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Edward Turos, PhD

Where You Are:
Edward Turos, PhD

Office  (813) 974-7312

Education And Training
  • NIH Postdoctoral Fellow, Yale University, 1989 - Organic Synthesis
  • PhD, Penn State University, 1986 - Organic Chemistry
  • BS, Towson State University, 1982 - Chemistry

Dr. Turos' laboratory is interested in the design and synthesis of novel organic substances that can be used to inhibit cancer cell replication pathways or those pertaining to drug-resistant bacterial infections, as well as new types of nanoparticle polymers as vehicles for delivery of various classes of antibiotics and therapeutic agents.

  • Ramamoorthy D, Turos E, Guida WC. Identification of a New Binding Site in E. coli FabH using Molecular Dynamics Simulations: Validation by Computational Alanine Mutagenesis and Docking Studies. J Chem Inf Model. 2013 Apr;53(5):1138-1156. Pubmedid: 23581389.
  • Cormier R, Burda WN, Harrington L, Edlinger J, Kodigepalli KM, Thomas J, Kapolka R, Roma G, Anderson BE, Turos E, Shaw LN. Studies on the antimicrobial properties of N-acylated ciprofloxacins. Bioorg Med Chem Lett. 2012 Oct;22(20):6513-6520. Pubmedid: 22995622. Pmcid: PMC3757340.
  • Labruère R, Turos E. Attenuating the size and molecular carrier capabilities of polyacrylate nanoparticles by a hydrophobic fluorine effect. Bioorgan Med Chem. 2012 Aug;20(16):5042-5045. Pubmedid: 22789705.
  • Ramaraju P, Gergeres D, Turos E, Dickey S, Lim DV, Thomas J, Anderson B. Synthesis and antimicrobial activities of structurally novel S,S'-bis(heterosubstituted) disulfides. Bioorg Med Chem Lett. 2012 Jun;22(11):3623-3631. Pubmedid: 22560472.
  • Prosen KR, Carroll RK, Burda WN, Krute CN, Bhattacharya B, Dao ML, Turos E, Shaw LN. The impact of fatty acids on the antibacterial properties of N-thiolated β-lactams. Bioorg Med Chem Lett. 2011 Sep;21(18):5293-5295. Pubmedid: 21821415. Pmcid: PMC3159845.
  • Garay-Jimenez JC, Turos E. A convenient method to prepare emulsified polyacrylate nanoparticles from powders [corrected] for drug delivery applications. Bioorg Med Chem Lett. 2011 Aug;21(15):4589-4591. Pubmedid: 21704525.
  • Labruère R, Sicard R, Cormier R, Turos E, West L. Poly(vinyl benzoate) nanoparticles for molecular delivery: Studies on their preparation and in vitro properties. J Control Release. 2010 Dec;148(2):234-240. Pubmedid: 20728487.
  • Garay-Jimenez JC, Gergeres D, Young A, Lim DV, Turos E. Physical properties and biological activity of poly(butyl acrylate-styrene) nanoparticle emulsions prepared with conventional and polymerizable surfactants. Nanomedicine. 2010 Mar;5(4):443-451. Pubmedid: 19523413. Pmcid: PMC2806811.
  • Greenhalgh K, Turos E. In vivo studies of polyacrylate nanoparticle emulsions for topical and systemic applications. Nanomedicine. 2009 Mar;5(1):46-54. Pubmedid: 18824416.
  • Abeylath SC, Turos E. Drug delivery approaches to overcome bacterial resistance to beta-lactam antibiotics. Expert Opin Drug Deliv. 2008 Sep;5(9):931-949. Pubmedid: 18754746.
  • Chen D, Falsetti S, Frezza M, Milacic V, Kazi A, Cui Q, Long T, Turos E, Dou Q. Anti-tumor activity of N-thiolated beta-lactam antibiotics. Cancer Lett. 2008 Sep;268(1):63-69. Pubmedid: 18468785. Pmcid: PMC3777718.
