Gary Daughdrill, PhD

Where You Are:
Gary Daughdrill, PhD

Office  (813) 974-2503

Education And Training
  • PhD, University of Oregon, 1997 - Biochemistry

  • Chen L, Borcherds W, Wu S, Becker A, Schonbrunn E, Daughdrill GW, Chen J. Autoinhibition of MDMX by intramolecular p53 mimicry. Proc Natl Acad Sci U S A. 2015 Apr;112(15):4624-4629. Pubmedid: 25825738. Pmcid: PMC4403185.
  • Kennedy JA, Daughdrill GW, Schmidt KH. A transient α-helical molecular recognition element in the disordered N-terminus of the Sgs1 helicase is critical for chromosome stability and binding of Top3/Rmi1. Nucleic Acids Res. 2013 Dec;41(22):10215-10227. Pubmedid: 24038467. Pmcid: PMC3905885.
  • Zhan YA, Wu H, Powell AT, Daughdrill GW, Ytreberg FM. Impact of the K24N mutation on the transactivation domain of p53 and its binding to murine double-minute clone 2. Proteins. 2013 Oct;81(10):1738-1747. Pubmedid: 23609977. Pmcid: PMC4160123.
  • Borcherds W, Kashtanov S, Wu H, Daughdrill GW. Structural divergence is more extensive than sequence divergence for a family of intrinsically disordered proteins. Proteins. 2013 Apr;81(10):1686-1698. Pubmedid: 23606624.
  • Daughdrill GW, Borcherds WM, Wu H. Disorder predictors also predict backbone dynamics for a family of disordered proteins. PLoS One. 2012 Aug;6(12):e29207. Pubmedid: 22195023. Pmcid: PMC3240651.
  • Doi K, Li R, Sung SS, Wu H, Liu Y, Manieri W, Krishnegowda G, Awwad A, Dewey A, Liu X, Amin S, Cheng C, Qin Y, Schonbrunn E, Daughdrill G, Loughran TP, Sebti S, Wang HG. Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation. J Biol Chem. 2012 Mar;287(13):10224-10235. Pubmedid: 22311987. Pmcid: PMC3323047.
  • Daughdrill GW, Kashtanov S, Stancik A, Hill SE, Helms G, Muschol M, Receveur-Bréchot V, Ytreberg FM. Understanding the structural ensembles of a highly extended disordered protein. Mol Biosyst. 2012 Jan;8(1):308-319. Pubmedid: 21979461. Pmcid: PMC3645981.
  • Kashtanov S, Borcherds W, Wu H, Daughdrill GW, Ytreberg FM. Using chemical shifts to assess transient secondary structure and generate ensemble structures of intrinsically disordered proteins. Methods Mol Biol. 2012;895:139-152. Pubmedid: 22760318.
  • Daughdrill GW. Protein dynamics: bridging the gap. Nat Chem Biol. 2011 Apr;7(4):193-194. Pubmedid: 21423160.
  • Sota M, Yano H, Hughes JM, Daughdrill GW, Abdo Z, Forney LJ, Top EM. Shifts in the host range of a promiscuous plasmid through parallel evolution of its replication initiation protein. ISME J. 2010 Dec;4(12):1568-1580. Pubmedid: 20520653. Pmcid: PMC3042886.
  • Daughdrill GW, Narayanaswami P, Gilmore SH, Belczyk A, Brown CJ. Dynamic behavior of an intrinsically unstructured linker domain is conserved in the face of negligible amino acid sequence conservation. J Mol Evol. 2007 Sep;65(3):277-288. Pubmedid: 17721672.
  • Olson KE, Narayanaswami P, Vise PD, Lowry DF, Wold MS, Daughdrill GW. Secondary structure and dynamics of an intrinsically unstructured linker domain. J Biomol Struct Dyn. 2005 Oct;23(2):113-124. Pubmedid: 16060685.
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