II A, Sweeney J, Albrink M, Wei S, Djeu J. Implication of Candida antigens titers in injured adults. Contemp Surg. 1993;42:327-332.
  • Barton D, Blanchard D, Michelini Norris B, Roberts W, Hoffman M, Fiorica J, Nicosia S, Cavanagh D, Djeu J. Serum soluble interleukin-2 receptor alpha levels in patients with gynecologic cancers: early effect of surgery. Am J Reprod Immunol. 1993;30:202-206.
  • Sweeney J, Rosemurgy II A, Wei S, Djeu J. Lymphocytes dysfunction in injured adults with elevated Candida antigen titers. Surgery. 1993;114:698-698.
  • Wei S, Blanchard D, Liu J, Leonard W, Djeu J. Activation of tumor necrosis factor-(alpha) production from human neutrophils by IL-2 via Il-2R(beta)1. J Immunol. 1993;150(5):1979-1987.
  • Epling-Burnett P, Wei S, Blanchard D, Spranzi E, Djeu J. Coinduction of granulocyte-macrophage colony stimulating factor release and lymphokine-activated killer cell susceptibility in monocytes by interleukin-2 via interleukin-2 receptor-beta. Blood. 1993;81:3130-3130.
  • Sweeney J, Rosemurgy II A, Sheng W, Djeu J. Impaired polymorphonuclear anticandidal function in injured adults with elevated Candida antigen titers. Arch Surg. 1993;128:40-46.
  • Djeu J, Liu J, Wei S, Rui H, Pearson C, Leonard W, Blanchard D. Function associated with IL-2 receptor (beta) on human neutrophils: mechanism of activation of antifungal activity against candida albicans by IL-2. J Immunol. 1993;150:960-960.
  • Palma C, Cassone A, Serbousek D, Pearson CA, Djeu JY. Lactoferrin release and interleukin-1, interleukin-6, and tumor necrosis factor production by human polymorphonuclear cells stimulated by various lipopolysaccharides: relationship to growth inhibition of Candida albicans. Infect Immun. 1992 Nov;60(11):4604-4611. Pubmedid: 1398974. Pmcid: PMC258209.
  • Palma C, Serbousek D, Torosantucci A, Cassone A, Djeu JY. Identification of a mannoprotein fraction from Candida albicans that enhances human polymorphonuclear leukocyte (PMNL) functions and stimulates lactoferrin in PMNL inhibition of candidal growth. J Infect Dis. 1992 Nov;166(5):1103-1112. Pubmedid: 1402022.
  • Rui H, Djeu JY, Evans GA, Kelly PA, Farrar WL. Prolactin receptor triggering. Evidence for rapid tyrosine kinase activation. J Biol Chem. 1992 Nov;267(33):24076-24081. Pubmedid: 1385436.
  • Liu JH, Blanchard DK, Wei S, Djeu JY. Recombinant interleukin-8 induces changes in cytosolic Ca2+ in human neutrophils. J Infect Dis. 1992 Nov;166(5):1089-1096. Pubmedid: 1402020.
  • Wei S, Blanchard DK, McMillen S, Djeu JY. Lymphokine-activated killer cell regulation of T-cell-mediated immunity to Candida albicans. Infect Immun. 1992 Sep;60(9):3586-3595. Pubmedid: 1500166. Pmcid: PMC257365.
  • Blanchard DK, McMillen S, Hoffman SL, Djeu JY. Mycobacterial induction of activated killer cells: possible role of tyrosine kinase activity in interleukin-2 receptor alpha expression. Infect Immun. 1992 Jul;60(7):2843-2849. Pubmedid: 1612749. Pmcid: PMC257243.
  • Liu J, Blanchard D, McMillen S, Hoffman S, Djeu J. Recombinant interleukin-8 induces cytosolic Ca(2+) change in human neutrophils. J Infect Dis. 1992;166:1089-1089.
  • Palma C, Cassone A, Serbousek D, Pearson C, Djeu J. Identification of a mannoprotein fraction from Candida albicans enhancing human PMNL functions and involvement in PMNL inhibition of Candida growth. J Infect Dis. 1992;166:1103-1103.
