Eduardo Moros, PhD

Where You Are:
Eduardo Moros, PhD

Senior Member

"To create physics and engineering models and systems for the scientific testing of biomedical hypothesis in vitro, in vivo, and in clinical trials."

Education And Training
  • PhD, University of Arizona, 1990 - Mechanical Engineering, Minor in Electrical Engineering
  • MSci, University of Arizona, 1987 - Mechanical Engineering

My career has been characterized by the development of mathematical models, devices, techniques and systems for both the laboratory and the clinic for the advancement of cancer research. Currently, I am interested in novel ways of using our ability to sculpt radiation dose in radiation oncology to enhance the beneficial effects of radiotherapy; for example, by activating drugs, genes or nanoparticles in a dose-dependent manner.  I am also interested in novel therapeutic applications of high intensity focused ultrasound.

  • Lieblong BJ, Sridharan V, Srivastava AK, Moros EG, Sharma SK, Boerma M. Role of the bradykinin B2 receptor in a rat model of local heart irradiation. Int J Radiat Biol. 2015 May;1-29. Pubmedid: 25955317.
  • Sridharan V, Tripathi P, Aykin-Burns N, Krager KJ, Sharma SK, Moros EG, Melnyk SB, Pavliv O, Hauer-Jensen M, Boerma M. A tocotrienol-enriched formulation protects against radiation-induced changes in cardiac mitochondria without modifying late cardiac function or structure. Radiat Res. 2015 Mar;183(3):357-366. Pubmedid: 25710576.
  • Sharma S, Moros EG, Boerma M, Sridharan V, Han EY, Clarkson R, Hauer-Jensen M, Corry PM. A novel technique for image-guided local heart irradiation in the rat. Technol Cancer Res Treat. 2014 Dec;13(6):593-603. Pubmedid: 24000983. Pmcid: PMC3951712.
  • Mellon EA, Javedan K, Strom TJ, Moros EG, Biagioli MC, Fernandez DC, Wasserman SG, Wilder RB. A dosimetric comparison of volumetric modulated arc therapy with step-and-shoot intensity modulated radiation therapy for prostate cancer. Pract Radiat Oncol. 2014 Nov;5(1):11-15. Pubmedid: 25413432.
  • Zhang DG, Feygelman V, Moros EG, Latifi K, Zhang GG. Monte carlo study of radiation dose enhancement by gadolinium in megavoltage and high dose rate radiotherapy. PLoS One. 2014 Oct;9(10):e109389. Pubmedid: 25275550. Pmcid: PMC4183586.
  • Javedan K, Feygelman V, Zhang RR, Moros EG, Correa CR, Trotti A, Li W, Zhang GG. Monte Carlo comparison of superficial dose between flattening filter free and flattened beams. Phys Med. 2014 Jun;30(4):503-508. Pubmedid: 24662096.
  • Nelms BE, Opp D, Zhang G, Moros E, Feygelman V. Motion as perturbation. II. Development of the method for dosimetric analysis of motion effects with fixed-gantry IMRT. Med Phys. 2014 Jun;41(6):061704. Pubmedid: 24877799.
  • Latifi K, Oliver J, Baker R, Dilling TJ, Stevens CW, Kim J, Yue B, Demarco M, Zhang GG, Moros EG, Feygelman V. Study of 201 non-small cell lung cancer patients given stereotactic ablative radiation therapy shows local control dependence on dose calculation algorithm. Int J Radiat Oncol Biol Phys. 2014 Apr;88(5):1108-1113. Pubmedid: 24529716.
  • Kuykendall CC, Budzevich MM, Latifi K, Moros EG, Hoffe SE, Dilling TJ, Zhang GG, Montilla-Soler JL, Eikman EA. 4D PET/CT: Radiology Imaging to Radiation Therapy. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S28. Pubmedid: 24674534.
  • Budzevich MM, Kuykendall CC, Latifi K, Oliver J, Dilling TJ, Hoffe SE, Eikman EA, Montilla-Soler JI, Zhang GG, Moros EG. A Method to Determine the Optimal Number of Bins in 4D PET. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S25. Pubmedid: 24674527.
  • Zhang GG, Latifi K, Huang T, Feygelman V, Stevens CW, Dilling TJ, Moros EG, Elmpt Wv, Dekker A. Effects of Noise in 4D CT on Deformable Image Registration and Derived Ventilation Data. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S7-S8. Pubmedid: 24674566.
