Jia-Wang Wang, PhD

Where You Are:
Jia-Wang Wang, PhD

Office  (813) 972-7631

Education And Training
  • Postdoctoral Fellow, University of Pennsylvania, 1999 - Genetics/Immunology
  • Postdoctoral Fellow, Chinese Academy of Medical Sciences, 1996 - Cancer and Cell Biology
  • PhD, Wuhan University, China, 1994 - Mol. Biol. and Virology
  • MS, Sichuan University, China, 1988 - Genetics
  • BS, Yunnan Normal University, China, 1984 - Biology

The recent discovery of miRNAs (miRs) may bring fundamental and revolutionary changes in understanding and treatment of human diseases.  So far 2154 human miRs are discovered.  It is believed that most human protein coding genes and the entire spectrum of biological pathways are under the control of miRs, as one miR can regulate hundreds or even thousands of genes.  Deregulation of miRs may contribute to various diseases and be used as robust biomarkers for diagnosis, staging, prognosis and the response to therapy.  We are interested in the role of miRs in human diseases such as cancer.  We are developing an miR profiling method the only RT-qPCR assay that can specifically profile all miRs.  We are using this novel technique to screen miR biomarkers for human diseases such as cancer and inflammatory diseases.  On the other hand, we are studying miRs' role in immune suppression and immune over-activation/autoimmunity in vivo by knockin and knockout techniques.  Four miR transgenic mouse models have been generated, all of which show interesting phenotype related to cancer.  The epigenic regulations of these miRs related to HDACs will be explored.   

  • Yang H, Kong W, He L, Zhao JJ, O'Donnell JD, Wang J, Wenham RM, Coppola D, Kruk PA, Nicosia SV, Cheng JQ. MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. Cancer Res. 2008 Jan;68(2):425-433. Pubmedid: 18199536.
  • Webb T, Jiang L, Sviridov S, Venegas R, Vlaskina A, McGrath D, Tucker J, Wang J, Deschenes A, Li R. Application of a novel design paradigm to generate general nonpeptide combinatorial templates mimicking beta-turns: synthesis of ligands for melanocortin receptors. J Comb Chem. 2007 Jul;9(4):704-710. Pubmedid: 17429950.
  • Wang J, Wang X, Hussain S, Zheng Y, Sanjabi S, Ouaaz F, Beg A. Distinct Roles of Different NF-{kappa}B Subunits in Regulating Inflammatory and T Cell Stimulatory Gene Expression in Dendritic Cells. J Immunol. 2007 Jun;178(11):6777-6788. Pubmedid: 17513725.
  • Li R, Xue L, Zhu T, Jiang Q, Cui X, Yan Z, McGee D, Wang J, Gantla VR, Pickens JC, McGrath D, Chucholowski A, Morris SW, Webb TR. Design and synthesis of 5-aryl-pyridone-carboxamides as inhibitors of anaplastic lymphoma kinase. J Med Chem. 2006 Feb;49(3):1006-1015. Pubmedid: 16451066.
  • Ghansah T, Paraiso K, Highfill S, Desponts C, May S, McIntosh J, Wang J, Ninos J, Brayer J, Cheng F, Sotomayor E, Kerr W. Expansion of myeloid suppressor cells in SHIP-deficient mice represses allogeneic T cell responses. J Immunol. 2004;173(12):7324-7330. Pubmedid: 15585856.
  • Wang J, Gamsby J, Highfill S, Mora L, Bloom G, Yeatman T, Pan T, Ramne A, Chodosh L, Cress W, Chen J, Kerr W. Deregulated expression of LRBA facilitates cancer cell growth. Oncogene. 2004;23(23):4089-4097. Pubmedid: 15064745.
  • Wang J, Howson J, Ghansah T, Desponts C, Ninos J, May S, Nguyen K, Toyama-Sorimachi N, Kerr W. Influence of SHIP on the NK repertoire and allogeneic bone marrow transplantation. Science. 2002;295(5562):2094-2097. Pubmedid: 11896280.
  • Wang J, Li Y, Shi J, Li L, Bai W, Yu A, Jiang S. The inherent characteristics and DNA polymorphism of Vibrio cholerae and othervibrios. Chin Med J (Engl). 2002;115:589-592. Pubmedid: 12133305.
  • Tu Z, Ninos J, Ma Z, Wang J, Lemos M, Desponts C, Ghansah T, Howson J, Kerr W. Embryonic and hematopoietic stem cells express a novel SH2-containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein. Blood. 2001;98(7):2028-2038. Pubmedid: 11567986.
  • Wang J, Howson J, Haller E, Kerr W. Identification of a novel lipopolysaccharide-inducible gene with key features of both A kinase anchor proteins and chs1/beige proteins. J Immunol. 2001;166(7):4586-4595. Pubmedid: 11254716.
  • Cox C, Bass S, McCann C, Ku N, Berman C, Durand K, Bolano M, Wang J, Peltz E, Cox S, Salud C, Reintgen D, Lyman G. Lymphatic mapping and sentinel lymph node biopsy in patients with breast cancer. Annu Rev Med. 2000;51:525-542. Pubmedid: 10774480.
  • Mahajan K, Gangi-Peterson L, Sorscher D, Wang J, Gathy K, Mahajan N, Reeves W, Mitchell B. Association of terminal deoxynucleotidyl transferase with Ku. Proc Natl Acad Sci U S A. 1999 Nov;96(24):13926-13931. Pubmedid: 10570175. Pmcid: PMC24167.
  • Li R, Farmer P, Wang J, Boyd R, Cameron T, Quilliam M, Walter J, HowlettSE. Molecular geometries of dibenzothiazepinone and dibenzoxazepinone calcium antagonists. Drug Des Discov. 1995 Apr;12(4):337-358. Pubmedid: 9040993 .
  • Wang J, Qi Y, Huang Y, Li S. Nucleotide sequence of a 1446 base pair sall fragment and structure of a novel early gene of leucania separata nuclear polyhedrosis virus. Arch Virol. 1995;140(12):2283-2291. Pubmedid: 8572949.
  • Wang J, Cheng J. A simple method for profiling miRNA expression. Methods Mol Biol. 2008 414;414:183-190. Pubmedid: 18175820.
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