James J. Mule, PhD

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James J. Mule, PhD

Senior Member

Office  (813) 745-1536

Education And Training
  • Fellow, National Cancer Institute, Bethesda, Maryland, 1986 - Surgery
  • Postdoctoral Fellow, University of Washington School of Medicine, 1983 - Surgery
  • PhD, Fred Hutchinson Cancer Research Center, 1981 - Tumor Immunology and Immunopathology
  • MS, University of Washington, School of Medicine, 1977 - Cellular Immunology

The clinical application of immunotherapy for cancer is rapidly moving forward in multiple areas, which incorporate the adoptive transfer of antitumor-reactive T cells and the use of 'therapeutic' vaccines. Both clinical and immunologic endpoints have shown new promise to the field. Novel dendritic cell-based vaccine strategies designed in the laboratory and proven in preclinical animal tumor models are now entering the clinic, with the intent of providing therapeutic efficacy. Improvements on this approach involve breaking tolerance to tumor 'self' antigens by inhibiting regulatory cells, boosting T cell co-stimulation, and administering combinations of recombinant cytokines and other defined molecules with 'immuno-enhancing' activities. Development of these improvements is the primary research interest of Dr. Mule.

On the basis of encouraging data from their preclinical studies, Dr. Mule and his colleagues initiated and completed two phase I clinical trials of autologous tumor lysate/keyhole limpet haemocyanin (KLH)-pulsed dendritic cells (TP-DCs) in children and adults with advanced solid tumors. The DCs, characterized as immature by phenotypic marker profiling, yielded both immunologic and very modest clinical responses. Immunologic assays revealed evidence of the induction of peripheral blood T-cell reactivity to both KLH and tumor lysates after immunization, particularly in children.

Because durable and complete regression of established tumors has been difficult to achieve through administration of TP-DCs alone, Dr. Mule and his colleagues have embarked on a new series of clinical trails to evaluate potential improvements in their DC-based vaccine strategy that incorporate intratumoral delivery of KLH-pulsed DCs; systemic administration of interleukin-2 (IL-2); use of locally produced secondary lymphoid tissue chemokine; and the setting of lymphopenia-induced, homeostatic-driven T-cell proliferation. These clinical trials include (1) a phase Ib trial assessing autologous TP-DCs as a tumor vaccine administered with or without IL-2 in patients with metastatic melanoma; (2) a phase II trial assessing autologous TP-DCs as a tumor vaccine administered with low-dose IL-2 in patients with colorectal cancer; (3) a phase I trial assessing intratumoral administration of autologous DCs activated by granulocyte-macrophage colony-stimulating factor and interleukin-4 as a vaccine in muscle-invasive bladder cancer; (4) a phase I trial of escalating doses of fludarabine followed by intranodal delivery of MHC class I/II peptide-pulsed DCs in patients with chemotherapy-naive metastatic melanoma; (5) a randomized phase II trial of fludarabine followed by intranodal delivery of peptide-pulsed DCs with or without autologous lymphocyte infusion; (6) a phase II trial of TP-DC vaccines early after autologous hematopoietic stem cell transplantation to prolong progression-free survival in children with sarcoma; and (7) a phase I clinical study assessing autologous DCs gene-modified to secrete secondary lymphoid tissue chemokine as a vaccine to enhance T-cell priming in patients with advanced solid tumors.

  • Weber JS, Mulé JJ. Cancer immunotherapy meets biomaterials. Nat Biotechnol. 2015 Jan;33(1):44-45. Pubmedid: 25574635.
  • Ding L, Kim M, Kanchi KL, Dees ND, Lu C, Griffith M, Fenstermacher D, Sung H, Miller CA, Goetz B, Wendl MC, Griffith O, Cornelius LA, Linette GP, McMichael JF, Sondak VK, Fields RC, Ley TJ, Mulé JJ, Wilson RK, Weber JS. Clonal architectures and driver mutations in metastatic melanomas. PLoS One. 2014 Nov;9(11):e111153. Pubmedid: 25393105. Pmcid: PMC4230926.
