Ed Seto, PhD

Where You Are:
Ed Seto, PhD

Senior Member

"The focus of our research is to obtain a complete understanding of the functions, mechanisms of action, and regulation of histone deacetylases (HDACs)."

Office  (813) 745-6754

Education And Training
  • Fellow, Princeton University, 1992 - Molecular Biology
  • PhD, University of California, San Francisco, 1990


The major interest of the Seto laboratory is in the area of functions, mechanisms of action, and regulations of histone deacetylases (HDACs). In addition to the work on HDACs in transcriptional co-repressor complexes, our lab discovered that HDACs regulate important biological processes beyond histone modification.

  • Cheng F, Lienlaf M, Wang HW, Perez-Villarroel P, Lee C, Woan K, Rock-Klotz J, Sahakian E, Woods D, Pinilla-Ibarz J, Kalin J, Tao J, Hancock W, Kozikowski A, Seto E, Villagra A, Sotomayor EM. A Novel Role for Histone Deacetylase 6 in the Regulation of the Tolerogenic STAT3/IL-10 Pathway in APCs. J Immunol. 2014 Sep;193(6):2850-2862. Pubmedid: 25108026.
  • Wang J, Elahi A, Ajidahun A, Clark W, Hernandez J, Achille A, Hao JH, Seto E, Shibata D. The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer. Cancer Biol Ther. 2014 Sep;15(9):1198-1207. Pubmedid: 24919179.
  • Cheng F, Lienlaf M, Perez-Villarroel P, Wang HW, Lee C, Woan K, Woods D, Knox T, Bergman J, Pinilla-Ibarz J, Kozikowski A, Seto E, Sotomayor EM, Villagra A. Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells. Mol Immunol. 2014 Jul;60(1):44-53. Pubmedid: 24747960. Pmcid: PMC4020151.
  • Zhang M, Xiang S, Joo HY, Wang L, Williams KA, Liu W, Hu C, Tong D, Haakenson J, Wang C, Zhang S, Pavlovicz RE, Jones A, Schmidt KH, Tang J, Dong H, Shan B, Fang B, Radhakrishnan R, Glazer PM, Matthias P, Koomen J, Seto E, Bepler G, Nicosia SV, Chen J, Li C, Gu L, Li GM, Bai W, Wang H, Zhang X. HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα. Mol Cell. 2014 Jul;55(1):31-46. Pubmedid: 24882211. Pmcid: PMC4188514.
  • Monteiro JB, Colón-Díaz M, García M, Gutierrez S, Colón M, Seto E, Laboy J, Flores I. Endometriosis is characterized by a distinct pattern of histone 3 and histone 4 lysine modifications. Reprod Sci. 2014 Mar;21(3):305-318. Pubmedid: 23899551.
  • Zheng H, Yang L, Peng L, Izumi V, Koomen J, Seto E, Chen J. hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SirT1. Mol Cell Biol. 2013 Dec;33(24):4960-4970. Pubmedid: 24126058. Pmcid: PMC3889553.
  • Yang L, Song T, Chen L, Kabra N, Zheng H, Koomen J, Seto E, Chen J. Regulation of SirT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability. Mol Cell Biol. 2013 Oct;33(19):3835-3848. Pubmedid: 23897426. Pmcid: PMC3811878.
  • Woods DM, Woan K, Cheng F, Wang H, Perez-Villarroel P, Lee C, Lienlaf M, Atadja P, Seto E, Weber J, Sotomayor EM, Villagra A. The antimelanoma activity of the histone deacetylase inhibitor panobinostat (LBH589) is mediated by direct tumor cytotoxicity and increased tumor immunogenicity. Melanoma Res. 2013 Aug. Pubmedid: 23963286.
  • Ling H, Peng L, Seto E, Fukasawa K. Suppression of centrosome duplication and amplification by deacetylases. Cell Cycle. 2012 Oct;11(20):3779-3791. Pubmedid: 23022877. Pmcid: PMC3495821.
  • Zhang X, Zhao X, Fiskus W, Lin J, Lwin T, Rao R, Zhang Y, Chan JC, Fu K, Marquez VE, Chen-Kiang S, Moscinski LC, Seto E, Dalton WS, Wright KL, Sotomayor E, Bhalla K, Tao J. Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-Cell lymphomas. Cancer Cell. 2012 Oct;22(4):506-523. Pubmedid: 23079660. Pmcid: PMC3973134.
