G. Douglas Letson, MD

Where You Are:
G. Douglas Letson, MD

Senior Member

"Dr. Letson and his collaborators strive to expand the development of novel drugs for the treatment of sarcomas."

Office  (813) 745-3976

Education And Training
  • Resident, Louisiana State Medical School Affiliated Hospitals, 1993 - Orthopaedics
  • Fellow, Harvard Medical School, 1992 - Musculoskeletal Oncology
  • MD, Louisiana State University, 1988
  • Intern, Charity Hospital of Louisiana, 1988


Matrix metalloproteinases.

  • Xu H, Niu X, Li Y, Binitie OT, Letson GD, Cheong D. What Are the Results Using the Modified Trapdoor Procedure to Treat Chondroblastoma of the Femoral Head?. Clin Orthop Relat Res. 2014 Aug. Pubmedid: 25115583.
  • Wu H, Zhang L, Shao H, Sokol L, Sotomayor E, Letson D, Bui MM. Prognostic significance of soft tissue extension, international prognostic index, and multifocality in primary bone lymphoma: a single institutional experience. Brit J Haematol. 2014 Jul;166(1):60-68. Pubmedid: 24673481.
  • Haddox CL, Han G, Anijar L, Binitie O, Letson GD, Bui MM, Reed DR. Osteosarcoma in pediatric patients and young adults: a single institution retrospective review of presentation, therapy, and outcome. Sarcoma. 2014 Jun;2014:402509. Pubmedid: 24976784. Pmcid: PMC4021746.
  • Cubitt CL, Menth J, Dawson J, Martinez GV, Foroutan P, Morse DL, Bui MM, Letson GD, Sullivan DM, Reed DR. Rapid screening of novel agents for combination therapy in sarcomas. Sarcoma. 2013 Nov;2013:365723. Pubmedid: 24282374. Pmcid: PMC3824404.
  • Deneve JL, Messina JL, Bui MM, Marzban SS, Letson GD, Cheong D, Gonzalez RJ, Sondak VK, Zager JS. Cutaneous leiomyosarcoma: treatment and outcomes with a standardized margin of resection. Cancer Control. 2013 Oct;20(4):307-312. Pubmedid: 24077407.
  • Kreahling JM, Foroutan P, Reed D, Martinez G, Razabdouski T, Bui MM, Raghavan M, Letson D, Gillies RJ, Altiok S. Wee1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomas. PLoS One. 2013 Sep;8(3):e57523. Pubmedid: 23520471. Pmcid: PMC3592874.
  • Mavrogenis AF, Lenze U, Rechl H, Letson GD, Ruggieri P. Recent developments in the surgical treatment of bone tumors and their impact on quality of life. Sarcoma. 2013 Aug;2013:826432. Pubmedid: 23935391. Pmcid: PMC3725717.
  • Perez MC, Padhya TA, Messina JL, Jackson RS, Gonzalez RJ, Bui MM, Letson GD, Cruse CW, Lavey RS, Cheong D, Forster MR, Fulp WJ, Sondak VK, Zager JS. Cutaneous angiosarcoma: a single-institution experience. Ann Surg Oncol. 2013 Jul;20(11):3391-3397. Pubmedid: 23835652.
  • Vohra NA, Turaga KK, Gonzalez RJ, Conley A, Reed D, Bui MM, Cheong D, Letson DG, Zager JS. The use of isolated limb infusion in limb threatening extremity sarcomas. Int J Hyperthermia. 2013 Jun;29(1):1-7. Pubmedid: 23205633.
  • Alexander GE, Gutierrez S, Nayak A, Palumbo BT, Cheong D, Letson GD, Santoni BG. Biomechanical model of a high risk impending pathologic fracture of the femur: Lesion creation based on clinically implemented scoring systems. Clin Biomech (Bristol, Avon). 2013 Apr;28(4):408-414. Pubmedid: 23597777.
  • Binitie O, Tejiram S, Conway S, Cheong D, Temple HT, Letson GD. Adult soft tissue sarcoma local recurrence after adjuvant treatment without resection of core needle biopsy tract. Clin Orthop Relat R. 2013 Mar;471(3):891-898. Pubmedid: 22968531. Pmcid: PMC3563812.