  • Komine H, Kuhn L, Matsushita N, Mulé JJ, Pilon-Thomas S. Examination of MARCO activity on dendritic cell phenotype and function using a gene knockout mouse. PLoS One. 2014 Feb;8(7):e67795. Pubmedid: 23840879. Pmcid: PMC3698187.
  • Radvanyi L, Pilon-Thomas S, Peng W, Sarnaik A, Mulé JJ, Weber J, Hwu P. Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer--letter. Clin Cancer Res. 2013 Oct;19(19):5541. Pubmedid: 24048330. Pmcid: PMC3823378.
  • Messina JL, Fenstermacher DA, Eschrich S, Qu X, Berglund AE, Lloyd MC, Schell MJ, Sondak VK, Weber JS, Mulé JJ. 12-Chemokine gene signature identifies lymph node-like structures in melanoma: potential for patient selection for immunotherapy?. Sci Rep. 2013 Mar;2:765. Pubmedid: 23097687. Pmcid: PMC3479449.
  • Pilon-Thomas S, Kuhn L, Ellwanger S, Janssen W, Royster E, Marzban S, Kudchadkar R, Zager J, Gibney G, Sondak VK, Weber J, Mulé JJ, Sarnaik AA. Efficacy of adoptive cell transfer of tumor-infiltrating lymphocytes after lymphopenia induction for metastatic melanoma. J Immunother. 2012 Oct;35(8):615-620. Pubmedid: 22996367.
  • Coppola D, Nebozhyn M, Khalil F, Dai H, Yeatman T, Loboda A, Mulé JJ. Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profiling. Am J Pathol. 2011 Jul;179(1):37-45. Pubmedid: 21703392. Pmcid: PMC3123872.
  • Matsushita N, Komine H, Grolleau-Julius A, Pilon-Thomas S, Mulé JJ. Targeting MARCO can lead to enhanced dendritic cell motility and anti-melanoma activity. Cancer Immunol Immun. 2010 Jun;59(6):875-884. Pubmedid: 20054688. Pmcid: PMC2861905.
  • Pilon-Thomas S, Mackay A, Vohra N, Mulé JJ. Blockade of programmed death ligand 1 enhances the therapeutic efficacy of combination immunotherapy against melanoma. J Immunol. 2010 Apr;184(7):3442-3449. Pubmedid: 20194714. Pmcid: PMC2913584.
  • Mulé JJ. Dendritic cell-based vaccines for pancreatic cancer and melanoma. Ann N Y Acad Sci. 2009 Sep;1174:33-40. Pubmedid: 19769734.
  • Coppola D, Mule J. Ectopic lymph nodes within human solid tumors. J Clin Oncol. 2008 Sep;26(27):4369-4370. Pubmedid: 18802146.
  • Yeatman TJ, Mule J, Dalton WS, Sullivan D. On the eve of personalized medicine in oncology. Cancer Res. 2008 Sep;68(18):7250-7252. Pubmedid: 18794109.
  • Koike N, Pilon-Thomas S, Mulé JJ. Nonmyeloablative chemotherapy followed by T-cell adoptive transfer and dendritic cell-based vaccination results in rejection of established melanoma. J Immunother. 2008 May;31(4):402-412. Pubmedid: 18391755.
  • Takahashi Y, Coppola D, Matsushita N, Cualing HD, Sun M, Sato Y, Liang C, Jung JU, Cheng JQ, Mule JJ, Pledger WJ, Wang HG. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol. 2007 Oct;9(10):1142-1151. Pubmedid: 17891140. Pmcid: PMC2254521.
  • Anasetti C, Mulé JJ. To ablate or not to ablate? HSCs in the T cell driver's seat. J Clin Invest. 2007 Feb;117(2):306-310. Pubmedid: 17273553. Pmcid: PMC1783831.