  • Liu Y, Peng L, Seto E, Huang S, Qiu Y. Modulation of histone deacetylase 6 (HDAC6) nuclear import and tubulin deacetylase activity through acetylation. J Biol Chem. 2012 Aug;287(34):29168-29174. Pubmedid: 22778253. Pmcid: PMC3436516.
  • Peng L, Ling H, Yuan Z, Fang B, Bloom G, Fukasawa K, Koomen J, Chen J, Lane WS, Seto E. SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60. Mol Cell Biol. 2012 Jul;32(14):2823-2836. Pubmedid: 22586264. Pmcid: PMC3416197.
  • Zhang X, Chen X, Lin J, Lwin T, Wright G, Moscinski LC, Dalton WS, Seto E, Wright K, Sotomayor E, Tao J. Myc represses miR-15a/miR-16-1 expression through recruitment of HDAC3 in mantle cell and other non-Hodgkin B-cell lymphomas. Oncogene. 2012 Jun;31(24):3002-3008. Pubmedid: 22002311. Pmcid: PMC3982396.
  • Kahali S, Sarcar B, Prabhu A, Seto E, Chinnaiyan P. Class I histone deacetylases localize to the endoplasmic reticulum and modulate the unfolded protein response. FASEB J. 2012 Jun;26(6):2437-2445. Pubmedid: 22389438.
  • Pellett PE, Ablashi DV, Ambros PF, Agut H, Caserta MT, Descamps V, Flamand L, Gautheret-Dejean A, Hall CB, Kamble RT, Kuehl U, Lassner D, Lautenschlager I, Loomis KS, Luppi M, Lusso P, Medveczky PG, Montoya JG, Mori Y, Ogata M, Pritchett JC, Rogez S, Seto E, Ward KN, Yoshikawa T, Razonable RR. Chromosomally integrated human herpesvirus 6: questions and answers. Rev Med Virol. 2012 May;22(3):144-155. Pubmedid: 22052666. Pmcid: PMC3498727.
  • Colón-Díaz M, Báez-Vega P, García M, Ruiz A, Monteiro JB, Fourquet J, Bayona M, Alvarez-Garriga C, Achille A, Seto E, Flores I. HDAC1 and HDAC2 are differentially expressed in endometriosis. Reprod Sci. 2012 May;19(5):483-492. Pubmedid: 22344732. Pmcid: PMC3343094.
  • Woan KV, Sahakian E, Sotomayor EM, Seto E, Villagra A. Modulation of antigen-presenting cells by HDAC inhibitors: implications in autoimmunity and cancer. Immunol Cell Biol. 2012 Jan;90(1):55-65. Pubmedid: 22105512. Pmcid: PMC3990411.
  • Peng L, Yuan Z, Ling H, Fukasawa K, Robertson K, Olashaw N, Koomen J, Chen J, Lane WS, Seto E. SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. Mol Cell Biol. 2011 Dec;31(23):4720-4734. Pubmedid: 21947282. Pmcid: PMC3232929.
  • Tang M, Chen B, Lin T, Li Z, Pardo C, Pampo C, Chen J, Lien CL, Wu L, Ai L, Wang H, Yao K, Oh SP, Seto E, Smith LE, Siemann DW, Kladde MP, Cepko CL, Lu J. Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation. Proc Natl Acad Sci U S A. 2011 Sep;108(37):15231-15236. Pubmedid: 21896759. Pmcid: PMC3174592.
  • Kaluza D, Kroll J, Gesierich S, Yao TP, Boon RA, Hergenreider E, Tjwa M, Rössig L, Seto E, Augustin HG, Zeiher AM, Dimmeler S, Urbich C. Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. EMBO J. 2011 Aug;30(20):4142-4156. Pubmedid: 21847094.
  • Yang Y, Tse AK, Li P, Ma Q, Xiang S, Nicosia SV, Seto E, Zhang X, Bai W. Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation. Oncogene. 2011 Jul;30(19):2207-2218. Pubmedid: 21242980. Pmcid: PMC3093431.
  • Wang H, Cheng F, Woan K, Sahakian E, Merino O, Rock-Klotz J, Vicente-Suarez I, Pinilla-Ibarz J, Wright KL, Seto E, Bhalla K, Villagra A, Sotomayor EM. Histone deacetylase inhibitor LAQ824 augments inflammatory responses in macrophages through transcriptional regulation of IL-10. J Immunol. 2011 Apr;186(7):3986-3996. Pubmedid: 21368229. Pmcid: PMC3998678.
