A major interest of our laboratory is to study the genetic alterations and their molecular mechanisms in human ovarian and breast cancer. Specifically, we are interested in elucidation of normal cellular function of the PI3K/Akt and Aurora-A pathways and to characterize their role in human ovarian carcinogenesis. In particular, we are focusing on the identification of molecules that are specifically regulated by Akt or Aurora-A as well as the molecules that are regulated by PI3K/PTEN but not Akt. We are also interested in the identification of small molecule inhibitors of Akt and Aurora-A for cancer intervention. In addition, we are also working on the role of microRNA and a newly identified NGB tumor suppressor gene in human cancer.