  • Moyer J, Maine G, Mule J. Early vaccination with tumor lysate-pulsed dendritic cells after allogeneic bone marrow transplantation has antitumor effects. Biol Blood Marrow Transplant. 2006 Oct;12(10):1010-1019. Pubmedid: 17084367.
  • Pilon-Thomas S, Verhaegen M, Kuhn L, Riker A, Mule J. Induction of anti-tumor immunity by vaccination with dendritic cells pulsedwith anti-CD44 IgG opsonized tumor cells. Cancer Immunol Immunother. 2006 Oct;55(10):1238-1246. Pubmedid: 16315029.
  • Pilon-Thomas S, Li W, Briggs J, Djeu J, Mule J, Riker A. Immunostimulatory Effects of CpG-ODN Upon Dendritic Cell-Based Immunotherapy in a Murine Melanoma Model. J Immunother. 2006 Jul;29(4):381-387. Pubmedid: 16799333.
  • Sondak V, Sabel M, Mule J. Allogeneic and autologous melanoma vaccines: where have we been and where are we going. Clin Cancer Res. 2006 Apr;12(7 pt2):2337s-2341s. Pubmedid: 16609055.
  • Kortylewski M, Kujawski M, Wang T, Wei S, Zhang S, Pilon-Thomas S, Niu G, Kay H, Mulé J, Kerr WG, Jove R, Pardoll D, Yu H. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med. 2005 Dec;11(12):1314-1321. Pubmedid: 16288283.
  • Terando A, Roessler B, Mule J. Chemokine gene modification of human dendritic cell-based tumor vaccines using a recombinant adenoviral vector. Cancer Gene Ther. 2004 Mar;11(3):165-173. Pubmedid: 14726959.
  • Mule J, Weber J. Translation of cancer immunotherapies. Nat Med. 2004;10(11):1153-1154. Pubmedid: 15516900.
  • Asavaroengchai W, Kotera Y, Koike N, Pilon-Thomas S, Mule J. Augmentation of antitumor immune responses after adoptive transfer of bone marrow derived from donors immunized with tumor lysate-pulsed dendritic cells. Biol Blood Marrow Transplant. 2004;10:524-533. Pubmedid: 15282530.
  • Antonia S, Mule J, Weber J. Current developments of immunotherapy in the clinic. Curr Opin Immunol. 2004;16(2):130-136. Pubmedid: 15023403.
  • Pilon-Thomas S, Verhaegen M, Mule J. Dendritic cell-based therapeutics for breast cancer. Breast Dis. 2004;20:65-71. Pubmedid: 15687708.
  • Terando A, Mule J. On combining antineoplastic drugs with tumor vaccines. Cancer Immunol Immunother. 2003;52(11):680-685. Pubmedid: 12955481.
  • Terando A, Mule J. Enhancing dendritic cell-based vaccines by gene modification. Blood Cells Mol Dis. 2003;31(1):80-83. Pubmedid: 12850489.
  • Grolleau A, Misek D, Kuick R, Hanash S, Mule J. Inducible expression of macrophage receptor Marco by dendritic cells following phagocytic uptake of dead cells uncovered by oligonucleotide arrays. J Immunol. 2003;171(6):2879-2888. Pubmedid: 12960310.
  • Quintana A, Raczka E, Piehler L, Lee I, Myc A, Majoros I, Patri AK, Thomas T, Mulé J, Baker JR. Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptor. Pharm Res. 2002 Sep;19(9):1310-1316. Pubmedid: 12403067.
  • Maine GN, Mulé JJ. Making room for T cells. J Clin Invest. 2002 Jul;110(2):157-159. Pubmedid: 12122106. Pmcid: PMC151072.