  • Peng L, Seto E. Deacetylation of Nonhistone Proteins by HDACs and the Implications in Cancer. Handb Exp Pharmacol. 2011;(206):39-56. Pubmedid: 21879445.
  • Wong PG, Glozak MA, Cao TV, Vaziri C, Seto E, Alexandrow M. Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin. Cell Cycle. 2010 Nov;9(21):4351-4363. Pubmedid: 20980834. Pmcid: PMC3055186.
  • Yuan Z, Villagra A, Peng L, Coppola D, Glozak M, Sotomayor EM, Chen J, Lane WS, Seto E. The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions. Mol Cell Biol. 2010 Jun;30(12):3004-3015. Pubmedid: 20368352. Pmcid: PMC2876676.
  • Villagra A, Sotomayor EM, Seto E. Histone deacetylases and the immunological network: implications in cancer and inflammation. Oncogene. 2010 Jan;29(2):157-173. Pubmedid: 19855430.
  • Glozak MA, Seto E. Acetylation/deacetylation modulates the stability of DNA replication licensing factor CDt1. J Biol Chem. 2009 Apr;284(17):11446-11453. Pubmedid: 19276081.
  • Villagra A, Cheng F, Wang HW, Suarez I, Glozak M, Maurin M, Nguyen D, Wright KL, Atadja PW, Bhalla K, Pinilla-Ibarz J, Seto E, Sotomayor EM. The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance. Nat Immunol. 2009 Jan;10(1):92-100. Pubmedid: 19011628. Pmcid: PMC3925685.
  • Yuan Z, Rezai-Zadeh N, Zhang X, Seto E. Histone deacetylase activity assay. Methods Mol Biol. 2009;523:279-293. Pubmedid: 19381932.
  • Ellis D, Yuan Z, Seto E. Determination of protein lysine deacetylation. Curr Protoc Protein Sci. 2008 Nov;Chapter 14:Unit 14.12-Unit 14.12. Pubmedid: 19016433.
  • Roy S, Shor AC, Bagui TK, Seto E, Pledger WJ. Histone deacetylase 5 represses the transcription of cyclin D3. J Cell Biochem. 2008 Aug;104(6):2143-2154. Pubmedid: 18404677.
  • Villagra A, Ulloa N, Zhang X, Yuan Z, Sotomayor E, Seto E. Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression. J Biol Chem. 2007 Dec;282(49):35457-35470. Pubmedid: 17925399.
  • Yuan Z, Seto E. A Functional Link Between SIRT1 Deacetylase and NBS1 in DNA Damage Response. Cell Cycle. 2007 Dec;6(23):2869-2871. Pubmedid: 18156798.
  • Glozak M, Seto E. Histone deacetylases and cancer. Oncogene. 2007 Aug;26(37):5420-5432. Pubmedid: 17694083.
  • Zhang X, Yuan Z, Zhang Y, Yong S, Salas-Burgos A, Koomen J, Olashaw N, Parsons JT, Yang XJ, Dent SR, Yao TP, Lane WS, Seto E. HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell. 2007 Jul;27(2):197-213. Pubmedid: 17643370. Pmcid: PMC2684874.
  • Yuan Z, Zhang X, Sengupta N, Lane WS, Seto E. SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell. 2007 Jul;27(1):149-162. Pubmedid: 17612497. Pmcid: PMC2679807.
  • Feng W, Lu Z, Luo RZ, Zhang X, Seto E, Liao WS, Yu Y. Multiple histone deacetylases repress tumor suppressor gene ARHI in breast cancer. Int J Cancer. 2007 Apr;120(8):1664-1668. Pubmedid: 17230502.
  • Gregoire S, Xiao L, Nie J, Zhang X, Xu M, Li J, Wong J, Seto E, Yang X. Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. Mol Cell Biol. 2007 Feb;27(4):1280-1295. Pubmedid: 17158926. Pmcid: PMC1800729.
  • Joshi B, Rastogi S, Morris M, Carastro L, DeCook C, Seto E, Chellappan S. Differential regulation of human YY1 and caspase 7 promoters by prohibitin through E2F1 and p53 binding sites. Biochem J. 2007 Jan;401(1):155-166. Pubmedid: 16918502.
  • Lee H, Sengupta N, Villagra A, Rezai-Zadeh N, Seto E. Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation. Mol Cell Biol. 2006 Jul;26(14):5259-5269. Pubmedid: 16809764.