  • O'Driscoll M, Greenhalgh K, Young A, Turos E, Dickey S, Lim DV. Studies on the antifungal properties of N-thiolated beta-lactams. Bioorgan Med Chem. 2008 Aug;16(16):7832-7837. Pubmedid: 18672374. Pmcid: PMC2617728.
  • Turos E, Revell KD, Ramaraju P, Gergeres DA, Greenhalgh K, Young A, Sathyanarayan N, Dickey S, Lim D, Alhamadsheh MM, Reynolds K. Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis. Bioorg Med Chem. 2008 Aug;16(13):6501-6508. Pubmedid: 18524602. Pmcid: PMC2526022.
  • Frezza M, Garay J, Chen D, Cui C, Turos E, Dou Q. Induction of tumor cell apoptosis by a novel class of N-thiolated beta-lactam antibiotics with structural modifications at N1 and C3 of the lactam ring. Int J Mol Med. 2008 Jun;21(6):689-695. Pubmedid: 18506361. Pmcid: PMC3786433.
  • Garay-Jimenez JC, Young A, Gergeres D, Greenhalgh K, Turos E. Methods for purifying and detoxifying sodium dodecyl sulfate-stabilized polyacrylate nanoparticles. Nanomedicine. 2008 Jun;4(2):98-105. Pubmedid: 18472305. Pmcid: PMC2580797.
  • Jung Y, Yoon C, Turos E, Yoo K, Jung K. Total Syntheses of (-)-alpha-Kainic Acid and (+)-alpha-Allokainic Acid via Stereoselective C-H Insertion and Efficient 3,4-Stereocontrol. J Org Chem. 2008 Apr;73(7):2959-2959. Pubmedid: 18275220.
  • Abeylath SC, Turos E, Dickey S, Lim DV. Glyconanobiotics: Novel carbohydrated nanoparticle antibiotics for MRSA and Bacillus anthracis. Bioorgan Med Chem. 2008 Mar;16(5):2412-2418. Pubmedid: 18063370. Pmcid: PMC2442916.
  • Jung YC, Yoon CH, Turos E, Yoo KS, Jung KW. Total syntheses of (-)-alpha-kainic acid and (+)-alpha-allokainic acid via stereoselective C-H insertion and efficient 3,4-stereocontrol. J Org Chem. 2007 Dec;72(26):10114-10122. Pubmedid: 18044924. Pmcid: PMC2536682.
  • Abeylath S, Turos E. Glycosylated polyacrylate nanoparticles by emulsion polymerization. Carbohydr Polym. 2007 Aug;70(1):32-37. Pubmedid: 18677404.
  • Turos E, Reddy GS, Greenhalgh K, Ramaraju P, Abeylath SC, Jang S, Dickey S, Lim DV. Penicillin-bound polyacrylate nanoparticles: restoring the activity of beta-lactam antibiotics against MRSA. Bioorg Med Chem Lett. 2007 Jun;17(12):3468-3472. Pubmedid: 17420125. Pmcid: PMC1992523.
  • Revell KD, Heldreth B, Long TE, Jang S, Turos E. N-thiolated beta-lactams: Studies on the mode of action and identification of a primary cellular target in Staphylococcus aureus. Bioorg Med Chem. 2007 Mar;15(6):2453-2467. Pubmedid: 17258460. Pmcid: PMC1850389.
  • Mishra R, Coates C, Revell K, Turos E. Synthesis of 2-oxazolidinones from beta-lactams: stereospecific total synthesis of (-)-cytoxazone and all of its stereoisomers. Org Lett. 2007 Feb;9(4):575-578. Pubmedid: 17286366.
  • Turos E, Shim JY, Wang Y, Greenhalgh K, Reddy GS, Dickey S, Lim DV. Antibiotic-conjugated polyacrylate nanoparticles: new opportunities for development of anti-MRSA agents. Bioorg Med Chem Lett. 2007 Jan;17(1):53-56. Pubmedid: 17049850. Pmcid: PMC1798659.
  • Heldreth B, Long T, Jang S, Reddy G, Turos E, Dickey S, Lim D. N-Thiolated beta-lactam antibacterials: effects of the N-organothio substituent on anti-MRSA activity. Bioorg Med Chem. 2006 Jun;14(11):3775-3784. Pubmedid: 16480881.