  • Chang A, Redman B, Whitfield J, Nickoloff B, Braun T, Lee P, GeigerJD, Mule J. A phase I trial of tumor lysate-pulsed dendritic cells in the treatment of advanced cancer. Clin Cancer Res. 2002 Apr;8(4):1021-1032. Pubmedid: 11948109.
  • Asavaroengchai W, Kotera Y, Mulé JJ. Tumor lysate-pulsed dendritic cells can elicit an effective antitumor immune response during early lymphoid recovery. Proc Natl Acad Sci U S A. 2002 Jan;99(2):931-936. Pubmedid: 11792864. Pmcid: PMC117408.
  • Maine G, Mule J. Comparing tumor antigen specificity of lysate versus peptide-pulsed dendritic cell-based vaccines. Faseb J. 2002;0.
  • Kotera Y, Maine G, Mule J. T lymphocytes in bone marrow of mice immunized with tumor lysate-pulsed dendritic cells mediate regression of establishe dB16 melanoma in vivo. Proc Am Assoc Cancer Res. 2002;43:96-96.
  • Hartigan-O'Connor D, Kirk CJ, Crawford R, Mulé JJ, Chamberlain JS. Immune evasion by muscle-specific gene expression in dystrophic muscle. Mol Ther. 2001 Dec;4(6):525-533. Pubmedid: 11735336.
  • Geiger J, Hutchinson R, Hohenkirk L, McKenna E, Yanik G, Levine J, Chang A, Braun T, Mule J. Vaccination of pediatric solid tumor patients with tumor lysate-pulsed dendritic cells can expand specific T cells and mediate tumor regression. Cancer Res. 2001 Dec;61(23):8513-8519. Pubmedid: 11731436.
  • Weber J, Mule J. How much help does a vaccine-induced T-cell response need. J Clin Invest. 2001 Mar;107(5):553-554. Pubmedid: 11238555.
  • Shimizu K, Thomas E, Giedlin M, Mule J. Enhancement of tumor lysate- and peptide-pulsed dendritic cell-based vaccines by the addition of foreign helper protein. Cancer Res. 2001 Mar;61(6):2618-2624. Pubmedid: 11289139.
  • Kirk CJ, Hartigan-O'Connor D, Nickoloff BJ, Chamberlain JS, Giedlin M, Aukerman L, Mule JJ. T cell-dependent antitumor immunity mediated by secondary lymphoid tissue chemokine: augmentation of dendritic cell-based immunotherapy. Cancer Res. 2001 Mar;61(5):2062-2070. Pubmedid: 11280767.
  • Candido K, Shimizu K, McLaughlin J, Kunkel R, Fuller J, Redman B, Thomas E, Nickoloff B, Mule J. Local administration of dendritic cells inhibits established breast tumor growth: implications for apoptosis-inducing agents. Cancer Res. 2001 Jan;61(1):228-236. Pubmedid: 11196166.
  • Xie C, Restifo N, Mule J, Hollenbeck B, Eng M, Sandra M. Overcoming transformation-potentiated, peripheral tolerance for oncogene-specific prostate cancer therapy. Proc Am Assoc Cancer Res. 2001;42:561-561. Pubmedid: no pub med.
  • Kotera Y, Shimizu K, Mule J. Comparative analysis of necrotic and apoptotic tumor cells as a source of antigen(s) in dendritic cell-based immunization. Cancer Res. 2001;61(22):8105-8109. Pubmedid: 11719436.
  • Kirk C, Hartigan-O'Connor D, Mule J. The dynamics of the T-cell antitumor response: chemokine-secreting dendritic cells can prime tumor-reactive T cells extranodally. Cancer Res. 2001;61(24):8794-8802. Pubmedid: 11751401.
  • Morita Y, Yang J, Gupta R, Shimizu K, Shelden E, Endres J, Mule J, McDonagh K, Fox D. Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis. J Clin Invest. 2001;107(10):1275-1284. Pubmedid: 11375417.