  • Glozak M, Sengupta N, Zhang X, Seto E. Acetylation and deacetylation of non-histone proteins. Gene. 2005 Dec;363:15-23. Pubmedid: 16289629.
  • Wang C, Ivanov A, Chen L, Fredericks WJ, Seto E, Rauscher FJ, Chen J. MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. Embo J. 2005 Nov;24(18):3279-3290. Pubmedid: 16107876. Pmcid: PMC1224681.
  • Bali P, Pranpat M, Bradner J, Balasis M, Fiskus W, Guo F, Rocha K, Kumaraswamy S, Boyapalle S, Atadja P, Seto E, Bhalla K. Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors. J Biol Chem. 2005 Jul;280(29):26729-26734. Pubmedid: 15937340.
  • Baumeister P, Luo S, Skarnes W, Sui G, Seto E, Shi Y, Lee A. Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers. Mol Cell Biol. 2005 Jun;25(11):4529-4540. Pubmedid: 15899857.
  • Gao Z, Chiao P, Zhang X, Zhang X, Lazar MA, Seto E, Young HA, Ye J. Coactivators and corepressors of NF-kappaB in IkappaB alpha gene promoter. J Biol Chem. 2005 Jun;280(22):21091-21098. Pubmedid: 15811852. Pmcid: PMC1237005.
  • Zhang X, Ozawa Y, Lee H, Wen Y, Tan T, Wadzinski B, Seto E. Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. Gene Dev. 2005 Apr;19(7):827-839. Pubmedid: 15805470. Pmcid: PMC1074320.
  • Zhang X, Wharton W, Yuan Z, Tsai SC, Olashaw N, Seto E. Activation of the growth-differentiation factor 11 gene by the histone deacetylase (HDAC) inhibitor trichostatin A and repression by HDAC3. Mol Cell Biol. 2004 Jun;24(12):5106-5118. Pubmedid: 15169878. Pmcid: PMC419886.
  • Rezai-Zadeh N, Tsai S, Wen Y, Yang W, Seto E. Histone deacetylases: purification of the enzymes, substrates, and assay conditions. Methods Enzymol. 2004;377:167-179. Pubmedid: 14979024.
  • Lee H, Rezai-Zadeh N, Seto E. Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A. Mol Cell Biol. 2004;24(2):765-773. Pubmedid: 14701748.
  • Sengupta N, Seto E. Regulation of histone deacetylase activities. J Cell Biochem. 2004;93(1):57-67. Pubmedid: 15352162.
  • Gyory I, Wu J, Fejer G, Seto E, Wright K. PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing. Nat Immunol. 2004;5(3):299-308. Pubmedid: 14985713.
  • Nguyen N, Zhang X, Olashaw N, Seto E. Molecular cloning and functional characterization of the transcription factor YY2. J Biol Chem. 2004;279(24):25927-25934. Pubmedid: 15087442.
  • Weiss C, Schneider S, Wagner E, Zhang X, Seto E, Bohmann D. JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun. Embo J. 2003 Jul;22(14):3686-3695. Pubmedid: 12853483. Pmcid: PMC165634.
  • Rezai-Zadeh N, Zhang X, Namour F, Fejer G, Wen YD, Yao YL, Gyory I, Wright K, Seto E. Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1. Gene Dev. 2003 Apr;17(8):1019-1029. Pubmedid: 12704081. Pmcid: PMC196041.
  • Gyory I, Fejer G, Ghosh N, Seto E, Wright KL. Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines. J Immunol. 2003 Mar;170(6):3125-3133. Pubmedid: 12626569.
  • Wen YD, Cress WD, Roy AL, Seto E. Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I. J Biol Chem. 2003;278(3):1841-1847. Pubmedid: 12393887.
  • Seto E. Histone modifications. Methods. 2003;31(1-2):1-2. Pubmedid: 12893167.
  • Kapustin G, Fejer G, Gronlund J, McCafferty D, Seto E, Etzkorn F. Phosphorus-based SAHA analogues as histone deacetylase inhibitors. Org Lett. 2003;5(17):3053-3056. Pubmedid: 12916979.
  • Yang W, Tsai S, Wen Y, Fejer G, Seto E. Functional domains of histone deacetylase-3. J Biol Chem. 2002;277(11):9447-9454. Pubmedid: 11779848.
  • Tsai S, Seto E. Regulation of histone deacetylase 2 by protein kinase CK2. J Biol Chem. 2002;277(35):31826-31833. Pubmedid: 12082111.
