David Basanta Gutierrez, PhD

Where You Are:
David Basanta Gutierrez, PhD

Assistant Member

"To understand the evolutionary dynamics of cancer using integrative approaches so that one day we will be able to exert some control on cancer progression."

Office  (813) 745-6433

Education And Training
  • Postdoctoral fellow, H. Lee Moffitt Cancer Center & Research Institute, 2011 - Integrated Mathematical Oncology
  • PhD, Kings College, London, 2005 - Computational Materials Science
  • MEng, Universidad de Oviedo, School of Technical Engineers, 2000 - Computer Science
  • BSc, Universidad de Oviedo, School of Technical Engineers, 1997 - Computer Science

Cancer is a disease in which genetic mutations play an important role but one in which evolution, in the Darwinian sense of the world, directs progression. Oftentimes this progression is towards increasingly malignant phenotypes. This evolutionary process is influenced by the interactions of the different tumour cells with each other but also by the interactions of these tumour populations with their environment.

If we are going to understand and learn how to exert some control in cancer progression we need methods and approaches that can handle this evolutionary and ecological perspective of cancer. Given the complexity of this disease, mathematical and computational methods are not only useful but also necessary. For this reason my work will focus on mathematical and computational models of cancer evolution. I will be using tools already employed in theoretical ecology but will also develop new ones as needed and will make sure that they are part of an integrated research where the models are biologically inspired and validated and the results have a clinical impact.

  • Frieling JS, Basanta D, Lynch CC. Current and emerging therapies for bone metastatic castration-resistant prostate cancer. Cancer Control. 2015 Jan;22(1):109-120. Pubmedid: 25504285.
  • Gallaher J, Cook LM, Gupta S, Araujo A, Dhillon J, Park JY, Scott JG, Pow-Sang J, Basanta D, Lynch CC. Improving treatment strategies for patients with metastatic castrate resistant prostate cancer through personalized computational modeling. Clin Exp Metastas. 2014 Dec;31(8):991-999. Pubmedid: 25173680.
  • Araujo A, Cook LM, Lynch CC, Basanta D. An integrated computational model of the bone microenvironment in bone-metastatic prostate cancer. Cancer Res. 2014 May;74(9):2391-2401. Pubmedid: 24788098. Pmcid: PMC4023121.
  • Scott JG, Hjelmeland AB, Chinnaiyan P, Anderson AR, Basanta D. Microenvironmental variables must influence intrinsic phenotypic parameters of cancer stem cells to affect tumourigenicity. PLoS Comput Biol. 2014 Jan;10(1):e1003433. Pubmedid: 24453958.
  • Kim E, Rebecca VW, Fedorenko IV, Messina JL, Mathew R, Maria-Engler SS, Basanta D, Smalley KS, Anderson AR. Senescent fibroblasts in melanoma initiation and progression: an integrated theoretical, experimental, and clinical approach. Cancer Res. 2013 Dec;73(23):6874-6885. Pubmedid: 24080279. Pmcid: PMC3926439.
  • Basanta D, Anderson AR. Exploiting ecological principles to better understand cancer progression and treatment. Interface Focus. 2013 Aug;3(4):20130020. Pubmedid: 24511383. Pmcid: PMC3915838.
  • Scott JG, Basanta D, Anderson AR, Gerlee P. A mathematical model of tumour self-seeding reveals secondary metastatic deposits as drivers of primary tumour growth. J R Soc Interface. 2013 May;10(82):20130011. Pubmedid: 23427099. Pmcid: PMC3627086.
  • Basanta D, Gatenby RA, Anderson AR. Exploiting evolution to treat drug resistance: combination therapy and the double bind. Mol Pharm. 2012 Apr;9(4):914-921. Pubmedid: 22369188. Pmcid: PMC3325107.
  • Hatzikirou H, Basanta D, Simon M, Schaller K, Deutsch A. 'Go or Grow': the key to the emergence of invasion in tumour progression?. Math Med Biol. 2012 Mar;29(1):49-65. Pubmedid: 20610469.
  • Basanta D, Scott JG, Fishman MN, Ayala G, Hayward SW, Anderson AR. Investigating prostate cancer tumour-stroma interactions: clinical and biological insights from an evolutionary game. Brit J Cancer. 2012 Jan;106(1):174-181. Pubmedid: 22134510. Pmcid: PMC3251863.
  • Scott JG, Basanta D, Chinnaiyan P, Canoll P, Swanson KR, Anderson AR. Production of 2-hydroxyglutarate by isocitrate dehydrogenase 1-mutated gliomas: an evolutionary alternative to the Warburg shift?. Neurooncol. 2011 Dec;13(12):1262-1264. Pubmedid: 21784755. Pmcid: PMC3223086.
  • Gerlee P, Basanta D, Anderson AR. Evolving homeostatic tissue using genetic algorithms. Prog Biophys Mol Biol. 2011 Aug;106(2):414-425. Pubmedid: 21419156. Pmcid: PMC3812677.
  • Basanta D, Scott JG, Rockne R, Swanson KR, Anderson AR. The role of IDH1 mutated tumour cells in secondary glioblastomas: an evolutionary game theoretical view. Phys Biol. 2011 Feb;8(1):015016. Pubmedid: 21301070. Pmcid: PMC3166886.
  • Basanta D, Ribba B, Watkin E, You B, Deutsch A. Computational analysis of the influence of the microenvironment on carcinogenesis. Math Biosci. 2011 Jan;229(1):22-29. Pubmedid: 21044636.
  • Strand DW, Franco OE, Basanta D, Anderson AR, Hayward SW. Perspectives on tissue interactions in development and disease. Curr Mol Med. 2010 Feb;10(1):95-112. Pubmedid: 20205682. Pmcid: PMC4195241.
  • Anderson AR, Hassanein M, Branch KM, Lu J, Lobdell NA, Maier J, Basanta D, Weidow B, Narasanna A, Arteaga CL, Reynolds AB, Quaranta V, Estrada L, Weaver AM. Microenvironmental independence associated with tumor progression. Cancer Res. 2009 Nov;69(22):8797-8806. Pubmedid: 19887618. Pmcid: PMC2783510.
  • Basanta D, Strand DW, Lukner RB, Franco OE, Cliffel DE, Ayala GE, Hayward SW, Anderson AR. The role of transforming growth factor-beta-mediated tumor-stroma interactions in prostate cancer progression: an integrative approach. Cancer Res. 2009 Sep;69(17):7111-7120. Pubmedid: 19706777. Pmcid: PMC2748342.
  • Basanta D, Simon M, Hatzikirou H, Deutsch A. Evolutionary game theory elucidates the role of glycolysis in glioma progression and invasion. Cell Prolif. 2008 Dec;41(6):980-987. Pubmedid: 19040573.
  • Basanta D, Miodownik M, Baum B. The evolution of robust development and homeostasis in artificial organisms. PLoS Comput Biol. 2008 Mar;4(3):e1000030. Pubmedid: 18369424. Pmcid: PMC2274883.
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