The long-term goals of my laboratory are to reveal the signal transduction mechanisms that control cell proliferation, differentiation, survival, and motility and to explore key signaling molecules as targets for cancer therapy. We are interested in understanding fundamental cell signaling mechanisms that regulate cellular responses to extracellular cues as well as abnormal signal transduction pathways that mediate malignant growth and metastasis. Our research areas include ErbB, Src, and Bcr-Abl tyrosine kinases, Gab family docking proteins, SHP1 and SHP2 tyrosine phosphatases, MAP kinases, lysophosphatidic acid, and molecular chaperones. Over the last several years, the lab has been focused characterizing the regulation and function of Shp2 in growth factor signaling and oncogenesisWe are particularly interested in breast cancer, prostate cancer, and leukemia. Multidisciplinary approaches of molecular biology, biochemistry, cell biology, immunology, and bioinformatics are routinely used in our studies.