  • Mulé JJ. Tumor vaccine strategies that employ dendritic cells and tumor lysates: experimental and clinical studies. Immunol Invest. 2000 May;29(2):127-129. Pubmedid: 10854180.
  • Yang J, Friedman M, Fuller J, Braun T, Eshhar Z, Mule J, Mcdonagh K. Antigen specific elimination of established tumor metastases in mice following adoptive immunotherapy with genetically modified murine T cells expressing a chimeric T cell receptor (chTCR) specific for p185HER2. Blood. 2000;96:551a-551a. Pubmedid: no pub med.
  • Kirk C, Mule J. Gene-modified dendritic cells for use in tumor vaccines. Hum Gene Ther. 2000;11(6):797-806. Pubmedid: 10779157.
  • Shimizu K, Fields R, Redman B, Giedlin M, Mule J. Potentiation of immunologic responsiveness to dendritic cell-based tumor vaccines by recombinant interleukin-2. Cancer J Sci Am. 2000;6:S67-S75. Pubmedid: 10685663.
  • Shimizu K, Fields RC, Giedlin M, Mulé JJ. Systemic administration of interleukin 2 enhances the therapeutic efficacy of dendritic cell-based tumor vaccines. Proc Natl Acad Sci U S A. 1999 Mar;96(5):2268-2273. Pubmedid: 10051630. Pmcid: PMC26772.
  • Xie Y, Hwang C, Overwijk W, Zeng Z, Eng M, Mule J, Imperiale M, RestifoNP, Sanda M. Induction of tumor antigen-specific immunity in vivo by a novel vaccinia vectorencoding safety-modified simian virus 40 T antigen. J Natl Cancer Inst. 1999;91:169-175. Pubmedid: 9923859 .
  • Fields RC, Shimizu K, Mulé JJ. Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responses in vitro and in vivo. Proc Natl Acad Sci U S A. 1998 Aug;95(16):9482-9487. Pubmedid: 9689106. Pmcid: PMC21364.
  • Mulé JJ, Custer M, Averbook B, Yang JC, Weber JS, Goeddel DV, Rosenberg SA, Schall TJ. RANTES secretion by gene-modified tumor cells results in loss of tumorigenicity in vivo: role of immune cell subpopulations. Hum Gene Ther. 1996 Aug;7(13):1545-1553. Pubmedid: 8864755.
  • Mule J, Custer M, Averbook B, Yang J, Weber J, Goeddel D, Rosenberg S, Schall T. RANTES secretion by gene-modified tumor cells results in loss of tumorigenicity in vivo: role of immune cell subpopulations. Hum Gene Ther. 1996 Aug;7(13):1545-1553. Pubmedid: 8864755 .
  • Kerr WG, Mulé JJ. Gene therapy: current status and future prospects. J Leukoc Biol. 1994 Aug;56(2):210-214. Pubmedid: 8071597.
  • Marincola FM, Shamamian P, Simonis TB, Abati A, Hackett J, O'Dea T, Fetsch P, Yannelli J, Restifo NP, Mulé JJ. Locus-specific analysis of human leukocyte antigen class I expression in melanoma cell lines. J Immunother Emphasis Tumor Immunol. 1994 Jul;16(1):13-23. Pubmedid: 8081556. Pmcid: PMC2561308.
  • Marincola FM, Ettinghausen S, Cohen PA, Cheshire LB, Restifo NP, Mulé JJ, Rosenberg SA. Treatment of established lung metastases with tumor-infiltrating lymphocytes derived from a poorly immunogenic tumor engineered to secrete human TNF-alpha. J Immunol. 1994 Apr;152(7):3500-3513. Pubmedid: 8144931. Pmcid: PMC2248454.