  • Yang W, Seto E. Regulation of transcription factor YY1 by acetylation and deacetylation. Mol Cell Biol. 2001;21(17):5979-5991. Pubmedid: 11486036.
  • Wu W, Vallian S, Seto E, Yang W, Edmondson D, Roth S, Chang K. The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases. Mol Cell Biol. 2001;21(7):2259-2268. Pubmedid: 11259576.
  • Yang W, Seto E. The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1. Embo J. 2001;20(17):4814-4825. Pubmedid: 11532945.
  • Osborne A, Zhang H, Yang W, Seto E, Blanck G. Histone deacetylase activity represses gamma interferon-inducible HLA-DR gene expression following the establishment of a DNase I-hypersensitive chromatin conformation. Mol Cell Biol. 2001;21(19):6495-6506. Pubmedid: 11533238.
  • Wharton W, Savell J, Cress WD, Seto E, Pledger WJ. Inhibition of mitogenesis in Balb/c-3T3 cells by Trichostatin A. Multiple alterations in the induction and activation of cyclin-cyclin-dependent kinase complexes. J Biol Chem. 2000 Oct;275(43):33981-33987. Pubmedid: 10945992.
  • Juan L, Shia W, Chen M, Yang W, Seto E, Lin Y, Wu C. Histone deacetylases specifically down-regulate p53-dependent gene activation. J Biol Chem. 2000;275(27):20436-20443. Pubmedid: 10777477.
  • Cress, Jr. W, Seto E. Histone deacetylases, transcriptional control, and cancer. J Cell Physiol. 2000;184(1):1-16. Pubmedid: 10825229.
  • Wei L, Hu X, Chandra D, Seto E, Faroqui M. Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing. J Biol Chem. 2000;275(52):40782-40787. Pubmedid: 15130509.
  • Lutterbach B, Westendorf J, Linggi B, Isaac S, Seto E, Hiebert S. A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia. J Biol Chem. 2000;275(1):651-656. Pubmedid: 10617663.
  • Tsai S, Valkov N, Yang W, Gump J, Sullivan D, Seto E. Histone deacetylase interacts directly with DNA topoisomerase II. Nat Genet. 2000;26(3):349-353. Pubmedid: 11062478.
  • Wen Y, Perissi V, Staszewski L, Yang W, Krones A, Glass C, Rosenfeld M, Seto E. The histone deacetylase-3 complex contains nuclear receptor corepressors. Proc Natl Acad Sci U S A. 2000;97(13):7202-7207. Pubmedid: 10860984.
  • Jepsen K, Hermanson O, Onami O, Gleiberman A, Lunyak V, McEvilly R, Kurokawa R, Kumar V, Liu F, Seto E, Hedrick S, Mandel G, Glass C, Rose D, Rosenfeld M. Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell. 2000;102(6):753-763. Pubmedid: 11030619.
  • Thomas M, Seto E. Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?. Gene. 1999;236(2):197-208. Pubmedid: 10452940.
  • Lai A, Lee J, Yang W, DeCaprio J, Kaelin W, Seto E, Branton P. RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins. Mol Cell Biol. 1999;19(10):6632-6641. Pubmedid: 10490602.
  • Sasaki S, Lesoon-Wood L, Dey A, Kuwata T, Weintraub B, Humphrey G, Yang W, Seto E, Howard B, Ozato K. Ligand-induced recruitment of a histone deacetylase in the negative-feedback regulation of the thyrotropin-beta gene. Embo J. 1999;18(19):5389-5398. Pubmedid: 10508171.
  • Tang C, Westling J, Seto E. Trans-repression of the human metallothionein IIA gene promoter by PZ120, a novel 120 kilodalton zinc finger protein. Mol Cell Biol. 1999;19(1):680-689. Pubmedid: 9858591.
  • McNeil S, Guo B, Stein J, Lian J, Bushmeyer S, Seto E, Atchison M, Penman S, Wijnen A, Stein G. Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking. J Cell Biochem. 1998;68(4):500-510. Pubmedid: 9493912.
  • Azizan A, Cong Y, Shain K, Tsai S, Olashaw N, Seto E. Transactivation by expression of the hepatitis B virus X protein with an inducible system. Mol Biol Rep. 1998;25(4):231-236. Pubmedid: 9870613.