  • Mishra R, Revell K, Coates C, Turos E, Dickey S, Lim D. N-thiolated 2-oxazolidinones: a new family of antibacterial agents for methicillin-resistant Staphylococcus aureus and Bacillus anthracis. Bioorg Med Chem Lett. 2006 Apr;16(8):2081-2083. Pubmedid: 16464583.
  • Turos E, Long T, Heldreth B, Leslie J, Reddy G, Wang Y, Coates C, Konaklieva M, Dickey S, Lim D, Alonso E, Gonzalez J. N-thiolated beta-lactams: a new family of anti-Bacillus agents. Bioorg Med Chem Lett. 2006 Apr;16(8):2084-2090. Pubmedid: 16473509.
  • Turos E, Coates C, Shim J, Wang Y, Leslie J, Long T, Reddy G, Ortiz A, Culbreath M, Dickey S, Lim D, Alonso E, Gonzalez J. N-Methylthio beta-lactam antibacterials: effects of the C3/C4 ring substituents on anti-MRSA activity. Bioorg Med Chem. 2005 Dec;13(23):6289-6308. Pubmedid: 16185880.
  • Kuhn D, Wang Y, Minic V, Coates C, Reddy G, Daniel K, Shim J, Chen D, Landis-Piwowar K, Miller F, Turos E, Dou Q. Structure-activity relationships OF N-methylthiolated beta-lactam antibiotics with C3 substitutions and their selective induction of apoptosis in human cancer cells. Front Biosci. 2005 May;10:1183-1190. Pubmedid: 15769617.
  • Kuhn D, Coates C, Daniel K, Chen D, Bhuiyan M, Kazi A, Turos E, Dou Q. Beta-lactams and their potential use as novel anticancer chemotherapeutics drugs. Front Biosci. 2004;9:2605-2617. Pubmedid: 15358584.
  • Kazi A, Hill R, Long T, Kuhn D, Turos E, Dou Q. Novel N-thiolated beta-lactam antibiotics selectively induce apoptosis in human tumor and transformed, but not normal or nontransformed, cells. Biochem Pharmacol. 2004;67(2):365-374. Pubmedid: 14698048.
  • Long TE, Turos E, Konaklieva MI, Blum AL, Amry A, Baker EA, Suwandi LS, McCain MD, Rahman MF, Dickey S, Lim DV. Effect of aryl ring fluorination on the antibacterial properties of C4 aryl-substituted N-methylthio beta-lactams. Bioorg Med Chem. 2003 Apr;11(8):1859-1863. Pubmedid: 12659772.
  • Coates C, Long T, Turos E, Dickey S, Lim D. N-Thiolated beta-lactam antibacterials: defining the role of unsaturation in the C(4) side chain. Bioorg Med Chem. 2003;11(2):193-196. Pubmedid: 12470713.
  • Smith DM, Kazi A, Smith L, Long TE, Heldreth B, Turos E, Dou QP. A novel beta-lactam antibiotic activates tumor cell apoptotic program by inducing DNA damage. Mol Pharmacol. 2002 Jun;61(6):1348-1358. Pubmedid: 12021396.
  • Turos E, Long T, Konaklieva M, Coates C, Shim J, Dickey S, Lim D, Cannons A. N-thiolated beta-lactams: novel antibacterial agents for methicillin-resistant Staphylococcus aureus. Bioorg Med Chem Lett. 2002;12(16):2229-2231. Pubmedid: 12127544.
  • Lin Y, Turos E. Studies of silyl-accelerated 1,5-hydrogen migrations in vinylcyclopropanes. J Org Chem. 2001;66(26):8751-8759. Pubmedid: 11749603.
  • Lin Y, Turos E. Silyl-accelerated 1,5-hydrogen migrations in vinylcyclopropanes. J Am Chem Soc. 1999;121:856-857. Pubmedid: noPMID.
  • M. Konaklieva, H. Shi, Turos E. Palladium-promoted derivatizations of novel C-fused penum ring systems. Tetrahedron Lett. 1997;38:8647-8647. Pubmedid: noPMID.
  • Jiang S, Agoston G, Chen T, Paz-Cabal M, Riaz U, Ahsan K, Turos E. New allylation and [3+2]-cycloaddition methodology using allylic (cyclopentadienyl) iron(II) dicarbonyl complexes. Recent Res Dev Org Chem. 1997;1:229-237. Pubmedid: noPMID.
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