  • Shiloni E, Karp SE, Custer MC, Shilyansky J, Restifo NP, Rosenberg SA, Mulé JJ. Retroviral transduction of interferon-gamma cDNA into a nonimmunogenic murine fibrosarcoma: generation of T cells in draining lymph nodes capable of treating established parental metastatic tumor. Cancer Immunol Immun. 1993 Oct;37(5):286-292. Pubmedid: 8402732. Pmcid: PMC2248452.
  • Restifo NP, Esquivel F, Kawakami Y, Yewdell JW, Mulé JJ, Rosenberg SA, Bennink JR. Identification of human cancers deficient in antigen processing. J Exp Med. 1993 Feb;177(2):265-272. Pubmedid: 8426105. Pmcid: PMC1950463.
  • Karp SE, Farber A, Salo JC, Hwu P, Jaffe G, Asher AL, Shiloni E, Restifo NP, Mulé JJ, Rosenberg SA. Cytokine secretion by genetically modified nonimmunogenic murine fibrosarcoma. Tumor inhibition by IL-2 but not tumor necrosis factor. J Immunol. 1993 Feb;150(3):896-908. Pubmedid: 8423345. Pmcid: PMC2121323.
  • Karp SE, Hwu P, Farber A, Restifo NP, Kriegler M, Mulé JJ, Rosenberg SA. In vivo activity of tumor necrosis factor (TNF) mutants. Secretory but not membrane-bound TNF mediates the regression of retrovirally transduced murine tumor. J Immunol. 1992 Sep;149(6):2076-2081. Pubmedid: 1517571. Pmcid: PMC2121327.
  • Hwu P, Schwarz S, Custer M, Smith CA, Mulé JJ, Rosenberg SA. Use of soluble recombinant TNF receptor to improve detection of TNF secretion in cultures of tumor infiltrating lymphocytes. J Immunol Methods. 1992 Jul;151(1-2):139-147. Pubmedid: 1321199.
  • Restifo NP, Spiess PJ, Karp SE, Mulé JJ, Rosenberg SA. A nonimmunogenic sarcoma transduced with the cDNA for interferon gamma elicits CD8+ T cells against the wild-type tumor: correlation with antigen presentation capability. J Exp Med. 1992 Jun;175(6):1423-1431. Pubmedid: 1588273. Pmcid: PMC1974839.
  • Mulé JJ, Custer MC, Travis WD, Rosenberg SA. Cellular mechanisms of the antitumor activity of recombinant IL-6 in mice. J Immunol. 1992 Apr;148(8):2622-2629. Pubmedid: 1348521.
  • Restifo NP, Esquivel F, Asher AL, Stötter H, Barth RJ, Bennink JR, Mulé JJ, Yewdell JW, Rosenberg SA. Defective presentation of endogenous antigens by a murine sarcoma. Implications for the failure of an anti-tumor immune response. J Immunol. 1991 Aug;147(4):1453-1459. Pubmedid: 1907999. Pmcid: PMC1950464.
  • Asher AL, Mulé JJ, Kasid A, Restifo NP, Salo JC, Reichert CM, Jaffe G, Fendly B, Kriegler M, Rosenberg SA. Murine tumor cells transduced with the gene for tumor necrosis factor-alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors. J Immunol. 1991 May;146(9):3227-3234. Pubmedid: 2016545. Pmcid: PMC1950469.
  • Fox BA, Spiess PJ, Kasid A, Puri R, Mulé JJ, Weber JS, Rosenberg SA. In vitro and in vivo antitumor properties of a T-cell clone generated from murine tumor-infiltrating lymphocytes. J Biol Response Mod. 1990 Oct;9(5):499-511. Pubmedid: 2174966.
  • Fox B, Spiess P, Kasid A, Puri R, Mule J, Weber J, Rosenberg S. In vitro and in vivo antitumor properties of a T-cell clone generated from murine tumor-infiltrating lymphocytes. J Biol Response Mod. 1990 Oct;9(5):499-511. Pubmedid: 2174966 .