  • Zeng Y, Tang C, Yang W, Seto E. Cloning and characterization of the mouse histone deacetylase-2 gene. J Biol Chem. 1998;273(44):28921-28930. Pubmedid: 9786895.
  • Dupont B, Ghosh S, Fang Y, Leach R, Seto E. Cloning, chromosomal localization and promoter analysis of the human transcription factor YY1. Nucleic Acids Res. 1998;26(16):3776-3783. Pubmedid: 9685495.
  • Heinzel T, Lavinsky R, Mullen T, Soderstrom M, Laherty C, Torchia J, Yang W, Brard G, Ngo S, Davie J, Seto E, Eisenman R, Rose D, Glass C, Rosenfield M. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature. 1997;387:43-48. Pubmedid: 9139820.
  • Cong Y, Kuzhandaivelu N, Seto E. The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein. J Biol Chem. 1997;272:16482-16489. Pubmedid: 9195957.
  • Soderstrom M, Vo A, Heinzel T, Lavinsky R, Yang W, Seto E, Peterson D, Rosenfield M, Glass C. Differential effects of nuclear receptor corepressor (N-CoR) expression levels on retinoic acid receptor-mediated repression support the existence of dynamically regulated corepressor complexes. Mol Endocrinol. 1997;11:682-692. Pubmedid: 9171232.
  • Laherty C, Yang W, Sun J, Davie J, Seto E, Eisenman R. Histone deacetylases associated with the mSIN3 corepressor mediate mad transcriptional repression. Cell. 1997;89:349-356. Pubmedid: 9150134.
  • Yang W, Yao Y, Sun J, Davie J, Seto E. Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family. J Biol Chem. 1997;272(44):28001-28007. Pubmedid: 9346952.
  • Tang C, Tomkinson A, Lane W, Wold M, Seto E. Replication protein A is a component of a complex that binds the human metallothionein IIA gene transcription start site. J Biol Chem. 1996;271:21637-21645. Pubmedid: 8702952.
  • Kuzhandaivelu N, Cong Y, Inouye C, Yang W, Seto E. XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation. Nucleic Acids Res. 1996;24:4741-4750. Pubmedid: 8972861.
  • Adrian G, Seto E, Fischbach K, Rivera E, Adrian E, Herbert D, Walters C, Weaker F, Bowman B. YY1 and Sp1 transcription factors bind the human transferrin gene in an age-related manner. J Gerontol. 1996;51:66-75. Pubmedid: 8548503.
  • Yang W, Inouye C, Zeng Y, Bearss D, Seto E. Replication protein A is a component of a complex that binds the human metallothionein IIA gene transcription start site. J Biol Chem. 1996;93:12845-12850.
  • Ghosh S, Toth C, Peterlin BM, Seto E. Synergistic activation of transcription by the mutant and wild-type minimal transcriptional activation domain of VP16. J Biol Chem. 1996;271(17):9911-9918. Pubmedid: 8626627.
  • Yang W, Inouye C, Zeng Y, Bearss D, Seto E. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc Natl Acad Sci U S A. 1996;93:12845-12850. Pubmedid: 8917507.
  • Lewis B, Tullis G, Seto E, Horikoshi N, Weinmann R, Shenk T. Adenovirus E1A proteins interact with the cellular YY1 transcription factor. J Virol. 1995;69:1628-1636. Pubmedid: 7853498.
  • Yang W, Inouye C, Seto E. Cyclophilin A and FKBP12 interacts with YY1 and alters its transcriptional activity. J Biol Chem. 1995;270:15187-15193. Pubmedid: 7541038.
  • Inouye C, Seto E. Relief of YY1-induced transcriptional repression by protein-protein interaction with the nucleolar phosphoprotein B 23. J Biol Chem. 1994;269(9):6506-6510. Pubmedid: 8120001.
  • Seto E, Lewis B, Shenk T. Interaction between transcription factors Sp1 and YY1. Nature. 1993;365:462-464.
  • Seto E, Usheva A, Zambetti G, Momand J, Horikoshi N, Weinmann R, Levine A, Shenk T. Wild-type p53 binds to the TATA-binding protein and represses transcription. Proc Natl Acad Sci U S A. 1992;89:12028-12032.
  • Lutterbach B, Westendorf J, Linggi B, Patten T, Moniwa M, Davie J, Huynh K, Bardwell V, Lavinsky R, Rosenfeld M, Glass C, Seto E, Hiebert S. ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors. Mol Cell Biol. 1998;18(12):7176-7184. Pubmedid: 9819404.
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