  • Blanchard D, McMillen S, Hoffman S, Djeu J. Mycobacterial induction of activated killer cells: possible role of tyrosine kinase activity in interleukin-2 receptor alpha expression. Infect Immun. 1992;60:2843-2843.
  • Michelini-Norris, Blanchard D, Pearson C, Djeu J. Differential release of interluekin 1 (IL)-1 alpha and beta and IL-6 from normal human monocytes stimulated with a virulent and avirulent isogenic variant of Mycobacterium avium-intravellulare complex. J Infect Dis. 1992;165:702-702.
  • Rui H, Djeu J, Evans G, Kelly P, Farrar W. Prolactin receptor triggering: evidence for rapid tyrosine kinase activation. J Biol Chem. 1992;267:24076-24076.
  • Wei S, Blanchard D, McMillen S, Djeu J. LAK regulation of T cell immunity to Candida albicans. Infect Immun. 1992;60:3586-3586.
  • Palma C, Cassone A, Serbousek C, Pearson C, Djeu J. Lactoferrin release and IL1, IL6 and TNF production by human polymorphonuclear cells stimulated by arious lipopolysaccharides: relationship to growth inhibition of C albicans. Infect Immun. 1992;60:4604-4604.
  • Michelini-Norris M, Blanchard D, Friedman H, Djeu J. Involvement of HLA-DR+ large granular lymphocytes in the induction of tumor necrosis factor by Mycobacterium avium-intracellulare complex. J Leukoc Biol. 1992;50:529-538.
  • Blanchard DK, McMillen S, Djeu JY. IFN-gamma enhances sensitivity of human macrophages to extracellular ATP-mediated lysis. J Immunol. 1991 Oct;147(8):2579-2585. Pubmedid: 1918978.
  • Wang M, Richards AL, Friedman H, Djeu JY. Selective inhibition of natural killer but not natural cytotoxic activity in a cloned cell line by delta-9-tetrahydrocannabinol. J Leukoc Biol. 1991 Aug;50(2):192-197. Pubmedid: 1649242.
  • Blanchard DK, Michelini-Norris MB, Djeu JY. Interferon decreases the growth inhibition of Mycobacterium avium-intracellulare complex by fresh human monocytes but not by culture-derived macrophages. J Infect Dis. 1991 Jul;164(1):152-157. Pubmedid: 1905332.
  • Blanchard DK, Michelini-Norris MB, Pearson CA, McMillen S, Djeu JY. Production of granulocyte-macrophage colony-stimulating factor (GM-CSF) by monocytes and large granular lymphocytes stimulated with Mycobacterium avium-M. intracellulare: activation of bactericidal activity by GM-CSF. Infect Immun. 1991 Jul;59(7):2396-2402. Pubmedid: 2050405. Pmcid: PMC258024.
  • Robicsek SA, Blanchard DK, Djeu JY, Krzanowski JJ, Szentivanyi A, Polson JB. Multiple high-affinity cAMP-phosphodiesterases in human T-lymphocytes. Biochem Pharmacol. 1991 Jul;42(4):869-877. Pubmedid: 1651080.
  • Djeu JY, Wang M, Friedman H. Adverse effect of delta 9-tetrahydrocannabinol on human neutrophil function. Adv Exp Med Biol. 1991;288:57-62. Pubmedid: 1659138.
  • Richards AL, Djeu JY. Calcium-dependent natural killer and calcium-independent natural cytotoxic activities in an IL-2-dependent killer cell line. J Immunol. 1990 Nov;145(9):3144-3149. Pubmedid: 2120346.
  • Blanchard DK, Michelini-Norris MB, Djeu JY. A rapid [3H]glycerol radioassay for determination of monocyte-mediated growth inhibition of Mycobacterium avium. J Immunol Methods. 1990 Oct;133(2):285-290. Pubmedid: 2230143.