  • Sridharan V, Aykin-Burns N, Tripathi P, Krager KJ, Sharma SK, Moros EG, Corry PM, Nowak G, Hauer-Jensen M, Boerma M. Radiation-induced alterations in mitochondria of the rat heart. Radiat Res. 2014 Mar;181(3):324-334. Pubmedid: 24568130. Pmcid: PMC4029615.
  • Figura N, Latifi K, Dilling TJ, Kuykendall CC, Eikman EA, Moros EG, Zhang GG, Leuthold S, Mehra C, Hoffe SE. Dosimetric Implications of Treating 4D PET/CT-Defined Maximum Inhale Versus Exhale Target Volumes in Esophageal Cancer. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S34-S35. Pubmedid: 24674556.
  • Feygelman V, Stambaugh C, Opp D, Zhang G, Moros EG, Nelms BE. Cross-validation of two commercial methods for volumetric high-resolution dose reconstruction on a phantom for non-coplanar VMAT beams. Radiother Oncol. 2014 Mar;110(3):558-561. Pubmedid: 24440044.
  • Latifi K, Dilling TJ, Hoffe SE, Stevens CW, Moros EG, Zhang GG. Evaluating Effects of Radiation Therapy Treatment on 4DCT-Calculated Lung Ventilation. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S6-S7. Pubmedid: 24674563.
  • Myerson RJ, Moros EG, Diederich CJ, Haemmerich D, Hurwitz MD, Hsu IC, McGough RJ, Nau WH, Straube WL, Turner PF, Vujaskovic Z, Stauffer PR. Components of a hyperthermia clinic: Recommendations for staffing, equipment, and treatment monitoring. Int J Hyperthermia. 2014 Feb;30(1):1-5. Pubmedid: 24350642.
  • Sridharan V, Tripathi P, Sharma S, Corry PM, Moros EG, Singh A, Compadre CM, Hauer-Jensen M, Boerma M. Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation. PLoS One. 2014 Feb;8(7):e68762. Pubmedid: 23894340. Pmcid: PMC3718790.
  • Sridharan V, Tripathi P, Sharma S, Moros EG, Zheng J, Hauer-Jensen M, Boerma M. Roles of sensory nerves in the regulation of radiation-induced structural and functional changes in the heart. Int J Radiat Oncol Biol Phys. 2014 Jan;88(1):167-174. Pubmedid: 24331664. Pmcid: PMC3868013.
  • Mihaylov IB, Moros EG. Mathematical Formulation of DMH-Based Inverse Optimization. Front Oncol. 2014;4:331. Pubmedid: 25478325. Pmcid: PMC4235072.
  • Latifi K, Huang TC, Feygelman V, Budzevich MM, Moros EG, Dilling TJ, Stevens CW, van Elmpt W, Dekker A, Zhang GG. Effects of quantum noise in 4D-CT on deformable image registration and derived ventilation data. Phys Med Biol. 2013 Nov;58(21):7661-7672. Pubmedid: 24113375.
  • Stambaugh C, Nelms BE, Dilling T, Stevens C, Latifi K, Zhang G, Moros E, Feygelman V. Experimentally studied dynamic dose interplay does not meaningfully affect target dose in VMAT SBRT lung treatments. Med Phys. 2013 Sep;40(9):091710. Pubmedid: 24007143.
  • Sridharan V, Sharma SK, Moros EG, Corry PM, Tripathi P, Lieblong BJ, Guha C, Hauer-Jensen M, Boerma M. Effects of radiation on the epidermal growth factor receptor pathway in the heart. Int J Radiat Biol. 2013 Jul;89(7):539-547. Pubmedid: 23488537. Pmcid: PMC3700655.
  • Saeed N, Latifi K, Hoffe SE, Cruz A, Opp DW, Moros EG, Zhang GG, Budzevich MM, Shridhar R, Dilling TJ. Optimizing Options for Re-irradiation With Deformable Image Registration of Prior Plans. Pract Radiat Oncol. 2013 Apr;3(2 Suppl 1):S16-S17. Pubmedid: 24674497.
  • Varma S, Myerson R, Moros E, Taylor M, Straube W, Zoberi I. Simultaneous radiotherapy and superficial hyperthermia for high-risk breast carcinoma: a randomised comparison of treatment sequelae in heated versus non-heated sectors of the chest wall hyperthermia. Int J Hyperthermia. 2013 Mar;28(7):583-590. Pubmedid: 22946861.
