Our laboratory mainly focuses on studying the p53 pathway in tumor cells. Recent work involve the p53 regulator MDMX. We are investigating the regulation of MDMX by ubiquitination and phosphorylation, the roles of MDMX in regulating p53 response to DNA damage and ribosomal stress, and the role of MDMX in tumor formation. We are also trying to develop inhibitors against MDM2 and MDMX as therapeutic agents. A second area of research addresses the role of SirT1 in stress response in tumor cells, regulation of SirT1 expression by E2F1, and the role of SirT1 phosphorylation.