  • Isakoff MS, Barkauskas DA, Ebb D, Morris C, Letson GD. Poor survival for osteosarcoma of the pelvis: a report from the Children's Oncology Group. Clin Orthop Relat R. 2012 Jul;470(7):2007-2013. Pubmedid: 22354612. Pmcid: PMC3369072.
  • Henderson ER, Pepper AM, Letson GD. What are estimated reimbursements for lower extremity prostheses capable of surgical and nonsurgical lengthening?. Clin Orthop Relat Res. 2012 Apr;470(4):1194-1203. Pubmedid: 22125242. Pmcid: PMC3293973.
  • Henderson ER, Pepper AM, Marulanda G, Binitie OT, Cheong D, Letson GD. Outcome of lower-limb preservation with an expandable endoprosthesis after bone tumor resection in children. J Bone Joint Surg Am. 2012 Mar;94(6):537-547. Pubmedid: 22438003.
  • Henderson ER, Marulanda GA, Cheong D, Temple HT, Letson GD. Hip abductor moment arm--a mathematical analysis for proximal femoral replacement. J Orthop Surg Res. 2012 Mar;6:6. Pubmedid: 21266066. Pmcid: PMC3247065.
  • Finkelstein SE, Iclozan C, Bui MM, Cotter MJ, Ramakrishnan R, Ahmed J, Noyes DR, Cheong D, Gonzalez RJ, Heysek RV, Berman C, Lenox BC, Janssen W, Zager JS, Sondak VK, Letson GD, Antonia SJ, Gabrilovich DI. Combination of external beam radiotherapy (EBRT) with intratumoral injection of dendritic cells as neo-adjuvant treatment of high-risk soft tissue sarcoma patients. Int J Radiat Oncol Biol Phys. 2012 Feb;82(2):924-932. Pubmedid: 21398051.
  • Parsons CM, Pimiento JM, Cheong D, Marzban SS, Gonzalez RJ, Johnson D, Letson GD, Zager JS. The role of radical amputations for extremity tumors: a single institution experience and review of the literature. J Surg Oncol. 2012 Feb;105(2):149-155. Pubmedid: 21837679.
  • Kreahling JM, Gemmer JY, Reed D, Letson D, Bui M, Altiok S. MK1775, a Selective Wee1 Inhibitor, Shows Single-Agent Antitumor Activity against Sarcoma Cells. Mol Cancer Ther. 2012 Jan;11(1):174-182. Pubmedid: 22084170.
  • Mavrogenis AF, Lesensky J, Romagnoli C, Alberghini M, Letson GD, Ruggieri P. Atypical Lipomatous Tumors/Well-differentiated Liposarcomas: Clinical Outcome of 67 Patients. Orthopedics. 2011 Dec;34(12):e893-e898. Pubmedid: 22146207.
  • Palumbo BT, Henderson E, Letson D, Cheong D. Biology, classification, and managment of recurrent myxofibrosarcoma 21 years after resection. Am J Orthop (Belle Mead NJ). 2011 Nov;40(11):579-582. Pubmedid: 22263212.
  • Palumbo BT, Henderson ER, Groundland JS, Cheong D, Pala E, Letson GD, Ruggieri P. Advances in segmental endoprosthetic reconstruction for extremity tumors: a review of contemporary designs and techniques. Cancer Control. 2011 Jul;18(3):160-170. Pubmedid: 21666578.
  • Cheong D, Letson GD. Computer-assisted navigation and musculoskeletal sarcoma surgery. Cancer Control. 2011 Jul;18(3):171-176. Pubmedid: 21666579.
  • Turaga KK, Beasley GM, Kane JM, Delman KA, Grobmyer SR, Gonzalez RJ, Letson GD, Cheong D, Tyler DS, Zager JS. Limb preservation with isolated limb infusion for locally advanced nonmelanoma cutaneous and soft-tissue malignant neoplasms. Arch Surg. 2011 Jul;146(7):870-875. Pubmedid: 21768436.
  • Henderson ER, Groundland JS, Pala E, Dennis JA, Wooten R, Cheong D, Windhager R, Kotz RI, Mercuri M, Funovics PT, Hornicek FJ, Temple HT, Ruggieri P, Letson GD. Failure mode classification for tumor endoprostheses: retrospective review of five institutions and a literature review. J Bone Joint Surg Am. 2011 Mar;93(5):418-429. Pubmedid: 21368074.