  • Zhang RR, Feygelman V, Harris ER, Rao N, Moros EG, Zhang GG. Is wax equivalent to tissue in electron conformal therapy planning? A Monte Carlo study of material approximation introduced dose difference. J Appl Clin Med Phys. 2013;14(1):3991. Pubmedid: 23318384.
  • Latifi K, Feygelman V, Moros EG, Dilling TJ, Stevens CW, Zhang GG. Normalization of ventilation data from 4D-CT to facilitate comparison between datasets acquired at different times. PLoS One. 2013;8(12):e84083. Pubmedid: 24358330. Pmcid: PMC3866128.
  • Sridharan V, Tripathi P, Sharma SK, Moros EG, Corry PM, Lieblong BJ, Kaschina E, Unger T, Thöne-Reineke C, Hauer-Jensen M, Boerma M. Cardiac inflammation after local irradiation is influenced by the kallikrein-kinin system. Cancer Res. 2012 Oct;72(19):4984-4992. Pubmedid: 22865451. Pmcid: PMC3463770.
  • Nelms BE, Opp D, Robinson J, Wolf TK, Zhang G, Moros E, Feygelman V. VMAT QA: measurement-guided 4D dose reconstruction on a patient. Med Phys. 2012 Jul;39(7):4228-4238. Pubmedid: 22830756.
  • Griffin RJ, Koonce NA, Dings RP, Siegel E, Moros EG, Bräuer-Krisch E, Corry PM. Microbeam radiation therapy alters vascular architecture and tumor oxygenation and is enhanced by a galectin-1 targeted anti-angiogenic peptide. Radiat Res. 2012 Jun;177(6):804-812. Pubmedid: 22607585. Pmcid: PMC3391740.
  • Asur RS, Sharma S, Chang CW, Penagaricano J, Kommuru IM, Moros EG, Corry PM, Griffin RJ. Spatially fractionated radiation induces cytotoxicity and changes in gene expression in bystander and radiation adjacent murine carcinoma cells. Radiat Res. 2012 Jun;177(6):751-765. Pubmedid: 22559204. Pmcid: PMC3395590.
  • Chao M, Penagaricano J, Yan Y, Moros EG, Corry P, Ratanatharathorn V. Voxel-based dose reconstruction for total body irradiation with helical tomotherapy. Int J Radiat Oncol Biol Phys. 2012 Apr;82(5):1575-1583. Pubmedid: 21470791.
  • Han EY, Zhang X, Yan Y, Sharma S, Penagaricano J, Moros E, Corry P. Static jaw collimation settings to minimize radiation dose to normal brain tissue during stereotactic radiosurgery. Med Dosim. 2012 Apr. Pubmedid: 22552119.
  • Mihaylov IB, Fatyga M, Bzdusek K, Gardner K, Moros EG. Biological optimization in volumetric modulated arc radiotherapy for prostate carcinoma. Int J Radiat Oncol Biol Phys. 2012 Mar;82(3):1292-1298. Pubmedid: 21570214.
  • Chen D, Xia R, Corry PM, Moros EG, Shafirstein G. SonoKnife for ablation of neck tissue: In vivo verification of a computer layered medium model. Int J Hyperthermia. 2012;28(7):698-705. Pubmedid: 22946601.
  • Chen D, Xia R, Chen X, Shafirstein G, Corry PM, Griffin RJ, Penagaricano JA, Tulunay-Ugur OE, Moros EG. SonoKnife: feasibility of a line-focused ultrasound device for thermal ablation therapy. Med Phys. 2011 Jul;38(7):4372-4385. Pubmedid: 21859038. Pmcid: PMC3145222.
  • Chen X, Novák P, Benson DG, Webber JS, Hennings L, Shafirstein G, Corry PM, Griffin RJ, Moros EG. An alternating focused ultrasound system for thermal therapy studies in small animals. Med Phys. 2011 Apr;38(4):1877-1887. Pubmedid: 21626921. Pmcid: PMC3069994.
  • Chao M, Xie Y, Moros EG, Le QT, Xing L. Image-based modeling of tumor shrinkage in head and neck radiation therapy. Med Phys. 2010 May;37(5):2351-2358. Pubmedid: 20527569. Pmcid: PMC2874043.
  • Peñagarícano JA, Moros EG, Ratanatharathorn V, Yan Y, Corry P. Evaluation of spatially fractionated radiotherapy (GRID) and definitive chemoradiotherapy with curative intent for locally advanced squamous cell carcinoma of the head and neck: initial response rates and toxicity. Int J Radiat Oncol Biol Phys. 2010 Apr;76(5):1369-1375. Pubmedid: 19625138.
