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Heiko Enderling, PhD

Where You Are:
Heiko Enderling, PhD

Assistant Member

Office  (813) 745-4316

Education And Training
  • Postdoctoral Fellow, Tufts University School of Medicine, 2008
  • PhD, University of Dundee, 2006 - Mathematical Biology
  • Postdoctoral Researcher, University of Dundee, 2006 - Mathematics, Surgery, Molecular Oncology


Dr. Enderling's research interests are focused on developing clinically and experimentally motivated and quatitative models of cell-cell interactions within a tumor as well as at the tumor-host interface. In particular, the work in his laboratory focuses on the role of cancer stem cells in tumor progression and treatment response, with the ultimate goal to improve patient-specific treatment design.

  • P Sasi S, Song J, Park D, Enderling H, McDonald JT, Gee H, Garrity B, Shtifman A, Yan X, Walsh K, Natarajan M, Kishore R, Goukassian DA. TNF-TNFR2/p75 Signaling Inhibits Early and Increases Delayed Non-Targeted Effects in Bone Marrow-Derived Endothelial Progenitor Cells. J Biol Chem. 2014 Apr. Pubmedid: 24711449.
  • Sasi SP, Song J, Enderling H, Yan X, Goukassian DA. TNF-α and IL-1α but not MCP-1 and Rantes increase significantly the formation of p-H2AX foci in naive BM-derived TNFR1/p55KO EPCs. J Radiat Res. 2014 Mar;55 Suppl 1:i122-i123. Pubmedid: 24585960.
  • Sasi SP, Bae S, Song J, Perepletchikov A, Schneider D, Carrozza J, Yan X, Kishore R, Enderling H, Goukassian DA. Therapeutic Non-Toxic Doses of TNF Induce Significant Regression in TNFR2-p75 Knockdown Lewis Lung Carcinoma Tumor Implants. PLoS One. 2014;9(3):e92373. Pubmedid: 24664144.
  • Enderling H, A J Chaplain M. Mathematical Modeling of Tumor Growth and Treatment. Curr Pharm Des. 2013 Nov. Pubmedid: 24283955.
  • McGuire MF, Enderling H, Wallace DI, Batra JS, Jordan M, Kumar S, Panetta JC, Pasquier E. Formalizing an Integrative, Multidisciplinary Cancer Therapy Discovery Workflow. Cancer Res. 2013 Oct;73(20):6111-6117. Pubmedid: 23955390.
  • Enderling H, Hlatky L, Hahnfeldt P. Immunoediting: evidence of the multifaceted role of the immune system in self-metastatic tumor growth. Theor Biol Med Model. 2013 Apr;9:31. Pubmedid: 22838395. Pmcid: PMC3499182.
  • Gao X, McDonald JT, Hlatky L, Enderling H. Acute and fractionated irradiation differentially modulate glioma stem cell division kinetics. Cancer Res. 2013 Mar;73(5):1481-1490. Pubmedid: 23269274. Pmcid: PMC3594421.
  • Enderling H. Cancer stem cells and tumor dormancy. Adv Exp Med Biol. 2013;734:55-71. Pubmedid: 23143975.
  • Enderling H, Hlatky L, Hahnfeldt P. Cancer Stem Cells: A Minor Cancer Subpopulation that Redefines Global Cancer Features. Front Oncol. 2013;3:76. Pubmedid: 23596563. Pmcid: PMC3625721.
  • Enderling H. Unveiling stem cell kinetics: prime time for integrating experimental and computational models. Front Oncol. 2013;3:291. Pubmedid: 24350056. Pmcid: PMC3842622.
  • Enderling H, Rejniak KA. Simulating cancer: computational models in oncology. Front Oncol. 2013;3:233. Pubmedid: 24062986. Pmcid: PMC3772565.