  • Henderson ER, Jennings JM, Marulanda GA, Groundland JS, Cheong D, Letson GD. Enhancing soft tissue ingrowth in proximal femoral arthroplasty with aortograft sleeve a novel technique and early results. J Arthroplasty. 2011 Jan;26(1):161-163. Pubmedid: 20801613.
  • Marulanda GA, Henderson E, Cheong D, Letson GD. Proximal and total humerus reconstruction with the use of an aortograft mesh. Clin Orthop Relat Res. 2010 Nov;468(11):2896-2903. Pubmedid: 20568029. Pmcid: PMC2947671.
  • Henderson ER, Pepper AM, Marulanda GA, Millard JD, Letson GD. What is the emotional acceptance after limb salvage with an expandable prosthesis?. Clin Orthop Relat Res. 2010 Nov;468(11):2933-2938. Pubmedid: 20632139. Pmcid: PMC2947674.
  • Kraybill WG, Harris J, Spiro IJ, Ettinger DS, DeLaney TF, Blum RH, Lucas DR, Harmon DC, Letson GD, Eisenberg B. Long-term results of a phase 2 study of neoadjuvant chemotherapy and radiotherapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall: Radiation Therapy Oncology Group Trial 9514. Cancer. 2010 Oct;116(19):4613-4621. Pubmedid: 20572040. Pmcid: PMC3780573.
  • Farma JM, Ammori JB, Zager JS, Marzban SS, Bui MM, Bichakjian CK, Johnson TM, Lowe L, Sabel MS, Wong SL, Letson GD, Messina JL, Cimmino VM, Sondak VK. Dermatofibrosarcoma protuberans: how wide should we resect?. Ann Surg Oncol. 2010 Aug;17(8):2112-2118. Pubmedid: 20354798.
  • Demetri GD, Antonia S, Benjamin RS, Bui MM, Casper ES, Conrad EU, DeLaney TF, Ganjoo KN, Heslin MJ, Hutchinson RJ, Kane JM, Letson GD, McGarry SV, O'Donnell RJ, Paz IB, Pfeifer JD, Pollock RE, Randall RL, Riedel RF, Schupak KD, Schwartz HS, Thornton K, von Mehren M, Wayne J. Soft tissue sarcoma. J Natl Compr Canc Ne. 2010 Jun;8(6):630-674. Pubmedid: 20581298.
  • Biermann JS, Adkins DR, Benjamin RS, Brigman B, Chow W, Conrad EU, Frassica DA, Frassica FJ, George S, Hande KR, Hornicek FJ, Letson GD, Mayerson J, McGarry SV, McGrath B, Morris CD, O'Donnell RJ, Randall RL, Santana VM, Satcher RL, Siegel HJ, Somaiah N, Yasko AW. Bone cancer. J Natl Compr Canc Netw. 2010 Jun;8(6):688-712. Pubmedid: 20581300.
  • Henderson ER, Jennings JM, Marulanda GA, Palumbo BT, Cheong D, Letson GD. Purse-string capsule repair to reduce proximal femoral arthroplasty dislocation for tumor--a novel technique with results. J Arthroplasty. 2010 Jun;25(4):654-657. Pubmedid: 20097040.
  • Alexander GE, Henderson ER, Rodriguez AR, Bui MM, Cheong D, Letson GD. Extraskeletal myxoid chondrosarcoma: rare presentation in the knee joint space. Orthopedics. 2009 Dec;32(12):919. Pubmedid: 19968226.
  • Potter BK, Chow VE, Adams SC, Letson GD, Temple HT. Endoprosthetic proximal femur replacement: metastatic versus primary tumors. Surg Oncol. 2009 Dec;18(4):343-349. Pubmedid: 18835153.
  • Marulanda G, Henderson E, Palumbo B, Alexander G, Cheong D, Letson G. Use of extendable prostheses: a limb-salvaging alternative for patients with malignant bone tumors. Expert Rev Med Devices. 2008 Jul;5(4):467-474. Pubmedid: 18573046.
  • Marulanda G, Mont M, Lucci A, Letson G, Khakpour N. Orthopedic surgery implications of breast cancer. Expert Rev Anticancer Ther. 2008 Jun;8(6):949-956. Pubmedid: 18533804.