  • Pickard WF, Moros EG, Shafirstein G. Electromagnetic and thermal evaluation of an applicator specialized to permit high-resolution non-perturbing optical evaluation of cells being irradiated in the W-band. Bioelectromagnetics. 2010 Feb;31(2):140-149. Pubmedid: 19731242.
  • Moros EG, Peñagaricano J, Novàk P, Straube WL, Myerson RJ. Present and future technology for simultaneous superficial thermoradiotherapy of breast cancer. Int J Hyperthermia. 2010;26(7):699-709. Pubmedid: 20849263. Pmcid: PMC2943851.
  • Nahirnyak VM, Moros EG, Novák P, Suzanne Klimberg V, Shafirstein G. Doppler signals observed during high temperature thermal ablation are the result of boiling. Int J Hyperthermia. 2010;26(6):586-593. Pubmedid: 20569109. Pmcid: PMC2922477.
  • Peñagarícano JA, Moros E, Novák P, Yan Y, Corry P. Feasibility of concurrent treatment with the scanning ultrasound reflector linear array system (SURLAS) and the helical tomotherapy system. Int J Hyperthermia. 2008 Aug;24(5):377-388. Pubmedid: 18608592. Pmcid: PMC2879076.
  • Trobaugh JW, Arthur RM, Straube WL, Moros EG. A simulation model for ultrasonic temperature imaging using change in backscattered energy. Ultrasound Med Biol. 2008 Jul;34(2):289-298. Pubmedid: 17935869. Pmcid: PMC2269725.
  • Shafirstein G, Novák P, Moros EG, Siegel E, Hennings L, Kaufmann Y, Ferguson S, Myhill J, Swaney M, Spring P. Conductive interstitial thermal therapy device for surgical margin ablation: in vivo verification of a theoretical model. Int J Hyperthermia. 2007 Sep;23(6):477-492. Pubmedid: 17852514.
  • Myerson RJ, Singh AK, Bigott HM, Cha B, Engelbach JA, Kim J, Lamoreaux WT, Moros E, Novak P, Sharp TL, Straube W, Welch MJ, Xu M. Monitoring the effect of mild hyperthermia on tumour hypoxia by Cu-ATSM PET scanning. Int J Hyperthermia. 2006 Mar;22(2):93-115. Pubmedid: 16754595.
  • Arthur RM, Trobaugh JW, Straube WL, Moros EG. Temperature dependence of ultrasonic backscattered energy in motion-compensated images. Ieee Trans Ultrason Ferroelectr Freq Control. 2005 Oct;52(10):1644-1652. Pubmedid: 16382617.
  • Laszlo A, Moros EG, Davidson T, Bradbury M, Straube W, Roti Roti J. The heat-shock factor is not activated in mammalian cells exposed to cellular phone frequency microwaves. Radiat Res. 2005 Aug;164(2):163-172. Pubmedid: 16038587.
  • Hook GJ, Spitz DR, Sim JE, Higashikubo R, Baty JD, Moros EG, Roti Roti JL. Evaluation of parameters of oxidative stress after in vitro exposure to FMCW- and CDMA-modulated radiofrequency radiation fields. Radiat Res. 2004 Nov;162(5):497-504. Pubmedid: 15624304.
  • Hook GJ, Zhang P, Lagroye I, Li L, Higashikubo R, Moros EG, Straube WL, Pickard WF, Baty JD, Roti Roti JL. Measurement of DNA damage and apoptosis in Molt-4 cells after in vitro exposure to radiofrequency radiation. Radiat Res. 2004 Feb;161(2):193-200. Pubmedid: 14731070.
  • La Regina M, Moros EG, Pickard WF, Straube WL, Baty J, Roti Roti JL. The effect of chronic exposure to 835.62 MHz FDMA or 847.74 MHz CDMA radiofrequency radiation on the incidence of spontaneous tumors in rats. Radiat Res. 2003 Aug;160(2):143-151. Pubmedid: 12859224.
  • Bisht KS, Moros EG, Straube WL, Baty JD, Roti Roti JL. The effect of 835.62 MHz FDMA or 847.74 MHz CDMA modulated radiofrequency radiation on the induction of micronuclei in C3H 10T(1/2) cells. Radiat Res. 2002 May;157(5):506-515. Pubmedid: 11966316.
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