  • Mulé JJ, McIntosh JK, Jablons DM, Rosenberg SA. Antitumor activity of recombinant interleukin 6 in mice. J Exp Med. 1990 Mar;171(3):629-636. Pubmedid: 2307930. Pmcid: PMC2187775.
  • McIntosh JK, Jablons DM, Mulé JJ, Nordan RP, Rudikoff S, Lotze MT, Rosenberg SA. In vivo induction of IL-6 by administration of exogenous cytokines and detection of de novo serum levels of IL-6 in tumor-bearing mice. J Immunol. 1989 Jul;143(1):162-167. Pubmedid: 2499626.
  • McIntosh JK, Mulé JJ, Krosnick JA, Rosenberg SA. Combination cytokine immunotherapy with tumor necrosis factor alpha, interleukin 2, and alpha-interferon and its synergistic antitumor effects in mice. Cancer Res. 1989 Mar;49(6):1408-1414. Pubmedid: 2784349.
  • Jablons DM, Mulé JJ, McIntosh JK, Sehgal PB, May LT, Huang CM, Rosenberg SA, Lotze MT. IL-6/IFN-beta-2 as a circulating hormone. Induction by cytokine administration in humans. J Immunol. 1989 Mar;142(5):1542-1547. Pubmedid: 2783945.
  • Krosnick JA, McIntosh JK, Mulé JJ, Rosenberg SA. Studies of the mechanisms of toxicity of the administration of recombinant tumor necrosis factor alpha in normal and tumor-bearing mice. Cancer Immunol Immun. 1989;30(3):133-138. Pubmedid: 2598182.
  • Mulé JJ, Smith CA, Rosenberg SA. Interleukin 4 (B cell stimulatory factor 1) can mediate the induction of lymphokine-activated killer cell activity directed against fresh tumor cells. J Exp Med. 1987 Sep;166(3):792-797. Pubmedid: 3498002. Pmcid: PMC2188702.
  • Papa MZ, Vetto JT, Ettinghausen SE, Mulé JJ, Rosenberg SA. Effect of corticosteroid on the antitumor activity of lymphokine-activated killer cells and interleukin 2 in mice. Cancer Res. 1986 Nov;46(11):5618-5623. Pubmedid: 3489525.
  • Rosenberg SA, Mulé JJ, Spiess PJ, Reichert CM, Schwarz SL. Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2. J Exp Med. 1985 May;161(5):1169-1188. Pubmedid: 3886826. Pmcid: PMC2187617.
  • Mulé JJ, Rosenstein M, Shu S, Rosenberg SA. Eradication of a disseminated syngeneic mouse lymphoma by systemic adoptive transfer of immune lymphocytes and its dependence upon a host component(s). Cancer Res. 1985 Feb;45(2):526-531. Pubmedid: 3881168.
  • Mulé JJ, Stanton TH, Hellström I, Hellström KE. Suppressor pathways in tumor immunity: a requirement for Qa-1 positive tumor-bearer spleen T cells in suppression of the afferent immune response to tumor antigens. Int J Cancer. 1981 Sep;28(3):353-359. Pubmedid: 6459294.
  • Redman BG, Chang AE, Whitfield J, Esper P, Jiang G, Braun T, Roessler B, Mulé JJ. Phase Ib trial assessing autologous, tumor-pulsed dendritic cells as a vaccine administered with or without IL-2 in patients with metastatic melanoma. J Immunother. 31(6):591-598. Pubmedid: 18528294. Pmcid: PMC2642589.
  • Dubinett SM, Lee JM, Sharma S, Mulé JJ. Chemokines: can effector cells be redirected to the site of the tumor?. Cancer J. 16(4):325-335. Pubmedid: 20693843. Pmcid: PMC3076643.
  • Mulé JJ, Jones FR, Hellström I, Hellström KE. Selective localization of radiolabeled immune lymphocytes into syngeneic tumors. J Immunol. 1979 Aug;123(2):600-606. Pubmedid: 458150.
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