  • Richards AL, Dennert G, Pluznik DH, Takagaki Y, Djeu JY. Natural cytotoxic activity in a cloned natural killer cell line is mediated by tumor necrosis factor. Nat Immun Cell Growth Regul. 1989;8(2):76-88. Pubmedid: 2761550.
  • Djeu JY, Blanchard DK. Interferon-gamma-induced alterations of monocyte susceptibility to lysis by autologous lymphokine-activated killer (LAK) cells. Int J Cancer. 1988 Sep;42(3):449-454. Pubmedid: 3138195.
  • Blanchard DK, Friedman H, Stewart WE, Klein TW, Djeu JY. Role of gamma interferon in induction of natural killer activity by Legionella pneumophila in vitro and in an experimental murine infection model. Infect Immun. 1988 May;56(5):1187-1193. Pubmedid: 3128479. Pmcid: PMC259782.
  • Coffey RG, Davis JS, Djeu JY. Stimulation of guanylate cyclase activity and reduction of adenylate cyclase activity by granulocyte-macrophage colony-stimulating factor in human blood neutrophils. J Immunol. 1988 Apr;140(8):2695-2701. Pubmedid: 2895792.
  • Kawakami Y, Klein TW, Newton C, Djeu JY, Dennert G, Specter S, Friedman H. Suppression by cannabinoids of a cloned cell line with natural killer cell activity. Proc Soc Exp Biol Med. 1988 Mar;187(3):355-359. Pubmedid: 2831542.
  • Kawakami Y, Klein TW, Newton C, Djeu JY, Specter S, Friedman H. Suppression by delta-9-tetrahydrocannabinol of interleukin 2-induced lymphocyte proliferation and lymphokine-activated killer cell activity. Int J Immunopharmacol. 1988;10(4):485-488. Pubmedid: 2844686.
  • Djeu JY, Blanchard DK. Regulation of human polymorphonuclear neutrophil (PMN) activity against Candida albicans by large granular lymphocytes via release of a PMN-activating factor. J Immunol. 1987 Oct;139(8):2761-2767. Pubmedid: 2443572.
  • Blanchard DK, Djeu JY, Klein TW, Friedman H, Stewart WE. Induction of tumor necrosis factor by Legionella pneumophila. Infect Immun. 1987 Feb;55(2):433-437. Pubmedid: 2433220. Pmcid: PMC260346.
  • Jadus MR, Schmunk G, Djeu JY, Parkman R. Morphology and lytic mechanisms of interleukin 3-dependent natural cytotoxic cells: tumor necrosis factor as a possible mediator. J Immunol. 1986 Nov;137(9):2774-2783. Pubmedid: 2428873.
  • Djeu JY, Kasahara T, Balow JE, Tsokos GC. Decreased interleukin 2 inhibitor in sera of patients with autoimmune disorders. Clin Exp Immunol. 1986 Aug;65(2):279-285. Pubmedid: 3791699. Pmcid: PMC1542294.
  • Djeu JY, Parapanissios A, Halkias D, Friedman H. A rapid [3H]glucose incorporation assay for determination of lymphoid cell-mediated inhibition of Candida albicans growth. J Immunol Methods. 1986 Aug;92(1):73-77. Pubmedid: 3528301.
  • Siegel JP, Djeu JY, Stocks NI, Masur H, Gelmann EP, Quinnan GV. Sera from patients with the acquired immunodeficiency syndrome inhibit production of interleukin-2 by normal lymphocytes. J Clin Invest. 1985 Jun;75(6):1957-1964. Pubmedid: 2989337. Pmcid: PMC425554.
  • Zoumbos NC, Gascon P, Djeu JY, Young NS. Interferon is a mediator of hematopoietic suppression in aplastic anemia in vitro and possibly in vivo. Proc Natl Acad Sci U S A. 1985 Jan;82(1):188-192. Pubmedid: 3918301. Pmcid: PMC396997.
  • Allavena P, Scala G, Djeu JY, Procopio AD, Oppenheim JJ, Herberman RB, Ortaldo JR. Production of multiple cytokines by clones of human large granular lymphocytes. Cancer Immunol Immun. 1985;19(2):121-126. Pubmedid: 3921231.