  • Hillen T, Enderling H, Hahnfeldt P. The tumor growth paradox and immune system-mediated selection for cancer stem cells. Bull Math Biol. 2012 Dec;75(1):161-184. Pubmedid: 23196354.
  • Sasi SP, Yan X, Enderling H, Park D, Gilbert HY, Curry C, Coleman C, Hlatky L, Qin G, Kishore R, Goukassian DA. Breaking the 'harmony' of TNF-α signaling for cancer treatment. Oncogene. 2012 Nov;31(37):4117-4127. Pubmedid: 22158049.
  • Enderling H, Hlatky L, Hahnfeldt P. The promoting role of a tumour-secreted chemorepellent in self-metastatic tumour progression. Math Med Biol. 2012 Jul;29(1):21-29. Pubmedid: 20929852.
  • Morton CI, Hlatky L, Hahnfeldt P, Enderling H. Non-stem cancer cell kinetics modulate solid tumor progression. Theor Biol Med Model. 2012 Jun;8:48. Pubmedid: 22208390. Pmcid: PMC3285090.
  • Enderling H, Hahnfeldt P, Hlatky L, Almog N. Systems biology of tumor dormancy: linking biology and mathematics on multiple scales to improve cancer therapy. Cancer Res. 2012 May;72(9):2172-2175. Pubmedid: 22414579. Pmcid: PMC3374524.
  • Enderling H, Hahnfeldt P. Cancer stem cells in solid tumors: is 'evading apoptosis' a hallmark of cancer?. Prog Biophys Mol Biol. 2011 Dec;106(2):391-399. Pubmedid: 21473880.
  • Tang J, Enderling H, Becker-Weimann S, Pham C, Polyzos A, Chen CY, Costes SV. Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling. Integr Biol (Camb). 2011 Apr;3(4):408-421. Pubmedid: 21373705.
  • Enderling H, Chaplain MA, Hahnfeldt P. Quantitative modeling of tumor dynamics and radiotherapy. Acta Biotheor. 2011 Jan;58(4):341-353. Pubmedid: 20658170.
  • Enderling H, Hlatky L, Hahnfeldt P. Tumor morphological evolution: directed migration and gain and loss of the self-metastatic phenotype. Biol Direct. 2010 Jul;5:23. Pubmedid: 20406441. Pmcid: PMC2868833.
  • Enderling H, Anderson AR, Chaplain MA, Beheshti A, Hlatky L, Hahnfeldt P. Paradoxical dependencies of tumor dormancy and progression on basic cell kinetics. Cancer Res. 2009 Nov;69(22):8814-8821. Pubmedid: 19887613.
  • Enderling H, Hlatky L, Hahnfeldt P. Migration rules: tumours are conglomerates of self-metastases. Br J Cancer. 2009 Jul;100(12):1917-1925. Pubmedid: 19455139. Pmcid: PMC2714240.
  • Enderling H, Alexander NR, Clark ES, Branch KM, Estrada L, Crooke C, JourquinJ, Lobdell N, Zaman MH, Guelcher SA, Anderson AR, Weaver AM. Dependence of invadopodia function on collagen fiber spacing and cross-linking: computational modeling and experimental evidence. Biophys J. 2008 Sep;95(5):2203-2218. Pubmedid: 18515372.
  • Enderling H, Chaplain M, Anderson A, Vaidya J. A mathematical model of breast cancer development, local treatment and recurrence. J Theor Biol. 2007 May;246(2):245-259. Pubmedid: 17289081.
  • Enderling H, Anderson AR, Chaplain MA, Rowe GW. Visualisation of the numerical solution of partial differential equation systems in three space dimensions and its importance for mathematical models in biology. Math Biosci Eng. 2006 Oct;3(4):571-582. Pubmedid: 20361833.
  • Enderling H, Anderson A, Chaplain M, Munro A, Vaidya J. Mathematical modelling of radiotherapy strategies for early breast cancer. J Theor Biol. 2006 Jul;241(1):158-171. Pubmedid: 16386275.
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