  • Marulanda G, Henderson E, Johnson D, Letson G, Cheong D. Orthopedic surgery options for the treatment of primary osteosarcoma. Cancer Control. 2008 Jan;15(1):13-20. Pubmedid: 18094657.
  • Bui M, Smith P, Agresta S, Cheong D, Letson G. Practical issues of intraoperative frozen section diagnosis of bone and soft tissue lesions. Cancer Control. 2008 Jan;15(1):7-12. Pubmedid: 18094656.
  • Biermann J, Adkins D, Benjamin R, Brigman B, Chow W, Conrad EU 3rd, Frassica D, Frassica F, George S, Healey J, Heck R J, Letson G, Mayerson J, McGarry S, O'donnell R, Patt J, Randall R, Santana V, Satcher R, Schmidt R, Siegel H, Wong M, Yasko A. Bone cancer. J Natl Compr Canc Netw. 2007 Apr;5(4):420-437. Pubmedid: 17442233.
  • Demetri G, Baker L, Benjamin R, Casper E, Conrad EU 3rd, D'Amato G, Delaney T, Ettinger D, Heck R J, Heslin M, Hutchinson R, Jacobs C, Kiel K, Kraybill W, Letson G, O'donnell R, Paz I, Pfeifer J, Pollock R, Randall R, Sasson A, Schupak K, Tyler D, Mehren M, Wayne J. Soft tissue sarcoma. J Natl Compr Canc Netw. 2007 Apr;5(4):364-399. Pubmedid: 17442230.
  • Shor AC, Keschman EA, Lee FY, Muro-Cacho C, Letson GD, Trent JC, Pledger WJ, Jove R. Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival. Cancer Res. 2007 Mar;67(6):2800-2808. Pubmedid: 17363602.
  • Kraybill W, Harris J, Spiro I, Ettinger D, DeLaney T, Blum R, Lucas DR, Harmon D, Letson G, Eisenberg B. Phase II study of neoadjuvant chemotherapy and radiation therapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall: Radiation Therapy Oncology Group Trial 9514. J Clin Oncol. 2006 Feb;24(4):619-625. Pubmedid: 16446334.
  • Letson G. Soft tissue sarcoma: status in 2005. Cancer Control. 2005 Jan;12(1):2-2. Pubmedid: 15668647.
  • Knapp E, Kransdorf M, Letson G. Diagnostic imaging update: soft tissue sarcomas. Cancer Control. 2005 Jan;12(1):22-26. Pubmedid: 15668649.
  • Saba HI, Morelli GA, Azam RR, Klein CJ, Letson GD. Efficacy of NovoSeven during surgery on a haemophiliac with previous history of inhibitors. Haemophilia. 2003 Jan;9(1):131-136. Pubmedid: 12558792.
  • Neel M, Letson G. Modular endoprostheses for children with malignant bone tumors. Cancer Control. 2001;8(4):344-348. Pubmedid: 11483888.
  • Kim C, Puleo C, Letson G, Reintgen D. Hyperthermic isolated limb perfusion for extremity sarcoma. Cancer Control. 2001;8(3):269-273. Pubmedid: 11378653.
  • Strickland L, Letson GD, Muro-Cacho C. Gastrointestinal stromal tumors. Cancer Control. 2001;8(3):252-261. Pubmedid: 11378651.
  • Letson G, Muro-Cacho C. Genetic and molecular abnormalities in tumors of the bone and soft tissues. Cancer Control. 2001;8(3):239-251. Pubmedid: 11378650.
  • Letson G, Ward W. Appropriate follow-up of orthopaedic oncology patients. Instr Course Lect. 1999;48:603-606. Pubmedid: 10098088.
  • Garcia E, Sandin R, Greene J, Baekey P, Walling A, Letson G, Choy J, Nicosia S, Moscinski L. Infections of the leg which mimic malignancy. Infect Med. 1998;15(8):557-567. Pubmedid: noPMID.
  • Letson G, Greenfield G, Heinrich S. Evaluation of the child with a bone or soft-tissue neoplasm. Orthop Clin North Am. 1996;27(3):431-451. Pubmedid: 8649727.
  • Letson G, et al.. Surgical treatment for osteosarcomas. A multimodality approach. Lippincott;
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