  • Ramsey KM, Djeu JY, Rook AH. Decreased circulating large granular lymphocytes associated with depressed natural killer cell activity in renal transplant recipients. Transplantation. 1984 Oct;38(4):351-356. Pubmedid: 6388061.
  • Rabin H, Hopkins RF, Desrosiers RC, Ortaldo JR, Djeu JY, Neubauer RH. Transformation of owl monkey T cells in vitro with Herpesvirus saimiri. Proc Natl Acad Sci U S A. 1984 Jul;81(14):4563-4567. Pubmedid: 6087333. Pmcid: PMC345631.
  • Rook AH, Masur H, Lane HC, Frederick W, Kasahara T, Macher AM, Djeu JY, Manischewitz JF, Jackson L, Fauci AS, Quinnan GV. Interleukin-2 enhances the depressed natural killer and cytomegalovirus-specific cytotoxic activities of lymphocytes from patients with the acquired immune deficiency syndrome. J Clin Invest. 1983 Jul;72(1):398-403. Pubmedid: 6308051. Pmcid: PMC1129196.
  • Grimm EA, Ramsey KM, Mazumder A, Wilson DJ, Djeu JY, Rosenberg SA. Lymphokine-activated killer cell phenomenon. II. Precursor phenotype is serologically distinct from peripheral T lymphocytes, memory cytotoxic thymus-derived lymphocytes, and natural killer cells. J Exp Med. 1983 Mar;157(3):884-897. Pubmedid: 6601174. Pmcid: PMC2186968.
  • Tsokos GC, Rook AH, Djeu JY, Balow JE. Natural killer cells and interferon responses in patients with systemic lupus erythematosus. Clin Exp Immunol. 1982 Nov;50(2):239-245. Pubmedid: 6817954. Pmcid: PMC1536692.
  • Djeu JY, Stocks N, Zoon K, Stanton GJ, Timonen T, Herberman RB. Positive self regulation of cytotoxicity in human natural killer cells by production of interferon upon exposure to influenza and herpes viruses. J Exp Med. 1982 Oct;156(4):1222-1234. Pubmedid: 6185608. Pmcid: PMC2186820.
  • Djeu JY, Stocks N, Varesio L, Holden HT, Herberman RB. Metabolic requirements for the in vitro augmentation of mouse natural killer activity by interferon. Cell Immunol. 1981 Feb;58(1):49-60. Pubmedid: 6164493.
  • Djeu JY, Huang KY, Herberman RB. Augmentation of mouse natural killer activity and induction of interferon by tumor cells in vivo. J Exp Med. 1980 Apr;151(4):781-789. Pubmedid: 6154760. Pmcid: PMC2185821.
  • Epling-Burnette PK, Garcia R, Catlet-Falcone R, Liu J, Gamero M, Yu L, Jove R, Djeu J, Wei S. Carboxy-terminal truncated STAT5 is induced by interleukin-2 and GM-CSF in human neutrophils. Cell Immunol. 217(1-2):1-11. Pubmedid: 12425996.
  • Djeu JY, Heinbaugh JA, Vieira WD, Holden HT, Herberman RB. The effect of immunopharmacological agents on mouse natural cell-mediated cytotoxicity and on its augmentation by poly I:C. Immunopharmacology. 1979 Jun;1(3):231-244. Pubmedid: 262451.
  • Herberman RB, Holden HT, Djeu JY, Jerrells TR, Varesio L, Tagliabue A, White SL, Oehler JR, Dean JH. Macrophages as regulators of immune responses against tumors. Adv Exp Med Biol. 1979;121B:361-379. Pubmedid: 232619.
  • Nunn ME, Djeu JY, Glaser M, Lavrin DH, Herberman RB. Natural cytotoxic reactivity of rat lymphocytes against syngeneic Gross virus-induced lymphoma. J Natl Cancer Inst. 1976 Feb;56(2):393-399. Pubmedid: 1082939.
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